APP Receptor? To Be or Not To Be.

PubWeight™: 0.85‹?›

🔗 View Article (PMID 26837733)

Published in Trends Pharmacol Sci on January 31, 2016

Authors

Carole Deyts1, Gopal Thinakaran1, Angèle T Parent2

Author Affiliations

1: Departments of Neurobiology, The University of Chicago, 924 East 57th Street, Chicago, IL, 60637, USA.
2: Departments of Neurobiology, The University of Chicago, 924 East 57th Street, Chicago, IL, 60637, USA. Electronic address: aparent@uchicago.edu.

Articles cited by this

(truncated to the top 100)

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science (2002) 49.51

Lipid rafts and signal transduction. Nat Rev Mol Cell Biol (2000) 25.87

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature (1987) 17.08

The canonical Notch signaling pathway: unfolding the activation mechanism. Cell (2009) 14.72

Lipid rafts as a membrane-organizing principle. Science (2010) 13.48

Alzheimer's disease. N Engl J Med (2010) 13.13

Cell signaling by receptor tyrosine kinases. Cell (2010) 12.39

Transduction of receptor signals by beta-arrestins. Science (2005) 9.87

Regulation of NMDA receptor trafficking by amyloid-beta. Nat Neurosci (2005) 9.17

Beta-arrestins and cell signaling. Annu Rev Physiol (2007) 8.65

Lipid rafts: elusive or illusive? Cell (2003) 7.99

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60. Science (2001) 7.03

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers. Nature (2009) 6.99

AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss. Neuron (2006) 6.76

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature (2009) 6.17

ADAMs: key components in EGFR signalling and development. Nat Rev Mol Cell Biol (2005) 5.97

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes. Nat Neurosci (2012) 4.92

Amyloid precursor protein trafficking, processing, and function. J Biol Chem (2008) 4.79

Heparan sulphate proteoglycans: the sweet side of development. Nat Rev Mol Cell Biol (2005) 3.92

Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model. Science (2013) 3.59

Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation. Cell (1999) 3.58

Memory impairment in transgenic Alzheimer mice requires cellular prion protein. J Neurosci (2010) 3.36

Reversing EphB2 depletion rescues cognitive functions in Alzheimer model. Nature (2010) 3.36

A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor. Nat Med (2000) 3.24

LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex. Nat Neurosci (2004) 3.24

Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus. J Neurosci (2008) 3.21

The complex world of WNT receptor signalling. Nat Rev Mol Cell Biol (2012) 3.16

The GSK3 hypothesis of Alzheimer's disease. J Neurochem (2007) 3.16

Heparan sulfate proteoglycans. Cold Spring Harb Perspect Biol (2011) 2.96

Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons. Nat Neurosci (2012) 2.92

Neurotoxicity of amyloid β-protein: synaptic and network dysfunction. Cold Spring Harb Perspect Med (2012) 2.77

Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis. Neuron (2006) 2.76

Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein. J Biol Chem (1998) 2.71

GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42. EMBO J (2007) 2.61

Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory. Prog Neurobiol (2003) 2.57

Trafficking and proteolytic processing of APP. Cold Spring Harb Perspect Med (2012) 2.56

Conformational coupling across the plasma membrane in activation of the EGF receptor. Cell (2013) 2.49

A TAG1-APP signalling pathway through Fe65 negatively modulates neurogenesis. Nat Cell Biol (2008) 2.34

Deleterious effects of amyloid beta oligomers acting as an extracellular scaffold for mGluR5. Neuron (2010) 2.34

Amyloid-beta as a positive endogenous regulator of release probability at hippocampal synapses. Nat Neurosci (2009) 2.31

Amyloid beta oligomers induce impairment of neuronal insulin receptors. FASEB J (2007) 2.25

A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth. J Neurosci (1994) 2.19

Alzheimer amyloid protein precursor complexes with brain GTP-binding protein G(o) Nature (1993) 2.08

The many substrates of presenilin/γ-secretase. J Alzheimers Dis (2011) 2.02

JIP1 regulates the directionality of APP axonal transport by coordinating kinesin and dynein motors. J Cell Biol (2013) 2.01

Biochemistry of amyloid β-protein and amyloid deposits in Alzheimer disease. Cold Spring Harb Perspect Med (2012) 2.01

Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone. Development (2004) 2.00

Homo- and heterodimerization of APP family members promotes intercellular adhesion. EMBO J (2005) 1.98

Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complex. Dev Cell (2010) 1.98

Spatial segregation of gamma-secretase and substrates in distinct membrane domains. J Biol Chem (2005) 1.98

Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface. Development (2003) 1.98

A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP. Proc Natl Acad Sci U S A (2002) 1.97

Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway. J Biol Chem (2007) 1.95

Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein. Neuron (2013) 1.87

Amyloid beta interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease. Nat Neurosci (2000) 1.84

Spatial structure of the dimeric transmembrane domain of the growth factor receptor ErbB2 presumably corresponding to the receptor active state. J Biol Chem (2008) 1.81

Presenilin diversifies its portfolio. Trends Genet (2007) 1.81

The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing. EMBO J (2002) 1.79

FE65 constitutes the functional link between the low-density lipoprotein receptor-related protein and the amyloid precursor protein. J Neurosci (2004) 1.79

Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1. Neural Dev (2008) 1.79

Binding of F-spondin to amyloid-beta precursor protein: a candidate amyloid-beta precursor protein ligand that modulates amyloid-beta precursor protein cleavage. Proc Natl Acad Sci U S A (2004) 1.76

The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture. J Neurochem (2001) 1.73

Alzheimer's disease: synaptic dysfunction and Abeta. Mol Neurodegener (2009) 1.73

The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus. Proc Natl Acad Sci U S A (2001) 1.72

The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain. Mol Cell (2004) 1.70

Not(ch) just development: Notch signalling in the adult brain. Nat Rev Neurosci (2011) 1.69

Interaction of reelin with amyloid precursor protein promotes neurite outgrowth. J Neurosci (2009) 1.68

The amyloid-beta precursor protein: integrating structure with biological function. EMBO J (2005) 1.68

Lysosomal sorting of amyloid-β by the SORLA receptor is impaired by a familial Alzheimer's disease mutation. Sci Transl Med (2014) 1.67

The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production. J Biol Chem (2005) 1.67

Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis. J Neurosci (2009) 1.65

Generation of an apoptotic intracellular peptide by gamma-secretase cleavage of Alzheimer's amyloid beta protein precursor. J Alzheimers Dis (2000) 1.61

Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons. EMBO J (2012) 1.61

Three dimensions of the amyloid hypothesis: time, space and 'wingmen'. Nat Neurosci (2015) 1.60

Membrane-anchored growth factors, the epidermal growth factor family: beyond receptor ligands. Cancer Sci (2008) 1.60

Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain. J Cell Biol (2005) 1.59

Biology and pathophysiology of the amyloid precursor protein. Mol Neurodegener (2011) 1.58

The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer's disease. Prog Neurobiol (2008) 1.58

Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain. EMBO J (2005) 1.56

Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein. Nat Struct Biol (1999) 1.56

Identification of beta-secretase (BACE1) substrates using quantitative proteomics. PLoS One (2009) 1.52

Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism. J Biol Chem (2003) 1.52

Proteolytic processing of Alzheimer's β-amyloid precursor protein. J Neurochem (2011) 1.50

BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production. J Biol Chem (2005) 1.48

Truncated beta-amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome. Proc Natl Acad Sci U S A (2010) 1.48

Regulation of amyloid protein precursor (APP) binding to collagen and mapping of the binding sites on APP and collagen type I. J Biol Chem (1996) 1.48

Phosphorylation of Alzheimer disease amyloid precursor peptide by protein kinase C and Ca2+/calmodulin-dependent protein kinase II. Proc Natl Acad Sci U S A (1988) 1.47

A new molecular explanation for age-related neurodegeneration: the Tyr682 residue of amyloid precursor protein. Bioessays (2013) 1.47

Physiological functions of APP family proteins. Cold Spring Harb Perspect Med (2012) 1.44

BRI2 inhibits amyloid beta-peptide precursor protein processing by interfering with the docking of secretases to the substrate. J Neurosci (2008) 1.42

PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein. Proc Natl Acad Sci U S A (1998) 1.41

The in vivo brain interactome of the amyloid precursor protein. Mol Cell Proteomics (2007) 1.38

A simple structure encodes G protein-activating function of the IGF-II/mannose 6-phosphate receptor. Cell (1990) 1.38

Processing of beta-amyloid precursor-like protein-1 and -2 by gamma-secretase regulates transcription. J Biol Chem (2002) 1.37

Membrane rafts in Alzheimer's disease beta-amyloid production. Biochim Biophys Acta (2010) 1.37

Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms. J Neurosci (2002) 1.33

DAB1 and Reelin effects on amyloid precursor protein and ApoE receptor 2 trafficking and processing. J Biol Chem (2006) 1.33

Amyloid precursor protein and Presenilin1 interact with the adaptor GRB2 and modulate ERK 1,2 signaling. J Biol Chem (2007) 1.31

Regulation of hippocampus-dependent memory by cyclic AMP-dependent protein kinase. Prog Brain Res (2008) 1.31

Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc. J Biol Chem (2002) 1.31