Published in Am J Physiol Gastrointest Liver Physiol on February 01, 2004
Nitric oxide and TNF-alpha trigger colonic inflammation and carcinogenesis in Helicobacter hepaticus-infected, Rag2-deficient mice. Proc Natl Acad Sci U S A (2009) 1.81
Isoflurane preconditioning increases B-cell lymphoma-2 expression and reduces cytochrome c release from the mitochondria in the ischemic penumbra of rat brain. Eur J Pharmacol (2008) 1.25
Trauma hemorrhagic shock-induced lung injury involves a gut-lymph-induced TLR4 pathway in mice. PLoS One (2011) 1.20
Gut motor function: immunological control in enteric infection and inflammation. Clin Exp Immunol (2006) 1.11
CO-releasing molecules (CORM-2)-liberated CO attenuates leukocytes infiltration in the renal tissue of thermally injured mice. Int J Biol Sci (2008) 0.98
Intestinal mucus layer preservation in female rats attenuates gut injury after trauma-hemorrhagic shock. J Trauma (2010) 0.91
Oxidative modification of the intestinal mucus layer is a critical but unrecognized component of trauma hemorrhagic shock-induced gut barrier failure. Am J Physiol Gastrointest Liver Physiol (2012) 0.89
Inducible nitric oxide synthase contributes to immune dysfunction following trauma. Shock (2012) 0.89
Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65. Sci Signal (2014) 0.87
RNA interference-produced autoregulation of inducible nitric oxide synthase expression. FEBS Lett (2011) 0.86
Protective effect of Astragalus membranaceus on intestinal mucosa reperfusion injury after hemorrhagic shock in rats. World J Gastroenterol (2005) 0.86
Lack of inducible nitric oxide synthases attenuates leukocyte-endothelial cell interactions in retinal microcirculation. Br J Ophthalmol (2008) 0.86
Mechanisms of smooth muscle responses to inflammation. Neurogastroenterol Motil (2012) 0.84
Downregulation of CPI-17 contributes to dysfunctional motility in chronic intestinal inflammation model mice and ulcerative colitis patients. J Gastroenterol (2008) 0.84
Antinociceptive effect of berberine on visceral hypersensitivity in rats. World J Gastroenterol (2013) 0.82
Carbon liberated from CO-releasing molecules attenuates leukocyte infiltration in the small intestine of thermally injured mice. World J Gastroenterol (2007) 0.82
A conscious mouse model of gastric ileus using clinically relevant endpoints. BMC Gastroenterol (2005) 0.81
Mechanical stress is a pro-inflammatory stimulus in the gut: in vitro, in vivo and ex vivo evidence. PLoS One (2014) 0.81
In vivo evaluation of ocular inflammatory responses in experimental diabetes. Br J Ophthalmol (2005) 0.81
Macrophage-produced IL-12p70 mediates hemorrhage-induced damage in a complement-dependent manner. Shock (2011) 0.80
The Molecular and Cellular Effect of Homocysteine Metabolism Imbalance on Human Health. Int J Mol Sci (2016) 0.80
Autoregulation of inducible nitric oxide synthase expression by RNA interference provides neuroprotection in neonatal rats. Theranostics (2015) 0.79
Three hydrogen-rich solutions protect against intestinal injury in uncontrolled hemorrhagic shock. Int J Clin Exp Med (2015) 0.79
Roles of nitric oxide and intestinal microbiota in the pathogenesis of necrotizing enterocolitis. J Pediatr Surg (2015) 0.79
Hyperhomocysteinemia decreases intestinal motility leading to constipation. Am J Physiol Gastrointest Liver Physiol (2012) 0.79
Interaction of hemorrhagic shock and subsequent polymicrobial sepsis on gastrointestinal motility. Shock (2009) 0.77
Evaluating the potential role of nitric oxide as a mediator of hydrostatic edema mediated intestinal contractile dysfunction. J Surg Res (2010) 0.75
iNOS as a Driver of Inflammation and Apoptosis in Mouse Skeletal Muscle after Burn Injury: Possible Involvement of Sirt1 S-Nitrosylation-Mediated Acetylation of p65 NF-κB and p53. PLoS One (2017) 0.75
TLR2 Regulates Complement-Mediated Inflammation Induced by Blood Loss During Hemorrhage. Shock (2016) 0.75
Direct detection of blood nitric oxide reveals a burn-dependent decrease of nitric oxide in response to Pseudomonas aeruginosa infection. Burns (2016) 0.75
Serum diamine oxidase as a hemorrhagic shock biomarker in a rabbit model. PLoS One (2014) 0.75
Anticoccidial activities of Chitosan on Eimeria papillata-infected mice. Parasitol Res (2016) 0.75
Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci U S A (2013) 16.74
The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. J Exp Med (2005) 6.86
A genomic storm in critically injured humans. J Exp Med (2011) 6.67
Fulminant Clostridium difficile: an underappreciated and increasing cause of death and complications. Ann Surg (2002) 4.91
HMGB1: endogenous danger signaling. Mol Med (2008) 4.02
HMGB1 release induced by liver ischemia involves Toll-like receptor 4 dependent reactive oxygen species production and calcium-mediated signaling. J Exp Med (2007) 3.72
Hepatic ischemia/reperfusion injury involves functional TLR4 signaling in nonparenchymal cells. J Immunol (2005) 2.78
Emerging paradigm: toll-like receptor 4-sentinel for the detection of tissue damage. Shock (2006) 2.61
Fresh frozen plasma is independently associated with a higher risk of multiple organ failure and acute respiratory distress syndrome. J Trauma (2009) 2.49
Oral hydrogen water prevents chronic allograft nephropathy in rats. Kidney Int (2009) 2.35
Debunking the survival bias myth: characterization of mortality during the initial 24 hours for patients requiring massive transfusion. J Trauma Acute Care Surg (2012) 2.32
Anti-HMGB1 neutralizing antibody ameliorates gut barrier dysfunction and improves survival after hemorrhagic shock. Mol Med (2006) 2.27
CD206-positive M2 macrophages that express heme oxygenase-1 protect against diabetic gastroparesis in mice. Gastroenterology (2010) 2.23
The changing pattern and implications of multiple organ failure after blunt injury with hemorrhagic shock. Crit Care Med (2012) 2.17
An FFP:PRBC transfusion ratio >/=1:1.5 is associated with a lower risk of mortality after massive transfusion. J Trauma (2008) 2.15
Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury. Nat Med (2003) 2.15
Targeting Stat3 in cancer therapy. Anticancer Drugs (2005) 2.13
Systemic inflammation and remote organ injury following trauma require HMGB1. Am J Physiol Regul Integr Comp Physiol (2007) 2.12
Single nucleotide polymorphisms in genes for 2'-5'-oligoadenylate synthetase and RNase L inpatients hospitalized with West Nile virus infection. J Infect Dis (2005) 2.11
Benchmarking outcomes in the critically injured trauma patient and the effect of implementing standard operating procedures. Ann Surg (2012) 2.07
Enterocyte TLR4 mediates phagocytosis and translocation of bacteria across the intestinal barrier. J Immunol (2006) 2.06
Hemorrhagic shock induces NAD(P)H oxidase activation in neutrophils: role of HMGB1-TLR4 signaling. J Immunol (2007) 2.02
Endotoxin uptake in mouse liver is blocked by endotoxin pretreatment through a suppressor of cytokine signaling-1-dependent mechanism. Hepatology (2009) 1.98
High-mobility group box 1 is essential for mitochondrial quality control. Cell Metab (2011) 1.89
Role of toll-like receptors in changes in gene expression and NF-kappa B activation in mouse hepatocytes stimulated with lipopolysaccharide. Infect Immun (2002) 1.85
The acute inflammatory response in diverse shock states. Shock (2005) 1.83
Amelioration of rat cardiac cold ischemia/reperfusion injury with inhaled hydrogen or carbon monoxide, or both. J Heart Lung Transplant (2009) 1.78
The practice of venous thromboembolism prophylaxis in the major trauma patient. J Trauma (2007) 1.76
Nitric oxide and wound repair: role of cytokines? Nitric Oxide (2002) 1.73
Brief inhalation of low-dose carbon monoxide protects rodents and swine from postoperative ileus. Crit Care Med (2005) 1.73
Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor. Cancer Res (2003) 1.73
Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor. Blood (2011) 1.69
A two-compartment mathematical model of endotoxin-induced inflammatory and physiologic alterations in swine. Crit Care Med (2012) 1.69
Inhibition of macrophage function prevents intestinal inflammation and postoperative ileus in rodents. Gut (2006) 1.65
Nuclear matrix protein alterations associated with colon cancer metastasis to the liver. Clin Cancer Res (2002) 1.65
Early events in the recognition of danger signals after tissue injury. J Leukoc Biol (2007) 1.65
Early use of vasopressors after injury: caution before constriction. J Trauma (2008) 1.64
The evolving management of venous bullet emboli: a case series and literature review. Injury (2011) 1.62
Characterization of acute coagulopathy and sexual dimorphism after injury: females and coagulopathy just do not mix. J Trauma Acute Care Surg (2012) 1.60
Carbon monoxide signals via inhibition of cytochrome c oxidase and generation of mitochondrial reactive oxygen species. FASEB J (2007) 1.60
Pivotal advance: The pattern recognition receptor ligands lipopolysaccharide and polyinosine-polycytidylic acid stimulate factor B synthesis by the macrophage through distinct but overlapping mechanisms. J Leukoc Biol (2010) 1.59
Intestinal epithelial Toll-like receptor 4 regulates goblet cell development and is required for necrotizing enterocolitis in mice. Gastroenterology (2012) 1.59
Inhaled carbon monoxide suppresses the development of postoperative ileus in the murine small intestine. Gastroenterology (2003) 1.59
Prehospital Hypotension Is Associated With Altered Inflammation Dynamics and Worse Outcomes Following Blunt Trauma in Humans. Crit Care Med (2015) 1.58
Toll-like receptor-4 signaling mediates hepatic injury and systemic inflammation in hemorrhagic shock. J Am Coll Surg (2006) 1.57
Inducible protein-10, a potential driver of neurally controlled interleukin-10 and morbidity in human blunt trauma. Crit Care Med (2014) 1.57
Interleukin-6 treatment reverses apoptosis and blunts susceptibility to intraperitoneal bacterial challenge following hemorrhagic shock. Crit Care Med (2006) 1.52
Male gender is associated with excessive IL-6 expression following severe injury. J Trauma (2008) 1.51
Thioredoxin catalyzes the denitrosation of low-molecular mass and protein S-nitrosothiols. Biochemistry (2007) 1.49
Beta2-integrin-induced p38 MAPK activation is a key mediator in the CD14/TLR4/MD2-dependent uptake of lipopolysaccharide by hepatocytes. J Biol Chem (2008) 1.49
Inhibition of interleukin-12 p40 transcription and NF-kappaB activation by nitric oxide in murine macrophages and dendritic cells. J Biol Chem (2003) 1.49
Stat3 activation links a C/EBPδ to myostatin pathway to stimulate loss of muscle mass. Cell Metab (2013) 1.49
A genomic score prognostic of outcome in trauma patients. Mol Med (2009) 1.48
Over reliance on computed tomography imaging in patients with severe abdominal injury: is the delay worth the risk? J Trauma (2011) 1.45
Thioredoxin and lipoic acid catalyze the denitrosation of low molecular weight and protein S-nitrosothiols. J Am Chem Soc (2005) 1.45
Systolic blood pressure criteria in the National Trauma Triage Protocol for geriatric trauma: 110 is the new 90. J Trauma Acute Care Surg (2015) 1.42
Intra-abdominal activation of a local inflammatory response within the human muscularis externa during laparotomy. Ann Surg (2003) 1.42
Profiling molecular changes induced by hydrogen treatment of lung allografts prior to procurement. Biochem Biophys Res Commun (2012) 1.42
Cutting edge: high-mobility group box 1 preconditioning protects against liver ischemia-reperfusion injury. J Immunol (2006) 1.42
Systemic inflammation and remote organ damage following bilateral femur fracture requires Toll-like receptor 4. Am J Physiol Regul Integr Comp Physiol (2006) 1.40
Calcium/calmodulin-dependent protein kinase (CaMK) IV mediates nucleocytoplasmic shuttling and release of HMGB1 during lipopolysaccharide stimulation of macrophages. J Immunol (2008) 1.39
Carbon monoxide protects against liver failure through nitric oxide-induced heme oxygenase 1. J Exp Med (2003) 1.39
Biliverdin protects the functional integrity of a transplanted syngeneic small bowel. Gastroenterology (2004) 1.39
Chemical probes that competitively and selectively inhibit Stat3 activation. PLoS One (2009) 1.37
Hemorrhagic shock augments lung endothelial cell activation: role of temporal alterations of TLR4 and TLR2. Am J Physiol Regul Integr Comp Physiol (2009) 1.36
Protection against ischemia/reperfusion injury in cardiac and renal transplantation with carbon monoxide, biliverdin and both. Am J Transplant (2005) 1.36
Goal-directed resuscitation in the prehospital setting: a propensity-adjusted analysis. J Trauma Acute Care Surg (2013) 1.36
Benzyl alcohol attenuates acetaminophen-induced acute liver injury in a Toll-like receptor-4-dependent pattern in mice. Hepatology (2014) 1.35
Analysis of factorial time-course microarrays with application to a clinical study of burn injury. Proc Natl Acad Sci U S A (2010) 1.33
Role of heme oxygenase 1 in TNF/TNF receptor-mediated apoptosis after hepatic ischemia/reperfusion in rats. Shock (2013) 1.32
Systemic inflammation and end organ damage following trauma involves functional TLR4 signaling in both bone marrow-derived cells and parenchymal cells. J Leukoc Biol (2007) 1.31
Role of nitric oxide in liver injury. Curr Mol Med (2003) 1.30
Tissue hypoxia activates JNK in the liver during hemorrhagic shock. Shock (2004) 1.30
Therapeutic antioxidant medical gas. J Clin Biochem Nutr (2008) 1.29
Sepsis: Something old, something new, and a systems view. J Crit Care (2011) 1.29
G-quartet oligonucleotides: a new class of signal transducer and activator of transcription 3 inhibitors that suppresses growth of prostate and breast tumors through induction of apoptosis. Cancer Res (2004) 1.29
Blood soluble drag-reducing polymers prevent lethality from hemorrhagic shock in acute animal experiments. Biorheology (2004) 1.29
Selective jejunal manipulation causes postoperative pan-enteric inflammation and dysmotility. Gastroenterology (2004) 1.28
Structural requirements for signal transducer and activator of transcription 3 binding to phosphotyrosine ligands containing the YXXQ motif. J Biol Chem (2004) 1.28
Increasing numbers of hepatic dendritic cells promote HMGB1-mediated ischemia-reperfusion injury. J Leukoc Biol (2006) 1.27
In silico and in vivo approach to elucidate the inflammatory complexity of CD14-deficient mice. Mol Med (2006) 1.25
Hemorrhagic shock activation of NLRP3 inflammasome in lung endothelial cells. J Immunol (2011) 1.25
Nitric oxide facilitates cardiomyogenesis in mouse embryonic stem cells. Proc Natl Acad Sci U S A (2004) 1.25
A dynamic view of trauma/hemorrhage-induced inflammation in mice: principal drivers and networks. PLoS One (2011) 1.24
Targeting Stat3 with G-quartet oligodeoxynucleotides in human cancer cells. DNA Cell Biol (2003) 1.23
Lipopolysaccharide clearance, bacterial clearance, and systemic inflammatory responses are regulated by cell type-specific functions of TLR4 during sepsis. J Immunol (2013) 1.23