A hybrid molecule that prohibits amyloid fibrils and alleviates neuronal toxicity induced by beta-amyloid (1-42).

PubWeight™: 0.80‹?›

🔗 View Article (PMID 15707952)

Published in Biochem Biophys Res Commun on March 25, 2005

Authors

Kyung Hyun Lee1, Byung Hee Shin, Kye Jung Shin, Dong Jin Kim, Jaehoon Yu

Author Affiliations

1: Department of Chemistry and Education, Seoul National University, Seoul 151-742, Republic of Korea.

Articles by these authors

A high-throughput screen for compounds that inhibit aggregation of the Alzheimer's peptide. ACS Chem Biol (2006) 2.09

Application of the HALF index obviates the need for liver biopsy in half of all patients with chronic hepatitis B. J Gastroenterol Hepatol (2011) 1.63

beta-catenin regulates multiple steps of RNA metabolism as revealed by the RNA aptamer in colon cancer cells. Cancer Res (2007) 1.11

Comparison of the efficacies of lamivudine versus entecavir in patients with hepatitis B virus-related decompensated cirrhosis. Liver Int (2011) 1.05

Safety of intracorporeal circular stapling esophagojejunostomy using trans-orally inserted anvil (OrVil) following laparoscopic total or proximal gastrectomy - comparison with extracorporeal anastomosis. World J Surg Oncol (2013) 1.00

Phosphorylation of hepatitis B virus Cp at Ser87 facilitates core assembly. Biochem J (2006) 0.96

Synthesis and biological evaluations of pyrazolo[3,4-d]pyrimidines as cyclin-dependent kinase 2 inhibitors. Eur J Med Chem (2003) 0.95

Expression of liver X receptor correlates with intrahepatic inflammation and fibrosis in patients with nonalcoholic fatty liver disease. Dig Dis Sci (2014) 0.91

Betulinic acid inhibits growth factor-induced in vitro angiogenesis via the modulation of mitochondrial function in endothelial cells. Jpn J Cancer Res (2002) 0.91

Identification of hNopp140 as a binding partner for doxorubicin with a phage display cloning method. Chem Biol (2002) 0.90

Amelioration of Alzheimer's disease by neuroprotective effect of sulforaphane in animal model. Amyloid (2012) 0.88

An approach to enhance specificity against RNA targets using heteroconjugates of aminoglycosides and chloramphenicol (or linezolid). J Am Chem Soc (2004) 0.87

Pattern generation of biological ligands on a biodegradable poly(glycolic acid) film. Langmuir (2004) 0.87

Bimolecular fluorescence complementation; lighting-up tau-tau interaction in living cells. PLoS One (2013) 0.87

Aminostyrylbenzofuran derivatives as potent inhibitors for Abeta fibril formation. Bioorg Med Chem Lett (2008) 0.86

Biomimetic asymmetric total synthesis of (-)-laurefucin via an organoselenium-mediated intramolecular hydroxyetherification. J Am Chem Soc (2008) 0.86

Intracellular expression of the T-cell factor-1 RNA aptamer as an intramer. Mol Cancer Ther (2006) 0.86

Amphiphilic helical peptides containing two acridine moieties display picomolar affinity toward HIV-1 RRE and TAR. Angew Chem Int Ed Engl (2008) 0.85

IKKbeta inhibitors identification part II: ligand and structure-based virtual screening. Bioorg Med Chem (2010) 0.85

Preparation and characterization of reconstructed small intestinal brush border membranes for surface plasmon resonance analysis. Pharm Res (2004) 0.85

Bis-styrylpyridine and bis-styrylbenzene derivatives as inhibitors for Abeta fibril formation. Bioorg Med Chem Lett (2006) 0.85

[Liver abscess caused by Gemella morbillorum]. Korean J Gastroenterol (2005) 0.84

Effect of hinged ankle-foot orthoses on standing balance control in children with bilateral spastic cerebral palsy. Yonsei Med J (2010) 0.84

Biomimetic formation of silica thin films by surface-initiated polymerization of 2-(dimethylamino)ethyl methacrylate and silicic acid. Langmuir (2004) 0.84

A strategy for the design of selective RNA binding agents. Preparation and RRE RNA binding affinities of a neomycin-peptide nucleic acid heteroconjugate library. Bioorg Med Chem Lett (2006) 0.83

Multivalent & multifunctional ligands to beta-amyloid. Curr Pharm Des (2009) 0.82

Sociodemographic and smoking behavioral predictors associated with smoking cessation according to follow-up periods: a randomized, double-blind, placebo-controlled trial of transdermal nicotine patches. J Korean Med Sci (2007) 0.82

Novel cyanine dyes with vinylsulfone group for labeling biomolecules. Bioconjug Chem (2012) 0.82

A speed-up scheme based on multiple-instance pruning for pedestrian detection using a support vector machine. IEEE Trans Image Process (2013) 0.82

Regulation of in vitro Aβ1-40 aggregation mediated by small molecules. J Alzheimers Dis (2010) 0.82

Tentacle type peptides as artificial lectins against sulfated Lewis X and A. Bioorg Med Chem Lett (2008) 0.82

A comparison of total versus partial omentectomy for advanced gastric cancer in laparoscopic gastrectomy. World J Surg Oncol (2014) 0.82

Cell-penetrating autoantibody induces caspase-mediated apoptosis through catalytic hydrolysis of DNA. Bioorg Med Chem (2006) 0.82

Preparation of 7-alkylamino-2-methylquinoline-5,8-diones. J Org Chem (2002) 0.81

Apoptosis inducing, conformationally constrained, dimeric peptide analogs of KLA with submicromolar cell penetrating abilities. Biomacromolecules (2014) 0.81

Biomimetic approach to the formation of gold nanoparticle/silica core/shell structures and subsequent bioconjugation. Nanotechnology (2006) 0.80

IKKβ inhibitor identification: a multi-filter driven novel scaffold. BMC Bioinformatics (2010) 0.80

Two helices in the third intracellular loop determine anoctamin 1 (TMEM16A) activation by calcium. Pflugers Arch (2014) 0.79

Effects of asymmetric arginine dimethylation on RNA-binding peptides. Chembiochem (2008) 0.79

Specific modulation of the anti-DNA autoantibody-nucleic acids interaction by the high affinity RNA aptamer. Biochem Biophys Res Commun (2003) 0.79

An RNA aptamer that binds to the beta-catenin interaction domain of TCF-1 protein. Biochem Biophys Res Commun (2005) 0.79

Discovery of piperidinyl aminopyrimidine derivatives as IKK-2 inhibitors. Bioorg Med Chem Lett (2011) 0.79

Inhibition of tau aggregation by a rosamine derivative that blocks tau intermolecular disulfide cross-linking. Amyloid (2014) 0.79

Efficient access to highly pure β-amyloid peptide by optimized solid-phase synthesis. Amyloid (2012) 0.79

Surgical management of left ventricular outflow tract obstruction after biventricular repair of double outlet right ventricle. J Korean Med Sci (2010) 0.79

High-throughput profiling of peptide-RNA interactions using peptide microarrays. J Am Chem Soc (2012) 0.79

Phosphorylation of hepatitis B virus core C-terminally truncated protein (Cp149) by PKC increases capsid assembly and stability. Biochem J (2008) 0.79

Small molecules that protect against β-amyloid-induced cytotoxicity by inhibiting aggregation of β-amyloid. Bioorg Med Chem (2012) 0.78

Alpha-helical peptide containing N,N-dimethyl lysine residues displays low-nanomolar and highly specific binding to RRE RNA. J Am Chem Soc (2007) 0.78

An approach to the construction of tailor-made amphiphilic peptides that strongly and selectively bind to hairpin RNA targets. J Am Chem Soc (2009) 0.78

Methylation-mediated control of aurora kinase B and Haspin with epigenetically modified histone H3 N-terminal peptides. Bioorg Med Chem (2011) 0.78

Trichoepithelioma arising from facial scar tissue. J Craniofac Surg (2013) 0.78

An RNA aptamer that selectively recognizes symmetric dimethylation of arginine 8 in the histone H3 N-terminal peptide. Nucleic Acid Ther (2011) 0.78

Discovery of vinyl sulfones as a novel class of neuroprotective agents toward Parkinson's disease therapy. J Med Chem (2014) 0.78

3D QSAR pharmacophore model based on diverse IKKβ inhibitors. J Mol Model (2010) 0.78

Glucuronidation of a sarpogrelate active metabolite is mediated by UDP-glucuronosyltransferases 1A4, 1A9, and 2B4. Drug Metab Dispos (2013) 0.78

Dicer nuclease-promoted production of Let7a-1 microRNA is enhanced in the presence of tryptophan-containing amphiphilic peptides. Chembiochem (2014) 0.77

Reduction of helical content by insertion of a disulfide bond leads to an antimicrobial peptide with decreased hemolytic activity. ChemMedChem (2012) 0.77

Prognosis in the patients with prolonged extracorporeal membrane oxygenation. Korean J Thorac Cardiovasc Surg (2012) 0.77

Synthesis and evaluation of stilbene derivatives as a potential imaging agent of amyloid plaques. Bioorg Med Chem (2010) 0.77

Mimicry of tandem repeat peptides against cell surface carbohydrates. J Am Chem Soc (2002) 0.77

Formation of superhydrophobic surfaces by biomimetic silicification and fluorination. Langmuir (2006) 0.77

Protective effects of vacuolar H+ -ATPase c on hydrogen peroxide-induced cell death in C6 glioma cells. Neurosci Lett (2007) 0.77

Library construction of neomycin-dipeptide heteroconjugates and selection against RRE RNA. Bioorg Med Chem (2005) 0.77

Photocrosslinking of RNA and photoMet-containing amphiphilic alpha-helical peptides. Chembiochem (2009) 0.77

Synthesis and biological activity of novel 1beta-methylcarbapenems with oxyiminopyrrolidinylamide moiety. Bioorg Med Chem Lett (2003) 0.76

Synthesis and biological evaluation of novel 1 beta-methylcarbapenems with isothiazoloethenyl side chains. Bioorg Med Chem Lett (2003) 0.76

2-Phenylbenzofuran derivatives alleviate mitochondrial damage via the inhibition of β-amyloid aggregation. Bioorg Med Chem Lett (2013) 0.76

Histone H3 N-terminal peptide binds directly to its own mRNA: a possible mode of feedback inhibition to control translation. Chembiochem (2009) 0.76

Ferulic acid and benzothiazole dimer derivatives with high binding affinity to beta-amyloid fibrils. Bioorg Med Chem Lett (2007) 0.76

Synthesis and structure-activity relationships of tri-substituted thiazoles as RAGE antagonists for the treatment of Alzheimer's disease. Bioorg Med Chem Lett (2012) 0.76

Synthesis and evaluation of stilbenylbenzoxazole and stilbenylbenzothiazole derivatives for detecting beta-amyloid fibrils. Bioorg Med Chem Lett (2007) 0.76

RNA grooves can accommodate disulfide-bridged bundles of alpha-helical peptides. Chembiochem (2010) 0.76

Selection and syntheses of tentacle type peptides as 'artificial' lectins against various cell-surface carbohydrates. Bioorg Med Chem (2006) 0.76

Prediction and management of recurrent right colon diverticulitis. Int J Colorectal Dis (2014) 0.76

Isoindol-1,3-dione and isoindol-1-one derivatives with high binding affinity to beta-amyloid fibrils. Bioorg Med Chem Lett (2008) 0.76

Successful treatment of molluscum contagiosum with intralesional immunotherapy by measles, mumps, and rubella vaccine: a report of two cases. Dermatol Ther (2014) 0.76

[(18)F]-labeled isoindol-1-one and isoindol-1,3-dione derivatives as potential PET imaging agents for detection of beta-amyloid fibrils. Bioorg Med Chem Lett (2008) 0.75

Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of α-helical amphipathic peptides. ChemMedChem (2013) 0.75

Induction of NQO1 and Neuroprotection by a Novel Compound KMS04014 in Parkinson's Disease Models. J Mol Neurosci (2015) 0.75

Aortic Surgery without Infusion of Cardioplegic Solution at Total Circulatory Arrest. Korean J Thorac Cardiovasc Surg (2013) 0.75

Novel 1beta-methylcarbapenems with isoxazoloethenyl moieties containing carboxylic acid sodium salt. Bioorg Med Chem Lett (2005) 0.75

Substrate-controlled asymmetric total synthesis and structure revision of (+)-itomanallene A. Angew Chem Int Ed Engl (2010) 0.75

Surgical treatment for late-appearing adrenal metastasis from gastric cancer: report of two cases. World J Surg Oncol (2014) 0.75

Extensive venous thrombosis of the upper extremity in a diabetic patient with a hyperosmolar hyperglycemic state. Korean J Intern Med (2006) 0.75

Elucidation of the RNA target of linezolid by using a linezolid-neomycin B heteroconjugate and genomic SELEX. Bioorg Med Chem (2007) 0.75

Seven synchronous early gastric cancer with 28 lymph nodes metastasis. World J Gastroenterol (2013) 0.75

Antegrade intramedullary pinning versus retrograde intramedullary pinning for displaced fifth metacarpal neck fractures. Clin Orthop Relat Res (2014) 0.75

Mycosis fungoides misdiagnosed as squamous cell carcinoma. Arch Plast Surg (2013) 0.75

A novel compound VSC2 has anti-inflammatory and antioxidant properties in microglia and in Parkinson's disease animal model. Br J Pharmacol (2014) 0.75

Long-term experience with the Bjork-Shiley Monostrut tilting disc valve. J Korean Med Sci (2007) 0.75

Optimization of two-step bioleaching of spent petroleum refinery catalyst by Acidithiobacillus thiooxidans using response surface methodology. J Environ Sci Health A Tox Hazard Subst Environ Eng (2014) 0.75