John P Richard

Author PubWeight™ 78.32‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Activation of orotidine 5'-monophosphate decarboxylase by phosphite dianion: the whole substrate is the sum of two parts. J Am Chem Soc 2005 2.06
2 Formation and stability of a vinyl carbanion at the active site of orotidine 5'-monophosphate decarboxylase: pKa of the C-6 proton of enzyme-bound UMP. J Am Chem Soc 2008 1.85
3 Enzymatic catalysis of proton transfer at carbon: activation of triosephosphate isomerase by phosphite dianion. Biochemistry 2007 1.72
4 A role for flexible loops in enzyme catalysis. Curr Opin Struct Biol 2010 1.62
5 Product deuterium isotope effect for orotidine 5'-monophosphate decarboxylase: evidence for the existence of a short-lived carbanion intermediate. J Am Chem Soc 2007 1.56
6 A substrate in pieces: allosteric activation of glycerol 3-phosphate dehydrogenase (NAD+) by phosphite dianion. Biochemistry 2008 1.51
7 Dissecting the total transition state stabilization provided by amino acid side chains at orotidine 5'-monophosphate decarboxylase: a two-part substrate approach. Biochemistry 2008 1.45
8 Substituent effects on carbocation stability: the pK(R) for p-quinone methide. J Am Chem Soc 2003 1.44
9 Hydron transfer catalyzed by triosephosphate isomerase. Products of the direct and phosphite-activated isomerization of [1-(13)C]-glycolaldehyde in D(2)O. Biochemistry 2009 1.33
10 Hydron transfer catalyzed by triosephosphate isomerase. Products of isomerization of (R)-glyceraldehyde 3-phosphate in D2O. Biochemistry 2005 1.30
11 Phosphate binding energy and catalysis by small and large molecules. Acc Chem Res 2008 1.30
12 Mechanism of the orotidine 5'-monophosphate decarboxylase-catalyzed reaction: evidence for substrate destabilization. Biochemistry 2009 1.27
13 Hydron transfer catalyzed by triosephosphate isomerase. Products of isomerization of dihydroxyacetone phosphate in D2O. Biochemistry 2005 1.23
14 Mechanism of the orotidine 5'-monophosphate decarboxylase-catalyzed reaction: effect of solvent viscosity on kinetic constants. Biochemistry 2009 1.22
15 Formation and stability of peptide enolates in aqueous solution. J Am Chem Soc 2002 1.22
16 Specificity in transition state binding: the Pauling model revisited. Biochemistry 2013 1.19
17 An examination of the relationship between active site loop size and thermodynamic activation parameters for orotidine 5'-monophosphate decarboxylase from mesophilic and thermophilic organisms. Biochemistry 2009 1.18
18 Role of Lys-12 in catalysis by triosephosphate isomerase: a two-part substrate approach. Biochemistry 2010 1.18
19 Activation of R235A mutant orotidine 5'-monophosphate decarboxylase by the guanidinium cation: effective molarity of the cationic side chain of Arg-235. Biochemistry 2010 1.17
20 Orotidine 5'-monophosphate decarboxylase: transition state stabilization from remote protein-phosphodianion interactions. Biochemistry 2012 1.12
21 Formation and stability of N-heterocyclic carbenes in water: the carbon acid pKa of imidazolium cations in aqueous solution. J Am Chem Soc 2004 1.10
22 OMP decarboxylase: phosphodianion binding energy is used to stabilize a vinyl carbanion intermediate. J Am Chem Soc 2011 1.10
23 Kinetic and thermodynamic barriers to carbon and oxygen alkylation of phenol and phenoxide ion by the 1-(4-methoxyphenyl)ethyl carbocation. J Am Chem Soc 2003 1.09
24 Covalent catalysis by pyridoxal: evaluation of the effect of the cofactor on the carbon acidity of glycine. J Am Chem Soc 2007 1.05
25 Scrambling of oxygen-18 during the "borderline" solvolysis of 1-(3-nitrophenyl)ethyl tosylate. Org Lett 2004 1.05
26 Product deuterium isotope effects for orotidine 5'-monophosphate decarboxylase: effect of changing substrate and enzyme structure on the partitioning of the vinyl carbanion reaction intermediate. J Am Chem Soc 2010 1.03
27 Reactions of ion-pair intermediates of solvolysis. Chem Rec 2005 1.03
28 Rescue of K12G triosephosphate isomerase by ammonium cations: the reaction of an enzyme in pieces. J Am Chem Soc 2010 1.02
29 Mechanism for activation of triosephosphate isomerase by phosphite dianion: the role of a ligand-driven conformational change. J Am Chem Soc 2011 1.01
30 Formation and stability of the enolates of N-protonated proline methyl ester and proline zwitterion in aqueous solution: a nonenzymatic model for the first step in the racemization of proline catalyzed by proline racemase. Biochemistry 2003 0.99
31 Proton transfer from C-6 of uridine 5'-monophosphate catalyzed by orotidine 5'-monophosphate decarboxylase: formation and stability of a vinyl carbanion intermediate and the effect of a 5-fluoro substituent. J Am Chem Soc 2012 0.99
32 A simple method to determine kinetic deuterium isotope effects provides evidence that proton transfer to carbon proceeds over and not through the reaction barrier. J Am Chem Soc 2007 0.98
33 Hydrogen bonding and catalysis of solvolysis of 4-methoxybenzyl fluoride. J Am Chem Soc 2002 0.97
34 Mechanism for activation of triosephosphate isomerase by phosphite dianion: the role of a hydrophobic clamp. J Am Chem Soc 2012 0.97
35 Direct excitation luminescence spectroscopy of Eu(III) complexes of 1,4,7-tris(carbamoylmethyl)-1,4,7,10- tetraazacyclododecane derivatives and kinetic studies of their catalytic cleavage of an RNA analog. Dalton Trans 2007 0.96
36 Glycine enolates: the effect of formation of iminium ions to simple ketones on alpha-amino carbon acidity and a comparison with pyridoxal iminium ions. J Am Chem Soc 2008 0.96
37 Wildtype and engineered monomeric triosephosphate isomerase from Trypanosoma brucei: partitioning of reaction intermediates in D2O and activation by phosphite dianion. Biochemistry 2011 0.95
38 Physical and kinetic analysis of the cooperative role of metal ions in catalysis of phosphodiester cleavage by a dinuclear Zn(II) complex. J Am Chem Soc 2003 0.95
39 When does an intermediate become a transition state? Degenerate isomerization without competing racemization during solvolysis of (S)-1-(3-nitrophenyl)ethyl tosylate. J Am Chem Soc 2006 0.94
40 Magnitude and origin of the enhanced basicity of the catalytic glutamate of triosephosphate isomerase. J Am Chem Soc 2013 0.94
41 Conformational changes in orotidine 5'-monophosphate decarboxylase: "remote" residues that stabilize the active conformation. Biochemistry 2010 0.93
42 Enzyme architecture: remarkably similar transition states for triosephosphate isomerase-catalyzed reactions of the whole substrate and the substrate in pieces. J Am Chem Soc 2014 0.92
43 Substituent effects on the thermodynamic stability of imines formed from glycine and aromatic aldehydes: implications for the catalytic activity of pyridoxal-5'-phosphate. J Am Chem Soc 2009 0.92
44 Claisen-type addition of glycine to pyridoxal in water. J Am Chem Soc 2004 0.92
45 Slow proton transfer from the hydrogen-labelled carboxylic acid side chain (Glu-165) of triosephosphate isomerase to imidazole buffer in D2O. Org Biomol Chem 2007 0.91
46 Dynamics for Reactions of Ion Pairs in Aqueous Solution: Reactivity of Tosylate Anion Ion Paired with the Highly Destabilized 1-(4-Methylphenyl)-2,2,2-Trifluoroethyl Carbocation. J Phys Org Chem 2010 0.91
47 Formation and stability of the 4-methoxyphenonium ion in aqueous solution. J Org Chem 2011 0.91
48 Altered transition state for the reaction of an RNA model catalyzed by a dinuclear zinc(II) catalyst. J Am Chem Soc 2008 0.90
49 Structural mutations that probe the interactions between the catalytic and dianion activation sites of triosephosphate isomerase. Biochemistry 2013 0.90
50 Role of a guanidinium cation-phosphodianion pair in stabilizing the vinyl carbanion intermediate of orotidine 5'-phosphate decarboxylase-catalyzed reactions. Biochemistry 2013 0.89
51 Claisen-type addition of glycine to a pyridoxal iminium ion in water. J Org Chem 2006 0.89
52 Conformational changes in orotidine 5'-monophosphate decarboxylase: a structure-based explanation for how the 5'-phosphate group activates the enzyme. Biochemistry 2012 0.88
53 Carbon acidity of the alpha-pyridinium carbon of a pyridoxamine analog. Org Biomol Chem 2005 0.88
54 Enzyme architecture: deconstruction of the enzyme-activating phosphodianion interactions of orotidine 5'-monophosphate decarboxylase. J Am Chem Soc 2014 0.87
55 Structure-reactivity effects on primary deuterium isotope effects on protonation of ring-substituted alpha-methoxystyrenes. J Am Chem Soc 2009 0.87
56 The activating oxydianion binding domain for enzyme-catalyzed proton transfer, hydride transfer, and decarboxylation: specificity and enzyme architecture. J Am Chem Soc 2015 0.86
57 Cooperativity between metal ions in the cleavage of phosphate diesters and RNA by dinuclear Zn(II) catalysts. Inorg Chem 2003 0.86
58 Catalysis by orotidine 5'-monophosphate decarboxylase: effect of 5-fluoro and 4'-substituents on the decarboxylation of two-part substrates. Biochemistry 2013 0.86
59 Bovine serum albumin-catalyzed deprotonation of [1-(13)C]glycolaldehyde: protein reactivity toward deprotonation of the alpha-hydroxy alpha-carbonyl carbon. Biochemistry 2010 0.85
60 Theoretical analysis of kinetic isotope effects on proton transfer reactions between substituted alpha-methoxystyrenes and substituted acetic acids. J Am Chem Soc 2009 0.85
61 Enzyme architecture: the activating oxydianion binding domain for orotidine 5'-monophophate decarboxylase. J Am Chem Soc 2013 0.84
62 Substrate specificity of an active dinuclear Zn(II) catalyst for cleavage of RNA analogues and a dinucleoside. J Am Chem Soc 2006 0.84
63 Structure-activity studies on the cleavage of an RNA analogue by a potent dinuclear metal ion catalyst: effect of changing the metal ion. Inorg Chem 2004 0.84
64 Solvent deuterium isotope effects on phosphodiester cleavage catalyzed by an extraordinarily active Zn(II) complex. J Am Chem Soc 2005 0.83
65 A transition state analog for phosphate diester cleavage catalyzed by a small enzyme-like metal ion complex. Bioorg Chem 2007 0.82
66 A comparison of the electrophilic reactivities of Zn2+ and acetic acid as catalysts of enolization: imperatives for enzymatic catalysis of proton transfer at carbon. J Am Chem Soc 2004 0.82
67 Alanine-dependent reactions of 5'-deoxypyridoxal in water. Bioorg Chem 2008 0.81
68 Enhancement of a Lewis acid-base interaction via solvation: ammonia molecules and the benzene radical cation. J Phys Chem A 2007 0.81
69 A minimalist approach to understanding the efficiency of mononuclear Zn(II) complexes as catalysts of cleavage of an RNA analog. Dalton Trans 2007 0.81
70 Enzyme architecture: the effect of replacement and deletion mutations of loop 6 on catalysis by triosephosphate isomerase. Biochemistry 2014 0.81
71 Isopentenyl diphosphate isomerase catalyzed reactions in D2O: product release limits the rate of this sluggish enzyme-catalyzed reaction. J Am Chem Soc 2012 0.79
72 Binding energy and catalysis by D-xylose isomerase: kinetic, product, and X-ray crystallographic analysis of enzyme-catalyzed isomerization of (R)-glyceraldehyde. Biochemistry 2011 0.79
73 Substituent effects on electrophilic catalysis by the carbonyl group: anatomy of the rate acceleration for PLP-catalyzed deprotonation of glycine. J Am Chem Soc 2011 0.79
74 Substrate specificity for catalysis of phosphodiester cleavage by a dinuclear Zn(II) complex. Chem Commun (Camb) 2003 0.78
75 Formation and stability of mononuclear and dinuclear Eu(III) complexes and their catalytic reactivity toward cleavage of an RNA analog. Inorg Chem 2007 0.78
76 Ketonization of the remarkably strongly acidic elongated enol generated by flash photolytic decarboxylation of p-benzoylphenylacetic acid in aqueous solution. Chem Commun (Camb) 2005 0.77
77 Rational design of transition-state analogues as potent enzyme inhibitors with therapeutic applications. ACS Chem Biol 2007 0.76
78 Complex biological processes and their central chemical events. Curr Opin Chem Biol 2003 0.75