Intracellular VacA is a valuable marker to predict whether Helicobacter pylori induces progressive atrophic gastritis that is associated with the development of gastric cancer.

PubWeight™: 0.78‹?›

🔗 View Article (PMID 15712638)

Published in Dig Dis Sci on January 01, 2005

Authors

Mikio Karita1, Satoshi Teramukai, Satoru Matsumoto, Hidemi Shibuta

Author Affiliations

1: Internal Medicine, Hofu-Onsen Hospital, 1640, Daidou, Houfu-shi, Yamaguchi-ken, Japan. makarita@ymg.urban.ne.jp

Articles citing this

Updates on esophageal and gastric cancers. World J Gastroenterol (2006) 1.39

Articles cited by this

Helicobacter pylori infection and the risk of gastric carcinoma. N Engl J Med (1991) 23.89

Helicobacter pylori infection and the development of gastric cancer. N Engl J Med (2001) 17.13

Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration. J Biol Chem (1995) 12.61

Helicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii. N Engl J Med (1991) 11.98

Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer. Proc Natl Acad Sci U S A (1993) 11.85

Helicobacter pylori infection and gastric lymphoma. N Engl J Med (1994) 10.26

Cytotoxic activity in broth-culture filtrates of Campylobacter pylori. J Med Microbiol (1988) 8.69

Purification and characterization of the vacuolating toxin from Helicobacter pylori. J Biol Chem (1992) 6.54

Characterization of and human serologic response to proteins in Helicobacter pylori broth culture supernatants with vacuolizing cytotoxin activity. Infect Immun (1990) 5.85

Helicobacter pylori infection induces gastric cancer in mongolian gerbils. Gastroenterology (1998) 5.15

Long-term sequelae of Helicobacter pylori gastritis. Lancet (1995) 4.26

Interobserver variation in the histopathological assessment of Helicobacter pylori gastritis. Hum Pathol (1996) 3.57

Parasitism by the "slow" bacterium Helicobacter pylori leads to altered gastric homeostasis and neoplasia. J Clin Invest (1994) 3.40

Mice deficient in protein tyrosine phosphatase receptor type Z are resistant to gastric ulcer induction by VacA of Helicobacter pylori. Nat Genet (2003) 2.67

Binding and internalization of the Helicobacter pylori vacuolating cytotoxin by epithelial cells. Infect Immun (1996) 2.08

Role of Helicobacter pylori in the pathogenesis of gastritis, peptic ulcer and gastric cancer. Scand J Gastroenterol Suppl (1993) 1.86

Effect of growth phase and acid shock on Helicobacter pylori cagA expression. Infect Immun (1996) 1.35

Helicobacter pylori infection enhances N-methyl-N-nitrosourea-induced stomach carcinogenesis in the Mongolian gerbil. Cancer Res (1998) 1.32

The bacteria behind ulcers. Sci Am (1996) 1.19

Relationship between pepsinogen I&II and H. pylori infection considered with grade of atrophy and gastroduodenal diseases. Dig Dis Sci (2003) 0.79

Articles by these authors

Association of hypoadiponectinemia with coronary artery disease in men. Arterioscler Thromb Vasc Biol (2003) 4.86

The baseline ratio of neutrophils to lymphocytes is associated with patient prognosis in advanced gastric cancer. Oncology (2008) 2.83

Diagnostic criteria, clinical features, and incidence of thyroid storm based on nationwide surveys. Thyroid (2012) 2.78

Present status of ABO-incompatible living donor liver transplantation in Japan. Hepatology (2008) 2.31

Vinorelbine plus gemcitabine followed by docetaxel versus carboplatin plus paclitaxel in patients with advanced non-small-cell lung cancer: a randomised, open-label, phase III study. Lancet Oncol (2008) 1.87

UGT1A1*6 polymorphism is most predictive of severe neutropenia induced by irinotecan in Japanese cancer patients. Int J Clin Oncol (2009) 1.82

Clinical significance of high-molecular weight form of adiponectin in male patients with coronary artery disease. Circ J (2008) 1.81

Simple sequence repeat-based comparative genomics between Brassica rapa and Arabidopsis thaliana: the genetic origin of clubroot resistance. Genetics (2006) 1.73

Long-term clinical outcome after intramuscular implantation of bone marrow mononuclear cells (Therapeutic Angiogenesis by Cell Transplantation [TACT] trial) in patients with chronic limb ischemia. Am Heart J (2008) 1.70

Prospective evaluation of whole-body cancer screening with multiple modalities including [18F]fluorodeoxyglucose positron emission tomography in a healthy population: a preliminary report. J Clin Oncol (2009) 1.68

Outcome of different post-orchiectomy management for stage I seminoma: Japanese multi-institutional study including 425 patients. Int J Urol (2010) 1.65

Japanese-US common-arm analysis of paclitaxel plus carboplatin in advanced non-small-cell lung cancer: a model for assessing population-related pharmacogenomics. J Clin Oncol (2009) 1.61

siRNA-based therapy ameliorates glomerulonephritis. J Am Soc Nephrol (2010) 1.58

Efficacy of adjuvant immunochemotherapy with OK-432 for patients with curatively resected gastric cancer: a meta-analysis of centrally randomized controlled clinical trials. J Immunother (2002) 1.58

Combinations of olmesartan and a calcium channel blocker or a diuretic in elderly hypertensive patients: a randomized, controlled trial. J Hypertens (2014) 1.56

Risk factors for alcohol relapse after liver transplantation for alcoholic cirrhosis in Japan. Liver Transpl (2014) 1.52

Validity of cerebrospinal fluid biomarkers as endpoints in early-phase clinical trials for Alzheimer's disease. J Alzheimers Dis (2009) 1.49

A consensus linkage map for molecular markers and quantitative trait loci associated with economically important traits in melon (Cucumis melo L.). BMC Plant Biol (2011) 1.33

Pharmacokinetics, safety, and endocrine and appetite effects of ghrelin administration in young healthy subjects. Eur J Endocrinol (2004) 1.29

Rationale, study design, baseline characteristics and blood pressure at 16 weeks in the HONEST Study. Hypertens Res (2012) 1.22

Clinical outcome of a large-scale multi-institutional retrospective study for locally advanced bladder cancer: a survey including 1131 patients treated during 1990-2000 in Japan. Eur Urol (2004) 1.13

Serum osteopontin levels are highly prognostic for survival in advanced non-small cell lung cancer: results from JMTO LC 0004. J Thorac Oncol (2009) 1.12

Risk factors for lower limb lymphedema after lymph node dissection in patients with ovarian and uterine carcinoma. BMC Cancer (2009) 1.12

Use of a serum-based antifungal susceptibility assay to predict the in vivo efficacy of novel echinocandin compounds. Microbiol Immunol (2008) 1.11

Efficacy of adjuvant immunochemotherapy with polysaccharide K for patients with curative resections of gastric cancer. Cancer Immunol Immunother (2006) 1.09

Adiponectin I164T mutation is associated with the metabolic syndrome and coronary artery disease. J Am Coll Cardiol (2004) 1.07

Preoperative positron emission tomography with fluorine-18-fluorodeoxyglucose is predictive of prognosis in patients with hepatocellular carcinoma after resection. World J Surg (2006) 1.06

Prevention and treatment of dementia or Alzheimer's disease by statins: a meta-analysis. Dement Geriatr Cogn Disord (2007) 1.05

Identification and characterization of Crr1a, a gene for resistance to clubroot disease (Plasmodiophora brassicae Woronin) in Brassica rapa L. PLoS One (2013) 1.04

Single-agent gemcitabine for biliary tract cancers. Study outcomes and systematic review of the literature. Oncology (2006) 1.03

Robot-assisted thoracoscopic lymphadenectomy along the left recurrent laryngeal nerve for esophageal squamous cell carcinoma in the prone position: technical report and short-term outcomes. World J Surg (2012) 1.02

Safety and pharmacokinetics of recombinant human hepatocyte growth factor (rh-HGF) in patients with fulminant hepatitis: a phase I/II clinical trial, following preclinical studies to ensure safety. J Transl Med (2011) 1.02

Interstitial lung disease in gefitinib-treated Japanese patients with non-small cell lung cancer - a retrospective analysis: JMTO LC03-02. BMC Res Notes (2009) 1.02

An eClinical trial system for cancer that integrates with clinical pathways and electronic medical records. Clin Trials (2012) 1.01

Phase II study of capecitabine and trastuzumab combination chemotherapy in patients with HER2 overexpressing metastatic breast cancers resistant to both anthracyclines and taxanes. Cancer Chemother Pharmacol (2008) 1.01

Clinical effect of qigong practice on essential hypertension: a meta-analysis of randomized controlled trials. J Altern Complement Med (2008) 1.00

Comparison of visual outcome and regression pattern of myopic choroidal neovascularization after intravitreal bevacizumab or after photodynamic therapy. Am J Ophthalmol (2009) 1.00

A review of 331 rhabdomyosarcoma cases in patients treated between 1991 and 2002 in Japan. Int J Clin Oncol (2007) 0.99

The reversal of recurrence hazard rate between ER positive and negative breast cancer patients with axillary lymph node dissection (pathological stage I-III) 3 years after surgery. BMC Cancer (2008) 0.96

Analysis of risk factors for severe adverse effects of oral 5-fluorouracil S-1 in patients with advanced gastric cancer. Gastric Cancer (2007) 0.95

Cancer screening of healthy volunteers using whole-body 18F-FDG-PET scans: The Nishidai clinic study. Eur J Cancer (2007) 0.95

Topical insulin-like growth factor 1 treatment using gelatin hydrogels for glucocorticoid-resistant sudden sensorineural hearing loss: a prospective clinical trial. BMC Med (2010) 0.95

Photodynamic therapy with verteporfin for choroidal neovascularization of pathologic myopia in Japanese patients: comparison with nontreated controls. Am J Ophthalmol (2008) 0.95

Long-term clinical outcomes for patients with lower limb ischemia implanted with G-CSF-mobilized autologous peripheral blood mononuclear cells. Atherosclerosis (2009) 0.94

Long-term outcomes of coronary-artery bypass graft surgery versus percutaneous coronary intervention for multivessel coronary artery disease in the bare-metal stent era. Circulation (2008) 0.94

Mapping of quantitative trait loci for high level of self-incompatibility in Brassica rapa L. Genome (2010) 0.94

Randomized, multicenter trial comparing tacrolimus plus mycophenolate mofetil to tacrolimus plus steroids in hepatitis C virus-positive recipients of living donor liver transplantation. Liver Transpl (2013) 0.94

Phase II trial of combined treatment consisting of preoperative S-1 plus cisplatin followed by gastrectomy and postoperative S-1 for stage IV gastric cancer. Gastric Cancer (2011) 0.93

Fine mapping of the clubroot resistance gene CRb and development of a useful selectable marker in Brassica rapa. Breed Sci (2013) 0.92

Novel collagen/gelatin scaffold with sustained release of basic fibroblast growth factor: clinical trial for chronic skin ulcers. Tissue Eng Part A (2013) 0.91

Killing activity of micafungin against Aspergillus fumigatus hyphae assessed by specific fluorescent staining for cell viability. Antimicrob Agents Chemother (2003) 0.91

Safety evaluation of oral fluoropyrimidine S-1 for short- and long-term delivery in advanced gastric cancer: analysis of 3,758 patients. Cancer Chemother Pharmacol (2007) 0.90

Coronary risk factor profile and prognostic factors for young Japanese patients undergoing coronary revascularization. Circ J (2009) 0.90

Risk of Helicobacter pylori transmission from drinking well water is higher than that from infected intrafamilial members in Japan. Dig Dis Sci (2003) 0.90

Prognostic factors after complete resection of pN2 non-small cell lung cancer. J Thorac Cardiovasc Surg (2013) 0.89

The current status of perioperative chemotherapy for invasive bladder cancer: a multiinstitutional retrospective study in Japan. Int J Clin Oncol (2005) 0.89

Initial steroid bolus injection promotes vigorous CD8+ alloreactive responses toward early graft acceptance immediately after liver transplantation in humans. Liver Transpl (2007) 0.89

Microstructure of a Brassica rapa genome segment homoeologous to the resistance gene cluster on Arabidopsis chromosome 4. Breed Sci (2012) 0.89

Effect of EP4 agonist (ONO-4819CD) for patients with mild to moderate ulcerative colitis refractory to 5-aminosalicylates: a randomized phase II, placebo-controlled trial. Inflamm Bowel Dis (2010) 0.88

Potential of dendritic-cell immunotherapy for relapse after allogeneic hematopoietic stem cell transplantation, shown by WT1 peptide- and keyhole-limpet-hemocyanin-pulsed, donor-derived dendritic-cell vaccine for acute myeloid leukemia. Am J Hematol (2008) 0.88

Sodium intake in men and potassium intake in women determine the prevalence of metabolic syndrome in Japanese hypertensive patients: OMEGA Study. Hypertens Res (2011) 0.87

Development of CAPS markers based on three key genes of the phenylpropanoid pathway in tea, Camellia sinensis (L.) O. Kuntze, and differentiation between assamica and sinensis varieties. Theor Appl Genet (2002) 0.87

Identificaiton of a clubroot resistance locus conferring resistance to a Plasmodiophora brassicae classified into pathotype group 3 in Chinese cabbage (Brassica rapa L.). Breed Sci (2012) 0.87

A pragmatic method for electronic medical record-based observational studies: developing an electronic medical records retrieval system for clinical research. BMJ Open (2012) 0.87

Population pharmacokinetics/pharmacodynamics of erlotinib and pharmacogenomic analysis of plasma and cerebrospinal fluid drug concentrations in Japanese patients with non-small cell lung cancer. Clin Pharmacokinet (2013) 0.87

Retrospective analysis of 27 consecutive patients treated with docetaxel/nedaplatin combination therapy as a second-line regimen for advanced esophageal cancer. Int J Clin Oncol (2007) 0.87

FR290581, a novel sordarin derivative: synthesis and antifungal activity. Bioorg Med Chem Lett (2009) 0.87

Risk classification in mild cognitive impairment patients for developing Alzheimer's disease. J Alzheimers Dis (2012) 0.87

Relationship between achieved blood pressure, dietary habits and cardiovascular disease in hypertensive patients treated with olmesartan: the OMEGA study. Hypertens Res (2012) 0.87

Repeated administration of ghrelin to patients with functional dyspepsia: its effects on food intake and appetite. Eur J Endocrinol (2008) 0.85

Classification of human liver transplant recipients by their preoperative CD8+ T cell subpopulation and its relation to outcome. Liver Transpl (2006) 0.85

OMEGA study: design, baseline data, metabolic syndrome prevalence in a large-scale observational study of hypertensive patients: The Olmesartan Mega Study to Determine the Relationship between Cardiovascular Endpoints and Blood Pressure Goal Achievement study. Hypertens Res (2008) 0.85

Role of micafungin in the antifungal armamentarium. Curr Med Chem (2007) 0.85

Comparison of DSM-IV versus proposed DSM-5 diagnostic criteria for eating disorders in a Japanese sample. Eur Eat Disord Rev (2012) 0.85

Prognostic factors for survival after first recurrence in breast cancer: a retrospective analysis of 252 recurrent cases at a single institution. Breast Cancer (2012) 0.85

Efficacy of goserelin plus anastrozole in premenopausal women with advanced or recurrent breast cancer refractory to an LH-RH analogue with tamoxifen: results of the JMTO BC08-01 phase II trial. Oncol Rep (2013) 0.85

Identification of QTLs for resistance to powdery mildew and SSR markers diagnostic for powdery mildew resistance genes in melon (Cucumis melo L.). Theor Appl Genet (2008) 0.85

Estimation of visual outcome without treatment in patients with subfoveal choroidal neovascularization in pathologic myopia. Graefes Arch Clin Exp Ophthalmol (2006) 0.84

Effects of renin-angiotensin system blockades on cardiovascular outcomes in patients with diabetes mellitus: A systematic review and meta-analysis. Diabetes Res Clin Pract (2011) 0.84

Bayesian design and conduct of phase II single-arm clinical trials with binary outcomes: a tutorial. Contemp Clin Trials (2007) 0.84

Lipid and blood pressure control for the prevention of cardiovascular disease in hypertensive patients: a subanalysis of the OMEGA study. J Atheroscler Thromb (2014) 0.84

Associations between glutathione S-transferase pi Ile105Val and glyoxylate aminotransferase Pro11Leu and Ile340Met polymorphisms and early-onset oxaliplatin-induced neuropathy. Cancer Epidemiol (2010) 0.84

Association of clinical characteristics with disease subtypes, initial visual acuity, and visual prognosis in neovascular age-related macular degeneration. Jpn J Ophthalmol (2009) 0.84

An exploratory clinical trial for idiopathic osteonecrosis of femoral head by cultured autologous multipotent mesenchymal stromal cells augmented with vascularized bone grafts. Tissue Eng Part B Rev (2014) 0.83

Difference in survival and prognostic factors between smokers and never-smokers with advanced non-small-cell lung cancer. Int J Clin Oncol (2011) 0.83

Map-based cloning of a candidate gene conferring Fusarium yellows resistance in Brassica oleracea. Theor Appl Genet (2014) 0.83

The size of cagA based on repeat sequence has the responsibility of the location of Helicobacter pylori in the gastric mucus and the degree of gastric mucosal inflammation. Microbiol Immunol (2003) 0.83

The correlation between the number of eligible patients in routine clinical practice and the low recruitment level in clinical trials: a retrospective study using electronic medical records. Trials (2013) 0.83

Prevalence and incidence of anemia in Japanese cancer patients receiving outpatient chemotherapy. Int J Hematol (2007) 0.83

A data capture system for outcomes studies that integrates with electronic health records: development and potential uses. J Med Syst (2008) 0.83

Heterologous nuclear and chloroplast microsatellite amplification and variation in tea, Camellia sinensis. Genome (2002) 0.83

In situ differentiation of CD8αα Τ cells from CD4 T cells in peripheral lymphoid tissues. Sci Rep (2012) 0.82

Predominance of infiltrating IL-4-producing T cells in conjunctiva of patients with allergic conjunctival disease. Curr Eye Res (2004) 0.82

Effect of baseline glycemic level on long-term cardiovascular outcomes after coronary revascularization therapy in patients with type 2 diabetes mellitus treated with hypoglycemic agents. Am J Cardiol (2010) 0.82

Serial assessment of immune status by circulating CD8 effector T cell frequencies for posttransplant infectious complications. Clin Dev Immunol (2008) 0.82

An exploratory clinical study on the safety and efficacy of an autologous fibroblast-seeded artificial skin cultured with animal product-free medium in patients with diabetic foot ulcers. Int Wound J (2012) 0.82

Non-inflammatory centrilobular sinusoidal fibrosis in pediatric liver transplant recipients under tacrolimus withdrawal. Hepatol Res (2012) 0.81

Oxaliplatin-free interval as a risk factor for hypersensitivity reaction among colorectal cancer patients treated with FOLFOX. Oncology (2010) 0.81

Diversity in neuroblastomas and discrimination of the risk to progress. Cancer Lett (2005) 0.81