PubRank

David J Tweardy

Author PubWeight™ 55.58‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Targeting Stat3 in cancer therapy. Anticancer Drugs 2005 2.13
2 Single nucleotide polymorphisms in genes for 2'-5'-oligoadenylate synthetase and RNase L inpatients hospitalized with West Nile virus infection. J Infect Dis 2005 2.11
3 Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor. Cancer Res 2003 1.73
4 Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor. Blood 2011 1.69
5 Interleukin-6 treatment reverses apoptosis and blunts susceptibility to intraperitoneal bacterial challenge following hemorrhagic shock. Crit Care Med 2006 1.52
6 Stat3 activation links a C/EBPδ to myostatin pathway to stimulate loss of muscle mass. Cell Metab 2013 1.49
7 Intra-abdominal activation of a local inflammatory response within the human muscularis externa during laparotomy. Ann Surg 2003 1.42
8 Chemical probes that competitively and selectively inhibit Stat3 activation. PLoS One 2009 1.37
9 Induced nitric oxide promotes intestinal inflammation following hemorrhagic shock. Am J Physiol Gastrointest Liver Physiol 2004 1.33
10 G-quartet oligonucleotides: a new class of signal transducer and activator of transcription 3 inhibitors that suppresses growth of prostate and breast tumors through induction of apoptosis. Cancer Res 2004 1.29
11 Structural requirements for signal transducer and activator of transcription 3 binding to phosphotyrosine ligands containing the YXXQ motif. J Biol Chem 2004 1.28
12 Targeting Stat3 with G-quartet oligodeoxynucleotides in human cancer cells. DNA Cell Biol 2003 1.23
13 Interactions of STAT5b-RARalpha, a novel acute promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways. Blood 2002 1.18
14 Targeting signal transducer and activator of transcription 3 with G-quartet oligonucleotides: a potential novel therapy for head and neck cancer. Mol Cancer Ther 2006 1.16
15 Selective small molecule Stat3 inhibitor reduces breast cancer tumor-initiating cells and improves recurrence free survival in a human-xenograft model. PLoS One 2012 1.14
16 Targeting transcription factors for cancer therapy. Curr Pharm Des 2005 1.10
17 Stat3 isoforms, alpha and beta, demonstrate distinct intracellular dynamics with prolonged nuclear retention of Stat3beta mapping to its unique C-terminal end. J Biol Chem 2007 1.08
18 Increased susceptibility to liver injury after hemorrhagic shock in rats chronically fed ethanol: role of nuclear factor-kappa B, interleukin-6, and granulocyte colony-stimulating factor. Shock 2004 1.03
19 Mechanism and preclinical prevention of increased breast cancer risk caused by pregnancy. Elife 2013 1.02
20 Induction of IL-6 within the rodent intestinal muscularis after intestinal surgical stress. Surgery 2005 1.01
21 STAT3 signaling is activated preferentially in tumor-initiating cells in claudin-low models of human breast cancer. Stem Cells 2014 0.99
22 FACS analysis of Stat3/5 signaling reveals sensitivity to G-CSF and IL-6 as a significant prognostic factor in pediatric AML: a Children's Oncology Group report. Blood 2012 0.97
23 Reduced intranuclear mobility of APL fusion proteins accompanies their mislocalization and results in sequestration and decreased mobility of retinoid X receptor alpha. Mol Cell Biol 2004 0.96
24 Rational drug design of G-quartet DNA as anti-cancer agents. Curr Pharm Des 2005 0.96
25 Cross-talk between retinoic acid and STAT3 signaling pathways in acute promyelocytic leukemia. Leuk Lymphoma 2003 0.95
26 Prevention of hypovolemic circulatory collapse by IL-6 activated Stat3. PLoS One 2008 0.93
27 Functional significance of inflammatory mediators in a murine model of resuscitated hemorrhagic shock. Am J Physiol Heart Circ Physiol 2005 0.93
28 Substance P causes seizures in neurocysticercosis. PLoS Pathog 2012 0.91
29 Substance P is required for the pathogenesis of EMCV infection in mice. Int J Clin Exp Med 2009 0.90
30 Increased expression of type-1 fimbriae by nonpathogenic Escherichia coli 83972 results in an increased capacity for catheter adherence and bacterial interference. J Infect Dis 2008 0.89
31 Prevention of trauma/hemorrhagic shock-induced lung apoptosis by IL-6-mediated activation of Stat3. Clin Transl Sci 2009 0.87
32 Conditional overexpression of Stat3alpha in differentiating myeloid cells results in neutrophil expansion and induces a distinct, antiapoptotic and pro-oncogenic gene expression pattern. J Leukoc Biol 2007 0.86
33 Prevention of trauma and hemorrhagic shock-mediated liver apoptosis by activation of stat3alpha. Int J Clin Exp Med 2008 0.86
34 The effect of recombinant factor VIIa on noncoagulopathic pigs with grade V liver injuries. J Am Coll Surg 2003 0.86
35 Synthetic and biological studies of phaeosphaerides. J Org Chem 2014 0.84
36 T40214/PEI complex: a potent therapeutics for prostate cancer that targets STAT3 signaling. Prostate 2008 0.84
37 Substance P is responsible for physiological alterations such as increased chloride ion secretion and glucose malabsorption in cryptosporidiosis. Infect Immun 2006 0.83
38 Unique structural determinants for Stat3 recruitment and activation by the granulocyte colony-stimulating factor receptor at phosphotyrosine ligands 704 and 744. J Immunol 2006 0.83
39 Leukemic transformation by the APL fusion protein PRKAR1A-RAR{alpha} critically depends on recruitment of RXR{alpha}. Blood 2009 0.83
40 Substance P signaling contributes to granuloma formation in Taenia crassiceps infection, a murine model of cysticercosis. J Biomed Biotechnol 2010 0.82
41 A nitric oxide scavenger protects against pulmonary inflammation following hemorrhagic shock. Shock 2002 0.82
42 Amplification of the proinflammatory transcription factor cascade increases with severity of uncontrolled hemorrhage in swine. J Surg Res 2003 0.82
43 IL-6-mediated activation of Stat3α prevents trauma/hemorrhagic shock-induced liver inflammation. PLoS One 2011 0.82
44 Nanoscale surface modification favors benign biofilm formation and impedes adherence by pathogens. Nanomedicine 2011 0.81
45 Aberrant chromatin remodeling by retinoic acid receptor alpha fusion proteins assessed at the single-cell level. Mol Biol Cell 2007 0.80
46 A novel role of microRNA146b in promoting mammary alveolar progenitor cell maintenance. J Cell Sci 2013 0.80
47 Essential role for the dimerization domain of NuMA-RARalpha in its oncogenic activities and localization to NuMA sites within the nucleus. Oncogene 2003 0.80
48 Lethal human neutropenic entercolitis caused by Clostridium chauvoei in the United States: tip of the iceberg? J Infect 2011 0.79
49 Severe pulmonary involvement in a case attributed to domestically acquired Seoul hantavirus in the United States. Clin Infect Dis 2011 0.79
50 SH2 domain binding to phosphopeptide ligands: potential for drug targeting. Front Biosci (Landmark Ed) 2009 0.78
51 Nanoparticle delivery of inhibitory signal transducer and activator of transcription 3 G-quartet oligonucleotides blocks tumor growth in HMGA1 transgenic model of T-cell leukemia. Leuk Lymphoma 2013 0.77
52 Modulation of the unfolded protein response during hepatocyte and cardiomyocyte apoptosis in trauma/hemorrhagic shock. Sci Rep 2013 0.77
53 Increased apoptosis of peripheral blood neutrophils is associated with reduced incidence of infection in trauma patients with hemorrhagic shock. J Infect 2012 0.76
54 Correction: Piperlongumine Blocks JAK2-STAT3 to Inhibit Collagen-Induced Platelet Reactivity Independent of Reactive Oxygen Species†. PLoS One 2016 0.75
55 Intracranial tuberculomas in adults: a report of twelve consecutive patients in Houston, Texas. Scand J Infect Dis 2011 0.75
56 Successful ceftriaxone therapy of endocarditis due to penicillin non-susceptible viridans streptococci. J Infect 2006 0.75
57 Requirements for NF-kappaB activation in hemorrhagic shock. Arch Orthop Trauma Surg 2002 0.75