Published in J Neurosci on February 09, 2005
Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation. Cell (2010) 2.23
Axon growth and guidance: receptor regulation and signal transduction. Annu Rev Neurosci (2009) 2.20
The many substrates of presenilin/γ-secretase. J Alzheimers Dis (2011) 2.02
Spatial segregation of gamma-secretase and substrates in distinct membrane domains. J Biol Chem (2005) 1.98
Signaling from axon guidance receptors. Cold Spring Harb Perspect Biol (2010) 1.62
RAGE inhibition in microglia prevents ischemia-dependent synaptic dysfunction in an amyloid-enriched environment. J Neurosci (2014) 1.47
Pathological and physiological functions of presenilins. Mol Neurodegener (2006) 1.38
Presenilin: RIP and beyond. Semin Cell Dev Biol (2008) 1.33
Presenilin-dependent receptor processing is required for axon guidance. Cell (2011) 1.22
Protein kinase A-dependent step(s) in hepatitis C virus entry and infectivity. J Virol (2008) 1.12
Presenilin-dependent intramembrane cleavage of ephrin-B1. Mol Neurodegener (2006) 1.11
Synaptic autoregulation by metalloproteases and γ-secretase. J Neurosci (2011) 1.08
Regulation of tyrosinase trafficking and processing by presenilins: partial loss of function by familial Alzheimer's disease mutation. Proc Natl Acad Sci U S A (2005) 1.07
Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel gamma-secretase substrates. Mol Neurodegener (2006) 1.05
Novel GαS-protein signaling associated with membrane-tethered amyloid precursor protein intracellular domain. J Neurosci (2012) 1.02
Protease regulation: the Yin and Yang of neural development and disease. Neuron (2011) 1.00
Presenilin/gamma-secretase cleaves CD46 in response to Neisseria infection. J Immunol (2009) 0.91
Amyloid precursor protein regulates netrin-1-mediated commissural axon outgrowth. J Biol Chem (2012) 0.90
The neogenin intracellular domain regulates gene transcription via nuclear translocation. Mol Cell Biol (2008) 0.89
Cellular distribution of gamma-secretase subunit nicastrin in the developing and adult rat brains. Neurobiol Aging (2007) 0.87
APP Receptor? To Be or Not To Be. Trends Pharmacol Sci (2016) 0.85
Localization and regional distribution of p23/TMP21 in the brain. Neurobiol Dis (2008) 0.82
Steady-state increase of cAMP-response element binding protein, Rac, and PAK signaling in presenilin-deficient neurons. J Neurochem (2007) 0.79
Modeling presenilin-dependent familial Alzheimer's disease: emphasis on presenilin substrate-mediated signaling and synaptic function. Int J Alzheimers Dis (2010) 0.78
Loss of presenilin function is associated with a selective gain of APP function. Elife (2016) 0.77
The Intracellular Domain of the Frazzled/DCC Receptor Is a Transcription Factor Required for Commissural Axon Guidance. Neuron (2015) 0.77
The role of presenilin cofactors in the gamma-secretase complex. Nature (2003) 5.03
Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice. Cell (2005) 4.25
Differential usage of non-homologous end-joining and homologous recombination in double strand break repair. DNA Repair (Amst) (2006) 3.61
Heterogeneity of CNS myeloid cells and their roles in neurodegeneration. Nat Neurosci (2011) 3.06
Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes. J Biol Chem (2004) 2.85
Trafficking and proteolytic processing of APP. Cold Spring Harb Perspect Med (2012) 2.56
Non-cell-autonomous effects of presenilin 1 variants on enrichment-mediated hippocampal progenitor cell proliferation and differentiation. Neuron (2008) 2.44
Evidence that synaptically released beta-amyloid accumulates as extracellular deposits in the hippocampus of transgenic mice. J Neurosci (2002) 2.35
Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease. Neuron (2010) 2.20
Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited. J Neurosci (2005) 2.04
Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway. Immunity (2003) 2.03
Spatial segregation of gamma-secretase and substrates in distinct membrane domains. J Biol Chem (2005) 1.98
A mutated EGFR is sufficient to induce malignant melanoma with genetic background-dependent histopathologies. J Invest Dermatol (2010) 1.78
PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1. J Biol Chem (2003) 1.77
Ctp1/CtIP and the MRN complex collaborate in the initial steps of homologous recombination. Mol Cell (2007) 1.77
Collaborative action of Brca1 and CtIP in elimination of covalent modifications from double-strand breaks to facilitate subsequent break repair. PLoS Genet (2010) 1.66
The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage. J Biol Chem (2003) 1.66
Activation and intrinsic gamma-secretase activity of presenilin 1. Proc Natl Acad Sci U S A (2010) 1.62
Presenilin 1 is required for maturation and cell surface accumulation of nicastrin. J Biol Chem (2002) 1.61
Notch and MAML signaling drives Scl-dependent interneuron diversity in the spinal cord. Neuron (2007) 1.52
DNMT3B7, a truncated DNMT3B isoform expressed in human tumors, disrupts embryonic development and accelerates lymphomagenesis. Cancer Res (2010) 1.49
Psychosine accumulates in membrane microdomains in the brain of krabbe patients, disrupting the raft architecture. J Neurosci (2009) 1.47
Genetic dissection of vertebrate 53BP1: a major role in non-homologous end joining of DNA double strand breaks. DNA Repair (Amst) (2006) 1.46
Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models". Science (2013) 1.45
Characterization of stanniocalcin 2, a novel target of the mammalian unfolded protein response with cytoprotective properties. Mol Cell Biol (2004) 1.44
RAD18 and poly(ADP-ribose) polymerase independently suppress the access of nonhomologous end joining to double-strand breaks and facilitate homologous recombination-mediated repair. Mol Cell Biol (2007) 1.41
Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation. Proc Natl Acad Sci U S A (2006) 1.41
Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE. J Biol Chem (2007) 1.41
Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1. J Neurosci (2007) 1.39
Pathological and physiological functions of presenilins. Mol Neurodegener (2006) 1.38
Membrane rafts in Alzheimer's disease beta-amyloid production. Biochim Biophys Acta (2010) 1.37
Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components. J Biol Chem (2005) 1.37
Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein. J Biol Chem (2002) 1.34
Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts. J Biol Chem (2008) 1.34
Amyloidogenic processing of beta-amyloid precursor protein in intracellular compartments. Neurology (2006) 1.34
Accelerated Abeta deposition in APPswe/PS1deltaE9 mice with hemizygous deletions of TTR (transthyretin). J Neurosci (2007) 1.29
Evidence that the "NF" motif in transmembrane domain 4 of presenilin 1 is critical for binding with PEN-2. J Biol Chem (2005) 1.28
Presenilin-dependent "gamma-secretase" processing of deleted in colorectal cancer (DCC). J Biol Chem (2003) 1.25
Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates. J Biol Chem (2003) 1.21
Pen2 and presenilin-1 modulate the dynamic equilibrium of presenilin-1 and presenilin-2 gamma-secretase complexes. J Biol Chem (2008) 1.20
Dual roles of the transmembrane protein p23/TMP21 in the modulation of amyloid precursor protein metabolism. Mol Neurodegener (2007) 1.18
APP transgenic mice Tg2576 accumulate Abeta peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques. Biochemistry (2002) 1.18
Proteolytic processing of familial British dementia-associated BRI variants: evidence for enhanced intracellular accumulation of amyloidogenic peptides. J Biol Chem (2001) 1.16
Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons. Proc Natl Acad Sci U S A (2006) 1.14
Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components. J Biol Chem (2004) 1.11
Biogenesis of gamma-secretase early in the secretory pathway. J Cell Biol (2007) 1.11
Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF. Mol Neurodegener (2009) 1.10
S-palmitoylation of gamma-secretase subunits nicastrin and APH-1. J Biol Chem (2008) 1.09
Fen-1 facilitates homologous recombination by removing divergent sequences at DNA break ends. Mol Cell Biol (2005) 1.09
Evidence that CD147 modulation of beta-amyloid (Abeta) levels is mediated by extracellular degradation of secreted Abeta. J Biol Chem (2008) 1.07
Nigrostriatal dysfunction in familial Alzheimer's disease-linked APPswe/PS1DeltaE9 transgenic mice. J Neurosci (2005) 1.07
A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1. J Biol Chem (2004) 1.07
Structure of gamma-secretase and its trimeric pre-activation intermediate by single-particle electron microscopy. J Biol Chem (2011) 1.06
Identification of a tetratricopeptide repeat-like domain in the nicastrin subunit of γ-secretase using synthetic antibodies. Proc Natl Acad Sci U S A (2012) 1.06
A novel approach using DNA-repair-deficient chicken DT40 cell lines for screening and characterizing the genotoxicity of environmental contaminants. Environ Health Perspect (2009) 1.06
Mechanisms of disease: new therapeutic strategies for Alzheimer's disease--targeting APP processing in lipid rafts. Nat Clin Pract Neurol (2007) 1.06
Presenilin 1 mutants impair the self-renewal and differentiation of adult murine subventricular zone-neuronal progenitors via cell-autonomous mechanisms involving notch signaling. J Neurosci (2010) 1.06
Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis. J Neurosci (2008) 1.05
Genetic evidence for single-strand lesions initiating Nbs1-dependent homologous recombination in diversification of Ig v in chicken B lymphocytes. PLoS Genet (2009) 1.05
A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface. Neurobiol Dis (2002) 1.04
Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway. J Biol Chem (2004) 1.04
Novel GαS-protein signaling associated with membrane-tethered amyloid precursor protein intracellular domain. J Neurosci (2012) 1.02
A role for presenilins in autophagy revisited: normal acidification of lysosomes in cells lacking PSEN1 and PSEN2. J Neurosci (2012) 1.02
Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy-truncated amyloid β species. Biochemistry (2014) 0.98
Plug-based microfluidics with defined surface chemistry to miniaturize and control aggregation of amyloidogenic peptides. Angew Chem Int Ed Engl (2009) 0.97
Adult neurogenesis is functionally associated with AD-like neurodegeneration. Neurobiol Dis (2007) 0.97
Gamma-secretase is a functional component of phagosomes. J Biol Chem (2005) 0.96
BMS-708,163 targets presenilin and lacks notch-sparing activity. Biochemistry (2012) 0.96
Mutation analysis of the presenilin 1 N-terminal domain reveals a broad spectrum of gamma-secretase activity toward amyloid precursor protein and other substrates. J Biol Chem (2010) 0.93
Identification of NEEP21 as a ß-amyloid precursor protein-interacting protein in vivo that modulates amyloidogenic processing in vitro. J Neurosci (2010) 0.93
Analysis of medaka sox9 orthologue reveals a conserved role in germ cell maintenance. PLoS One (2012) 0.92
Stanniocalcin 2 is a negative modulator of store-operated calcium entry. Mol Cell Biol (2011) 0.92
Presenilin-1-dependent transcriptome changes. J Neurosci (2005) 0.92
P75 neurotrophin receptor regulates expression of neural cell adhesion molecule 1. Neurobiol Dis (2005) 0.91
Bloom DNA helicase facilitates homologous recombination between diverged homologous sequences. J Biol Chem (2009) 0.91
RING1 inhibits transactivation of RBP-J by Notch through interaction with LIM protein KyoT2. Nucleic Acids Res (2004) 0.90
Dual functions of ASCIZ in the DNA base damage response and pulmonary organogenesis. PLoS Genet (2010) 0.90
Mutant presenilin 1 expression in excitatory neurons impairs enrichment-mediated phenotypes of adult hippocampal progenitor cells. Proc Natl Acad Sci U S A (2013) 0.90
A neural mechanism underlying mating preferences for familiar individuals in medaka fish. Science (2014) 0.89
Presenilin 1 in migration and morphogenesis in the central nervous system. Development (2004) 0.89
Loss of cleavage at β'-site contributes to apparent increase in β-amyloid peptide (Aβ) secretion by β-secretase (BACE1)-glycosylphosphatidylinositol (GPI) processing of amyloid precursor protein. J Biol Chem (2011) 0.88
DNA damage response protein ASCIZ links base excision repair with immunoglobulin gene conversion. Biochem Biophys Res Commun (2008) 0.88
Presenilins and Alzheimer disease: the calcium conspiracy. Nat Neurosci (2006) 0.88
Introduction of a foreign gene into zebrafish and medaka cells using adenoviral vectors. Zebrafish (2009) 0.87
ATF6α/β-mediated adjustment of ER chaperone levels is essential for development of the notochord in medaka fish. Mol Biol Cell (2013) 0.87
True and false discovery in DNA microarray experiments: transcriptome changes in the hippocampus of presenilin 1 mutant mice. Methods (2005) 0.87
Age-dependent, non-cell-autonomous deposition of amyloid from synthesis of β-amyloid by cells other than excitatory neurons. J Neurosci (2014) 0.86
Proteasome inhibition in medaka brain induces the features of Parkinson's disease. J Neurochem (2010) 0.85
A chemical neurotoxin, MPTP induces Parkinson's disease like phenotype, movement disorders and persistent loss of dopamine neurons in medaka fish. Neurosci Res (2009) 0.84
Rheb GTPase regulates β-secretase levels and amyloid β generation. J Biol Chem (2013) 0.84
Reduced Alzheimer's disease ß-amyloid deposition in transgenic mice expressing S-palmitoylation-deficient APH1aL and nicastrin. J Neurosci (2010) 0.84