Published in Biochemistry on October 27, 2011
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Enzymatic catalysis of proton transfer at carbon: activation of triosephosphate isomerase by phosphite dianion. Biochemistry (2007) 1.72
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Specificity in transition state binding: the Pauling model revisited. Biochemistry (2013) 1.19
An examination of the relationship between active site loop size and thermodynamic activation parameters for orotidine 5'-monophosphate decarboxylase from mesophilic and thermophilic organisms. Biochemistry (2009) 1.18
Role of Lys-12 in catalysis by triosephosphate isomerase: a two-part substrate approach. Biochemistry (2010) 1.18
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Product deuterium isotope effects for orotidine 5'-monophosphate decarboxylase: effect of changing substrate and enzyme structure on the partitioning of the vinyl carbanion reaction intermediate. J Am Chem Soc (2010) 1.03
Reactions of ion-pair intermediates of solvolysis. Chem Rec (2005) 1.03
Rescue of K12G triosephosphate isomerase by ammonium cations: the reaction of an enzyme in pieces. J Am Chem Soc (2010) 1.02
Engineering encodable lanthanide-binding tags into loop regions of proteins. J Am Chem Soc (2011) 1.02
Mechanism for activation of triosephosphate isomerase by phosphite dianion: the role of a ligand-driven conformational change. J Am Chem Soc (2011) 1.01
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Chirality holds the key for potent inhibition of the botulinum neurotoxin serotype a protease. Org Lett (2010) 0.99
Investigation of metal ion binding in phosphonoacetaldehyde hydrolase identifies sequence markers for metal-activated enzymes of the HAD enzyme superfamily. Biochemistry (2004) 0.99
Proton transfer from C-6 of uridine 5'-monophosphate catalyzed by orotidine 5'-monophosphate decarboxylase: formation and stability of a vinyl carbanion intermediate and the effect of a 5-fluoro substituent. J Am Chem Soc (2012) 0.99
A simple method to determine kinetic deuterium isotope effects provides evidence that proton transfer to carbon proceeds over and not through the reaction barrier. J Am Chem Soc (2007) 0.98
Double-lanthanide-binding tags: design, photophysical properties, and NMR applications. J Am Chem Soc (2007) 0.97
Conformational cycling in beta-phosphoglucomutase catalysis: reorientation of the beta-D-glucose 1,6-(Bis)phosphate intermediate. Biochemistry (2006) 0.97
Mechanism for activation of triosephosphate isomerase by phosphite dianion: the role of a hydrophobic clamp. J Am Chem Soc (2012) 0.97
Hydrogen bonding and catalysis of solvolysis of 4-methoxybenzyl fluoride. J Am Chem Soc (2002) 0.97
X-ray crystal structure of the hypothetical phosphotyrosine phosphatase MDP-1 of the haloacid dehalogenase superfamily. Biochemistry (2004) 0.97
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Glycine enolates: the effect of formation of iminium ions to simple ketones on alpha-amino carbon acidity and a comparison with pyridoxal iminium ions. J Am Chem Soc (2008) 0.96
Double-lanthanide-binding tags for macromolecular crystallographic structure determination. J Am Chem Soc (2007) 0.95
Wildtype and engineered monomeric triosephosphate isomerase from Trypanosoma brucei: partitioning of reaction intermediates in D2O and activation by phosphite dianion. Biochemistry (2011) 0.95
Chemical-modification rescue assessed by mass spectrometry demonstrates that gamma-thia-lysine yields the same activity as lysine in aldolase. Protein Sci (2002) 0.95
Physical and kinetic analysis of the cooperative role of metal ions in catalysis of phosphodiester cleavage by a dinuclear Zn(II) complex. J Am Chem Soc (2003) 0.95
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Structure of the thermolabile mutant aldolase B, A149P: molecular basis of hereditary fructose intolerance. J Mol Biol (2005) 0.94
Magnitude and origin of the enhanced basicity of the catalytic glutamate of triosephosphate isomerase. J Am Chem Soc (2013) 0.94
Conformational changes in orotidine 5'-monophosphate decarboxylase: "remote" residues that stabilize the active conformation. Biochemistry (2010) 0.93
Enzyme architecture: remarkably similar transition states for triosephosphate isomerase-catalyzed reactions of the whole substrate and the substrate in pieces. J Am Chem Soc (2014) 0.92
Substituent effects on the thermodynamic stability of imines formed from glycine and aromatic aldehydes: implications for the catalytic activity of pyridoxal-5'-phosphate. J Am Chem Soc (2009) 0.92
Human symbiont Bacteroides thetaiotaomicron synthesizes 2-keto-3-deoxy-D-glycero-D- galacto-nononic acid (KDN). Chem Biol (2008) 0.92
Structure of human brain fructose 1,6-(bis)phosphate aldolase: linking isozyme structure with function. Protein Sci (2004) 0.92
Claisen-type addition of glycine to pyridoxal in water. J Am Chem Soc (2004) 0.92
Slow proton transfer from the hydrogen-labelled carboxylic acid side chain (Glu-165) of triosephosphate isomerase to imidazole buffer in D2O. Org Biomol Chem (2007) 0.91
Consequences of domain insertion on sequence-structure divergence in a superfold. Proc Natl Acad Sci U S A (2013) 0.91
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Formation and stability of the 4-methoxyphenonium ion in aqueous solution. J Org Chem (2011) 0.91
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Altered transition state for the reaction of an RNA model catalyzed by a dinuclear zinc(II) catalyst. J Am Chem Soc (2008) 0.90
X-ray structure analysis of a designed oligomeric miniprotein reveals a discrete quaternary architecture. Proc Natl Acad Sci U S A (2004) 0.90
Structural mutations that probe the interactions between the catalytic and dianion activation sites of triosephosphate isomerase. Biochemistry (2013) 0.90
Role of a guanidinium cation-phosphodianion pair in stabilizing the vinyl carbanion intermediate of orotidine 5'-phosphate decarboxylase-catalyzed reactions. Biochemistry (2013) 0.89
Claisen-type addition of glycine to a pyridoxal iminium ion in water. J Org Chem (2006) 0.89
Spatial clustering of isozyme-specific residues reveals unlikely determinants of isozyme specificity in fructose-1,6-bisphosphate aldolase. J Biol Chem (2003) 0.89
Conformational changes in orotidine 5'-monophosphate decarboxylase: a structure-based explanation for how the 5'-phosphate group activates the enzyme. Biochemistry (2012) 0.88
Carbon acidity of the alpha-pyridinium carbon of a pyridoxamine analog. Org Biomol Chem (2005) 0.88
Evaluation of adamantane hydroxamates as botulinum neurotoxin inhibitors: synthesis, crystallography, modeling, kinetic and cellular based studies. Bioorg Med Chem (2012) 0.88
Enzyme architecture: deconstruction of the enzyme-activating phosphodianion interactions of orotidine 5'-monophosphate decarboxylase. J Am Chem Soc (2014) 0.87
Structure-reactivity effects on primary deuterium isotope effects on protonation of ring-substituted alpha-methoxystyrenes. J Am Chem Soc (2009) 0.87
The activating oxydianion binding domain for enzyme-catalyzed proton transfer, hydride transfer, and decarboxylation: specificity and enzyme architecture. J Am Chem Soc (2015) 0.86