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Superoxide in apoptosis. Mitochondrial generation triggered by cytochrome c loss. J Biol Chem (1998) 2.51

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BCL-2 and glutathione: alterations in cellular redox state that regulate apoptosis sensitivity. Free Radic Biol Med (1999) 1.95

Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux. Proc Natl Acad Sci U S A (1998) 1.92

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Oxygen sensing in yeast: evidence for the involvement of the respiratory chain in regulating the transcription of a subset of hypoxic genes. Proc Natl Acad Sci U S A (1999) 1.70

Oncogenic potential of bcl-2 demonstrated by gene transfer. Nature (1988) 1.60

Inhibition of glutathione synthesis reverses Bcl-2-mediated cisplatin resistance. Cancer Res (2003) 1.57

Regulation by bcl-2, c-myc, and p53 of susceptibility to induction of apoptosis by heat shock and cancer chemotherapy compounds in differentiation-competent and -defective myeloid leukemic cells. Cell Growth Differ (1993) 1.50

Thioredoxin peroxidase is a novel inhibitor of apoptosis with a mechanism distinct from that of Bcl-2. J Biol Chem (1997) 1.49

BH3 death domain peptide induces cell type-selective mitochondrial outer membrane permeability. J Biol Chem (2001) 1.31

Glutathione depletion enforces the mitochondrial permeability transition and causes cell death in Bcl-2 overexpressing HL60 cells. FASEB J (2002) 1.30

Shift of the cellular oxidation-reduction potential in neural cells expressing Bcl-2. J Neurochem (1996) 1.29

Regulation of hydrogen peroxide production by brain mitochondria by calcium and Bax. J Neurochem (2002) 1.26

Resistance to radiation-induced apoptosis in Bcl-2-expressing cells is reversed by depleting cellular thiols. Oncogene (1997) 1.25

Bcl-2 expression causes redistribution of glutathione to the nucleus. Proc Natl Acad Sci U S A (1998) 1.23

Apoptosis by a cytosolic extract from Fas-activated cells. EMBO J (1995) 1.21

Bcl-2 and mitochondrial oxygen radicals. New approaches with reactive oxygen species-sensitive probes. J Biol Chem (1999) 1.11

Apoptosis suppression by bcl-2 is correlated with the regulation of nuclear and cytosolic Ca2+. Oncogene (1996) 1.11

The thiol crosslinking agent diamide overcomes the apoptosis-inhibitory effect of Bcl-2 by enforcing mitochondrial permeability transition. Oncogene (1998) 1.09

Cholesterol impairs the adenine nucleotide translocator-mediated mitochondrial permeability transition through altered membrane fluidity. J Biol Chem (2003) 1.07

Enhanced oxidative stress and altered antioxidants in brains of Bcl-2-deficient mice. J Neurochem (1998) 1.05

Glutathione peroxidase-1 protects from CD95-induced apoptosis. J Biol Chem (2002) 1.03

Bcl-2 prevents mitochondrial permeability transition and cytochrome c release via maintenance of reduced pyridine nucleotides. Cell Death Differ (2000) 1.02

Effect of Bcl-2 overexpression on mitochondrial structure and function. J Biol Chem (2002) 1.02

Bcl-2 family proteins regulate mitochondrial reactive oxygen production and protect against oxidative stress. Free Radic Biol Med (2004) 1.01

Bcl-xL overexpression attenuates glutathione depletion in FL5.12 cells following interleukin-3 withdrawal. Biochem J (1997) 0.94

Expression of Bcl-2 increases intracellular glutathione by inhibiting methionine-dependent GSH efflux. Biochem Biophys Res Commun (1998) 0.93

Bcl-2 family members inhibit oxidative stress-induced programmed cell death in Saccharomyces cerevisiae. Free Radic Biol Med (2003) 0.93

Up-regulation of Bcl-xL in response to subtoxic beta-amyloid: role in neuronal resistance against apoptotic and oxidative injury. Neuroscience (2001) 0.92

Bcl-2 protects neural cells from cyanide/aglycemia-induced lipid oxidation, mitochondrial injury, and loss of viability. J Neurochem (1995) 0.91

Cytosolic thioredoxin peroxidase I is essential for the antioxidant defense of yeast with dysfunctional mitochondria. FEBS Lett (2001) 0.91

Generation of reactive oxygen species by the mitochondrial electron transport chain. J Neurochem (2002) 3.61

Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species. J Neurosci (2004) 2.57

Regulation of brain mitochondrial H2O2 production by membrane potential and NAD(P)H redox state. J Neurochem (2003) 2.46

Hyperoxic resuscitation improves survival but worsens neurologic outcome in a rat polytrauma model of traumatic brain injury plus hemorrhagic shock. J Trauma Acute Care Surg (2015) 1.97

Mitochondrial calcium and oxidative stress as mediators of ischemic brain injury. Cell Calcium (2004) 1.86

Mitochondrial mechanisms of neural cell apoptosis. J Neurochem (2004) 1.65

Diffusion kurtosis as an in vivo imaging marker for reactive astrogliosis in traumatic brain injury. Neuroimage (2011) 1.45

Hyperoxic reperfusion after global ischemia decreases hippocampal energy metabolism. Stroke (2007) 1.37

Normoxic resuscitation after cardiac arrest protects against hippocampal oxidative stress, metabolic dysfunction, and neuronal death. J Cereb Blood Flow Metab (2006) 1.36

Novel mitochondrial targets for neuroprotection. J Cereb Blood Flow Metab (2012) 1.35

Pyruvate dehydrogenase complex: metabolic link to ischemic brain injury and target of oxidative stress. J Neurosci Res (2004) 1.32

Mitochondrial mechanisms of cell death and neuroprotection in pediatric ischemic and traumatic brain injury. Exp Neurol (2009) 1.31

Oximetry-guided reoxygenation improves neurological outcome after experimental cardiac arrest. Stroke (2006) 1.31

Dietary omega-3 fatty acids alter cardiac mitochondrial phospholipid composition and delay Ca2+-induced permeability transition. J Mol Cell Cardiol (2009) 1.28

Regulation of hydrogen peroxide production by brain mitochondria by calcium and Bax. J Neurochem (2002) 1.26

Isolation of mitochondria with high respiratory control from primary cultures of neurons and astrocytes using nitrogen cavitation. J Neurosci Methods (2005) 1.24

Cyclosporin A-insensitive permeability transition in brain mitochondria: inhibition by 2-aminoethoxydiphenyl borate. J Biol Chem (2003) 1.18

Physiologic progesterone reduces mitochondrial dysfunction and hippocampal cell loss after traumatic brain injury in female rats. Exp Neurol (2005) 1.16

Upregulation of the Fas receptor death-inducing signaling complex after traumatic brain injury in mice and humans. J Neurosci (2002) 1.15

Postischemic hyperoxia reduces hippocampal pyruvate dehydrogenase activity. Free Radic Biol Med (2006) 1.15

Dietary supplementation with docosahexaenoic acid, but not eicosapentaenoic acid, dramatically alters cardiac mitochondrial phospholipid fatty acid composition and prevents permeability transition. Biochim Biophys Acta (2010) 1.14

Mechanisms of impaired mitochondrial energy metabolism in acute and chronic neurodegenerative disorders. J Neurosci Res (2007) 1.14

GABAergic mechanism of propofol toxicity in immature neurons. J Neurosurg Anesthesiol (2008) 1.13

Early microstructural and metabolic changes following controlled cortical impact injury in rat: a magnetic resonance imaging and spectroscopy study. J Neurotrauma (2011) 1.12

Nrf2 activators provide neuroprotection against 6-hydroxydopamine toxicity in rat organotypic nigrostriatal cocultures. J Neurosci Res (2009) 1.11

Sulforaphane protects astrocytes against oxidative stress and delayed death caused by oxygen and glucose deprivation. Glia (2009) 1.10

Inhibition of Bax-induced cytochrome c release from neural cell and brain mitochondria by dibucaine and propranolol. J Neurosci (2003) 1.09

Mechanisms of ischemic neuroprotection by acetyl-L-carnitine. Ann N Y Acad Sci (2005) 1.07

Hyperbaric oxygen reduces neuronal death and improves neurological outcome after canine cardiac arrest. Stroke (2003) 1.07

Mitochondrial dysfunction early after traumatic brain injury in immature rats. J Neurochem (2007) 1.06

Astrocyte mitochondrial mechanisms of ischemic brain injury and neuroprotection. Neurochem Res (2004) 1.06

Neuroprotection by acetyl-L-carnitine after traumatic injury to the immature rat brain. Dev Neurosci (2011) 1.06

Metabolism of acetyl-L-carnitine for energy and neurotransmitter synthesis in the immature rat brain. J Neurochem (2010) 1.05

Cyclosporin A increases mitochondrial calcium uptake capacity in cortical astrocytes but not cerebellar granule neurons. J Bioenerg Biomembr (2006) 1.05

Hyperoxic reperfusion after global cerebral ischemia promotes inflammation and long-term hippocampal neuronal death. J Neurotrauma (2010) 1.02

Effect of Bcl-2 overexpression on mitochondrial structure and function. J Biol Chem (2002) 1.02

The potential role of mitochondria in pediatric traumatic brain injury. Dev Neurosci (2006) 1.02

Bcl-2 family proteins regulate mitochondrial reactive oxygen production and protect against oxidative stress. Free Radic Biol Med (2004) 1.01

The role of tetrahydrobiopterin in the regulation of neuronal nitric-oxide synthase-generated superoxide. J Biol Chem (2002) 1.00

Heterogeneity of the calcium-induced permeability transition in isolated non-synaptic brain mitochondria. J Neurochem (2002) 0.98

Early processing of Bid and caspase-6, -8, -10, -14 in the canine brain during cardiac arrest and resuscitation. Exp Neurol (2004) 0.98

Delayed cerebral oxidative glucose metabolism after traumatic brain injury in young rats. J Neurochem (2009) 0.98

Influence of aging on membrane permeability transition in brain mitochondria. J Bioenerg Biomembr (2011) 0.96

Calcium-induced precipitate formation in brain mitochondria: composition, calcium capacity, and retention. J Neurochem (2007) 0.96

Sulforaphane inhibits mitochondrial permeability transition and oxidative stress. Free Radic Biol Med (2011) 0.96

Neuroprotective effects of hyperbaric oxygen treatment in experimental focal cerebral ischemia are associated with reduced brain leukocyte myeloperoxidase activity. Brain Res (2003) 0.95

Early and sustained alterations in cerebral metabolism after traumatic brain injury in immature rats. J Neurotrauma (2008) 0.95

Quantitative imaging of mitochondrial and cytosolic free zinc levels in an in vitro model of ischemia/reperfusion. J Bioenerg Biomembr (2012) 0.95

Hyperoxia promotes astrocyte cell death after oxygen and glucose deprivation. Glia (2008) 0.92

Inhibition of glutamate-induced delayed calcium deregulation by 2-APB and La3+ in cultured cortical neurones. J Neurochem (2004) 0.92

Neuron-specific conditional expression of a mitochondrially targeted fluorescent protein in mice. J Neurosci (2006) 0.91

Methoxychlor inhibits brain mitochondrial respiration and increases hydrogen peroxide production and CREB phosphorylation. Toxicol Sci (2005) 0.91

Brain mitochondria from rats treated with sulforaphane are resistant to redox-regulated permeability transition. J Bioenerg Biomembr (2010) 0.91

Postnatal developmental regulation of Bcl-2 family proteins in brain mitochondria. J Neurosci Res (2008) 0.91

Sulforaphane protects immature hippocampal neurons against death caused by exposure to hemin or to oxygen and glucose deprivation. J Neurosci Res (2010) 0.90

Effects of FK506 and cyclosporin a on calcium ionophore-induced mitochondrial depolarization and cytosolic calcium in astrocytes and neurons. J Neurosci Res (2011) 0.89

Cyclophilin D is expressed predominantly in mitochondria of gamma-aminobutyric acidergic interneurons. J Neurosci Res (2009) 0.89

A fluorescence-based technique for screening compounds that protect against damage to brain mitochondria. Brain Res Brain Res Protoc (2004) 0.87

Neuroprotection through stimulation of mitochondrial antioxidant protein expression. J Alzheimers Dis (2010) 0.86

Mitochondrial response to calcium in the developing brain. Brain Res Dev Brain Res (2004) 0.85

Expression of cellular FLICE inhibitory proteins (cFLIP) in normal and traumatic murine and human cerebral cortex. J Cereb Blood Flow Metab (2005) 0.85

Regulation of mitochondrial gene expression by energy demand in neural cells. J Neurochem (2005) 0.85

Anoxia-induced changes in pyridine nucleotide redox state in cortical neurons and astrocytes. Neurochem Res (2006) 0.83

Delayed therapy of experimental global cerebral ischemia with acetyl-L-carnitine in dogs. Neurosci Lett (2005) 0.83

TAT-mediated endocytotic delivery of the loop deletion Bcl-2 protein protects neurons against cell death. J Neurochem (2005) 0.83

Cellular alterations in human traumatic brain injury: changes in mitochondrial morphology reflect regional levels of injury severity. J Neurotrauma (2013) 0.82

Inhibition of mitochondrial neural cell death pathways by protein transduction of Bcl-2 family proteins. J Bioenerg Biomembr (2005) 0.82

Normoxic ventilatory resuscitation following controlled cortical impact reduces peroxynitrite-mediated protein nitration in the hippocampus. J Neurosurg (2008) 0.82

Visualization and quantification of NAD(H) in brain sections by a novel histo-enzymatic nitrotetrazolium blue staining technique. Brain Res (2009) 0.81

Cerebral glucose metabolism in an immature rat model of pediatric traumatic brain injury. J Neurotrauma (2013) 0.81

Effects of the organochlorine pesticide methoxychlor on dopamine metabolites and transporters in the mouse brain. Neurotoxicology (2009) 0.81

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Dietary restriction in cerebral bioenergetics and redox state. Redox Biol (2014) 0.80

Magnesium sulfate protects against the bioenergetic consequences of chronic glutamate receptor stimulation. PLoS One (2013) 0.79

Oxygen: could there be too much of a good thing? Hosp Med (2005) 0.78

Bilobalide, a component of the Ginkgo biloba extract (EGb 761), protects against neuronal death in global brain ischemia and in glutamate-induced excitotoxicity. Cell Mol Biol (Noisy-le-grand) (2002) 0.78

Hypotensive hemorrhage increases calcium uptake capacity and Bcl-XL content of liver mitochondria. Shock (2007) 0.77

Augmentation of normal and glutamate-impaired neuronal respiratory capacity by exogenous alternative biofuels. Transl Stroke Res (2013) 0.77

Calcium-dependent dephosphorylation of brain mitochondrial calcium/cAMP response element binding protein (CREB). J Neurochem (2005) 0.77

The IFN-beta and retinoic acid-induced cell death regulator GRIM-19 is upregulated during focal cerebral ischemia. J Interferon Cytokine Res (2007) 0.76

Synthes Award for Resident Research on Brain and Craniofacial Injury: normoxic ventilatory resuscitation after controlled cortical impact reduces peroxynitrite-mediated protein nitration in the hippocampus. Clin Neurosurg (2005) 0.76

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Permeability transition pore-dependent and PARP-mediated depletion of neuronal pyridine nucleotides during anoxia and glucose deprivation. J Bioenerg Biomembr (2014) 0.75

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Aeromedical evacuation-relevant hypobaria worsens axonal and neurologic injury in rats following underbody blast-induced hyperacceleration. J Trauma Acute Care Surg (2017) 0.75