SUMO modification of the ubiquitin-conjugating enzyme E2-25K.

The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition. Nat Rev Mol Cell Biol (2010) 4.72

Mechanisms, regulation and consequences of protein SUMOylation. Biochem J (2010) 3.22

Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b. EMBO J (2006) 3.21

SIZ1-mediated sumoylation of ICE1 controls CBF3/DREB1A expression and freezing tolerance in Arabidopsis. Plant Cell (2007) 2.54

Noncovalent interaction between Ubc9 and SUMO promotes SUMO chain formation. EMBO J (2007) 1.97

SUMO protease SENP1 induces isomerization of the scissile peptide bond. Nat Struct Mol Biol (2006) 1.89

The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation. Nat Rev Mol Cell Biol (2011) 1.73

SUMO-conjugating and SUMO-deconjugating enzymes from Arabidopsis. Plant Physiol (2006) 1.51

Apoptosis induction by Bid requires unconventional ubiquitination and degradation of its N-terminal fragment. J Cell Biol (2007) 1.50

A novel proteomics approach to identify SUMOylated proteins and their modification sites in human cells. Mol Cell Proteomics (2010) 1.34

Novel proteomics strategy brings insight into the prevalence of SUMO-2 target sites. Mol Cell Proteomics (2009) 1.26

Lysine-targeting specificity in ubiquitin and ubiquitin-like modification pathways. Nat Struct Mol Biol (2014) 1.16

"ChopNSpice," a mass spectrometric approach that allows identification of endogenous small ubiquitin-like modifier-conjugated peptides. Mol Cell Proteomics (2009) 1.13

Dual role of ancient ubiquitous protein 1 (AUP1) in lipid droplet accumulation and endoplasmic reticulum (ER) protein quality control. J Biol Chem (2011) 1.10

Sumoylation modulates the assembly and activity of the pre-mRNA 3' processing complex. Mol Cell Biol (2007) 1.07

Dynamic interactions of proteins in complex networks: identifying the complete set of interacting E2s for functional investigation of E3-dependent protein ubiquitination. FEBS J (2009) 1.06

Human proteome-scale structural modeling of E2-E3 interactions exploiting interface motifs. J Proteome Res (2012) 1.05

Neuronal SUMOylation: mechanisms, physiology, and roles in neuronal dysfunction. Physiol Rev (2014) 1.02

Ubiquitin proteolytic system: focus on SUMO. Expert Rev Proteomics (2008) 1.02

An electrophoretic mobility shift assay identifies a mechanistically unique inhibitor of protein sumoylation. Chem Biol (2013) 0.98

Protein SUMOylation in neuropathological conditions. Drug News Perspect (2009) 0.97

Sumoylation of forkhead L2 by Ubc9 is required for its activity as a transcriptional repressor of the Steroidogenic Acute Regulatory gene. Cell Signal (2009) 0.97

Modification of small hepatitis delta virus antigen by SUMO protein. J Virol (2009) 0.92

Sumoylation regulates Kap114-mediated nuclear transport. EMBO J (2012) 0.92

Solution structure and dynamics of human ubiquitin conjugating enzyme Ube2g2. Proteins (2010) 0.91

Monte Carlo refinement of rigid-body protein docking structures with backbone displacement and side-chain optimization. Protein Sci (2007) 0.91

UBC9 autosumoylation negatively regulates sumoylation of septins in Saccharomyces cerevisiae. J Biol Chem (2011) 0.90

Trojan horse strategies used by pathogens to influence the small ubiquitin-like modifier (SUMO) system of host eukaryotic cells. J Innate Immun (2012) 0.89

E2 enzymes: more than just middle men. Cell Res (2016) 0.87

Characterizing the N- and C-terminal Small ubiquitin-like modifier (SUMO)-interacting motifs of the scaffold protein DAXX. J Biol Chem (2011) 0.87

NMR metabolomic profiling reveals new roles of SUMOylation in DNA damage response. J Proteome Res (2010) 0.85

Structure of full-length ubiquitin-conjugating enzyme E2-25K (huntingtin-interacting protein 2). Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.85

Host cell sumoylation level influences papillomavirus E2 protein stability. Virology (2009) 0.85

Function of the C. elegans T-box factor TBX-2 depends on SUMOylation. Cell Mol Life Sci (2013) 0.84

A comprehensive compilation of SUMO proteomics. Nat Rev Mol Cell Biol (2016) 0.84

Identification of estrogen receptor β as a SUMO-1 target reveals a novel phosphorylated sumoylation motif and regulation by glycogen synthase kinase 3β. Mol Cell Biol (2012) 0.83

The spindle positioning protein Kar9p interacts with the sumoylation machinery in Saccharomyces cerevisiae. Genetics (2008) 0.82

DNA-dependent SUMO modification of PARP-1. DNA Repair (Amst) (2013) 0.81

Small ubiquitin-like modifier (SUMO) modification of zinc finger protein 131 potentiates its negative effect on estrogen signaling. J Biol Chem (2012) 0.80

Genome-Wide Identification, Phylogenetic and Expression Analyses of the Ubiquitin-Conjugating Enzyme Gene Family in Maize. PLoS One (2015) 0.79

The E2-25K ubiquitin-associated (UBA) domain aids in polyubiquitin chain synthesis and linkage specificity. Biochem Biophys Res Commun (2011) 0.79

Protein docking by Rotation-Based Uniform Sampling (RotBUS) with fast computing of intermolecular contact distance and residue desolvation. BMC Bioinformatics (2010) 0.79

Regulation of USP28 deubiquitinating activity by SUMO conjugation. J Biol Chem (2014) 0.78

Sequential posttranslational modifications regulate PKC degradation. Mol Biol Cell (2015) 0.77

gp78 elongates of polyubiquitin chains from the distal end through the cooperation of its G2BR and CUE domains. Sci Rep (2014) 0.77

The challenge of producing ubiquitinated proteins for structural studies. Cells (2014) 0.77

SUMOylation Confers Posttranslational Stability on NPM-ALK Oncogenic Protein. Neoplasia (2015) 0.76

Prediction of neddylation sites from protein sequences and sequence-derived properties. BMC Bioinformatics (2015) 0.75

E2-25K SUMOylation inhibits proteasome for cell death during cerebral ischemia/reperfusion. Cell Death Dis (2016) 0.75

Nucleus accumbens associated 1 is recruited within the promyelocytic leukemia nuclear body through SUMO modification. Cancer Sci (2015) 0.75

RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature (2002) 14.63

Concepts in sumoylation: a decade on. Nat Rev Mol Cell Biol (2007) 11.48

PCNA, the maestro of the replication fork. Cell (2007) 10.43

A genomic and functional inventory of deubiquitinating enzymes. Cell (2005) 9.36

Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures. Neuron (2004) 7.48

The nucleoporin RanBP2 has SUMO1 E3 ligase activity. Cell (2002) 5.80

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell (2008) 5.38

A series of ubiquitin binding factors connects CDC48/p97 to substrate multiubiquitylation and proteasomal targeting. Cell (2005) 4.97

SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase. Nature (2005) 4.88

Mechanism of replication-coupled DNA interstrand crosslink repair. Cell (2008) 4.53

Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis. Mol Biol Cell (2003) 4.28

Human Proteinpedia enables sharing of human protein data. Nat Biotechnol (2008) 4.21

Principles of ubiquitin and SUMO modifications in DNA repair. Nature (2009) 4.10

High-throughput retroviral tagging to identify components of specific signaling pathways in cancer. Nat Genet (2002) 3.81

PICH, a centromere-associated SNF2 family ATPase, is regulated by Plk1 and required for the spindle checkpoint. Cell (2007) 3.80

Human TPX2 is required for targeting Aurora-A kinase to the spindle. J Cell Biol (2002) 3.69

Nuclear pore complex structure and dynamics revealed by cryoelectron tomography. Science (2004) 3.61

Phosphoproteome analysis of the human mitotic spindle. Proc Natl Acad Sci U S A (2006) 3.56

HURP is a Ran-importin beta-regulated protein that stabilizes kinetochore microtubules in the vicinity of chromosomes. Curr Biol (2006) 3.21

Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b. EMBO J (2006) 3.21

Regulation of SUMOylation by reversible oxidation of SUMO conjugating enzymes. Mol Cell (2006) 2.90

Role of the ubiquitin-selective CDC48(UFD1/NPL4 )chaperone (segregase) in ERAD of OLE1 and other substrates. EMBO J (2002) 2.74

Sumoylation: a regulatory protein modification in health and disease. Annu Rev Biochem (2013) 2.66

RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling. Cell (2012) 2.60

The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase. EMBO J (2002) 2.56

The Smc5-Smc6 complex and SUMO modification of Rad52 regulates recombinational repair at the ribosomal gene locus. Nat Cell Biol (2007) 2.56

The RAD6 DNA damage tolerance pathway operates uncoupled from the replication fork and is functional beyond S phase. Cell (2010) 2.46

Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an alpha-conotoxin PnIA variant. Nat Struct Mol Biol (2005) 2.45

A role for PCNA ubiquitination in immunoglobulin hypermutation. PLoS Biol (2006) 2.43

ARP/wARP and molecular replacement: the next generation. Acta Crystallogr D Biol Crystallogr (2007) 2.43

Functional division of substrate processing cofactors of the ubiquitin-selective Cdc48 chaperone. Mol Cell (2006) 2.41

Transcription factor Sp3 is silenced through SUMO modification by PIAS1. EMBO J (2002) 2.41

Protein group modification and synergy in the SUMO pathway as exemplified in DNA repair. Cell (2012) 2.36

RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites. EMBO J (2012) 2.34

Proteome analysis of the human mitotic spindle. Mol Cell Proteomics (2004) 2.31

Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation. Dev Cell (2003) 2.18

Mechanism and consequences for paralog-specific sumoylation of ubiquitin-specific protease 25. Mol Cell (2008) 2.15

Chromosome-wide Rad51 spreading and SUMO-H2A.Z-dependent chromosome fixation in response to a persistent DNA double-strand break. Mol Cell (2009) 2.15

Proteasome-mediated protein processing by bidirectional degradation initiated from an internal site. Nat Struct Mol Biol (2006) 2.09

Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entry. PLoS Biol (2010) 2.07

Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer. J Clin Invest (2012) 2.03

Final stages of cytokinesis and midbody ring formation are controlled by BRUCE. Cell (2008) 2.02

PCNA controls establishment of sister chromatid cohesion during S phase. Mol Cell (2006) 1.97

Noncovalent interaction between Ubc9 and SUMO promotes SUMO chain formation. EMBO J (2007) 1.97

Plk1 docking to GRASP65 phosphorylated by Cdk1 suggests a mechanism for Golgi checkpoint signalling. EMBO J (2005) 1.96

The Plk1-dependent phosphoproteome of the early mitotic spindle. Mol Cell Proteomics (2010) 1.91

Deadly encounter: ubiquitin meets apoptosis. Nat Rev Mol Cell Biol (2002) 1.89

Structure of the cyclic-AMP-responsive exchange factor Epac2 in its auto-inhibited state. Nature (2006) 1.88

Ubc9 sumoylation regulates SUMO target discrimination. Mol Cell (2008) 1.86

Control of Rad52 recombination activity by double-strand break-induced SUMO modification. Nat Cell Biol (2006) 1.84

Chemical synthesis of ubiquitin, ubiquitin-based probes, and diubiquitin. Angew Chem Int Ed Engl (2010) 1.83

Ubiquitin-related modifier SUMO1 and nucleocytoplasmic transport. Traffic (2002) 1.82

Cell biology: SUMO. Nature (2008) 1.82

Structural determinants of selective alpha-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP. Proc Natl Acad Sci U S A (2006) 1.78

The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension. EMBO J (2012) 1.76

Crystal structure of acetylcholine-binding protein from Bulinus truncatus reveals the conserved structural scaffold and sites of variation in nicotinic acetylcholine receptors. J Biol Chem (2005) 1.74

Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase. Mol Cell (2004) 1.73

CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis. Mol Biol Cell (2003) 1.72

Midbody ring disposal by autophagy is a post-abscission event of cytokinesis. Nat Cell Biol (2008) 1.70

Monitoring homology search during DNA double-strand break repair in vivo. Mol Cell (2013) 1.69

Phosphorylation of human Argonaute proteins affects small RNA binding. Nucleic Acids Res (2010) 1.64

The RanBP2 SUMO E3 ligase is neither HECT- nor RING-type. Nat Struct Mol Biol (2004) 1.64

Structures of Escherichia coli DNA mismatch repair enzyme MutS in complex with different mismatches: a common recognition mode for diverse substrates. Nucleic Acids Res (2003) 1.62

The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types. Chem Biol (2011) 1.58

The proteasomal subunit Rpn6 is a molecular clamp holding the core and regulatory subcomplexes together. Proc Natl Acad Sci U S A (2011) 1.57

Opposed regulation of corepressor CtBP by SUMOylation and PDZ binding. Mol Cell (2003) 1.57

SUMO: regulating the regulator. Cell Div (2006) 1.56

Mechanism of USP7/HAUSP activation by its C-terminal ubiquitin-like domain and allosteric regulation by GMP-synthetase. Mol Cell (2011) 1.56

Quantitative analysis of the human spindle phosphoproteome at distinct mitotic stages. J Proteome Res (2009) 1.53

Insight in nAChR subtype selectivity from AChBP crystal structures. Biochem Pharmacol (2009) 1.44

Detecting endogenous SUMO targets in mammalian cells and tissues. Nat Struct Mol Biol (2013) 1.44

The alternating ATPase domains of MutS control DNA mismatch repair. EMBO J (2003) 1.43

The Nup358-RanGAP complex is required for efficient importin alpha/beta-dependent nuclear import. Mol Biol Cell (2008) 1.40

Co-expression of protein complexes in prokaryotic and eukaryotic hosts: experimental procedures, database tracking and case studies. Acta Crystallogr D Biol Crystallogr (2006) 1.39

Identification of cross-linked peptides for protein interaction studies using mass spectrometry and 18O labeling. Anal Chem (2002) 1.39

Structural analysis of the bipartite DNA-binding domain of Tc3 transposase bound to transposon DNA. Nucleic Acids Res (2004) 1.37

Human Wrnip1 is localized in replication factories in a ubiquitin-binding zinc finger-dependent manner. J Biol Chem (2008) 1.37

AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity. EMBO J (2007) 1.35

E3 ligase Rad18 promotes monoubiquitination rather than ubiquitin chain formation by E2 enzyme Rad6. Proc Natl Acad Sci U S A (2011) 1.32

Activation of transforming growth factor-beta signaling by SUMO-1 modification of tumor suppressor Smad4/DPC4. J Biol Chem (2003) 1.32

ATP increases the affinity between MutS ATPase domains. Implications for ATP hydrolysis and conformational changes. J Biol Chem (2004) 1.29

Phosphorylation regulates the activity of the SMN complex during assembly of spliceosomal U snRNPs. EMBO Rep (2005) 1.29

Functional characterization of Rad18 domains for Rad6, ubiquitin, DNA binding and PCNA modification. Nucleic Acids Res (2007) 1.28

Regulation of Smad4 sumoylation and transforming growth factor-beta signaling by protein inhibitor of activated STAT1. J Biol Chem (2004) 1.27

Noncanonical role of the 9-1-1 clamp in the error-free DNA damage tolerance pathway. Mol Cell (2012) 1.27

Taking a bite: proteasomal protein processing. Nat Cell Biol (2002) 1.26

The RanBP2/RanGAP1*SUMO1/Ubc9 complex is a multisubunit SUMO E3 ligase. Mol Cell (2012) 1.24

Role of Cdc48/p97 as a SUMO-targeted segregase curbing Rad51-Rad52 interaction. Nat Cell Biol (2013) 1.20

Productive RUPture: activation of transcription factors by proteasomal processing. Biochim Biophys Acta (2004) 1.19

Role of the ubiquitin-like protein Urm1 as a noncanonical lysine-directed protein modifier. Proc Natl Acad Sci U S A (2011) 1.16