Cholesterol impairs the adenine nucleotide translocator-mediated mitochondrial permeability transition through altered membrane fluidity.

PubWeight™: 1.07‹?› | Rank: Top 10%

🔗 View Article (PMID 12821666)

Published in J Biol Chem on June 23, 2003

Authors

Anna Colell1, Carmen García-Ruiz, Josep M Lluis, Olga Coll, Montse Mari, José C Fernández-Checa

Author Affiliations

1: Liver Unit, Institut de Malalties Digestives, Hospital Clínic y Provincial, Instituto Investigaciones Biomédicas August Pi Suñer, Barcelona, Spain.

Articles citing this

Regulation of hexokinase binding to VDAC. J Bioenerg Biomembr (2008) 1.73

Detergent-resistant microdomains determine the localization of sigma-1 receptors to the endoplasmic reticulum-mitochondria junction. Mol Pharmacol (2010) 1.44

Specific contribution of methionine and choline in nutritional nonalcoholic steatohepatitis: impact on mitochondrial S-adenosyl-L-methionine and glutathione. J Biol Chem (2010) 1.22

Anticancer activity of the cholesterol exporter ABCA1 gene. Cell Rep (2012) 1.14

Redox control of liver function in health and disease. Antioxid Redox Signal (2010) 1.12

MLN64 mediates egress of cholesterol from endosomes to mitochondria in the absence of functional Niemann-Pick Type C1 protein. J Lipid Res (2009) 1.07

Redox mechanisms of cytoprotection by Bcl-2. Antioxid Redox Signal (2005) 1.01

Cholesterol and peroxidized cardiolipin in mitochondrial membrane properties, permeabilization and cell death. Biochim Biophys Acta (2010) 0.95

Betulin is a potent anti-tumor agent that is enhanced by cholesterol. PLoS One (2009) 0.88

Metabolism of melatonin by cytochrome P450s in rat liver mitochondria and microsomes. J Pineal Res (2008) 0.85

LDL protein nitration: implication for LDL protein unfolding. Arch Biochem Biophys (2008) 0.84

Adaptations of energy metabolism associated with increased levels of mitochondrial cholesterol in Niemann-Pick type C1-deficient cells. J Biol Chem (2014) 0.83

Mitochondrial cholesterol accumulation in alcoholic liver disease: Role of ASMase and endoplasmic reticulum stress. Redox Biol (2014) 0.80

Bax inhibitor-1-mediated inhibition of mitochondrial Ca2+ intake regulates mitochondrial permeability transition pore opening and cell death. Sci Rep (2014) 0.79

Prolonged exposure to insulin induces mitochondrion-derived oxidative stress through increasing mitochondrial cholesterol content in hepatocytes. Endocrinology (2012) 0.78

Mitochondrial GWA Analysis of Lipid Profile Identifies Genetic Variants to Be Associated with HDL Cholesterol and Triglyceride Levels. PLoS One (2015) 0.77

Mitochondrial cholesterol: mechanisms of import and effects on mitochondrial function. J Bioenerg Biomembr (2014) 0.77

Role of membrane biophysics in Alzheimer's-related cell pathways. Front Neurosci (2015) 0.76

Ob/ob mouse livers show decreased oxidative phosphorylation efficiencies and anaerobic capacities after cold ischemia. PLoS One (2014) 0.75

Impacts of membrane biophysics in Alzheimer's disease: from amyloid precursor protein processing to aβ Peptide-induced membrane changes. Int J Alzheimers Dis (2011) 0.75

Changes in liver mitochondrial plasticity induced by brain tumor. BMC Cancer (2006) 0.75

MLN64 induces mitochondrial dysfunction associated with increased mitochondrial cholesterol content. Redox Biol (2017) 0.75

Enhanced Neuroplasticity by the Metabolic Enhancer Piracetam Associated with Improved Mitochondrial Dynamics and Altered Permeability Transition Pore Function. Neural Plast (2016) 0.75

The 2-oxoglutarate carrier promotes liver cancer by sustaining mitochondrial GSH despite cholesterol loading. Redox Biol (2017) 0.75

Zinc oxide nanoparticles induce apoptosis and autophagy in human ovarian cancer cells. Int J Nanomedicine (2017) 0.75

Articles by these authors

Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis. Cell Metab (2006) 3.95

Mitochondrial glutathione, a key survival antioxidant. Antioxid Redox Signal (2009) 2.28

Rapid determination of scopolamine in evidence of recreational and predatory use. Sci Justice (2013) 2.01

Critical role of tumor necrosis factor receptor 1, but not 2, in hepatic stellate cell proliferation, extracellular matrix remodeling, and liver fibrogenesis. Hepatology (2011) 1.73

Sensitivity of the 2-oxoglutarate carrier to alcohol intake contributes to mitochondrial glutathione depletion. Hepatology (2003) 1.72

Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH. J Hepatol (2009) 1.60

Defective TNF-alpha-mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout mice. J Clin Invest (2003) 1.58

Targeting cholesterol at different levels in the mevalonate pathway protects fatty liver against ischemia-reperfusion injury. J Hepatol (2010) 1.51

Caveolin-1 deficiency causes cholesterol-dependent mitochondrial dysfunction and apoptotic susceptibility. Curr Biol (2011) 1.31

Mitochondrial cholesterol loading exacerbates amyloid beta peptide-induced inflammation and neurotoxicity. J Neurosci (2009) 1.27

Trafficking of ganglioside GD3 to mitochondria by tumor necrosis factor-alpha. J Biol Chem (2002) 1.24

Acidic sphingomyelinase controls hepatic stellate cell activation and in vivo liver fibrogenesis. Am J Pathol (2010) 1.24

Cathepsins B and D drive hepatic stellate cell proliferation and promote their fibrogenic potential. Hepatology (2009) 1.23

Specific contribution of methionine and choline in nutritional nonalcoholic steatohepatitis: impact on mitochondrial S-adenosyl-L-methionine and glutathione. J Biol Chem (2010) 1.22

Mitochondrial cholesterol contributes to chemotherapy resistance in hepatocellular carcinoma. Cancer Res (2008) 1.21

Cytoplasmic polyadenylation and translational control. Curr Opin Genet Dev (2011) 1.15

Reactive oxygen species mediate liver injury through parenchymal nuclear factor-kappaB inactivation in prolonged ischemia/reperfusion. Am J Pathol (2009) 1.15

Acetaldehyde impairs mitochondrial glutathione transport in HepG2 cells through endoplasmic reticulum stress. Gastroenterology (2003) 1.14

Sphingolipid signalling and liver diseases. Liver Int (2007) 1.13

Redox control of liver function in health and disease. Antioxid Redox Signal (2010) 1.12

Mitochondrial glutathione: features, regulation and role in disease. Biochim Biophys Acta (2012) 1.11

Cathepsin B overexpression due to acid sphingomyelinase ablation promotes liver fibrosis in Niemann-Pick disease. J Biol Chem (2011) 1.07

Drosophila UNR is required for translational repression of male-specific lethal 2 mRNA during regulation of X-chromosome dosage compensation. Genes Dev (2006) 1.06

Growth arrest-specific protein 6 is hepatoprotective against murine ischemia/reperfusion injury. Hepatology (2010) 1.05

Mechanism of mitochondrial glutathione-dependent hepatocellular susceptibility to TNF despite NF-kappaB activation. Gastroenterology (2008) 1.04

Prevalence and mechanisms of hyperhomocysteinemia in chronic alcoholics. Alcohol Clin Exp Res (2005) 1.04

Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis. J Clin Invest (2004) 0.98

Ganglioside GD3 sensitizes human hepatoma cells to cancer therapy. J Biol Chem (2002) 0.93

Ceramide generated by acidic sphingomyelinase contributes to tumor necrosis factor-alpha-mediated apoptosis in human colon HT-29 cells through glycosphingolipids formation. Possible role of ganglioside GD3. FEBS Lett (2002) 0.91

S-Adenosyl-L-methionine and mitochondrial reduced glutathione depletion in alcoholic liver disease. Alcohol (2002) 0.91

Multi-compartmental environmental surveillance of a petrochemical area: levels of micropollutants. Environ Int (2008) 0.90

Redox regulation of hepatocyte apoptosis. J Gastroenterol Hepatol (2007) 0.90

Ceramide, tumor necrosis factor and alcohol-induced liver disease. Alcohol Clin Exp Res (2005) 0.90

Alcohol, signaling, and ECM turnover. Alcohol Clin Exp Res (2009) 0.89

Neutral sphingomyelinase-induced ceramide triggers germinal vesicle breakdown and oxidant-dependent apoptosis in Xenopus laevis oocytes. J Lipid Res (2007) 0.87

Mitochondrial cholesterol: a connection between caveolin, metabolism, and disease. Traffic (2011) 0.87

Mitochondrial S-adenosyl-L-methionine transport is insensitive to alcohol-mediated changes in membrane dynamics. Alcohol Clin Exp Res (2009) 0.86

Mitochondria, cholesterol and amyloid beta peptide: a dangerous trio in Alzheimer disease. J Bioenerg Biomembr (2009) 0.85

Systemic effects of cigarette smoke exposure in the guinea pig. Respir Med (2005) 0.85

Traceability markers to the botanical origin in olive oils. J Agric Food Chem (2010) 0.85

Mitochondrial permeability transition induced by reactive oxygen species is independent of cholesterol-regulated membrane fluidity. FEBS Lett (2004) 0.84

Determination of nitrocellulose by capillary electrophoresis with laser-induced fluorescence detection. Anal Chim Acta (2012) 0.82

Divergent role of ceramide generated by exogenous sphingomyelinases on NF-kappa B activation and apoptosis in human colon HT-29 cells. FEBS Lett (2002) 0.81

Alcoholic liver injury and apoptosis--synopsis of the symposium held at ESBRA 2001: 8th Congress of the European Society for Biomedical Research on Alcoholism, Paris, September 16, 2001. Alcohol (2002) 0.80

Environmental monitoring of metals, PCDD/Fs and PCBs as a complementary tool of biological surveillance to assess human health risks. Chemosphere (2010) 0.80

Monitoring environmental pollutants in the vicinity of a cement plant: a temporal study. Arch Environ Contam Toxicol (2010) 0.79

Ammunition identification by means of the organic analysis of gunshot residues using Raman spectroscopy. Anal Chem (2012) 0.79

Glycosphingolipids and cell death: one aim, many ways. Apoptosis (2015) 0.78

Identification and quantitation of cis-ketoconazole impurity by capillary zone electrophoresis-mass spectrometry. J Chromatogr A (2006) 0.78

Monitoring temporal trends in environmental levels of polychlorinated dibenzo-p-dioxins and dibenzofurans: results from a 10-year surveillance program of a hazardous waste incinerator. Arch Environ Contam Toxicol (2010) 0.78

Analysis of macroscopic gunshot residues by Raman spectroscopy to assess the weapon memory effect. Forensic Sci Int (2013) 0.78

Separation of etodolac enantiomers by capillary electrophoresis. Validation and application of the chiral method to the analysis of commercial formulations. Electrophoresis (2005) 0.78

Study of losses of volatile compounds from dynamites. Investigation of cross-contamination between dynamites stored in polyethylene bags. Forensic Sci Int (2011) 0.78

Molecular characterization of phospholipids by high-performance liquid chromatography combined with an evaporative light scattering detector, high-performance liquid chromatography combined with mass spectrometry, and gas chromatography combined with a flame ionization detector in different oat varieties. J Agric Food Chem (2012) 0.77

Sensitive determination of D-carnitine as enantiomeric impurity of levo-carnitine in pharmaceutical formulations by capillary electrophoresis-tandem mass spectrometry. J Pharm Biomed Anal (2010) 0.77

Raman spectroscopy for forensic analysis of inks in questioned documents. Forensic Sci Int (2013) 0.77

Modification of an environmental surveillance program to monitor PCDD/Fs and metals around a municipal solid waste incinerator. J Environ Sci Health A Tox Hazard Subst Environ Eng (2009) 0.77

Determination of trigonelline in seeds and vegetable oils by capillary electrophoresis as a novel marker for the detection of adulterations in olive oils. J Agric Food Chem (2010) 0.76

Use of sewage sludge as secondary fuel in a cement plant: human health risks. Environ Int (2011) 0.76

Enantioselective separation of azole compounds by EKC. Reversal of migration order of enantiomers with CD concentration. Electrophoresis (2007) 0.75

Separation of olive proteins by capillary gel electrophoresis. Talanta (2012) 0.75

Separation and online preconcentration by multistep stacking with large-volume injection of anabolic steroids by capillary electrokinetic chromatography using charged cyclodextrins and UV-absorption detection. J Sep Sci (2005) 0.75

Forensic discrimination of blue ballpoint pens on documents by laser ablation inductively coupled plasma mass spectrometry and multivariate analysis. Forensic Sci Int (2013) 0.75

CE methods for the determination of non-protein amino acids in foods. Electrophoresis (2007) 0.75

Differential modulation of interleukin 8 by interleukin 4 and interleukin 10 in HepG2 cells treated with acetaldehyde. Liver Int (2005) 0.75

Diphenylamine and derivatives as predictors of gunpowder age by means of HPLC and statistical models. Talanta (2012) 0.75

Dynamite analysis by Raman spectroscopy as a unique analytical tool. Anal Chem (2013) 0.75

Sensitive chiral analysis by CE: an update. Electrophoresis (2008) 0.75

Comparative analysis of smokeless gunpowders by Fourier transform infrared and Raman spectroscopy. Anal Chim Acta (2012) 0.75

Why is methenamine detected in Goma-2 dynamites originally methenamine free? An interpretation of relevant forensic results. Forensic Sci Int (2011) 0.75

Detection and quantitation of additions of soybean proteins in cured-meat products by perfusion reversed-phase high-performance liquid chromatography. J Sep Sci (2005) 0.75

Rapid determination of salbutamol in pharmaceutical preparations by chiral capillary electrophoresis. Electrophoresis (2003) 0.75

Acute and sub-acute effect of ferric carboxymaltose on inflammation and adhesion molecules in patients with predialysis chronic renal failure. Nefrologia (2013) 0.75

Peanut allergens: an overview. Crit Rev Food Sci Nutr (2013) 0.75

Enantioselective separation of the sunscreen agent 3-(4-methylbenzylidene)-camphor by electrokinetic chromatography: Quantitative analysis in cosmetic formulations. Electrophoresis (2005) 0.75