Published in Cell on May 18, 2007
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How the fanconi anemia pathway guards the genome. Annu Rev Genet (2009) 4.94
The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition. Nat Rev Mol Cell Biol (2010) 4.72
Epigenetic inheritance during the cell cycle. Nat Rev Mol Cell Biol (2009) 4.43
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Chromatin structure and the inheritance of epigenetic information. Nat Rev Genet (2010) 4.03
Y-family DNA polymerases and their role in tolerance of cellular DNA damage. Nat Rev Mol Cell Biol (2012) 3.43
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Most random gene expression signatures are significantly associated with breast cancer outcome. PLoS Comput Biol (2011) 3.33
What a difference a decade makes: insights into translesion DNA synthesis. Proc Natl Acad Sci U S A (2007) 3.32
The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing. Genes Dev (2008) 2.71
Inhibition of homologous recombination by the PCNA-interacting protein PARI. Mol Cell (2011) 2.61
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Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis. Nat Struct Mol Biol (2010) 2.40
Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage. Mol Cell (2010) 2.39
Murine features of neurogenesis in the human hippocampus across the lifespan from 0 to 100 years. PLoS One (2010) 2.34
CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation. Mol Cell (2010) 2.32
The mutational spectrum of non-CpG DNA varies with CpG content. Genome Res (2010) 2.26
Mechanisms that regulate localization of a DNA double-strand break to the nuclear periphery. Genes Dev (2009) 2.13
DNA damage tolerance: when it's OK to make mistakes. Nat Chem Biol (2009) 2.04
Docking of a specialized PIP Box onto chromatin-bound PCNA creates a degron for the ubiquitin ligase CRL4Cdt2. Mol Cell (2009) 1.97
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Direct interaction between SET8 and proliferating cell nuclear antigen couples H4-K20 methylation with DNA replication. J Biol Chem (2008) 1.93
Strand-specific analysis shows protein binding at replication forks and PCNA unloading from lagging strands when forks stall. Mol Cell (2014) 1.90
Regulation of PCNA-protein interactions for genome stability. Nat Rev Mol Cell Biol (2013) 1.88
Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks. Proc Natl Acad Sci U S A (2008) 1.84
Proliferating cell nuclear antigen (PCNA): a key factor in DNA replication and cell cycle regulation. Ann Bot (2010) 1.81
Quantitative fluorescence labeling of aldehyde-tagged proteins for single-molecule imaging. Nat Methods (2012) 1.80
Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress. Mol Cell (2012) 1.79
Histone H3 lysine 56 methylation regulates DNA replication through its interaction with PCNA. Mol Cell (2012) 1.79
Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Nat Cell Biol (2012) 1.74
The ubiquitin-proteasome system of Saccharomyces cerevisiae. Genetics (2012) 1.73
Regulation of Rev1 by the Fanconi anemia core complex. Nat Struct Mol Biol (2012) 1.72
Break-induced replication requires all essential DNA replication factors except those specific for pre-RC assembly. Genes Dev (2010) 1.71
More forks on the road to replication stress recovery. J Mol Cell Biol (2011) 1.64
Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components. Nat Cell Biol (2014) 1.64
Identification of a novel, widespread, and functionally important PCNA-binding motif. J Cell Biol (2009) 1.63
Regulation of heterochromatic DNA replication by histone H3 lysine 27 methyltransferases. Nature (2010) 1.63
Impact of conformational heterogeneity of OxoG lesions and their pairing partners on bypass fidelity by Y family polymerases. Structure (2009) 1.59
Regulated proteolysis of DNA polymerase eta during the DNA-damage response in C. elegans. Mol Cell (2008) 1.53
Proliferating cell nuclear antigen uses two distinct modes to move along DNA. J Biol Chem (2009) 1.53
PCNA is required for initiation of recombination-associated DNA synthesis by DNA polymerase delta. Mol Cell (2009) 1.52
DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks. Nat Struct Mol Biol (2012) 1.51
Chk1 and Claspin potentiate PCNA ubiquitination. Genes Dev (2008) 1.51
Chemically ubiquitylated PCNA as a probe for eukaryotic translesion DNA synthesis. Nat Chem Biol (2010) 1.51
Rtt101 and Mms1 in budding yeast form a CUL4(DDB1)-like ubiquitin ligase that promotes replication through damaged DNA. EMBO Rep (2008) 1.51
Fat10 is an epigenetic marker for liver preneoplasia in a drug-primed mouse model of tumorigenesis. Exp Mol Pathol (2008) 1.48
Structural basis for novel interactions between human translesion synthesis polymerases and proliferating cell nuclear antigen. J Biol Chem (2009) 1.48
BRCA1 is required for postreplication repair after UV-induced DNA damage. Mol Cell (2011) 1.48
DNA polymerase POLN participates in cross-link repair and homologous recombination. Mol Cell Biol (2009) 1.47
Overexpression of lecithin:retinol acyltransferase in the epithelial basal layer makes mice more sensitive to oral cavity carcinogenesis induced by a carcinogen. Cancer Biol Ther (2009) 1.47
Structure of the Siz/PIAS SUMO E3 ligase Siz1 and determinants required for SUMO modification of PCNA. Mol Cell (2009) 1.46
Multiple degradation pathways regulate versatile CIP/KIP CDK inhibitors. Trends Cell Biol (2011) 1.46
CRL4Cdt2: master coordinator of cell cycle progression and genome stability. Cell Cycle (2011) 1.45
Tissue biomarkers for prognosis in cutaneous melanoma: a systematic review and meta-analysis. J Natl Cancer Inst (2009) 1.44
Identification of proteins at active, stalled, and collapsed replication forks using isolation of proteins on nascent DNA (iPOND) coupled with mass spectrometry. J Biol Chem (2013) 1.43
Target validation and structure-activity analysis of a series of novel PCNA inhibitors. Pharmacol Res Perspect (2015) 1.43
A feed-forward loop involving protein kinase Calpha and microRNAs regulates tumor cell cycle. Cancer Res (2009) 1.43
Human ELG1 regulates the level of ubiquitinated proliferating cell nuclear antigen (PCNA) through Its interactions with PCNA and USP1. J Biol Chem (2010) 1.43
Regulation of ribosomal RNA synthesis in T cells: requirement for GTP and Ebp1. Blood (2015) 1.40
Crystal structure of human REV7 in complex with a human REV3 fragment and structural implication of the interaction between DNA polymerase zeta and REV1. J Biol Chem (2010) 1.40
DNA Replication Is Required for Circadian Clock Function by Regulating Rhythmic Nucleosome Composition. Mol Cell (2017) 1.38
The HARP-like domain-containing protein AH2/ZRANB3 binds to PCNA and participates in cellular response to replication stress. Mol Cell (2012) 1.37
Human Wrnip1 is localized in replication factories in a ubiquitin-binding zinc finger-dependent manner. J Biol Chem (2008) 1.37
H2AX is required for cell cycle arrest via the p53/p21 pathway. Mol Cell Biol (2009) 1.36
Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype. EMBO J (2012) 1.35
Rescuing stalled or damaged replication forks. Cold Spring Harb Perspect Biol (2013) 1.34
SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation. J Cell Biol (2011) 1.34
Cellular responses to DNA double-strand breaks after low-dose gamma-irradiation. Nucleic Acids Res (2009) 1.34
DNA damage tolerance: a double-edged sword guarding the genome. Transl Cancer Res (2013) 1.33
Recognition of SUMO-modified PCNA requires tandem receptor motifs in Srs2. Nature (2012) 1.33
Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression. Proc Natl Acad Sci U S A (2008) 1.32
Reverse the curse--the role of deubiquitination in cell cycle control. Curr Opin Cell Biol (2008) 1.31
Oligonucleotide/oligosaccharide-binding fold proteins: a growing family of genome guardians. Crit Rev Biochem Mol Biol (2010) 1.30
Spartan/C1orf124, a reader of PCNA ubiquitylation and a regulator of UV-induced DNA damage response. Mol Cell (2012) 1.30
A model for DNA polymerase switching involving a single cleft and the rim of the sliding clamp. Proc Natl Acad Sci U S A (2009) 1.27
PCNA ubiquitination is important, but not essential for translesion DNA synthesis in mammalian cells. PLoS Genet (2011) 1.27
Proliferating cell nuclear antigen acts as a cytoplasmic platform controlling human neutrophil survival. J Exp Med (2010) 1.27
Sister acts: coordinating DNA replication and cohesion establishment. Genes Dev (2010) 1.24
An 8-oxo-guanine repair pathway coordinated by MUTYH glycosylase and DNA polymerase lambda. Proc Natl Acad Sci U S A (2009) 1.23
Intercellular communication of cellular stress monitored by gamma-H2AX induction. Carcinogenesis (2009) 1.23
Epigenetic regulation, somatic homologous recombination, and abscisic acid signaling are influenced by DNA polymerase epsilon mutation in Arabidopsis. Plant Cell (2009) 1.23
ZRANB3 is a structure-specific ATP-dependent endonuclease involved in replication stress response. Genes Dev (2012) 1.23
The Smc5/6 complex and Esc2 influence multiple replication-associated recombination processes in Saccharomyces cerevisiae. Mol Biol Cell (2010) 1.22
Wolbachia-mediated cytoplasmic incompatibility is associated with impaired histone deposition in the male pronucleus. PLoS Pathog (2009) 1.22
Functional interaction between the Fanconi Anemia D2 protein and proliferating cell nuclear antigen (PCNA) via a conserved putative PCNA interaction motif. J Biol Chem (2009) 1.22
Replication timing and epigenetic reprogramming of gene expression: a two-way relationship? Nat Rev Genet (2009) 1.22
Metnase promotes restart and repair of stalled and collapsed replication forks. Nucleic Acids Res (2010) 1.21
Herpes simplex viruses: mechanisms of DNA replication. Cold Spring Harb Perspect Biol (2012) 1.21
Phytochrome regulation of branching in Arabidopsis. Plant Physiol (2010) 1.20
Coordinating DNA polymerase traffic during high and low fidelity synthesis. Biochim Biophys Acta (2009) 1.20
Nucleolin associates with the human cytomegalovirus DNA polymerase accessory subunit UL44 and is necessary for efficient viral replication. J Virol (2009) 1.19
Chromatin recruitment of DNA repair proteins: lessons from the fanconi anemia and double-strand break repair pathways. Mol Cell (2008) 1.19
DNA damage bypass operates in the S and G2 phases of the cell cycle and exhibits differential mutagenicity. Nucleic Acids Res (2011) 1.17
Dynamics of human replication factors in the elongation phase of DNA replication. Nucleic Acids Res (2007) 1.17
DNA repair mechanisms and the bypass of DNA damage in Saccharomyces cerevisiae. Genetics (2013) 1.17
Serine hydroxymethyltransferase anchors de novo thymidylate synthesis pathway to nuclear lamina for DNA synthesis. J Biol Chem (2012) 1.16
RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature (2002) 14.63
A series of ubiquitin binding factors connects CDC48/p97 to substrate multiubiquitylation and proteasomal targeting. Cell (2005) 4.97
SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase. Nature (2005) 4.88
Principles of ubiquitin and SUMO modifications in DNA repair. Nature (2009) 4.10
Role of the ubiquitin-selective CDC48(UFD1/NPL4 )chaperone (segregase) in ERAD of OLE1 and other substrates. EMBO J (2002) 2.74
The Smc5-Smc6 complex and SUMO modification of Rad52 regulates recombinational repair at the ribosomal gene locus. Nat Cell Biol (2007) 2.56
The RAD6 DNA damage tolerance pathway operates uncoupled from the replication fork and is functional beyond S phase. Cell (2010) 2.46
A role for PCNA ubiquitination in immunoglobulin hypermutation. PLoS Biol (2006) 2.43
Functional division of substrate processing cofactors of the ubiquitin-selective Cdc48 chaperone. Mol Cell (2006) 2.41
Protein group modification and synergy in the SUMO pathway as exemplified in DNA repair. Cell (2012) 2.36
Chromosome-wide Rad51 spreading and SUMO-H2A.Z-dependent chromosome fixation in response to a persistent DNA double-strand break. Mol Cell (2009) 2.15
Proteasome-mediated protein processing by bidirectional degradation initiated from an internal site. Nat Struct Mol Biol (2006) 2.09
Final stages of cytokinesis and midbody ring formation are controlled by BRUCE. Cell (2008) 2.02
PCNA controls establishment of sister chromatid cohesion during S phase. Mol Cell (2006) 1.97
Deadly encounter: ubiquitin meets apoptosis. Nat Rev Mol Cell Biol (2002) 1.89
Control of Rad52 recombination activity by double-strand break-induced SUMO modification. Nat Cell Biol (2006) 1.84
Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase. Mol Cell (2004) 1.73
Midbody ring disposal by autophagy is a post-abscission event of cytokinesis. Nat Cell Biol (2008) 1.70
Monitoring homology search during DNA double-strand break repair in vivo. Mol Cell (2013) 1.69
SUMO modification of the ubiquitin-conjugating enzyme E2-25K. Nat Struct Mol Biol (2005) 1.58
Noncanonical role of the 9-1-1 clamp in the error-free DNA damage tolerance pathway. Mol Cell (2012) 1.27
Taking a bite: proteasomal protein processing. Nat Cell Biol (2002) 1.26
Role of Cdc48/p97 as a SUMO-targeted segregase curbing Rad51-Rad52 interaction. Nat Cell Biol (2013) 1.20
Productive RUPture: activation of transcription factors by proteasomal processing. Biochim Biophys Acta (2004) 1.19
Role of the ubiquitin-like protein Urm1 as a noncanonical lysine-directed protein modifier. Proc Natl Acad Sci U S A (2011) 1.16
Elg1, an alternative subunit of the RFC clamp loader, preferentially interacts with SUMOylated PCNA. EMBO J (2010) 1.12
Role of the ubiquitin-like protein Hub1 in splice-site usage and alternative splicing. Nature (2011) 1.07
BRUCE, a giant E2/E3 ubiquitin ligase and inhibitor of apoptosis protein of the trans-Golgi network, is required for normal placenta development and mouse survival. Mol Cell Biol (2004) 1.03
DNA bending facilitates the error-free DNA damage tolerance pathway and upholds genome integrity. EMBO J (2014) 1.00
Synaptonemal complex formation and meiotic checkpoint signaling are linked to the lateral element protein Red1. Proc Natl Acad Sci U S A (2010) 1.00
The ubiquitin-like protein HUB1 forms SDS-resistant complexes with cellular proteins in the absence of ATP. EMBO Rep (2003) 0.99
Prolyl isomerase Pin1 acts as a switch to control the degree of substrate ubiquitylation. Nat Cell Biol (2009) 0.99
SnapShot: The SUMO system. Cell (2010) 0.91
SM-protein-controlled ER-associated degradation discriminates between different SNAREs. EMBO Rep (2007) 0.87
9-1-1: PCNA's specialized cousin. Trends Biochem Sci (2011) 0.86
Identification of SUMO-protein conjugates. Methods Enzymol (2005) 0.81
Pin1, a novel switch in the ubiquitin pathway. Cell Cycle (2009) 0.81
γH2AX spreading linked to homology search. Cell Cycle (2013) 0.79
The Slx4-Dpb11 scaffold complex: coordinating the response to replication fork stalling in S-phase and the subsequent mitosis. Cell Cycle (2015) 0.78
A new class of ubiquitin-Atg8 receptors involved in selective autophagy and polyQ protein clearance. Autophagy (2014) 0.78
Nerve growth factor-induced phosphorylation of amphiphysin-1 by casein kinase 2 regulates clathrin-amphiphysin interactions. J Neurochem (2006) 0.77
The ubiquitin system in health and disease. Preface. Ernst Schering Found Symp Proc (2008) 0.76
Varshavsky's contributions. Science (2004) 0.75