Published in Mol Cell on February 18, 2005
Human immunodeficiency virus type 1 cDNAs produced in the presence of APOBEC3G exhibit defects in plus-strand DNA transfer and integration. J Virol (2007) 2.95
Interactions of host APOBEC3 restriction factors with HIV-1 in vivo: implications for therapeutics. Expert Rev Mol Med (2010) 2.43
Inhibition of tRNA₃(Lys)-primed reverse transcription by human APOBEC3G during human immunodeficiency virus type 1 replication. J Virol (2006) 2.32
Human immunodeficiency virus type 1 Vpr induces the degradation of the UNG and SMUG uracil-DNA glycosylases. J Virol (2005) 2.17
Uracil DNA glycosylase is dispensable for human immunodeficiency virus type 1 replication and does not contribute to the antiviral effects of the cytidine deaminase Apobec3G. J Virol (2006) 1.98
HIV-1 Vpr loads uracil DNA glycosylase-2 onto DCAF1, a substrate recognition subunit of a cullin 4A-ring E3 ubiquitin ligase for proteasome-dependent degradation. J Biol Chem (2010) 1.49
The antiviral factor APOBEC3G enhances the recognition of HIV-infected primary T cells by natural killer cells. Nat Immunol (2011) 1.35
The role of unintegrated DNA in HIV infection. Retrovirology (2011) 1.23
Uracil-directed ligand tethering: an efficient strategy for uracil DNA glycosylase (UNG) inhibitor development. J Am Chem Soc (2005) 1.21
Intracellular nucleotide levels and the control of retroviral infections. Virology (2012) 1.19
HIV infection and HERV expression: a review. Retrovirology (2012) 1.19
Tumultuous relationship between the human immunodeficiency virus type 1 viral infectivity factor (Vif) and the human APOBEC-3G and APOBEC-3F restriction factors. Microbiol Mol Biol Rev (2009) 1.12
Probing enzyme phosphoester interactions by combining mutagenesis and chemical modification of phosphate ester oxygens. Chem Rev (2006) 1.09
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Vif is a RNA chaperone that could temporally regulate RNA dimerization and the early steps of HIV-1 reverse transcription. Nucleic Acids Res (2007) 1.07
Uracil DNA glycosylase initiates degradation of HIV-1 cDNA containing misincorporated dUTP and prevents viral integration. Proc Natl Acad Sci U S A (2013) 1.04
APOBEC3G restricts early HIV-1 replication in the cytoplasm of target cells. Virology (2008) 1.04
Physical and functional interaction of human nuclear uracil-DNA glycosylase with proliferating cell nuclear antigen. DNA Repair (Amst) (2005) 0.97
Human immunodeficiency virus type 1 Vpr modulates cellular expression of UNG2 via a negative transcriptional effect. J Virol (2009) 0.96
Abundant non-canonical dUTP found in primary human macrophages drives its frequent incorporation by HIV-1 reverse transcriptase. J Biol Chem (2011) 0.95
The HIV-1 protein Vpr targets the endoribonuclease Dicer for proteasomal degradation to boost macrophage infection. Virology (2013) 0.93
The HIV1 protein Vpr acts to enhance constitutive DCAF1-dependent UNG2 turnover. PLoS One (2012) 0.93
The functions of the HIV1 protein Vpr and its action through the DCAF1.DDB1.Cullin4 ubiquitin ligase. Cytokine (2010) 0.93
Uracil within DNA: an actor of antiviral immunity. Retrovirology (2008) 0.89
X4 and R5 HIV-1 have distinct post-entry requirements for uracil DNA glycosylase during infection of primary cells. J Biol Chem (2010) 0.89
Recruitment of the nuclear form of uracil DNA glycosylase into virus particles participates in the full infectivity of HIV-1. J Virol (2011) 0.88
Uracil DNA Glycosylase 2 negatively regulates HIV-1 LTR transcription. Nucleic Acids Res (2009) 0.87
HIV relies on neddylation for ubiquitin ligase-mediated functions. Retrovirology (2013) 0.86
Review of the twelfth West Coast Retrovirus Meeting. Retrovirology (2005) 0.86
Intracellular immunity to HIV-1: newly defined retroviral battles inside infected cells. Retrovirology (2005) 0.85
Cellular kinases incorporated into HIV-1 particles: passive or active passengers? Retrovirology (2011) 0.85
HIV-1 Integrase-DNA Recognition Mechanisms. Viruses (2009) 0.84
Small interfering RNA-directed knockdown of uracil DNA glycosylase induces apoptosis and sensitizes human prostate cancer cells to genotoxic stress. Mol Cancer Res (2009) 0.83
Molecular mechanisms of HIV immune evasion of the innate immune response in myeloid cells. Viruses (2012) 0.82
Vpr expression abolishes the capacity of HIV-1 infected cells to repair uracilated DNA. Nucleic Acids Res (2013) 0.80
Cullin4A and cullin4B are interchangeable for HIV Vpr and Vpx action through the CRL4 ubiquitin ligase complex. J Virol (2014) 0.80
dUTPase: the frequently overlooked enzyme encoded by many retroviruses. Retrovirology (2015) 0.78
Prospective strategies for targeting HIV-1 integrase function. Future Med Chem (2010) 0.78
Stem-loop binding protein is a multifaceted cellular regulator of HIV-1 replication. J Clin Invest (2016) 0.77
Diverse fates of uracilated HIV-1 DNA during infection of myeloid lineage cells. Elife (2016) 0.76
The dUTPase-related gene of bovine immunodeficiency virus is critical for viral replication, despite the lack of dUTPase activity of the encoded protein. Retrovirology (2014) 0.76
Structural and biophysical analysis of interactions between cod and human uracil-DNA N-glycosylase (UNG) and UNG inhibitor (Ugi). Acta Crystallogr D Biol Crystallogr (2014) 0.75
Uracil DNA glycosylase interacts with the p32 subunit of the replication protein A complex to modulate HIV-1 reverse transcription for optimal virus dissemination. Retrovirology (2016) 0.75
An RNA cap (nucleoside-2'-O-)-methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization. EMBO J (2002) 3.87
Crystal structure of the dengue virus RNA-dependent RNA polymerase catalytic domain at 1.85-angstrom resolution. J Virol (2007) 2.65
Assessing protein disorder and induced folding. Proteins (2006) 2.33
Crystal structure of the RNA polymerase domain of the West Nile virus non-structural protein 5. J Biol Chem (2007) 2.28
A practical overview of protein disorder prediction methods. Proteins (2006) 2.18
Discovery of an RNA virus 3'->5' exoribonuclease that is critically involved in coronavirus RNA synthesis. Proc Natl Acad Sci U S A (2006) 2.07
The C-terminal domain of the measles virus nucleoprotein is intrinsically disordered and folds upon binding to the C-terminal moiety of the phosphoprotein. J Biol Chem (2003) 1.87
Structure and functionality in flavivirus NS-proteins: perspectives for drug design. Antiviral Res (2009) 1.87
The hexamer structure of Rift Valley fever virus nucleoprotein suggests a mechanism for its assembly into ribonucleoprotein complexes. PLoS Pathog (2011) 1.78
Detection and characterization of proteinase K-sensitive disease-related prion protein with thermolysin. Biochem J (2008) 1.77
Recombinase, chromosomal translocations and lymphoid neoplasia: targeting mistakes and repair failures. DNA Repair (Amst) (2006) 1.76
Structural and functional basis for ADP-ribose and poly(ADP-ribose) binding by viral macro domains. J Virol (2006) 1.70
Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5. J Mol Biol (2007) 1.69
A second, non-canonical RNA-dependent RNA polymerase in SARS coronavirus. EMBO J (2006) 1.69
Mechanistic basis for reduced viral and enzymatic fitness of HIV-1 reverse transcriptase containing both K65R and M184V mutations. J Biol Chem (2003) 1.66
A structural basis for the inhibition of the NS5 dengue virus mRNA 2'-O-methyltransferase domain by ribavirin 5'-triphosphate. J Biol Chem (2004) 1.65
The severe acute respiratory syndrome-coronavirus replicative protein nsp9 is a single-stranded RNA-binding subunit unique in the RNA virus world. Proc Natl Acad Sci U S A (2004) 1.61
Conventional and unconventional mechanisms for capping viral mRNA. Nat Rev Microbiol (2011) 1.61
Comparative mechanistic studies of de novo RNA synthesis by flavivirus RNA-dependent RNA polymerases. Virology (2006) 1.61
The N-terminal domain of the arenavirus L protein is an RNA endonuclease essential in mRNA transcription. PLoS Pathog (2010) 1.57
Coronavirus nonstructural protein 16 is a cap-0 binding enzyme possessing (nucleoside-2'O)-methyltransferase activity. J Virol (2008) 1.52
Follicular lymphoma-like B cells in healthy individuals: a novel intermediate step in early lymphomagenesis. J Exp Med (2006) 1.43
Crystal structure of the measles virus phosphoprotein domain responsible for the induced folding of the C-terminal domain of the nucleoprotein. J Biol Chem (2003) 1.43
In vitro reconstitution of SARS-coronavirus mRNA cap methylation. PLoS Pathog (2010) 1.41
Towards the design of antiviral inhibitors against flaviviruses: the case for the multifunctional NS3 protein from Dengue virus as a target. Antiviral Res (2008) 1.41
The C-terminal domain of measles virus nucleoprotein belongs to the class of intrinsically disordered proteins that fold upon binding to their physiological partner. Virus Res (2004) 1.38
The flavivirus polymerase as a target for drug discovery. Antiviral Res (2008) 1.36
Structural disorder and modular organization in Paramyxovirinae N and P. J Gen Virol (2003) 1.35
Crystal structure and mechanistic determinants of SARS coronavirus nonstructural protein 15 define an endoribonuclease family. Proc Natl Acad Sci U S A (2006) 1.33
The crystal structures of Chikungunya and Venezuelan equine encephalitis virus nsP3 macro domains define a conserved adenosine binding pocket. J Virol (2009) 1.32
A loss of viral replicative capacity correlates with altered DNA polymerization kinetics by the human immunodeficiency virus reverse transcriptase bearing the K65R and L74V dideoxynucleoside resistance substitutions. J Biol Chem (2004) 1.30
RNA-dependent RNA polymerases from flaviviruses and Picornaviridae. Curr Opin Struct Biol (2009) 1.28
Viral RNA-polymerases -- a predicted 2'-O-ribose methyltransferase domain shared by all Mononegavirales. Trends Biochem Sci (2002) 1.27
Structural disorder within the replicative complex of measles virus: functional implications. Virology (2006) 1.25
Recognition of RNA cap in the Wesselsbron virus NS5 methyltransferase domain: implications for RNA-capping mechanisms in Flavivirus. J Mol Biol (2008) 1.25
Posttranscriptional deregulation of MYC via PTEN constitutes a major alternative pathway of MYC activation in T-cell acute lymphoblastic leukemia. Blood (2011) 1.20
The intrinsically disordered C-terminal domain of the measles virus nucleoprotein interacts with the C-terminal domain of the phosphoprotein via two distinct sites and remains predominantly unfolded. Protein Sci (2005) 1.20
The SARS-Coronavirus PLnc domain of nsp3 as a replication/transcription scaffolding protein. Virus Res (2008) 1.20
Crystal structure and activity of Kunjin virus NS3 helicase; protease and helicase domain assembly in the full length NS3 protein. J Mol Biol (2007) 1.17
Practical application of bioinformatics by the multidisciplinary VIZIER consortium. Antiviral Res (2010) 1.17
Hsp72 recognizes a P binding motif in the measles virus N protein C-terminus. Virology (2005) 1.16
General catalytic deficiency of hepatitis C virus RNA polymerase with an S282T mutation and mutually exclusive resistance towards 2'-modified nucleotide analogues. Antimicrob Agents Chemother (2006) 1.15
Essential amino acids of the hantaan virus N protein in its interaction with RNA. J Virol (2005) 1.13
Structural bases for substrate recognition and activity in Meaban virus nucleoside-2'-O-methyltransferase. Protein Sci (2007) 1.13
A relaxed discrimination of 2'-O-methyl-GTP relative to GTP between de novo and Elongative RNA synthesis by the hepatitis C RNA-dependent RNA polymerase NS5B. J Biol Chem (2004) 1.13
Crystal structure and functional analysis of the SARS-coronavirus RNA cap 2'-O-methyltransferase nsp10/nsp16 complex. PLoS Pathog (2011) 1.13
Agricultural pesticide exposure and the molecular connection to lymphomagenesis. J Exp Med (2009) 1.10
Measles virus (MV) nucleoprotein binds to a novel cell surface receptor distinct from FcgammaRII via its C-terminal domain: role in MV-induced immunosuppression. J Virol (2003) 1.10
The molecular mechanism of multidrug resistance by the Q151M human immunodeficiency virus type 1 reverse transcriptase and its suppression using alpha-boranophosphate nucleotide analogues. J Biol Chem (2002) 1.09
Virtual screening and bioassay study of novel inhibitors for dengue virus mRNA cap (nucleoside-2'O)-methyltransferase. Bioorg Med Chem (2007) 1.09
The N-terminal domain of the phosphoprotein of Morbilliviruses belongs to the natively unfolded class of proteins. Virology (2002) 1.07
Predicting protein disorder and induced folding: from theoretical principles to practical applications. Curr Protein Pept Sci (2007) 1.07
Isolation of proteinase K-sensitive prions using pronase E and phosphotungstic acid. PLoS One (2010) 1.06
The human polycomb group EED protein interacts with the integrase of human immunodeficiency virus type 1. J Virol (2003) 1.04
Synthetic Vpr protein activates activator protein-1, c-Jun N-terminal kinase, and NF-kappaB and stimulates HIV-1 transcription in promonocytic cells and primary macrophages. J Biol Chem (2005) 1.03
MeDor: a metaserver for predicting protein disorder. BMC Genomics (2008) 1.03
Structural and functional characterization of sapovirus RNA-dependent RNA polymerase. J Virol (2006) 1.03
The thiazolobenzimidazole TBZE-029 inhibits enterovirus replication by targeting a short region immediately downstream from motif C in the nonstructural protein 2C. J Virol (2008) 1.02
Flavivirus NS3 and NS5 proteins interaction network: a high-throughput yeast two-hybrid screen. BMC Microbiol (2011) 1.01
Structural genomics of the SARS coronavirus: cloning, expression, crystallization and preliminary crystallographic study of the Nsp9 protein. Acta Crystallogr D Biol Crystallogr (2003) 1.01
Flaviviral methyltransferase/RNA interaction: structural basis for enzyme inhibition. Antiviral Res (2009) 1.00
Spontaneous generation of mammalian prions. Proc Natl Acad Sci U S A (2010) 1.00
De novo initiation of RNA synthesis by the arterivirus RNA-dependent RNA polymerase. J Virol (2007) 0.98
VaZyMolO: a tool to define and classify modularity in viral proteins. J Gen Virol (2005) 0.98
Uracils as a cellular weapon against viruses and mechanisms of viral escape. Curr HIV Res (2006) 0.97
Molecular basis for nucleotide conservation at the ends of the dengue virus genome. PLoS Pathog (2012) 0.97
Synthesis, in vitro antiviral evaluation, and stability studies of novel alpha-borano-nucleotide analogues of 9-[2-(phosphonomethoxy)ethyl]adenine and (R)-9-[2-(phosphonomethoxy)propyl]adenine. J Med Chem (2006) 0.97
Picornavirus non-structural proteins as targets for new anti-virals with broad activity. Antiviral Res (2011) 0.96
Monoclonal antibodies to the West Nile virus NS5 protein map to linear and conformational epitopes in the methyltransferase and polymerase domains. J Gen Virol (2009) 0.96
Biochemical characterization of the (nucleoside-2'O)-methyltransferase activity of dengue virus protein NS5 using purified capped RNA oligonucleotides (7Me)GpppAC(n) and GpppAC(n). J Gen Virol (2009) 0.95
Selective serotonin reuptake inhibitor fluoxetine inhibits replication of human enteroviruses B and D by targeting viral protein 2C. Antimicrob Agents Chemother (2013) 0.95
Differential incorporation of uracil DNA glycosylase UNG2 into HIV-1, HIV-2, and SIV(MAC) viral particles. Virology (2003) 0.95
Substitution of two residues in the measles virus nucleoprotein results in an impaired self-association. Virology (2002) 0.95
The non-structural protein Nsp10 of mouse hepatitis virus binds zinc ions and nucleic acids. FEBS Lett (2006) 0.94
Molecular mapping of the RNA Cap 2'-O-methyltransferase activation interface between severe acute respiratory syndrome coronavirus nsp10 and nsp16. J Biol Chem (2010) 0.93
Mechanistic insights into the suppression of drug resistance by human immunodeficiency virus type 1 reverse transcriptase using alpha-boranophosphate nucleoside analogs. J Biol Chem (2004) 0.93
Reversion of the lethal phenotype of an HIV-1 integrase mutant virus by overexpression of the same integrase mutant protein. J Biol Chem (2003) 0.92
The viral RNA capping machinery as a target for antiviral drugs. Antiviral Res (2012) 0.92
The modeled structure of the RNA dependent RNA polymerase of GBV-C virus suggests a role for motif E in Flaviviridae RNA polymerases. BMC Bioinformatics (2005) 0.92
In vivo reinsertion of excised episomes by the V(D)J recombinase: a potential threat to genomic stability. PLoS Biol (2007) 0.92
RNA 3'-end mismatch excision by the severe acute respiratory syndrome coronavirus nonstructural protein nsp10/nsp14 exoribonuclease complex. Proc Natl Acad Sci U S A (2012) 0.91
Nuclear localization of dengue virus nonstructural protein 5 does not strictly correlate with efficient viral RNA replication and inhibition of type I interferon signaling. J Virol (2013) 0.91
Synthesis of 5' cap-0 and cap-1 RNAs using solid-phase chemistry coupled with enzymatic methylation by human (guanine-N⁷)-methyl transferase. RNA (2012) 0.90
Functional role of HIV-1 virion-associated uracil DNA glycosylase 2 in the correction of G:U mispairs to G:C pairs. J Biol Chem (2002) 0.90