Published in Eur J Endocrinol on April 01, 2004
Ghrelin suppresses glucose-stimulated insulin secretion and deteriorates glucose tolerance in healthy humans. Diabetes (2010) 2.01
Therapeutic potential of anamorelin, a novel, oral ghrelin mimetic, in patients with cancer-related cachexia: a multicenter, randomized, double-blind, crossover, pilot study. Support Care Cancer (2012) 1.87
Acute administration of unacylated ghrelin has no effect on Basal or stimulated insulin secretion in healthy humans. Diabetes (2014) 1.53
The pharmacokinetics of acyl, des-acyl, and total ghrelin in healthy human subjects. Eur J Endocrinol (2013) 1.36
Cancer cachexia--pathophysiology and management. J Gastroenterol (2013) 1.20
Ghrelin for cachexia. J Cachexia Sarcopenia Muscle (2010) 1.12
Safety, tolerability and pharmacokinetics of intravenous ghrelin for cancer-related anorexia/cachexia: a randomised, placebo-controlled, double-blind, double-crossover study. Br J Cancer (2008) 1.05
Peptides and food intake. Front Endocrinol (Lausanne) (2014) 1.01
Estrogen elevates the peak overnight production rate of acylated ghrelin. J Clin Endocrinol Metab (2008) 1.00
Ghrelin treatment of cachectic patients with chronic obstructive pulmonary disease: a multicenter, randomized, double-blind, placebo-controlled trial. PLoS One (2012) 0.96
Clinical review: The human experience with ghrelin administration. J Clin Endocrinol Metab (2013) 0.93
Ghrelin's second life: from appetite stimulator to glucose regulator. World J Gastroenterol (2012) 0.93
Ghrelin and functional dyspepsia. Int J Pept (2010) 0.88
Integrating GHS into the Ghrelin System. Int J Pept (2010) 0.88
The migrating motor complex: control mechanisms and its role in health and disease. Nat Rev Gastroenterol Hepatol (2012) 0.86
Use of ghrelin as a treatment for inflammatory bowel disease: mechanistic considerations. Int J Pept (2011) 0.86
Final answer: ghrelin can suppress insulin secretion in humans, but is it clinically relevant? Diabetes (2010) 0.84
Ghrelin therapy improves survival after whole-body ionizing irradiation or combined with burn or wound: amelioration of leukocytopenia, thrombocytopenia, splenomegaly, and bone marrow injury. Oxid Med Cell Longev (2014) 0.83
Impairment of ghrelin synthesis in Helicobacter pylori-colonized stomach: new clues for the pathogenesis of H. pylori-related gastric inflammation. World J Gastroenterol (2014) 0.83
Anamorelin (ONO-7643) in Japanese patients with non-small cell lung cancer and cachexia: results of a randomized phase 2 trial. Support Care Cancer (2016) 0.82
Neuropeptides in the pathophysiology and treatment of cachexia. Curr Opin Support Palliat Care (2010) 0.82
Clinical development of ghrelin axis-derived molecules for cancer cachexia treatment. Curr Opin Support Palliat Care (2013) 0.81
Metformin increases plasma ghrelin in Type 2 diabetes. Br J Clin Pharmacol (2009) 0.80
Effects of ghrelin treatment on exercise capacity in underweight COPD patients: a substudy of a multicenter, randomized, double-blind, placebo-controlled trial of ghrelin treatment. BMC Pulm Med (2013) 0.80
Preprandial ghrelin is not affected by macronutrient intake, energy intake or energy expenditure. J Negat Results Biomed (2005) 0.80
Ghrelin prevents levodopa-induced inhibition of gastric emptying and increases circulating levodopa in fasted rats. Neurogastroenterol Motil (2012) 0.80
Radiometric assay of ghrelin hydrolase activity and (3)H-ghrelin distribution into mouse tissues. Biochem Pharmacol (2015) 0.79
Ghrelin-ghrelin O-acyltransferase system in the pathogenesis of nonalcoholic fatty liver disease. World J Gastroenterol (2015) 0.79
Ghrelin and cachexia in chronic kidney disease. Pediatr Nephrol (2012) 0.79
Ghrelin administration for chronic respiratory failure: a randomized dose-comparison trial. Lung (2015) 0.79
Ghrelin partially protects against cisplatin-induced male murine gonadal toxicity in a GHSR-1a-dependent manner. Biol Reprod (2015) 0.78
Increased ghrelin sensitivity and calorie consumption in subordinate monkeys is affected by short-term astressin B administration. Endocrine (2010) 0.78
Twenty-four hour continuous ghrelin infusion augments physiologically pulsatile, nycthemeral, and entropic (feedback-regulated) modes of growth hormone secretion. J Clin Endocrinol Metab (2008) 0.77
The cardiovascular action of hexarelin. J Geriatr Cardiol (2014) 0.77
Effects of ghrelin administration on the early postoperative inflammatory response after esophagectomy. Surg Today (2014) 0.76
Central Ghrelin Resistance Permits the Overconsolidation of Fear Memory. Biol Psychiatry (2016) 0.76
From Belly to Brain: Targeting the Ghrelin Receptor in Appetite and Food Intake Regulation. Int J Mol Sci (2017) 0.76
A Novel Non-Peptidic Agonist of the Ghrelin Receptor with Orexigenic Activity In vivo. Sci Rep (2016) 0.75
Two ghrelin receptor agonists for adults with malnutrition: a systematic review and meta-analysis. Nutr J (2016) 0.75
Interaction between acyl-ghrelin and BMI predicts clinical outcomes in hemodialysis patients. BMC Nephrol (2017) 0.75
Therapeutic Potential of Targeting the Ghrelin Pathway. Int J Mol Sci (2017) 0.75
Research priorities in cancer cachexia: The University of Rochester Cancer Center NCI Community Oncology Research Program Research Base Symposium on Cancer Cachexia and Sarcopenia. Curr Opin Support Palliat Care (2017) 0.75
Ghrelin: structure and function. Physiol Rev (2005) 4.74
Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction. Nat Med (2006) 4.53
Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience. Nat Med (2004) 3.58
The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats. Gastroenterology (2002) 3.17
Transplantation of mesenchymal stem cells improves cardiac function in a rat model of dilated cardiomyopathy. Circulation (2005) 3.10
MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2 (Srebp2) regulates HDL in vivo. Proc Natl Acad Sci U S A (2010) 3.00
Laparoscopic radical nephroureterectomy: a multicenter analysis in Japan. Eur Urol (2009) 2.97
Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus/liver and CD34+ cell transplantation. Blood (2006) 2.94
Lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytes. J Exp Med (2004) 2.91
The baseline ratio of neutrophils to lymphocytes is associated with patient prognosis in advanced gastric cancer. Oncology (2008) 2.83
Cyclic AMP potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway. Mol Cell Biol (2005) 2.80
Diagnostic criteria, clinical features, and incidence of thyroid storm based on nationwide surveys. Thyroid (2012) 2.78
A high glycolytic flux supports the proliferative potential of murine embryonic stem cells. Antioxid Redox Signal (2007) 2.77
Controlled delivery of basic fibroblast growth factor promotes human cardiosphere-derived cell engraftment to enhance cardiac repair for chronic myocardial infarction. J Am Coll Cardiol (2008) 2.70
ATP hydrolysis is required for cohesin's association with chromosomes. Curr Biol (2003) 2.69
Intravenous administration of mesenchymal stem cells improves cardiac function in rats with acute myocardial infarction through angiogenesis and myogenesis. Am J Physiol Heart Circ Physiol (2004) 2.69
Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. J Clin Endocrinol Metab (2002) 2.62
Transcription-coupled events associating with immunoglobulin switch region chromatin. Science (2003) 2.50
The utility of marginal donors in liver transplantation. Liver Transpl (2003) 2.49
Management of hepatocellular carcinoma in Asia: consensus statement from the Asian Oncology Summit 2009. Lancet Oncol (2009) 2.41
Insulin independence after living-donor distal pancreatectomy and islet allotransplantation. Lancet (2005) 2.39
Pretreatment neutrophil count as an independent prognostic factor in advanced non-small-cell lung cancer: an analysis of Japan Multinational Trial Organisation LC00-03. Eur J Cancer (2009) 2.35
Present status of ABO-incompatible living donor liver transplantation in Japan. Hepatology (2008) 2.31
Nonalcoholic steatohepatitis in donors for living donor liver transplantation. Transplantation (2007) 2.25
Proliferative glomerulonephritis with monoclonal immunoglobulin G3κ deposits in association with parvovirus B19 infection. Hum Pathol (2012) 2.16
Operative morbidity of living liver donors in Japan. Lancet (2003) 2.13
Roles of thromboxane A(2) and prostacyclin in the development of atherosclerosis in apoE-deficient mice. J Clin Invest (2004) 2.12
Impact of human leukocyte antigen mismatching on outcomes of living donor liver transplantation for primary biliary cirrhosis. Liver Transpl (2007) 2.09
Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression. Curr Biol (2006) 2.04
Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca2+ signaling in beta-cells: implication in the glycemic control in rodents. Diabetes (2004) 2.04
Induction of antigen-specific immunologic tolerance by in vivo and in vitro antigen-specific expansion of naturally arising Foxp3+CD25+CD4+ regulatory T cells. Int Immunol (2004) 2.04
Adaptive servo-ventilation therapy for patients with chronic heart failure in a confirmatory, multicenter, randomized, controlled study. Circ J (2015) 2.03
A novel reticular stromal structure in lymph node cortex: an immuno-platform for interactions among dendritic cells, T cells and B cells. Int Immunol (2004) 2.02
The balance between Pax5 and Id2 activities is the key to AID gene expression. J Exp Med (2003) 1.96
Renal disease in the elderly and the very elderly Japanese: analysis of the Japan Renal Biopsy Registry (J-RBR). Clin Exp Nephrol (2012) 1.95
Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion. Diabetes (2002) 1.95
Organizer-like reticular stromal cell layer common to adult secondary lymphoid organs. J Immunol (2008) 1.92
Treatment of cachexia with ghrelin in patients with COPD. Chest (2005) 1.87
Vinorelbine plus gemcitabine followed by docetaxel versus carboplatin plus paclitaxel in patients with advanced non-small-cell lung cancer: a randomised, open-label, phase III study. Lancet Oncol (2008) 1.87
Hybrid cell-gene therapy for pulmonary hypertension based on phagocytosing action of endothelial progenitor cells. Circulation (2003) 1.86
Roles of p-ERM and Rho-ROCK signaling in lymphocyte polarity and uropod formation. J Cell Biol (2004) 1.85
UGT1A1*6 polymorphism is most predictive of severe neutropenia induced by irinotecan in Japanese cancer patients. Int J Clin Oncol (2009) 1.82
Single center experience of 39 patients with preoperative portal vein thrombosis among 404 adult living donor liver transplantations. Liver Transpl (2006) 1.81
Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure. Circulation (2004) 1.79
Weight loss increases circulating levels of ghrelin in human obesity. Clin Endocrinol (Oxf) (2002) 1.76
A combination of oral sildenafil and beraprost ameliorates pulmonary hypertension in rats. Am J Respir Crit Care Med (2003) 1.74
Essential role of Id2 in negative regulation of IgE class switching. Nat Immunol (2002) 1.71
Auxiliary partial orthotopic living donor liver transplantation: Kyoto University experience. Am J Transplant (2005) 1.70
Long-term clinical outcome after intramuscular implantation of bone marrow mononuclear cells (Therapeutic Angiogenesis by Cell Transplantation [TACT] trial) in patients with chronic limb ischemia. Am Heart J (2008) 1.70
Retrospective analysis of 45 consecutive patients with advanced gastric cancer treated with neoadjuvant chemotherapy using an S-1/CDDP combination. Gastric Cancer (2006) 1.70
Diagnostic criteria for dyslipidemia. Executive summary of Japan Atherosclerosis Society (JAS) guideline for diagnosis and prevention of atherosclerotic cardiovascular diseases for Japanese. J Atheroscler Thromb (2007) 1.70
A novel gain-of-function KCNJ2 mutation associated with short-QT syndrome impairs inward rectification of Kir2.1 currents. Cardiovasc Res (2011) 1.70
ANG II receptor blockade enhances anti-inflammatory macrophages in anti-glomerular basement membrane glomerulonephritis. Am J Physiol Renal Physiol (2010) 1.69
Prospective evaluation of whole-body cancer screening with multiple modalities including [18F]fluorodeoxyglucose positron emission tomography in a healthy population: a preliminary report. J Clin Oncol (2009) 1.68
Efficacy and safety of leptin-replacement therapy and possible mechanisms of leptin actions in patients with generalized lipodystrophy. J Clin Endocrinol Metab (2006) 1.68
Des-acyl ghrelin induces food intake by a mechanism independent of the growth hormone secretagogue receptor. Endocrinology (2006) 1.67
Ghrelin, a novel growth hormone-releasing peptide, in the treatment of cardiopulmonary-associated cachexia. Intern Med (2006) 1.66
Outcome of different post-orchiectomy management for stage I seminoma: Japanese multi-institutional study including 425 patients. Int J Urol (2010) 1.65
Bridging use of plasma exchange and continuous hemodiafiltration before living donor liver transplantation in fulminant Wilson's disease. Intern Med (2003) 1.64
Adrenomedullin induces lymphangiogenesis and ameliorates secondary lymphoedema. Cardiovasc Res (2008) 1.64
MicroRNA-33 deficiency reduces the progression of atherosclerotic plaque in ApoE-/- mice. J Am Heart Assoc (2012) 1.63
The presence of Foxp3 expressing T cells within grafts of tolerant human liver transplant recipients. Transplantation (2008) 1.61
Japanese-US common-arm analysis of paclitaxel plus carboplatin in advanced non-small-cell lung cancer: a model for assessing population-related pharmacogenomics. J Clin Oncol (2009) 1.61
Antigen-specific human T-cell responses and T cell-dependent production of human antibodies in a humanized mouse model. Blood (2008) 1.60
PIEPOC: a new prognostic index for advanced epithelial ovarian cancer--Japan Multinational Trial Organization OC01-01. J Clin Oncol (2007) 1.59
Efficacy of adjuvant immunochemotherapy with OK-432 for patients with curatively resected gastric cancer: a meta-analysis of centrally randomized controlled clinical trials. J Immunother (2002) 1.58
Combinations of olmesartan and a calcium channel blocker or a diuretic in elderly hypertensive patients: a randomized, controlled trial. J Hypertens (2014) 1.56
Ghrelin concentration in cord and neonatal blood: relation to fetal growth and energy balance. J Clin Endocrinol Metab (2003) 1.56
alpha1,3-Galactosyltransferase gene-knockout pig heart transplantation in baboons with survival approaching 6 months. Transplantation (2005) 1.56
Comparison of angiogenic potency between mesenchymal stem cells and mononuclear cells in a rat model of hindlimb ischemia. Cardiovasc Res (2005) 1.55
Hyperglycaemia suppresses the secretion of ghrelin, a novel growth-hormone-releasing peptide: responses to the intravenous and oral administration of glucose. Clin Sci (Lond) (2002) 1.54
Inhibitory effect of C-type natriuretic peptide (CNP) on cultured cardiac myocyte hypertrophy: interference between CNP and endothelin-1 signaling pathways. Endocrinology (2004) 1.53
Identification and characterization of a novel type of membrane-associated prostaglandin E synthase. Biochem Biophys Res Commun (2002) 1.52
Isolation and species distribution of staphylococci from animal and human skin. J Vet Med Sci (2002) 1.52
Renoprotective effect of erythropoietin against ischaemia-reperfusion injury in a non-human primate model. Nephrol Dial Transplant (2010) 1.52
Risk factors for alcohol relapse after liver transplantation for alcoholic cirrhosis in Japan. Liver Transpl (2014) 1.52
Temporal pattern of strokes after on-pump and off-pump coronary artery bypass graft surgery. Ann Thorac Surg (2009) 1.51
Validity of cerebrospinal fluid biomarkers as endpoints in early-phase clinical trials for Alzheimer's disease. J Alzheimers Dis (2009) 1.49
Noninvasive evaluation of graft steatosis in living donor liver transplantation. Transplantation (2004) 1.49
Role of endogenous adrenomedullin in the regulation of vascular tone and ischemic renal injury: studies on transgenic/knockout mice of adrenomedullin gene. Circ Res (2002) 1.49
Role of Rho-kinase signaling and endothelial dysfunction in modulating blood flow distribution in pulmonary hypertension. J Appl Physiol (1985) (2011) 1.48
Resistance to parathyroid hormone in two patients with familial intrahepatic cholestasis: possible involvement of the ATP8B1 gene in calcium regulation via parathyroid hormone. J Pediatr Gastroenterol Nutr (2004) 1.48