Published in Protein Sci on May 01, 2007
Structure and functionality in flavivirus NS-proteins: perspectives for drug design. Antiviral Res (2009) 1.87
West Nile virus methyltransferase catalyzes two methylations of the viral RNA cap through a substrate-repositioning mechanism. J Virol (2008) 1.44
Crystal Structure of the full-length Japanese encephalitis virus NS5 reveals a conserved methyltransferase-polymerase interface. PLoS Pathog (2013) 1.36
Flavivirus methyltransferase: a novel antiviral target. Antiviral Res (2008) 1.31
Analysis of flavivirus NS5 methyltransferase cap binding. J Mol Biol (2008) 1.27
Structural insights into the mechanism and evolution of the vaccinia virus mRNA cap N7 methyl-transferase. EMBO J (2007) 1.20
Phosphorylation of yellow fever virus NS5 alters methyltransferase activity. Virology (2008) 1.13
Genetic interactions among the West Nile virus methyltransferase, the RNA-dependent RNA polymerase, and the 5' stem-loop of genomic RNA. J Virol (2008) 1.09
Separate molecules of West Nile virus methyltransferase can independently catalyze the N7 and 2'-O methylations of viral RNA cap. Virology (2008) 1.03
Identification of a novel antiviral inhibitor of the flavivirus guanylyltransferase enzyme. J Virol (2012) 1.03
Structural and functional analyses of a conserved hydrophobic pocket of flavivirus methyltransferase. J Biol Chem (2010) 1.00
Flavivirus RNA cap methyltransferase: structure, function, and inhibition. Front Biol (Beijing) (2010) 0.97
Perturbation in the conserved methyltransferase-polymerase interface of flavivirus NS5 differentially affects polymerase initiation and elongation. J Virol (2014) 0.91
Structural analysis of human 2'-O-ribose methyltransferases involved in mRNA cap structure formation. Nat Commun (2014) 0.86
RNA methyltransferases involved in 5' cap biosynthesis. RNA Biol (2014) 0.80
Refolding of a fully functional flavivirus methyltransferase revealed that S-adenosyl methionine but not S-adenosyl homocysteine is copurified with flavivirus methyltransferase. Protein Sci (2014) 0.79
The crystal structure of Zika virus NS5 reveals conserved drug targets. EMBO J (2017) 0.76
Identification and Characterization of a Ribose 2'-O-Methyltransferase Encoded by the Ronivirus Branch of Nidovirales. J Virol (2016) 0.75
The CCP4 suite: programs for protein crystallography. Acta Crystallogr D Biol Crystallogr (1994) 187.88
The Protein Data Bank. Nucleic Acids Res (2000) 187.10
Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr D Biol Crystallogr (1998) 169.28
Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr A (1991) 119.63
Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features. Biopolymers (1983) 99.69
Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes. J Biol Chem (1987) 34.69
Use of TLS parameters to model anisotropic displacements in macromolecular refinement. Acta Crystallogr D Biol Crystallogr (2001) 21.01
Predictive motifs derived from cytosine methyltransferases. Nucleic Acids Res (1989) 7.63
The enzymes and control of eukaryotic mRNA turnover. Nat Struct Mol Biol (2004) 7.57
The CCP4 molecular-graphics project. Acta Crystallogr D Biol Crystallogr (2002) 7.15
Structure of the reovirus core at 3.6 A resolution. Nature (2000) 4.28
Structure-guided analysis reveals nine sequence motifs conserved among DNA amino-methyltransferases, and suggests a catalytic mechanism for these enzymes. J Mol Biol (1995) 4.10
Sequence of the D-aspartyl/L-isoaspartyl protein methyltransferase from human erythrocytes. Common sequence motifs for protein, DNA, RNA, and small molecule S-adenosylmethionine-dependent methyltransferases. J Biol Chem (1989) 3.16
West Nile virus 5'-cap structure is formed by sequential guanine N-7 and ribose 2'-O methylations by nonstructural protein 5. J Virol (2006) 3.07
Reaction in alphavirus mRNA capping: formation of a covalent complex of nonstructural protein nsP1 with 7-methyl-GMP. Proc Natl Acad Sci U S A (1995) 2.86
RNA methylation under heat shock control. Mol Cell (2000) 2.58
Computer-assisted identification of a putative methyltransferase domain in NS5 protein of flaviviruses and lambda 2 protein of reovirus. J Gen Virol (1993) 2.44
Crystal structure of a fibrillarin homologue from Methanococcus jannaschii, a hyperthermophile, at 1.6 A resolution. EMBO J (2000) 2.20
Genetic characterization of tick-borne flaviviruses: new insights into evolution, pathogenetic determinants and taxonomy. Virology (2006) 2.01
Structural basis for sequence-nonspecific recognition of 5'-capped mRNA by a cap-modifying enzyme. Mol Cell (1998) 1.92
Use of dynamic light scattering to assess crystallizability of macromolecules and macromolecular assemblies. Structure (1994) 1.82
The 1.85 A structure of vaccinia protein VP39: a bifunctional enzyme that participates in the modification of both mRNA ends. Cell (1996) 1.81
A structural basis for the inhibition of the NS5 dengue virus mRNA 2'-O-methyltransferase domain by ribavirin 5'-triphosphate. J Biol Chem (2004) 1.65
mRNA:guanine-N7 cap methyltransferases: identification of novel members of the family, evolutionary analysis, homology modeling, and analysis of sequence-structure-function relationships. BMC Bioinformatics (2001) 1.09
The isolation of Saumarez Reef virus, a new flavivirus, from bird ticks Ornithodoros capensis and Ixodes eudyptidis in Australia. Aust J Exp Biol Med Sci (1977) 1.01
High-yield production of short GpppA- and 7MeGpppA-capped RNAs and HPLC-monitoring of methyltransfer reactions at the guanine-N7 and adenosine-2'O positions. Nucleic Acids Res (2007) 0.96
The isolation of Meaban virus, a new Flavivirus from the seabird tick Ornithodoros (Alectorobius) maritimus in France. Arch Virol (1985) 0.86
[Tick-borne arboviruses associated with marine birds; a general review (author's transl)]. Med Trop (Mars) (1981) 0.81
Preliminary characterization of (nucleoside-2'-O-)-methyltransferase crystals from Meaban and Yokose flaviviruses. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.78
Evaluation of Convalescent Plasma for Ebola Virus Disease in Guinea. N Engl J Med (2016) 6.22
Chikungunya outbreaks--the globalization of vectorborne diseases. N Engl J Med (2007) 6.05
A giant virus in amoebae. Science (2003) 5.07
Marburg virus infection detected in a common African bat. PLoS One (2007) 4.01
An RNA cap (nucleoside-2'-O-)-methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization. EMBO J (2002) 3.87
Novel chikungunya virus variant in travelers returning from Indian Ocean islands. Emerg Infect Dis (2006) 3.43
Complete coding sequence of zika virus from a French polynesia outbreak in 2013. Genome Announc (2014) 3.23
Causes of non-malarial fever in Laos: a prospective study. Lancet Glob Health (2013) 3.20
Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages. J Clin Invest (2010) 2.92
Intravascular lymphoma: clinical presentation, natural history, management and prognostic factors in a series of 38 cases, with special emphasis on the 'cutaneous variant'. Br J Haematol (2004) 2.90
Emergence of Toscana virus in Europe. Emerg Infect Dis (2005) 2.70
Crystal structure of the dengue virus RNA-dependent RNA polymerase catalytic domain at 1.85-angstrom resolution. J Virol (2007) 2.65
Estimating Chikungunya prevalence in La Réunion Island outbreak by serosurveys: two methods for two critical times of the epidemic. BMC Infect Dis (2008) 2.61
Concurrent chikungunya and dengue virus infections during simultaneous outbreaks, Gabon, 2007. Emerg Infect Dis (2009) 2.53
Neuroglobin and cytoglobin. Fresh blood for the vertebrate globin family. EMBO Rep (2002) 2.50
Chikungunya infection: an emerging rheumatism among travelers returned from Indian Ocean islands. Report of 47 cases. Medicine (Baltimore) (2007) 2.48
Prognostic scoring system for primary CNS lymphomas: the International Extranodal Lymphoma Study Group experience. J Clin Oncol (2003) 2.44
Sequences of flavivirus-related RNA viruses persist in DNA form integrated in the genome of Aedes spp. mosquitoes. J Gen Virol (2004) 2.37
Recent introduction and rapid dissemination of Chikungunya virus and Dengue virus serotype 2 associated with human and mosquito coinfections in Gabon, central Africa. Clin Infect Dis (2012) 2.35
Assessing protein disorder and induced folding. Proteins (2006) 2.33
Crystal structure of the RNA polymerase domain of the West Nile virus non-structural protein 5. J Biol Chem (2007) 2.28
A practical overview of protein disorder prediction methods. Proteins (2006) 2.18
Next generation sequencing of viral RNA genomes. BMC Genomics (2013) 2.10
Discovery of an RNA virus 3'->5' exoribonuclease that is critically involved in coronavirus RNA synthesis. Proc Natl Acad Sci U S A (2006) 2.07
Genetic characterization of tick-borne flaviviruses: new insights into evolution, pathogenetic determinants and taxonomy. Virology (2006) 2.01
Concurrent dengue and malaria. Emerg Infect Dis (2005) 1.98
The C-terminal domain of the measles virus nucleoprotein is intrinsically disordered and folds upon binding to the C-terminal moiety of the phosphoprotein. J Biol Chem (2003) 1.87
Structure and functionality in flavivirus NS-proteins: perspectives for drug design. Antiviral Res (2009) 1.87
Arenaviruses other than Lassa virus. Antiviral Res (2003) 1.86
CtBP/BARS: a dual-function protein involved in transcription co-repression and Golgi membrane fission. EMBO J (2003) 1.86
Development and validation of real-time one-step reverse transcription-PCR for the detection and typing of dengue viruses. J Clin Virol (2009) 1.85
Chikungunya fever: epidemiology, clinical syndrome, pathogenesis and therapy. Antiviral Res (2013) 1.85
The three-dimensional structure of the human NK cell receptor NKp44, a triggering partner in natural cytotoxicity. Structure (2003) 1.82
Isolation of a new strain of the flavivirus cell fusing agent virus in a natural mosquito population from Puerto Rico. J Gen Virol (2006) 1.79
The hexamer structure of Rift Valley fever virus nucleoprotein suggests a mechanism for its assembly into ribonucleoprotein complexes. PLoS Pathog (2011) 1.78
Truncated hemoglobins: a new family of hemoglobins widely distributed in bacteria, unicellular eukaryotes, and plants. J Biol Chem (2001) 1.76
Human brain neuroglobin structure reveals a distinct mode of controlling oxygen affinity. Structure (2003) 1.75
Neuroglobin and cytoglobin in search of their role in the vertebrate globin family. J Inorg Biochem (2005) 1.71
Structural and functional basis for ADP-ribose and poly(ADP-ribose) binding by viral macro domains. J Virol (2006) 1.70
Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5. J Mol Biol (2007) 1.69
A second, non-canonical RNA-dependent RNA polymerase in SARS coronavirus. EMBO J (2006) 1.69
Mechanistic basis for reduced viral and enzymatic fitness of HIV-1 reverse transcriptase containing both K65R and M184V mutations. J Biol Chem (2003) 1.66
A structural basis for the inhibition of the NS5 dengue virus mRNA 2'-O-methyltransferase domain by ribavirin 5'-triphosphate. J Biol Chem (2004) 1.65
Origins, evolution, and vector/host coadaptations within the genus Flavivirus. Adv Virus Res (2003) 1.65
Comparative mechanistic studies of de novo RNA synthesis by flavivirus RNA-dependent RNA polymerases. Virology (2006) 1.61
Conventional and unconventional mechanisms for capping viral mRNA. Nat Rev Microbiol (2011) 1.61
The severe acute respiratory syndrome-coronavirus replicative protein nsp9 is a single-stranded RNA-binding subunit unique in the RNA virus world. Proc Natl Acad Sci U S A (2004) 1.61
Reclassification of giant viruses composing a fourth domain of life in the new order Megavirales. Intervirology (2012) 1.60
The N-terminal domain of the arenavirus L protein is an RNA endonuclease essential in mRNA transcription. PLoS Pathog (2010) 1.57
Change in Japanese encephalitis virus distribution, Thailand. Emerg Infect Dis (2008) 1.55
Anthrax toxin: a tripartite lethal combination. FEBS Lett (2002) 1.54
Yunnan orbivirus, a new orbivirus species isolated from Culex tritaeniorhynchus mosquitoes in China. J Gen Virol (2005) 1.54
Isolation of a novel species of flavivirus and a new strain of Culex flavivirus (Flaviviridae) from a natural mosquito population in Uganda. J Gen Virol (2009) 1.53
Coronavirus nonstructural protein 16 is a cap-0 binding enzyme possessing (nucleoside-2'O)-methyltransferase activity. J Virol (2008) 1.52
Massilia virus, a novel Phlebovirus (Bunyaviridae) isolated from sandflies in the Mediterranean. Vector Borne Zoonotic Dis (2009) 1.50
Cocirculation of 2 genotypes of Toscana virus, southeastern France. Emerg Infect Dis (2007) 1.50
Chikungunya fever: a clinical and virological investigation of outpatients on Reunion Island, South-West Indian Ocean. PLoS Negl Trop Dis (2013) 1.49
Phylogeny of the genus Arenavirus. Curr Opin Microbiol (2008) 1.49
Alkhurma hemorrhagic fever virus in Ornithodoros savignyi ticks. Emerg Infect Dis (2007) 1.47
The redox state of the cell regulates the ligand binding affinity of human neuroglobin and cytoglobin. J Biol Chem (2003) 1.47
Toscana virus RNA in Sergentomyia minuta files. Emerg Infect Dis (2006) 1.45
Phylogeny of New World arenaviruses based on the complete coding sequences of the small genomic segment identified an evolutionary lineage produced by intrasegmental recombination. Biochem Biophys Res Commun (2002) 1.45
Exploiting the Burkholderia pseudomallei acute phase antigen BPSL2765 for structure-based epitope discovery/design in structural vaccinology. Chem Biol (2013) 1.45
Crystal structure of the measles virus phosphoprotein domain responsible for the induced folding of the C-terminal domain of the nucleoprotein. J Biol Chem (2003) 1.43
HIV-1-associated uracil DNA glycosylase activity controls dUTP misincorporation in viral DNA and is essential to the HIV-1 life cycle. Mol Cell (2005) 1.42
In vitro reconstitution of SARS-coronavirus mRNA cap methylation. PLoS Pathog (2010) 1.41
Towards the design of antiviral inhibitors against flaviviruses: the case for the multifunctional NS3 protein from Dengue virus as a target. Antiviral Res (2008) 1.41
The C-terminal domain of measles virus nucleoprotein belongs to the class of intrinsically disordered proteins that fold upon binding to their physiological partner. Virus Res (2004) 1.38
Sandfly fever Sicilian virus, Algeria. Emerg Infect Dis (2008) 1.36
The flavivirus polymerase as a target for drug discovery. Antiviral Res (2008) 1.36
Specific recognition of ZNF217 and other zinc finger proteins at a surface groove of C-terminal binding proteins. Mol Cell Biol (2006) 1.36
Structural disorder and modular organization in Paramyxovirinae N and P. J Gen Virol (2003) 1.35
Molecular evolution of the insect-specific flaviviruses. J Gen Virol (2011) 1.34
Crystal structure and mechanistic determinants of SARS coronavirus nonstructural protein 15 define an endoribonuclease family. Proc Natl Acad Sci U S A (2006) 1.33
Analysis of the 5' noncoding region versus the NS5b region in genotyping hepatitis C virus isolates from blood donors in France. J Clin Microbiol (2006) 1.33
Sequence-specific transcription factor NF-Y displays histone-like DNA binding and H2B-like ubiquitination. Cell (2013) 1.33
The crystal structures of Chikungunya and Venezuelan equine encephalitis virus nsP3 macro domains define a conserved adenosine binding pocket. J Virol (2009) 1.32
Low diversity of Alkhurma hemorrhagic fever virus, Saudi Arabia, 1994-1999. Emerg Infect Dis (2005) 1.32
A loss of viral replicative capacity correlates with altered DNA polymerization kinetics by the human immunodeficiency virus reverse transcriptase bearing the K65R and L74V dideoxynucleoside resistance substitutions. J Biol Chem (2004) 1.30
Crystal structure of a novel conformational state of the flavivirus NS3 protein: implications for polyprotein processing and viral replication. J Virol (2009) 1.29
Rapid proton-detected NMR assignment for proteins with fast magic angle spinning. J Am Chem Soc (2014) 1.29
RNA-dependent RNA polymerases from flaviviruses and Picornaviridae. Curr Opin Struct Biol (2009) 1.28
Viral RNA-polymerases -- a predicted 2'-O-ribose methyltransferase domain shared by all Mononegavirales. Trends Biochem Sci (2002) 1.27
A simple method for molecular detection of Swine-origin and human-origin influenza a virus. Vector Borne Zoonotic Dis (2010) 1.27