PubRank

Heather P Harding

Author PubWeight™ 132.46‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature 2002 16.52
2 CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev 2004 9.24
3 A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science 2005 7.98
4 The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages. Nat Cell Biol 2003 6.34
5 Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response. J Cell Biol 2004 5.44
6 GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase. Immunity 2005 4.53
7 Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2. EMBO J 2004 3.77
8 Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response. Mol Cell Biol 2004 3.57
9 Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice. Cell Metab 2008 3.45
10 Targeting the unfolded protein response in disease. Nat Rev Drug Discov 2013 3.37
11 Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones. J Cell Sci 2004 3.31
12 Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis. Science 2011 3.29
13 Stress-induced gene expression requires programmed recovery from translational repression. EMBO J 2003 3.26
14 Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2. Mol Cell Biol 2004 3.00
15 Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease. J Neurosci 2002 2.83
16 Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1. Mol Cell 2010 2.74
17 Activating transcription factor 4 is translationally regulated by hypoxic stress. Mol Cell Biol 2004 2.68
18 Mammalian stress granules represent sites of accumulation of stalled translation initiation complexes. Am J Physiol Cell Physiol 2002 2.62
19 Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload. Cell 2006 2.54
20 The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule. Proc Natl Acad Sci U S A 2012 2.45
21 Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response. Genetics 2006 2.29
22 Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress. Mol Cell Biol 2006 2.16
23 Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cells. J Cell Biol 2003 2.15
24 Activation of GCN2 in UV-irradiated cells inhibits translation. Curr Biol 2002 2.02
25 The unfolded protein response element IRE1α senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling. Cell Host Microbe 2013 1.91
26 ERO1-beta, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis. J Cell Biol 2010 1.87
27 The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores. Cell Metab 2005 1.83
28 Antiviral effect of the mammalian translation initiation factor 2alpha kinase GCN2 against RNA viruses. EMBO J 2006 1.79
29 Interferon-gamma inhibits central nervous system remyelination through a process modulated by endoplasmic reticulum stress. Brain 2006 1.78
30 The integrated stress response prevents demyelination by protecting oligodendrocytes against immune-mediated damage. J Clin Invest 2007 1.74
31 Endoplasmic reticulum stress modulates the response of myelinating oligodendrocytes to the immune cytokine interferon-gamma. J Cell Biol 2005 1.69
32 Transmission of cell stress from endoplasmic reticulum to mitochondria: enhanced expression of Lon protease. J Cell Biol 2002 1.33
33 Enhanced integrated stress response promotes myelinating oligodendrocyte survival in response to interferon-gamma. Am J Pathol 2008 1.31
34 Activation-dependent substrate recruitment by the eukaryotic translation initiation factor 2 kinase PERK. J Cell Biol 2006 1.29
35 Role for the obesity-related FTO gene in the cellular sensing of amino acids. Proc Natl Acad Sci U S A 2013 1.24
36 Rapid B cell receptor-induced unfolded protein response in nonsecretory B cells correlates with pro- versus antiapoptotic cell fate. J Biol Chem 2005 1.23
37 Oligodendrocyte-specific activation of PERK signaling protects mice against experimental autoimmune encephalomyelitis. J Neurosci 2013 1.22
38 Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis. Diabetes 2012 1.16
39 A small molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1) with selectively reversible thiol reactivity. J Biol Chem 2010 1.15
40 Modulation of the eukaryotic initiation factor 2 alpha-subunit kinase PERK by tyrosine phosphorylation. J Biol Chem 2007 1.14
41 Heightened stress response in primary fibroblasts expressing mutant eIF2B genes from CACH/VWM leukodystrophy patients. Hum Genet 2005 1.12
42 Translation attenuation by PERK balances ER glycoprotein synthesis with lipid-linked oligosaccharide flux. J Cell Biol 2007 1.09
43 Protein-folding homeostasis in the endoplasmic reticulum and nutritional regulation. Cold Spring Harb Perspect Biol 2012 1.06
44 Lifetime imaging of a fluorescent protein sensor reveals surprising stability of ER thiol redox. J Cell Biol 2013 1.05
45 Mannose-6-phosphate regulates destruction of lipid-linked oligosaccharides. Mol Biol Cell 2011 1.01
46 ER stress disrupts Ca2+-signaling complexes and Ca2+ regulation in secretory and muscle cells from PERK-knockout mice. J Cell Sci 2005 0.98
47 Novel function of PERK as a mediator of force-induced apoptosis. J Biol Chem 2008 0.88
48 Selective inhibition of the unfolded protein response: targeting catalytic sites for Schiff base modification. Mol Biosyst 2013 0.85
49 A deregulated integrated stress response promotes interferon-γ-induced medulloblastoma. J Neurosci Res 2011 0.82
50 Arginine deficiency causes runting in the suckling period by selectively activating the stress kinase GCN2. J Biol Chem 2011 0.80
51 Kinetic analysis of FTO (fat mass and obesity-associated) reveals that it is unlikely to function as a sensor for 2-oxoglutarate. Biochem J 2012 0.79
52 Establishing a flow process to coumarin-8-carbaldehydes as important synthetic scaffolds. Chemistry 2012 0.77
53 Toward the discovery of new antifungal agents: the design and validation of a novel 2'P-RNA probe and high throughput screening assay against 2'-phosphotransferase Tpt1p. Nucleic Acids Symp Ser (Oxf) 2008 0.75