Published in FEBS Lett on February 14, 2005
A shared molecular mechanism underlies the human rasopathies Legius syndrome and Neurofibromatosis-1. Genes Dev (2012) 1.33
Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling. J Cell Biol (2009) 1.02
Diversity of polyproline recognition by EVH1 domains. Front Biosci (Landmark Ed) (2009) 0.95
Centromeric binding and activity of Protein Phosphatase 4. Nat Commun (2015) 0.85
The neurofibromin recruitment factor Spred1 binds to the GAP related domain without affecting Ras inactivation. Proc Natl Acad Sci U S A (2016) 0.79
Miniature protein ligands for EVH1 domains: interplay between affinity, specificity, and cell motility. Biochemistry (2007) 0.78
Ramachandran analysis of conserved glycyl residues in homologous proteins of known structure. Protein Sci (2014) 0.76
NMR resonance assignments of the EVH1 domain of neurofibromin's recruitment factor Spred1. Biomol NMR Assign (2017) 0.75
The genome of the Western clawed frog Xenopus tropicalis. Science (2010) 4.70
Insights into DNA recombination from the structure of a RAD51-BRCA2 complex. Nature (2002) 4.22
Heterogeneity and inaccuracy in protein structures solved by X-ray crystallography. Structure (2004) 3.32
Full-length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2. EMBO J (2003) 2.95
Is one solution good enough? Nat Struct Mol Biol (2006) 2.91
Tumor risks and genotype-phenotype-proteotype analysis in 358 patients with germline mutations in SDHB and SDHD. Hum Mutat (2010) 2.75
Knowledge-based real-space explorations for low-resolution structure determination. Structure (2006) 2.52
Crystallographic refinement by knowledge-based exploration of complex energy landscapes. Structure (2005) 2.42
Techniques and probes for the study of Xenopus tropicalis development. Dev Dyn (2002) 2.34
Analysis of the thyrotropin receptor-thyrotropin interaction by comparative modeling. Thyroid (2004) 2.28
SDM--a server for predicting effects of mutations on protein stability and malfunction. Nucleic Acids Res (2011) 2.28
BUB1 and BUBR1: multifaceted kinases of the cell cycle. Trends Biochem Sci (2010) 1.99
Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats. Nature (2009) 1.97
Defining a large set of full-length clones from a Xenopus tropicalis EST project. Dev Biol (2004) 1.87
Structural basis of hepatocyte growth factor/scatter factor and MET signalling. Proc Natl Acad Sci U S A (2006) 1.85
Amputation-induced reactive oxygen species are required for successful Xenopus tadpole tail regeneration. Nat Cell Biol (2013) 1.72
Sequence fingerprints in BRCA2 and RAD51: implications for DNA repair and cancer. DNA Repair (Amst) (2003) 1.72
pyDock: electrostatics and desolvation for effective scoring of rigid-body protein-protein docking. Proteins (2007) 1.69
mCSM: predicting the effects of mutations in proteins using graph-based signatures. Bioinformatics (2013) 1.69
Crystal structure of human XLF/Cernunnos reveals unexpected differences from XRCC4 with implications for NHEJ. EMBO J (2007) 1.66
Atomic interactions and profile of small molecules disrupting protein-protein interfaces: the TIMBAL database. Chem Biol Drug Des (2009) 1.64
Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody. Thyroid (2007) 1.64
Local tissue interactions across the dorsal midline of the forebrain establish CNS laterality. Neuron (2003) 1.63
Genome3D: a UK collaborative project to annotate genomic sequences with predicted 3D structures based on SCOP and CATH domains. Nucleic Acids Res (2012) 1.63
FGF signal interpretation is directed by Sprouty and Spred proteins during mesoderm formation. Dev Cell (2005) 1.61
FGF signalling: diverse roles during early vertebrate embryogenesis. Development (2010) 1.60
Structural biology and drug discovery. Drug Discov Today (2005) 1.59
A novel type of deubiquitinating enzyme. J Biol Chem (2003) 1.57
Chimeric glycosyltransferases for the generation of hybrid glycopeptides. Chem Biol (2009) 1.57
The crystal structure of fibroblast growth factor (FGF) 19 reveals novel features of the FGF family and offers a structural basis for its unusual receptor affinity. Biochemistry (2004) 1.57
Ab initio construction of polypeptide fragments: efficient generation of accurate, representative ensembles. Proteins (2003) 1.56
Distinguishing structural and functional restraints in evolution in order to identify interaction sites. J Mol Biol (2004) 1.52
Functional map and domain structure of MET, the product of the c-met protooncogene and receptor for hepatocyte growth factor/scatter factor. Proc Natl Acad Sci U S A (2003) 1.42
Structural biology in fragment-based drug design. Curr Opin Struct Biol (2010) 1.36
Structural and functional constraints in the evolution of protein families. Nat Rev Mol Cell Biol (2009) 1.35
Dynamic control of Rad51 recombinase by self-association and interaction with BRCA2. Mol Cell (2003) 1.33
Probing hot spots at protein-ligand binding sites: a fragment-based approach using biophysical methods. J Med Chem (2006) 1.31
On the origins of enzyme inhibitor selectivity and promiscuity: a case study of protein kinase binding to staurosporine. Chem Biol Drug Des (2009) 1.30
Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer. Open Biol (2012) 1.29
Structural biology and drug discovery of difficult targets: the limits of ligandability. Chem Biol (2012) 1.27
A structural bioinformatics approach to the analysis of nonsynonymous single nucleotide polymorphisms (nsSNPs) and their relation to disease. J Bioinform Comput Biol (2007) 1.26
Highly efficient bi-allelic mutation rates using TALENs in Xenopus tropicalis. Biol Open (2012) 1.24
Targeted gene expression in transgenic Xenopus using the binary Gal4-UAS system. Proc Natl Acad Sci U S A (2002) 1.23
Evidence that heparin saccharides promote FGF2 mitogenesis through two distinct mechanisms. J Biol Chem (2008) 1.19
Structural constraints on protein self-processing in L-aspartate-alpha-decarboxylase. EMBO J (2003) 1.19
Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase. Angew Chem Int Ed Engl (2009) 1.19
Andante: reducing side-chain rotamer search space during comparative modeling using environment-specific substitution probabilities. Bioinformatics (2007) 1.18
Structure of an Xrcc4-DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode. DNA Repair (Amst) (2006) 1.18
Prediction by graph theoretic measures of structural effects in proteins arising from non-synonymous single nucleotide polymorphisms. PLoS Comput Biol (2008) 1.16
Conformer generation under restraints. Curr Opin Struct Biol (2006) 1.16
Structural biology and drug discovery for protein-protein interactions. Trends Pharmacol Sci (2012) 1.15
Towards a resolution of the stoichiometry of the fibroblast growth factor (FGF)-FGF receptor-heparin complex. J Mol Biol (2004) 1.14
Functional specificity of the Xenopus T-domain protein Brachyury is conferred by its ability to interact with Smad1. Dev Cell (2005) 1.13
An algorithm for predicting protein-protein interaction sites: Abnormally exposed amino acid residues and secondary structure elements. Protein Sci (2006) 1.12
Cockroach allergen Bla g 2: structure, function, and implications for allergic sensitization. Am J Respir Crit Care Med (2002) 1.11
BIPA: a database for protein-nucleic acid interaction in 3D structures. Bioinformatics (2009) 1.10
Biophysical and computational fragment-based approaches to targeting protein-protein interactions: applications in structure-guided drug discovery. Q Rev Biophys (2012) 1.09
Using a fragment-based approach to target protein-protein interactions. Chembiochem (2013) 1.09
Cooperative dimerization of fibroblast growth factor 1 (FGF1) upon a single heparin saccharide may drive the formation of 2:2:1 FGF1.FGFR2c.heparin ternary complexes. J Biol Chem (2005) 1.08
Defining the molecular basis of BubR1 kinetochore interactions and APC/C-CDC20 inhibition. J Biol Chem (2010) 1.08
High-resolution crystal structure of the human Notch 1 ankyrin domain. Biochem J (2005) 1.06
The crystal structure of the N-terminal region of BUB1 provides insight into the mechanism of BUB1 recruitment to kinetochores. Structure (2009) 1.05
Ulla: a program for calculating environment-specific amino acid substitution tables. Bioinformatics (2009) 1.05
spib is required for primitive myeloid development in Xenopus. Blood (2008) 1.05
Inhibition of Mycobacterium tuberculosis pantothenate synthetase by analogues of the reaction intermediate. Chembiochem (2008) 1.05
Structure of a Blinkin-BUBR1 complex reveals an interaction crucial for kinetochore-mitotic checkpoint regulation via an unanticipated binding Site. Structure (2011) 1.04
Crystal structure of rat liver betaine homocysteine s-methyltransferase reveals new oligomerization features and conformational changes upon substrate binding. J Mol Biol (2004) 1.03
Germ layer specification and axial patterning in the embryonic development of the freshwater planarian Schmidtea polychroa. Dev Biol (2010) 1.03
Pilot morpholino screen in Xenopus tropicalis identifies a novel gene involved in head development. Dev Dyn (2004) 1.02
Non-homologous end-joining partners in a helical dance: structural studies of XLF-XRCC4 interactions. Biochem Soc Trans (2011) 1.02
Genome-wide analysis of gene expression during Xenopus tropicalis tadpole tail regeneration. BMC Dev Biol (2011) 1.01
Advantages of fine-grained side chain conformer libraries. Protein Eng (2003) 1.01
Structural bioinformatics mutation analysis reveals genotype-phenotype correlations in von Hippel-Lindau disease and suggests molecular mechanisms of tumorigenesis. Proteins (2009) 1.00
Identifying interaction motifs in CK2beta--a ubiquitous kinase regulatory subunit. Trends Biochem Sci (2006) 1.00
Multimers of the fibroblast growth factor (FGF)-FGF receptor-saccharide complex are formed on long oligomers of heparin. Biochem J (2006) 1.00
Cell biology: brief encounters bolster contacts. Nature (2006) 1.00
Effect of gamma-synuclein overexpression on matrix metalloproteinases in retinoblastoma Y79 cells. Arch Biochem Biophys (2003) 0.99
pTransgenesis: a cross-species, modular transgenesis resource. Development (2011) 0.99
Coupling growth-factor engineering with nanotechnology for therapeutic angiogenesis. Proc Natl Acad Sci U S A (2010) 0.99
Comprehensive, atomic-level characterization of structurally characterized protein-protein interactions: the PICCOLO database. BMC Bioinformatics (2011) 0.97
Characterization of spindle checkpoint kinase Mps1 reveals domain with functional and structural similarities to tetratricopeptide repeat motifs of Bub1 and BubR1 checkpoint kinases. J Biol Chem (2011) 0.97
Model-building strategies for low-resolution X-ray crystallographic data. Acta Crystallogr D Biol Crystallogr (2009) 0.96
Structural enzymology of Li(+)-sensitive/Mg(2+)-dependent phosphatases. J Mol Biol (2002) 0.95
Genome bioinformatic analysis of nonsynonymous SNPs. BMC Bioinformatics (2007) 0.95
Organisation of the pantothenate (vitamin B5) biosynthesis pathway in higher plants. Plant J (2004) 0.94
Protein-protein interactions as druggable targets: recent technological advances. Curr Opin Pharmacol (2013) 0.94
Characterisation of a new regulator of BDNF signalling, Sprouty3, involved in axonal morphogenesis in vivo. Development (2010) 0.94
A Xenopus tropicalis oligonucleotide microarray works across species using RNA from Xenopus laevis. Mech Dev (2004) 0.94
Crystal structures of Yersinia enterocolitica salicylate synthase and its complex with the reaction products salicylate and pyruvate. J Mol Biol (2006) 0.93
Satisfaction of hydrogen-bonding potential influences the conservation of polar sidechains. Proteins (2009) 0.93
Structural and functional restraints in the evolution of protein families and superfamilies. Biochem Soc Trans (2009) 0.93
Positive influence of AP-2alpha transcription factor on cadherin gene expression and differentiation of the ocular surface. Differentiation (2003) 0.93
Structural and functional restraints on the occurrence of single amino acid variations in human proteins. PLoS One (2010) 0.93
Discarding functional residues from the substitution table improves predictions of active sites within three-dimensional structures. PLoS Comput Biol (2008) 0.93
Novel gene expression domains reveal early patterning of the Xenopus endoderm. Gene Expr Patterns (2003) 0.92
Does a more precise chemical description of protein-ligand complexes lead to more accurate prediction of binding affinity? J Chem Inf Model (2014) 0.92
Structural insights into the role of domain flexibility in human DNA ligase IV. Structure (2012) 0.92
Temporal and spatial expression of FGF ligands and receptors during Xenopus development. Dev Dyn (2009) 0.92