Published in J Biol Chem on September 27, 2005
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat Cell Biol (2011) 8.75
Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signalling. Nat Cell Biol (2009) 2.42
Gametogenesis in malaria parasites is mediated by the cGMP-dependent protein kinase. PLoS Biol (2008) 1.63
Stimulation of surface IgM of chronic lymphocytic leukemia cells induces an unfolded protein response dependent on BTK and SYK. Blood (2014) 1.45
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The unfolded protein response of B-lymphocytes: PERK-independent development of antibody-secreting cells. Mol Immunol (2007) 1.39
Plasma cell-specific transcription factor XBP-1s binds to and transactivates the Epstein-Barr virus BZLF1 promoter. J Virol (2007) 1.31
The latent membrane protein 1 (LMP1) oncogene of Epstein-Barr virus can simultaneously induce and inhibit apoptosis in B cells. J Virol (2012) 1.04
Transcription factor Zfx controls BCR-induced proliferation and survival of B lymphocytes. Blood (2009) 0.92
Pharmacological modulation of the retinal unfolded protein response in Bardet-Biedl syndrome reduces apoptosis and preserves light detection ability. J Biol Chem (2012) 0.91
A Myc-regulated transcriptional network controls B-cell fate in response to BCR triggering. BMC Genomics (2009) 0.90
Editing and escape from editing in anti-DNA B cells. Proc Natl Acad Sci U S A (2008) 0.89
X-box binding protein 1 contributes to induction of the Kaposi's sarcoma-associated herpesvirus lytic cycle under hypoxic conditions. J Virol (2009) 0.88
Induction of unfolded protein response during neuronal induction of rat bone marrow stromal cells and mouse embryonic stem cells. Exp Mol Med (2009) 0.86
Dual functions for cytosolic α-mannosidase (Man2C1): its down-regulation causes mitochondria-dependent apoptosis independently of its α-mannosidase activity. J Biol Chem (2013) 0.82
Protein kinase C signaling during T cell activation induces the endoplasmic reticulum stress response. Cell Stress Chaperones (2008) 0.80
Lipopolysaccharide stress induces cell-type specific production of murine leukemia virus type-endogenous retroviral virions in primary lymphoid cells. J Gen Virol (2010) 0.79
The BiP cochaperone ERdj4 is required for B cell development and function. PLoS One (2014) 0.75
Eukaryotic initiation factor 2alpha phosphorylation is required for B-cell maturation and function in mice. Haematologica (2011) 0.75
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature (2002) 16.52
The unfolded protein response: from stress pathway to homeostatic regulation. Science (2011) 15.71
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell (2003) 15.12
CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev (2004) 9.24
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat Cell Biol (2011) 8.75
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science (2005) 7.98
Transcriptional and translational control in the Mammalian unfolded protein response. Annu Rev Cell Dev Biol (2002) 6.48
A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol. Nature (2004) 6.37
The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages. Nat Cell Biol (2003) 6.34
Endoplasmic reticulum stress signaling in disease. Physiol Rev (2006) 5.90
Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response. J Cell Biol (2004) 5.44
GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase. Immunity (2005) 4.53
Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability. Am J Pathol (2007) 4.45
Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes. J Clin Invest (2008) 4.30
ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth. EMBO J (2005) 3.79
Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2. EMBO J (2004) 3.77
The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation. EMBO J (2010) 3.76
Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response. Mol Cell Biol (2004) 3.57
Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/- mice lacking CHOP. Cell Metab (2009) 3.51
Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice. Cell Metab (2008) 3.45
Targeting the unfolded protein response in disease. Nat Rev Drug Discov (2013) 3.37
Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones. J Cell Sci (2004) 3.31
Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis. Science (2011) 3.29
Stress-induced gene expression requires programmed recovery from translational repression. EMBO J (2003) 3.26
The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans. Mol Cell (2010) 3.26
The mitochondrial UPR - protecting organelle protein homeostasis. J Cell Sci (2010) 3.06
Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2. Mol Cell Biol (2004) 3.00
Ablation of the UPR-mediator CHOP restores motor function and reduces demyelination in Charcot-Marie-Tooth 1B mice. Neuron (2008) 2.95
Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK. Proc Natl Acad Sci U S A (2002) 2.93
Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease. J Neurosci (2002) 2.83
Endoplasmic reticulum stress and the development of diabetes: a review. Diabetes (2002) 2.74
Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1. Mol Cell (2010) 2.74
A survival pathway for Caenorhabditis elegans with a blocked unfolded protein response. J Cell Biol (2002) 2.72
Activating transcription factor 4 is translationally regulated by hypoxic stress. Mol Cell Biol (2004) 2.68
Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2. Nature (2005) 2.67
Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis. J Cell Biol (2009) 2.66
Mammalian stress granules represent sites of accumulation of stalled translation initiation complexes. Am J Physiol Cell Physiol (2002) 2.62
ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans. Dev Cell (2007) 2.61
ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiae. Cell Metab (2006) 2.55
Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload. Cell (2006) 2.54
Oxidative protein folding by an endoplasmic reticulum-localized peroxiredoxin. Mol Cell (2010) 2.51
The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule. Proc Natl Acad Sci U S A (2012) 2.45
Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signalling. Nat Cell Biol (2009) 2.42
ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells. Proc Natl Acad Sci U S A (2009) 2.37
Divergent effects of PERK and IRE1 signaling on cell viability. PLoS One (2009) 2.30
Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response. Genetics (2006) 2.29
Infectious tolerance via the consumption of essential amino acids and mTOR signaling. Proc Natl Acad Sci U S A (2009) 2.22
Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress. Mol Cell Biol (2006) 2.16
Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cells. J Cell Biol (2003) 2.15
Role for activating transcription factor 3 in stress-induced beta-cell apoptosis. Mol Cell Biol (2004) 2.10
CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism. J Neurochem (2005) 2.08
Activation of GCN2 in UV-irradiated cells inhibits translation. Curr Biol (2002) 2.02
Tonic B cell antigen receptor signals supply an NF-kappaB substrate for prosurvival BLyS signaling. Nat Immunol (2008) 1.96
The unfolded protein response element IRE1α senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling. Cell Host Microbe (2013) 1.91
ERO1-beta, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis. J Cell Biol (2010) 1.87
The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores. Cell Metab (2005) 1.83
Antiviral effect of the mammalian translation initiation factor 2alpha kinase GCN2 against RNA viruses. EMBO J (2006) 1.79
Interferon-gamma inhibits central nervous system remyelination through a process modulated by endoplasmic reticulum stress. Brain (2006) 1.78
IRE1beta inhibits chylomicron production by selectively degrading MTP mRNA. Cell Metab (2008) 1.75
The integrated stress response prevents demyelination by protecting oligodendrocytes against immune-mediated damage. J Clin Invest (2007) 1.74
Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains. Proc Natl Acad Sci U S A (2013) 1.73
Endoplasmic reticulum stress modulates the response of myelinating oligodendrocytes to the immune cytokine interferon-gamma. J Cell Biol (2005) 1.69
Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development. Proc Natl Acad Sci U S A (2009) 1.68
B-cell targeted therapies in human autoimmune diseases: an updated perspective. Immunol Rev (2010) 1.60
Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2008) 1.54
Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha. Mol Cell Biol (2002) 1.54
Transcriptional regulation of VEGF-A by the unfolded protein response pathway. PLoS One (2010) 1.52
Regulated association of misfolded endoplasmic reticulum lumenal proteins with P58/DNAJc3. EMBO J (2008) 1.51
Transitional B cells: step by step towards immune competence. Trends Immunol (2003) 1.50
Oscillation between B-lymphoid and myeloid lineages in Myc-induced hematopoietic tumors following spontaneous silencing/reactivation of the EBF/Pax5 pathway. Blood (2002) 1.48