Published in Science on May 06, 2011
Molecular mechanisms of long noncoding RNAs. Mol Cell (2011) 11.44
Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1. Cell (2012) 3.77
Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds. Cell (2014) 3.76
Temporal regulation of EGF signalling networks by the scaffold protein Shc1. Nature (2013) 2.33
Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2. Cell (2013) 2.16
IQGAP1 scaffold-kinase interaction blockade selectively targets RAS-MAP kinase-driven tumors. Nat Med (2013) 2.07
Conformational control of the Ste5 scaffold protein insulates against MAP kinase misactivation. Science (2012) 1.92
Immunoglobulin class-switch DNA recombination: induction, targeting and beyond. Nat Rev Immunol (2012) 1.80
IQGAP1 and its binding proteins control diverse biological functions. Cell Signal (2011) 1.77
Parallel visualization of multiple protein complexes in individual cells in tumor tissue. Mol Cell Proteomics (2013) 1.60
Oscillatory stress stimulation uncovers an Achilles' heel of the yeast MAPK signaling network. Science (2015) 1.58
Quantifying protein interaction dynamics by SWATH mass spectrometry: application to the 14-3-3 system. Nat Methods (2013) 1.56
SH2 Domains Serve as Lipid-Binding Modules for pTyr-Signaling Proteins. Mol Cell (2016) 1.44
Balanced interactions of calcineurin with AKAP79 regulate Ca2+-calcineurin-NFAT signaling. Nat Struct Mol Biol (2012) 1.42
Making an effective switch at the kinetochore by phosphorylation and dephosphorylation. Chromosoma (2013) 1.39
Signalling scaffolds and local organization of cellular behaviour. Nat Rev Mol Cell Biol (2015) 1.35
The CK1 Family: Contribution to Cellular Stress Response and Its Role in Carcinogenesis. Front Oncol (2014) 1.33
An optimized optogenetic clustering tool for probing protein interaction and function. Nat Commun (2014) 1.33
MAP kinase pathways. Cold Spring Harb Perspect Biol (2012) 1.29
MEK1 and MEK2 inhibitors and cancer therapy: the long and winding road. Nat Rev Cancer (2015) 1.27
Features of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinity. Expert Rev Mol Med (2012) 1.18
Functional organization of Golgi N- and O-glycosylation pathways involves pH-dependent complex formation that is impaired in cancer cells. J Biol Chem (2011) 1.14
Spatiotemporal control of microtubule nucleation and assembly using magnetic nanoparticles. Nat Nanotechnol (2013) 1.11
Mechanisms of functional promiscuity by HP1 proteins. Trends Cell Biol (2014) 1.09
Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells. Proc Natl Acad Sci U S A (2014) 1.08
HIV-1 Tat recruits transcription elongation factors dispersed along a flexible AFF4 scaffold. Proc Natl Acad Sci U S A (2012) 1.08
The Aspergillus nidulans MAPK module AnSte11-Ste50-Ste7-Fus3 controls development and secondary metabolism. PLoS Genet (2012) 1.08
Genetic characterization of p27(kip1) and stathmin in controlling cell proliferation in vivo. Cell Cycle (2014) 1.07
Archaeal and eukaryotic homologs of Hfq: A structural and evolutionary perspective on Sm function. RNA Biol (2013) 1.07
Synthetic biology: advancing biological frontiers by building synthetic systems. Genome Biol (2012) 1.06
The Src homology 3 domain is required for junctional adhesion molecule binding to the third PDZ domain of the scaffolding protein ZO-1. J Biol Chem (2011) 1.03
One-step preservation of phosphoproteins and tissue morphology at room temperature for diagnostic and research specimens. PLoS One (2011) 1.03
Rewiring of PDZ domain-ligand interaction network contributed to eukaryotic evolution. PLoS Genet (2012) 1.02
Activation of the yeast Hippo pathway by phosphorylation-dependent assembly of signaling complexes. Science (2013) 1.02
Biomolecular condensates: organizers of cellular biochemistry. Nat Rev Mol Cell Biol (2017) 1.01
The HIV-1 Rev response element: an RNA scaffold that directs the cooperative assembly of a homo-oligomeric ribonucleoprotein complex. RNA Biol (2012) 0.99
Cilia, Wnt signaling, and the cytoskeleton. Cilia (2012) 0.99
Phosphorylation of a PDZ domain extension modulates binding affinity and interdomain interactions in postsynaptic density-95 (PSD-95) protein, a membrane-associated guanylate kinase (MAGUK). J Biol Chem (2011) 0.98
Nanobodies and recombinant binders in cell biology. J Cell Biol (2015) 0.96
IQGAP1 is a novel phosphatidylinositol 4,5 bisphosphate effector in regulation of directional cell migration. EMBO J (2013) 0.96
Shoc2 is targeted to late endosomes and required for Erk1/2 activation in EGF-stimulated cells. PLoS One (2012) 0.95
β-Arrestin2 regulates lysophosphatidic acid-induced human breast tumor cell migration and invasion via Rap1 and IQGAP1. PLoS One (2013) 0.95
Scaffold-mediated nucleation of protein signaling complexes: elementary principles. Math Biosci (2011) 0.95
Enhanced activation of p21-activated kinase 1 in heart failure contributes to dephosphorylation of connexin 43. Cardiovasc Res (2011) 0.94
How scaffolds shape MAPK signaling: what we know and opportunities for systems approaches. Front Physiol (2012) 0.94
The BASL polarity protein controls a MAPK signaling feedback loop in asymmetric cell division. Dev Cell (2015) 0.91
Blt1 and Mid1 provide overlapping membrane anchors to position the division plane in fission yeast. Mol Cell Biol (2012) 0.91
Inhibitors of difficult protein-protein interactions identified by high-throughput screening of multiprotein complexes. ACS Chem Biol (2013) 0.91
RACK1 to the future--a historical perspective. Cell Commun Signal (2013) 0.90
Supertertiary structure of the synaptic MAGuK scaffold proteins is conserved. Proc Natl Acad Sci U S A (2012) 0.90
Anchored p90 ribosomal S6 kinase 3 is required for cardiac myocyte hypertrophy. Circ Res (2012) 0.90
Structural basis for extracellular cis and trans RPTPσ signal competition in synaptogenesis. Nat Commun (2014) 0.90
A Phosphosignaling Adaptor Primes the AAA+ Protease ClpXP to Drive Cell Cycle-Regulated Proteolysis. Mol Cell (2015) 0.89
Effects of cardiotonic steroids on trabecular meshwork cells: search for mediator of ouabain-enhanced outflow facility. Exp Eye Res (2012) 0.89
The vaccinia virus O1 protein is required for sustained activation of extracellular signal-regulated kinase 1/2 and promotes viral virulence. J Virol (2011) 0.89
JNK3 enzyme binding to arrestin-3 differentially affects the recruitment of upstream mitogen-activated protein (MAP) kinase kinases. J Biol Chem (2013) 0.89
Phosphorylation of EBP50 negatively regulates β-PIX-dependent Rac1 activity in anoikis. Cell Death Differ (2012) 0.89
Targeting the prohibitin scaffold-CRAF kinase interaction in RAS-ERK-driven pancreatic ductal adenocarcinoma. Mol Cancer (2014) 0.89
Exploring the existence of lipid rafts in bacteria. Microbiol Mol Biol Rev (2015) 0.88
Machines vs. ensembles: effective MAPK signaling through heterogeneous sets of protein complexes. PLoS Comput Biol (2013) 0.88
PIP kinases define PI4,5P₂signaling specificity by association with effectors. Biochim Biophys Acta (2015) 0.88
Cardiomyocyte ATP release through pannexin 1 aids in early fibroblast activation. Am J Physiol Heart Circ Physiol (2012) 0.87
Synthetic biology with surgical precision: targeted reengineering of signaling proteins. Cell Signal (2012) 0.87
The nuclear membrane leukotriene synthetic complex is a signal integrator and transducer. Mol Biol Cell (2012) 0.87
Spinal atypical protein kinase C activity is necessary to stabilize inactivity-induced phrenic motor facilitation. J Neurosci (2012) 0.86
Functional Integration of the Conserved Domains of Shoc2 Scaffold. PLoS One (2013) 0.86
Cytotopic localization by long noncoding RNAs. Curr Opin Cell Biol (2012) 0.86
The surprising dynamics of scaffolding proteins. Mol Biol Cell (2014) 0.86
Structural mechanisms of allostery and autoinhibition in JNK family kinases. Structure (2012) 0.86
Design and implementation of a biomolecular concentration tracker. ACS Synth Biol (2014) 0.85
The scaffold protein muscle A-kinase anchoring protein β orchestrates cardiac myocyte hypertrophic signaling required for the development of heart failure. Circ Heart Fail (2014) 0.85
Arrestin-3 binds the MAP kinase JNK3α2 via multiple sites on both domains. Cell Signal (2014) 0.85
Scaffold Function of Ca2+-Dependent Protein Kinase: Tobacco Ca2+-DEPENDENT PROTEIN KINASE1 Transfers 14-3-3 to the Substrate REPRESSION OF SHOOT GROWTH after Phosphorylation. Plant Physiol (2014) 0.85
Efficient production of gamma-aminobutyric acid using Escherichia coli by co-localization of glutamate synthase, glutamate decarboxylase, and GABA transporter. J Ind Microbiol Biotechnol (2015) 0.84
What's that gene (or protein)? Online resources for exploring functions of genes, transcripts, and proteins. Mol Biol Cell (2014) 0.84
Intramolecular arrangement of sensor and regulator overcomes relaxed specificity in hybrid two-component systems. Proc Natl Acad Sci U S A (2012) 0.84
Subcellular compartmentalization of docking protein-1 contributes to progression in colorectal cancer. EBioMedicine (2016) 0.84
Photon-regulated DNA-enzymatic nanostructures by molecular assembly. ACS Nano (2011) 0.84
The Overexpression of IQGAP1 and β-Catenin Is Associated with Tumor Progression in Hepatocellular Carcinoma In Vitro and In Vivo. PLoS One (2015) 0.84
Disentangling biological signaling networks by dynamic coupling of signaling lipids to modifying enzymes. Adv Biol Regul (2013) 0.84
Autoinhibition of Mint1 adaptor protein regulates amyloid precursor protein binding and processing. Proc Natl Acad Sci U S A (2012) 0.84
Distal loop flexibility of a regulatory domain modulates dynamics and activity of C-terminal SRC kinase (csk). PLoS Comput Biol (2013) 0.84
Integration of signaling and cytoskeletal remodeling by Nck in directional cell migration. Bioarchitecture (2013) 0.83
Phosphorylation of HopQ1, a type III effector from Pseudomonas syringae, creates a binding site for host 14-3-3 proteins. Plant Physiol (2013) 0.83
Experimental detection of short regulatory motifs in eukaryotic proteins: tips for good practice as well as for bad. Cell Commun Signal (2015) 0.83
Sur8/Shoc2 promotes cell motility and metastasis through activation of Ras-PI3K signaling. Oncotarget (2015) 0.83
Pro-oncogenic function of HIP-55/Drebrin-like (DBNL) through Ser269/Thr291-phospho-sensor motifs. Oncotarget (2014) 0.83
A novel NHE1-centered signaling cassette drives epidermal growth factor receptor-dependent pancreatic tumor metastasis and is a target for combination therapy. Neoplasia (2015) 0.83
PX-FERM proteins: A link between endosomal trafficking and signaling? Small GTPases (2011) 0.83
Identification of ligand-target pairs from combined libraries of small molecules and unpurified protein targets in cell lysates. J Am Chem Soc (2014) 0.82
Multi-scale ensemble modeling of modular proteins with intrinsically disordered linker regions: application to p53. Biophys J (2014) 0.82
Short Stat5-interacting peptide derived from phospholipase C-β3 inhibits hematopoietic cell proliferation and myeloid differentiation. PLoS One (2011) 0.82
The emerging function of IQD proteins as scaffolds in cellular signaling and trafficking. Plant Signal Behav (2013) 0.82
HAM-5 functions as a MAP kinase scaffold during cell fusion in Neurospora crassa. PLoS Genet (2014) 0.82
Systematic Prediction of Scaffold Proteins Reveals New Design Principles in Scaffold-Mediated Signal Transduction. PLoS Comput Biol (2015) 0.82
JNK Signaling: Regulation and Functions Based on Complex Protein-Protein Partnerships. Microbiol Mol Biol Rev (2016) 0.81
Prevalence, specificity and determinants of lipid-interacting PDZ domains from an in-cell screen and in vitro binding experiments. PLoS One (2013) 0.81
Beyond the cytoskeleton: mesoscale assemblies and their function in spatial organization. Curr Opin Microbiol (2013) 0.81
The role of CARMA1 in T cells. Crit Rev Immunol (2013) 0.81
Post-translational modifications modulate ligand recognition by the third PDZ domain of the MAGUK protein PSD-95. PLoS One (2014) 0.81
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Nature (2002) 10.96
Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex. Science (2003) 10.79
Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science (1995) 8.61
Cell-signalling dynamics in time and space. Nat Rev Mol Cell Biol (2006) 7.25
HSP90 at the hub of protein homeostasis: emerging mechanistic insights. Nat Rev Mol Cell Biol (2010) 7.16
LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell (1998) 6.15
Entropic contributions to rate accelerations in enzymic and intramolecular reactions and the chelate effect. Proc Natl Acad Sci U S A (1971) 5.46
A dimerization-dependent mechanism drives RAF catalytic activation. Nature (2009) 5.39
Regulation of MAP kinase signaling modules by scaffold proteins in mammals. Annu Rev Cell Dev Biol (2003) 5.38
Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number. Proc Natl Acad Sci U S A (2002) 4.77
Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae. Cell (1994) 4.60
A cytoplasmic inhibitor of the JNK signal transduction pathway. Science (1997) 4.56
Using engineered scaffold interactions to reshape MAP kinase pathway signaling dynamics. Science (2008) 4.37
A mechanism for cell-cycle regulation of MAP kinase signaling in a yeast differentiation pathway. Cell (2007) 4.21
Synthetic protein scaffolds provide modular control over metabolic flux. Nat Biotechnol (2009) 4.11
Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation. Mol Cell (2008) 4.09
Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties. Proc Natl Acad Sci U S A (2000) 3.95
Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms. Science (2003) 3.90
Cell signaling in space and time: where proteins come together and when they're apart. Science (2009) 3.88
Membrane-associated guanylate kinases regulate adhesion and plasticity at cell junctions. Annu Rev Biochem (2005) 3.74
The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway. Science (2006) 3.64
Domains, motifs, and scaffolds: the role of modular interactions in the evolution and wiring of cell signaling circuits. Annu Rev Biochem (2006) 3.60
A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade. Nature (1997) 3.54
Reversible compartmentalization of de novo purine biosynthetic complexes in living cells. Science (2008) 2.98
The price of lost freedom: entropy of bimolecular complex formation. Protein Eng (1989) 2.96
Spatial regulation of Fus3 MAP kinase activity through a reaction-diffusion mechanism in yeast pheromone signalling. Nat Cell Biol (2007) 2.91
Protein-protein interactions in the yeast pheromone response pathway: Ste5p interacts with all members of the MAP kinase cascade. Genetics (1994) 2.83
BioNumbers--the database of key numbers in molecular and cell biology. Nucleic Acids Res (2009) 2.76
Symmetry-breaking polarization driven by a Cdc42p GEF-PAK complex. Curr Biol (2008) 2.56
Membrane recruitment of the kinase cascade scaffold protein Ste5 by the Gbetagamma complex underlies activation of the yeast pheromone response pathway. Genes Dev (1998) 2.55
The Ste5 scaffold directs mating signaling by catalytically unlocking the Fus3 MAP kinase for activation. Cell (2009) 2.50
KSR modulates signal propagation within the MAPK cascade. Genes Dev (1996) 2.46
Structure of carbamoyl phosphate synthetase: a journey of 96 A from substrate to product. Biochemistry (1997) 2.14
The molecular basis of substrate channeling. J Biol Chem (1999) 2.06
The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network. Mol Cell (2005) 1.94
The scaffold protein Ste5 directly controls a switch-like mating decision in yeast. Nature (2010) 1.90
Ste5 RING-H2 domain: role in Ste4-promoted oligomerization for yeast pheromone signaling. Science (1997) 1.88
Scaffold proteins and immune-cell signalling. Nat Rev Immunol (2009) 1.84
Identification of the minimal tyrosine residues required for linker for activation of T cell function. J Biol Chem (2001) 1.81
Signaling dynamics of the KSR1 scaffold complex. Proc Natl Acad Sci U S A (2009) 1.76
A membrane binding domain in the ste5 scaffold synergizes with gbetagamma binding to control localization and signaling in pheromone response. Mol Cell (2005) 1.74
Respiratory syncytial virus NS1 protein degrades STAT2 by using the Elongin-Cullin E3 ligase. J Virol (2007) 1.67
The yersinia virulence factor YopM forms a novel protein complex with two cellular kinases. J Biol Chem (2003) 1.61
The assembly of a GTPase-kinase signalling complex by a bacterial catalytic scaffold. Nature (2010) 1.58
Mitogen-activated protein kinases with distinct requirements for Ste5 scaffolding influence signaling specificity in Saccharomyces cerevisiae. Mol Cell Biol (2005) 1.56
PDZ domain proteins: scaffolds for signaling complexes. Curr Biol (1997) 1.42
Contribution of translational and rotational motions to molecular association in aqueous solution. Biophys J (2001) 1.39
Mutational analysis of STE5 in the yeast Saccharomyces cerevisiae: application of a differential interaction trap assay for examining protein-protein interactions. Genetics (1997) 1.38
Scaffold proteins confer diverse regulatory properties to protein kinase cascades. Proc Natl Acad Sci U S A (2007) 1.35
Function of the MAPK scaffold protein, Ste5, requires a cryptic PH domain. Genes Dev (2006) 1.23
Quantitative effect of scaffold abundance on signal propagation. Mol Syst Biol (2009) 1.15
The C-terminal tail of Yersinia pseudotuberculosis YopM is critical for interacting with RSK1 and for virulence. Infect Immun (2010) 1.14
Single-cell analysis reveals that insulation maintains signaling specificity between two yeast MAPK pathways with common components. Sci Signal (2010) 1.03
Control of MAPK signaling specificity by a conserved residue in the MEK-binding domain of the yeast scaffold protein Ste5. Curr Genet (2006) 1.03
Synthetic metabolic pipelines. Nat Biotechnol (2009) 0.86
Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell (2013) 13.43
CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes. Cell (2013) 9.55
Spatiotemporal control of cell signalling using a light-switchable protein interaction. Nature (2009) 6.74
The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans. Nature (2008) 6.69
Defining network topologies that can achieve biochemical adaptation. Cell (2009) 5.49
Using engineered scaffold interactions to reshape MAP kinase pathway signaling dynamics. Science (2008) 4.37
Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms. Science (2003) 3.90
Optimization of specificity in a cellular protein interaction network by negative selection. Nature (2003) 3.71
The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway. Science (2006) 3.64
Domains, motifs, and scaffolds: the role of modular interactions in the evolution and wiring of cell signaling circuits. Annu Rev Biochem (2006) 3.60
Reprogramming control of an allosteric signaling switch through modular recombination. Science (2003) 3.15
Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs. Sci Signal (2010) 2.95
A polybasic motif allows N-WASP to act as a sensor of PIP(2) density. Mol Cell (2005) 2.80
Systematic functional prioritization of protein posttranslational modifications. Cell (2012) 2.78
Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species. PLoS Biol (2009) 2.67
The Ste5 scaffold directs mating signaling by catalytically unlocking the Fus3 MAP kinase for activation. Cell (2009) 2.50
Rapid diversification of cell signaling phenotypes by modular domain recombination. Science (2010) 2.49
Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors. Nature (2007) 2.43
Positive selection of tyrosine loss in metazoan evolution. Science (2009) 2.28
Designing synthetic regulatory networks capable of self-organizing cell polarization. Cell (2012) 2.28
The structure and function of proline recognition domains. Sci STKE (2003) 2.25
Using optogenetics to interrogate the dynamic control of signal transmission by the Ras/Erk module. Cell (2013) 2.22
Scaffolds: interaction platforms for cellular signalling circuits. Trends Cell Biol (2009) 2.15
CRISPR interference (CRISPRi) for sequence-specific control of gene expression. Nat Protoc (2013) 2.05
Docking interactions in protein kinase and phosphatase networks. Curr Opin Struct Biol (2006) 2.00
The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network. Mol Cell (2005) 1.94
Biological phosphoryl-transfer reactions: understanding mechanism and catalysis. Annu Rev Biochem (2011) 1.94
Conformational control of the Ste5 scaffold protein insulates against MAP kinase misactivation. Science (2012) 1.92
The promise of optogenetics in cell biology: interrogating molecular circuits in space and time. Nat Methods (2010) 1.87
Complex inheritance of familial hypercholanemia with associated mutations in TJP2 and BAAT. Nat Genet (2003) 1.85
Cell-based therapeutics: the next pillar of medicine. Sci Transl Med (2013) 1.83
Rewiring cell signaling: the logic and plasticity of eukaryotic protein circuitry. Curr Opin Struct Biol (2004) 1.83
Secreting and sensing the same molecule allows cells to achieve versatile social behaviors. Science (2014) 1.80
Light-based feedback for controlling intracellular signaling dynamics. Nat Methods (2011) 1.79
Rewiring cells: synthetic biology as a tool to interrogate the organizational principles of living systems. Annu Rev Biophys (2010) 1.78
Bacterial virulence proteins as tools to rewire kinase pathways in yeast and immune cells. Nature (2012) 1.73
Structure of the N-WASP EVH1 domain-WIP complex: insight into the molecular basis of Wiskott-Aldrich Syndrome. Cell (2002) 1.70
Evolution of the phospho-tyrosine signaling machinery in premetazoan lineages. Proc Natl Acad Sci U S A (2008) 1.68
Engineering synthetic signaling proteins with ultrasensitive input/output control. Nat Biotechnol (2007) 1.66
The pathogen protein EspF(U) hijacks actin polymerization using mimicry and multivalency. Nature (2008) 1.48
Build life to understand it. Nature (2010) 1.46
Synthetic biology: lessons from the history of synthetic organic chemistry. Nat Chem Biol (2007) 1.27
A microfluidic system for dynamic yeast cell imaging. Biotechniques (2008) 1.26
Counting molecules in single organelles with superresolution microscopy allows tracking of the endosome maturation trajectory. Proc Natl Acad Sci U S A (2013) 1.26
Sho1 and Pbs2 act as coscaffolds linking components in the yeast high osmolarity MAP kinase pathway. Mol Cell (2004) 1.25
Improved blue, green, and red fluorescent protein tagging vectors for S. cerevisiae. PLoS One (2013) 1.25
Beta strand peptidomimetics as potent PDZ domain ligands. Chem Biol (2006) 1.17
Coordinated folding and association of the LIN-2, -7 (L27) domain. An obligate heterodimerization involved in assembly of signaling and cell polarity complexes. J Biol Chem (2002) 1.17
Light control of plasma membrane recruitment using the Phy-PIF system. Methods Enzymol (2011) 1.14
Role of electrostatic interactions in PDZ domain ligand recognition. Biochemistry (2003) 1.13
Control of protein signaling using a computationally designed GTPase/GEF orthogonal pair. Proc Natl Acad Sci U S A (2012) 1.13
Engineering modular protein interaction switches by sequence overlap. J Am Chem Soc (2007) 1.10
The first World Cell Race. Curr Biol (2012) 1.07
Arginine coordination in enzymatic phosphoryl transfer: evaluation of the effect of Arg166 mutations in Escherichia coli alkaline phosphatase. Biochemistry (2008) 1.02
SYNZIP protein interaction toolbox: in vitro and in vivo specifications of heterospecific coiled-coil interaction domains. ACS Synth Biol (2012) 1.01
Multiple WASP-interacting protein recognition motifs are required for a functional interaction with N-WASP. J Biol Chem (2007) 1.00
How signaling proteins integrate multiple inputs: a comparison of N-WASP and Cdk2. Curr Opin Cell Biol (2002) 0.99
Signalling change: signal transduction through the decades. Nat Rev Mol Cell Biol (2013) 0.99
Probing the origin of the compromised catalysis of E. coli alkaline phosphatase in its promiscuous sulfatase reaction. J Am Chem Soc (2007) 0.98
Recruitment interactions can override catalytic interactions in determining the functional identity of a protein kinase. Proc Natl Acad Sci U S A (2011) 0.98
Synthetic control of mammalian-cell motility by engineering chemotaxis to an orthogonal bioinert chemical signal. Proc Natl Acad Sci U S A (2014) 0.92
A reciprocal interdependence between Nck and PI(4,5)P(2) promotes localized N-WASp-mediated actin polymerization in living cells. Mol Cell (2009) 0.90
Exploitation of latent allostery enables the evolution of new modes of MAP kinase regulation. Cell (2013) 0.89
The minimal autoinhibited unit of the guanine nucleotide exchange factor intersectin. PLoS One (2010) 0.87
A general model for preferential hetero-oligomerization of LIN-2/7 domains: mechanism underlying directed assembly of supramolecular signaling complexes. J Biol Chem (2005) 0.84
Actin dynamics rapidly reset chemoattractant receptor sensitivity following adaptation in neutrophils. Philos Trans R Soc Lond B Biol Sci (2013) 0.83
Reengineering the signaling properties of a Src family kinase. Biochemistry (2009) 0.82
Specific gene repression by CRISPRi system transferred through bacterial conjugation. ACS Synth Biol (2014) 0.80
Probing the origins of catalytic discrimination between phosphate and sulfate monoester hydrolysis: comparative analysis of alkaline phosphatase and protein tyrosine phosphatases. Biochemistry (2014) 0.79
Cell biology 2.0. Trends Cell Biol (2012) 0.76
Conditional Recruitment to a DNA-Bound CRISPR-Cas Complex Using a Colocalization-Dependent Protein Switch. ACS Synth Biol (2020) 0.75