Published in Mol Cell Biol on March 01, 2005
Scaffold proteins: hubs for controlling the flow of cellular information. Science (2011) 4.00
Function and regulation in MAPK signaling pathways: lessons learned from the yeast Saccharomyces cerevisiae. Biochim Biophys Acta (2007) 3.07
The Ste5 scaffold directs mating signaling by catalytically unlocking the Fus3 MAP kinase for activation. Cell (2009) 2.50
Regulation of cell signaling dynamics by the protein kinase-scaffold Ste5. Mol Cell (2008) 2.00
Response to hyperosmotic stress. Genetics (2012) 1.95
Conformational control of the Ste5 scaffold protein insulates against MAP kinase misactivation. Science (2012) 1.92
Mechanisms of MAPK signalling specificity. Biochem Soc Trans (2006) 1.87
Membrane localization of scaffold proteins promotes graded signaling in the yeast MAP kinase cascade. Curr Biol (2008) 1.66
Kinetic insulation as an effective mechanism for achieving pathway specificity in intracellular signaling networks. Proc Natl Acad Sci U S A (2007) 1.36
GIV/Girdin is a rheostat that fine-tunes growth factor signals during tumor progression. Cell Adh Migr (2011) 1.31
Mathematical models of specificity in cell signaling. Biophys J (2007) 1.31
The regulation of filamentous growth in yeast. Genetics (2012) 1.29
A theoretical framework for specificity in cell signaling. Mol Syst Biol (2005) 1.27
Interacting JNK-docking sites in MKK7 promote binding and activation of JNK mitogen-activated protein kinases. J Biol Chem (2006) 1.18
Control of MAPK specificity by feedback phosphorylation of shared adaptor protein Ste50. J Biol Chem (2008) 1.16
A combination of multisite phosphorylation and substrate sequestration produces switchlike responses. Biophys J (2010) 1.15
Pheromone-induced anisotropy in yeast plasma membrane phosphatidylinositol-4,5-bisphosphate distribution is required for MAPK signaling. Proc Natl Acad Sci U S A (2010) 1.13
Dynamic studies of scaffold-dependent mating pathway in yeast. Biophys J (2006) 1.08
Control of MAPK signaling specificity by a conserved residue in the MEK-binding domain of the yeast scaffold protein Ste5. Curr Genet (2006) 1.03
How scaffolds shape MAPK signaling: what we know and opportunities for systems approaches. Front Physiol (2012) 0.94
Analysis of mitogen-activated protein kinase activation and interactions with regulators and substrates. Methods (2006) 0.89
Membrane recruitment of scaffold proteins drives specific signaling. PLoS One (2007) 0.87
Ultrasensitive responses and specificity in cell signaling. BMC Syst Biol (2010) 0.86
Mechanisms regulating the protein kinases of Saccharomyces cerevisiae. Eukaryot Cell (2007) 0.85
Combined computational and experimental analysis reveals mitogen-activated protein kinase-mediated feedback phosphorylation as a mechanism for signaling specificity. Mol Biol Cell (2012) 0.85
Signal transduction: turning a switch into a rheostat. Curr Biol (2008) 0.82
Signal response sensitivity in the yeast mitogen-activated protein kinase cascade. PLoS One (2010) 0.80
Mechanisms and constraints on yeast MAPK signaling specificity. Biophys J (2009) 0.78
Specificity of MAPK signaling towards FLO11 expression is established by crosstalk from cAMP pathway. Syst Synth Biol (2007) 0.77
The Dictyostelium MAPK ERK1 is phosphorylated in a secondary response to early developmental signaling. Cell Signal (2014) 0.76
G-protein signaling: a new branch in an old pathway. Curr Biol (2006) 0.76
Dse1 may control cross talk between the pheromone and filamentation pathways in yeast. Curr Genet (2009) 0.76
Nuclear relocation of Kss1 contributes to the specificity of the mating response. Sci Rep (2017) 0.75
Signal inhibition by a dynamically regulated pool of monophosphorylated MAPK. Mol Biol Cell (2015) 0.75
Signaling and circuitry of multiple MAPK pathways revealed by a matrix of global gene expression profiles. Science (2000) 13.20
Mutants of Saccharomyces cerevisiae unresponsive to cell division control by polypeptide mating hormone. J Cell Biol (1980) 6.94
Elements of a single MAP kinase cascade in Saccharomyces cerevisiae mediate two developmental programs in the same cell type: mating and invasive growth. Genes Dev (1994) 6.92
Elements of the yeast pheromone response pathway required for filamentous growth of diploids. Science (1993) 5.86
Osmotic activation of the HOG MAPK pathway via Ste11p MAPKKK: scaffold role of Pbs2p MAPKK. Science (1997) 5.02
MAP kinases with distinct inhibitory functions impart signaling specificity during yeast differentiation. Cell (1997) 4.69
Combinatorial control required for the specificity of yeast MAPK signaling. Science (1997) 4.67
Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae. Cell (1994) 4.60
Saccharomyces cerevisiae S288C has a mutation in FLO8, a gene required for filamentous growth. Genetics (1996) 4.39
Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms. Science (2003) 3.90
The Hog1 MAPK prevents cross talk between the HOG and pheromone response MAPK pathways in Saccharomyces cerevisiae. Genes Dev (1998) 3.79
The HOG pathway controls osmotic regulation of transcription via the stress response element (STRE) of the Saccharomyces cerevisiae CTT1 gene. EMBO J (1994) 3.73
Constitutive mutants of the protein kinase STE11 activate the yeast pheromone response pathway in the absence of the G protein. Genes Dev (1992) 3.65
Protein-protein interactions define specificity in signal transduction. Genes Dev (2000) 3.62
Analyzing protein-protein interactions using two-hybrid system. Methods Enzymol (1995) 3.42
Glucose depletion causes haploid invasive growth in yeast. Proc Natl Acad Sci U S A (2000) 3.12
Inhibitory and activating functions for MAPK Kss1 in the S. cerevisiae filamentous-growth signalling pathway. Nature (1997) 2.85
Order of action of components in the yeast pheromone response pathway revealed with a dominant allele of the STE11 kinase and the multiple phosphorylation of the STE7 kinase. Genes Dev (1992) 2.85
Structural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals. Trends Biochem Sci (1998) 2.83
The riddle of MAP kinase signaling specificity. Trends Genet (1998) 2.60
Signaling in the yeast pheromone response pathway: specific and high-affinity interaction of the mitogen-activated protein (MAP) kinases Kss1 and Fus3 with the upstream MAP kinase kinase Ste7. Mol Cell Biol (1996) 2.57
Membrane recruitment of the kinase cascade scaffold protein Ste5 by the Gbetagamma complex underlies activation of the yeast pheromone response pathway. Genes Dev (1998) 2.55
A walk-through of the yeast mating pheromone response pathway. Peptides (2005) 2.47
MAP kinase-related FUS3 from S. cerevisiae is activated by STE7 in vitro. Nature (1993) 2.33
The Ste5p scaffold. J Cell Sci (2001) 2.32
Pheromone response elements are necessary and sufficient for basal and pheromone-induced transcription of the FUS1 gene of Saccharomyces cerevisiae. Mol Cell Biol (1991) 1.96
A conserved docking site in MEKs mediates high-affinity binding to MAP kinases and cooperates with a scaffold protein to enhance signal transmission. J Biol Chem (2000) 1.96
Specificity of MAP kinase signaling in yeast differentiation involves transient versus sustained MAPK activation. Mol Cell (2001) 1.94
A signaling mucin at the head of the Cdc42- and MAPK-dependent filamentous growth pathway in yeast. Genes Dev (2004) 1.93
Ste5 RING-H2 domain: role in Ste4-promoted oligomerization for yeast pheromone signaling. Science (1997) 1.88
Role of scaffolds in MAP kinase pathway specificity revealed by custom design of pathway-dedicated signaling proteins. Curr Biol (2001) 1.82
Reconstitution of a yeast protein kinase cascade in vitro: activation of the yeast MEK homologue STE7 by STE11. Proc Natl Acad Sci U S A (1994) 1.82
Differential regulation of transcription: repression by unactivated mitogen-activated protein kinase Kss1 requires the Dig1 and Dig2 proteins. Proc Natl Acad Sci U S A (1998) 1.73
Phosphorylation of the MEKK Ste11p by the PAK-like kinase Ste20p is required for MAP kinase signaling in vivo. Curr Biol (2000) 1.68
The osmoregulatory pathway represses mating pathway activity in Saccharomyces cerevisiae: isolation of a FUS3 mutant that is insensitive to the repression mechanism. Mol Cell Biol (1996) 1.66
PBS2, a yeast gene encoding a putative protein kinase, interacts with the RAS2 pathway and affects osmotic sensitivity of Saccharomyces cerevisiae. J Gen Microbiol (1992) 1.61
MAPK specificity in the yeast pheromone response independent of transcriptional activation. Curr Biol (2001) 1.50
A conserved protein interaction network involving the yeast MAP kinases Fus3 and Kss1. J Cell Biol (2004) 1.42
Mutational analysis of STE5 in the yeast Saccharomyces cerevisiae: application of a differential interaction trap assay for examining protein-protein interactions. Genetics (1997) 1.38
Activation of the Saccharomyces cerevisiae filamentation/invasion pathway by osmotic stress in high-osmolarity glycogen pathway mutants. Genetics (1999) 1.33
Differential input by Ste5 scaffold and Msg5 phosphatase route a MAPK cascade to multiple outcomes. EMBO J (2004) 1.27
Mutational analysis suggests that activation of the yeast pheromone response mitogen-activated protein kinase pathway involves conformational changes in the Ste5 scaffold protein. Mol Biol Cell (2000) 1.25
Sho1 and Pbs2 act as coscaffolds linking components in the yeast high osmolarity MAP kinase pathway. Mol Cell (2004) 1.25
Spontaneous receptor-independent heterotrimeric G-protein signalling in an RGS mutant. Nat Cell Biol (2003) 1.07
Persistent activation by constitutive Ste7 promotes Kss1-mediated invasive growth but fails to support Fus3-dependent mating in yeast. Mol Cell Biol (2004) 1.07
Mutations in the SAM domain of STE50 differentially influence the MAPK-mediated pathways for mating, filamentous growth and osmotolerance in Saccharomyces cerevisiae. Mol Genet Genomics (2001) 1.07
MAP kinase cascades: scaffolding signal specificity. Curr Biol (2002) 1.02
Nuclear export and plasma membrane recruitment of the Ste5 scaffold are coordinated with oligomerization and association with signal transduction components. Mol Biol Cell (2003) 0.95
Enforced proximity in the function of a famous scaffold. Mol Cell (2003) 0.84
BRACHYURY and CDX2 mediate BMP-induced differentiation of human and mouse pluripotent stem cells into embryonic and extraembryonic lineages. Cell Stem Cell (2011) 2.79
A signaling mucin at the head of the Cdc42- and MAPK-dependent filamentous growth pathway in yeast. Genes Dev (2004) 1.93
Docking sites on mitogen-activated protein kinase (MAPK) kinases, MAPK phosphatases and the Elk-1 transcription factor compete for MAPK binding and are crucial for enzymic activity. Biochem J (2003) 1.46
A conserved protein interaction network involving the yeast MAP kinases Fus3 and Kss1. J Cell Biol (2004) 1.42
Selectivity of docking sites in MAPK kinases. J Biol Chem (2009) 1.36
Anthrax lethal factor-cleavage products of MAPK (mitogen-activated protein kinase) kinases exhibit reduced binding to their cognate MAPKs. Biochem J (2004) 1.33
A docking site in MKK4 mediates high affinity binding to JNK MAPKs and competes with similar docking sites in JNK substrates. J Biol Chem (2003) 1.31
A theoretical framework for specificity in cell signaling. Mol Syst Biol (2005) 1.27
Oscillatory phosphorylation of yeast Fus3 MAP kinase controls periodic gene expression and morphogenesis. Curr Biol (2008) 1.27
Interacting JNK-docking sites in MKK7 promote binding and activation of JNK mitogen-activated protein kinases. J Biol Chem (2006) 1.18
A combination of multisite phosphorylation and substrate sequestration produces switchlike responses. Biophys J (2010) 1.15
Computational prediction and experimental verification of new MAP kinase docking sites and substrates including Gli transcription factors. PLoS Comput Biol (2010) 1.06
Characterization of an ERK-binding domain in microphthalmia-associated transcription factor and differential inhibition of ERK2-mediated substrate phosphorylation. J Biol Chem (2005) 0.96
Protein scaffolds can enhance the bistability of multisite phosphorylation systems. PLoS Comput Biol (2012) 0.95
Noise filtering tradeoffs in spatial gradient sensing and cell polarization response. BMC Syst Biol (2011) 0.93
Casein kinase 2 reverses tail-independent inactivation of kinesin-1. Nat Commun (2012) 0.92
Ultrasensitive responses and specificity in cell signaling. BMC Syst Biol (2010) 0.86
Combining docking site and phosphosite predictions to find new substrates: identification of smoothelin-like-2 (SMTNL2) as a c-Jun N-terminal kinase (JNK) substrate. Cell Signal (2013) 0.77
Plant signalling pathways: a comparative evolutionary overview. Curr Biol (2011) 0.76
A scalable and integrative system for pathway bioinformatics and systems biology. Adv Exp Med Biol (2010) 0.75