Published in Infect Immun on March 01, 2005
Toll-like receptor 4 mediates neutrophil sequestration and lung injury induced by endotoxin and hyperinflation. Crit Care Med (2010) 1.87
Neutrophil recruitment to the lungs during bacterial pneumonia. Infect Immun (2008) 1.87
Induction of CXCL5 during inflammation in the rodent lung involves activation of alveolar epithelium. Am J Respir Cell Mol Biol (2005) 1.86
Innate immunity in the lungs. Proc Am Thorac Soc (2005) 1.66
Both TRIF- and MyD88-dependent signaling contribute to host defense against pulmonary Klebsiella infection. J Immunol (2009) 1.48
Endotoxin uptake by S1 proximal tubular segment causes oxidative stress in the downstream S2 segment. J Am Soc Nephrol (2011) 1.26
NLRC4 inflammasome-mediated production of IL-1β modulates mucosal immunity in the lung against gram-negative bacterial infection. J Immunol (2012) 1.22
Cross-talk between TLR4 and FcgammaReceptorIII (CD16) pathways. PLoS Pathog (2009) 1.20
Pulmonary epithelium, cigarette smoke, and chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis (2007) 1.15
The acute respiratory distress syndrome: from mechanism to translation. J Immunol (2015) 1.14
MD-2-dependent pulmonary immune responses to inhaled lipooligosaccharides: effect of acylation state. Am J Respir Cell Mol Biol (2008) 1.11
Pattern recognition receptor-dependent mechanisms of acute lung injury. Mol Med (2009) 1.04
Myeloid differentiation protein-2-dependent and -independent neutrophil accumulation during Escherichia coli pneumonia. Am J Respir Cell Mol Biol (2008) 1.02
Role of CD14 in lung inflammation and infection. Crit Care (2010) 1.01
CpG oligonucleotide activates Toll-like receptor 9 and causes lung inflammation in vivo. Respir Res (2007) 1.00
Bacterial Adaptation during Chronic Respiratory Infections. Pathogens (2015) 0.92
Syndecan-4 regulates early neutrophil migration and pulmonary inflammation in response to lipopolysaccharide. Am J Respir Cell Mol Biol (2012) 0.91
IL-36α exerts pro-inflammatory effects in the lungs of mice. PLoS One (2012) 0.88
Small interference RNA targeting TLR4 gene effectively attenuates pulmonary inflammation in a rat model. J Biomed Biotechnol (2012) 0.86
Evaluation of the inflammatory response in a two-hit acute lung injury model using [(18)F]FDG microPET. Exp Ther Med (2013) 0.83
Bupleurum polysaccharides attenuates lipopolysaccharide-induced inflammation via modulating Toll-like receptor 4 signaling. PLoS One (2013) 0.83
The protective effects of the supercritical-carbon dioxide fluid extract of Chrysanthemum indicum against lipopolysaccharide-induced acute lung injury in mice via modulating Toll-like receptor 4 signaling pathway. Mediators Inflamm (2014) 0.82
Role of CD14 in a mouse model of acute lung inflammation induced by different lipopolysaccharide chemotypes. PLoS One (2010) 0.82
Propofol exerts anti-inflammatory effects in rats with lipopolysaccharide-induced acute lung injury by inhibition of CD14 and TLR4 expression. Braz J Med Biol Res (2013) 0.82
TGF-β1 limits the onset of innate lung inflammation by promoting mast cell-derived IL-6. J Immunol (2013) 0.82
Can we predict the effects of NF-kappaB inhibition in sepsis? Studies with parthenolide and ethyl pyruvate. Expert Opin Investig Drugs (2009) 0.82
Controversial role of toll-like receptors in acute pancreatitis. World J Gastroenterol (2013) 0.81
Endotoxin receptor CD14 in PiZ alpha-1-antitrypsin deficiency individuals. Respir Res (2008) 0.81
Linking Endotoxins, African Dust PM10 and Asthma in an Urban and Rural Environment of Puerto Rico. Mediators Inflamm (2015) 0.80
5-Lipoxygenase activating protein (FLAP) dependent leukotriene biosynthesis inhibition (MK591) attenuates Lipid A endotoxin-induced inflammation. PLoS One (2014) 0.78
Association of Toll-like receptor 4 alleles with symptoms and sensitization to laboratory animals. J Allergy Clin Immunol (2008) 0.78
LYRM03, an ubenimex derivative, attenuates LPS-induced acute lung injury in mice by suppressing the TLR 4 signaling pathway. Acta Pharmacol Sin (2017) 0.75
Soluble CD14 Enhances the Response of Periodontal Ligament Stem Cells to P. gingivalis Lipopolysaccharide. PLoS One (2016) 0.75
Bone Morphogenetic Protein 9 Enhances Lipopolysaccharide-Induced Leukocyte Recruitment to the Vascular Endothelium. J Immunol (2016) 0.75
Cold-inducible RNA-binding protein (CIRP) causes sepsis-associated acute lung injury via induction of endoplasmic reticulum stress. Sci Rep (2017) 0.75
Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science (1998) 37.15
The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med (1994) 27.68
CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science (1990) 17.86
Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol (1999) 16.86
Macrophages and polymorphonuclear neutrophils in lung defense and injury. Am Rev Respir Dis (1990) 4.75
Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14. Proc Natl Acad Sci U S A (1993) 4.35
Endotoxin and lung injury. Am Rev Respir Dis (1986) 3.20
Cutting edge: cell surface expression and lipopolysaccharide signaling via the toll-like receptor 4-MD-2 complex on mouse peritoneal macrophages. J Immunol (2000) 3.10
Inflammatory cytokines in patients with persistence of the acute respiratory distress syndrome. Am J Respir Crit Care Med (1996) 2.81
Lung neutrophils in the adult respiratory distress syndrome. Clinical and pathophysiologic significance. Am Rev Respir Dis (1986) 2.62
A CD14-independent LPS receptor cluster. Nat Immunol (2001) 2.52
Reactive oxygen species in acute lung injury. Eur Respir J (1998) 2.50
Lipopolysaccharide interaction with cell surface Toll-like receptor 4-MD-2: higher affinity than that with MD-2 or CD14. J Exp Med (2003) 2.39
The molecular pathogenesis of endotoxic shock and organ failure. Mol Med Today (1999) 2.37
LPS-binding proteins and receptors. J Leukoc Biol (1998) 2.14
Functional characterization of the rat chemokine KC and its importance in neutrophil recruitment in a rat model of pulmonary inflammation. J Immunol (1995) 2.01
Transcriptional profiling of lipopolysaccharide-induced acute lung injury. Infect Immun (2004) 1.97
The acute respiratory distress syndrome. Ann Intern Med (2004) 1.96
CD11b/CD18 acts in concert with CD14 and Toll-like receptor (TLR) 4 to elicit full lipopolysaccharide and taxol-inducible gene expression. J Immunol (2001) 1.95
Fas/FasL-dependent apoptosis of alveolar cells after lipopolysaccharide-induced lung injury in mice. Am J Respir Crit Care Med (2001) 1.94
MD-2 binds to bacterial lipopolysaccharide. J Biol Chem (2001) 1.91
Divergent response to LPS and bacteria in CD14-deficient murine macrophages. J Immunol (2000) 1.84
MD-2 and TLR4 N-linked glycosylations are important for a functional lipopolysaccharide receptor. J Biol Chem (2001) 1.74
Recombinant soluble CD14 mediates the activation of endothelial cells by lipopolysaccharide. J Immunol (1993) 1.54
Hemorrhage-induced acute lung injury is TLR-4 dependent. Am J Physiol Regul Integr Comp Physiol (2004) 1.48
CD14-dependent and CD14-independent signaling pathways in murine macrophages from normal and CD14 knockout mice stimulated with lipopolysaccharide or taxol. J Immunol (1997) 1.46
Genes other than TLR4 are involved in the response to inhaled LPS. Am J Physiol Lung Cell Mol Physiol (2001) 1.39
Lipopolysaccharide-induced leukocyte-endothelial cell interactions: a role for CD14 versus toll-like receptor 4 within microvessels. J Immunol (2002) 1.38
Pathobiology of lipopolysaccharide. J Toxicol Environ Health (1997) 1.30
Genistein prevents nuclear factor-kappa B activation and acute lung injury induced by lipopolysaccharide. Am J Respir Crit Care Med (2001) 1.23
Selective suppression of neutrophil accumulation in ongoing pulmonary inflammation by systemic inhibition of p38 mitogen-activated protein kinase. J Immunol (2002) 1.22
Effect of CD14 blockade on endotoxin-induced acute lung injury in mice. Am J Respir Cell Mol Biol (2003) 1.07
The CD11/CD18 integrins: characterization of three novel LPS signaling receptors. Prog Clin Biol Res (1998) 1.01
ARDS-like lung injury produced by endotoxin in platelet-activating factor-primed rats. J Appl Physiol (1985) (1993) 0.98
Lipopolysaccharide binding protein and CD14 interaction induces tumor necrosis factor-alpha generation and neutrophil sequestration in lungs after intratracheal endotoxin. Circ Res (1993) 0.88
A 21-aminosteroid, U-74006F, attenuates endotoxin-induced lung injury in awake sheep. Respirology (1999) 0.87
Soluble CD14 in serum mediates LPS-induced increase in permeability of bovine pulmonary arterial endothelial cell monolayers in vitro. Life Sci (1995) 0.87
MD-2 binds to bacterial lipopolysaccharide. J Endotoxin Res (2000) 0.86
Hepatic killing but not clearance of systemically circulating bacteria is dependent upon peripheral leukocytes via Mac-1 (CD11b/CD18). Shock (2003) 0.79
Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN. Cancer Cell (2009) 8.21
C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway. Genes Dev (2002) 6.46
Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways. Nat Med (2004) 4.29
Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages. J Biol Chem (2002) 4.17
Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice. J Clin Invest (2005) 3.79
A sequence-oriented comparison of gene expression measurements across different hybridization-based technologies. Nat Biotechnol (2006) 3.68
Analysis of nitric oxide synthase and nitrotyrosine expression in human pulmonary tuberculosis. Am J Respir Crit Care Med (2002) 3.50
A CD36-initiated signaling cascade mediates inflammatory effects of beta-amyloid. J Biol Chem (2002) 2.85
Scavenger receptors in atherosclerosis: beyond lipid uptake. Arterioscler Thromb Vasc Biol (2006) 2.76
CD36 mediates the innate host response to beta-amyloid. J Exp Med (2003) 2.65
Efficacy and safety of the coadministration of ezetimibe with fenofibrate in patients with mixed hyperlipidaemia. Eur Heart J (2005) 2.52
Human pulmonary chimerism after hematopoietic stem cell transplantation. Am J Respir Crit Care Med (2003) 2.50
Pigment epithelium-derived factor in idiopathic pulmonary fibrosis: a role in aberrant angiogenesis. Am J Respir Crit Care Med (2004) 2.42
IL-23-dependent IL-17 production is essential in neutrophil recruitment and activity in mouse lung defense against respiratory Mycoplasma pneumoniae infection. Microbes Infect (2006) 2.39
Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis. Science (2004) 2.38
Loss of SR-A and CD36 activity reduces atherosclerotic lesion complexity without abrogating foam cell formation in hyperlipidemic mice. Arterioscler Thromb Vasc Biol (2008) 2.35
Cxcr2 and Cxcl5 regulate the IL-17/G-CSF axis and neutrophil homeostasis in mice. J Clin Invest (2012) 2.18
Role of the CXCR4/SDF-1 chemokine axis in circulating neutrophil homeostasis. Blood (2004) 2.17
CXCL5 regulates chemokine scavenging and pulmonary host defense to bacterial infection. Immunity (2010) 2.16
The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades. Physiol Genomics (2004) 2.03
Transcriptional profiling of lipopolysaccharide-induced acute lung injury. Infect Immun (2004) 1.97
Induction of CXCL5 during inflammation in the rodent lung involves activation of alveolar epithelium. Am J Respir Cell Mol Biol (2005) 1.86
Relationship of small airway chymase-positive mast cells and lung function in severe asthma. Am J Respir Crit Care Med (2004) 1.80
Enhanced Pseudomonas aeruginosa biofilm development mediated by human neutrophils. Infect Immun (2005) 1.79
Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways. J Immunol (2002) 1.63
A role for hydroxy-methylglutaryl coenzyme a reductase in pulmonary inflammation and host defense. Am J Respir Crit Care Med (2004) 1.60
Interleukin-15 inhibits spontaneous apoptosis in human eosinophils via autocrine production of granulocyte macrophage-colony stimulating factor and nuclear factor-kappaB activation. Am J Respir Cell Mol Biol (2002) 1.57
Cross-talk between ERK and p38 MAPK mediates selective suppression of pro-inflammatory cytokines by transforming growth factor-beta. J Biol Chem (2002) 1.53
Red blood cells induce necroptosis of lung endothelial cells and increase susceptibility to lung inflammation. Am J Respir Crit Care Med (2014) 1.52
Exome sequencing in suspected monogenic dyslipidemias. Circ Cardiovasc Genet (2015) 1.51
A genomic and proteomic analysis of activation of the human neutrophil by lipopolysaccharide and its mediation by p38 mitogen-activated protein kinase. J Biol Chem (2002) 1.47
Abca7 null mice retain normal macrophage phosphatidylcholine and cholesterol efflux activity despite alterations in adipose mass and serum cholesterol levels. J Biol Chem (2004) 1.41
Transcriptomic analysis comparing tumor-associated neutrophils with granulocytic myeloid-derived suppressor cells and normal neutrophils. PLoS One (2012) 1.40
Toll/IL-1R domain-containing adaptor protein (TIRAP) is a critical mediator of antibacterial defense in the lung against Klebsiella pneumoniae but not Pseudomonas aeruginosa. J Immunol (2006) 1.40
Extracellular superoxide dismutase attenuates lipopolysaccharide-induced neutrophilic inflammation. Am J Respir Cell Mol Biol (2004) 1.40
A trial of clarithromycin for the treatment of suboptimally controlled asthma. J Allergy Clin Immunol (2010) 1.39
Infusion of mature megakaryocytes into mice yields functional platelets. J Clin Invest (2010) 1.39
IL-17A and TNF-α exert synergistic effects on expression of CXCL5 by alveolar type II cells in vivo and in vitro. J Immunol (2011) 1.37
SPLUNC1 promotes lung innate defense against Mycoplasma pneumoniae infection in mice. Am J Pathol (2011) 1.35
ABCA3 inactivation in mice causes respiratory failure, loss of pulmonary surfactant, and depletion of lung phosphatidylglycerol. J Lipid Res (2006) 1.35
Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF)-mediated signaling contributes to innate immune responses in the lung during Escherichia coli pneumonia. J Immunol (2007) 1.35
Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment. Circulation (2005) 1.34
Pulmonary surfactant phosphatidylglycerol inhibits respiratory syncytial virus-induced inflammation and infection. Proc Natl Acad Sci U S A (2009) 1.33
Lipopolysaccharide-induced c-Jun NH2-terminal kinase activation in human neutrophils: role of phosphatidylinositol 3-Kinase and Syk-mediated pathways. J Biol Chem (2003) 1.32
Naturally occurring mutations in the largest extracellular loops of ABCA1 can disrupt its direct interaction with apolipoprotein A-I. J Biol Chem (2002) 1.31
Increased TGF-beta2 in severe asthma with eosinophilia. J Allergy Clin Immunol (2005) 1.27
Matrix metalloproteinase 3 is a mediator of pulmonary fibrosis. Am J Pathol (2011) 1.27
Neutrophil transmigration triggers repair of the lung epithelium via beta-catenin signaling. Proc Natl Acad Sci U S A (2011) 1.25
Toll-IL-1 receptor domain-containing adaptor protein is critical for early lung immune responses against Escherichia coli lipopolysaccharide and viable Escherichia coli. J Immunol (2005) 1.24
The in vitro production and characterization of neutrophils from embryonic stem cells. Blood (2003) 1.23
Selective suppression of neutrophil accumulation in ongoing pulmonary inflammation by systemic inhibition of p38 mitogen-activated protein kinase. J Immunol (2002) 1.22
TGF-beta and IL-13 synergistically increase eotaxin-1 production in human airway fibroblasts. J Immunol (2002) 1.22
ABCA12 maintains the epidermal lipid permeability barrier by facilitating formation of ceramide linoleic esters. J Biol Chem (2008) 1.21
Selective downregulation of prostaglandin E2-related pathways by the Th2 cytokine IL-13. J Allergy Clin Immunol (2006) 1.21
Subepithelial basement membrane immunoreactivity for matrix metalloproteinase 9: association with asthma severity, neutrophilic inflammation, and wound repair. J Allergy Clin Immunol (2003) 1.20
Lipid rafts regulate lipopolysaccharide-induced activation of Cdc42 and inflammatory functions of the human neutrophil. J Biol Chem (2004) 1.18
Neutrophil influx in response to a peritoneal infection with Salmonella is delayed in lipopolysaccharide-binding protein or CD14-deficient mice. J Immunol (2002) 1.18
Cross-linking and lipid efflux properties of apoA-I mutants suggest direct association between apoA-I helices and ABCA1. Biochemistry (2004) 1.17
A role for protein phosphatase-2A in p38 mitogen-activated protein kinase-mediated regulation of the c-Jun NH(2)-terminal kinase pathway in human neutrophils. J Biol Chem (2002) 1.15
Microarray analysis of lipopolysaccharide-treated human neutrophils. Am J Physiol Lung Cell Mol Physiol (2002) 1.13
Effects of liver X receptor agonist treatment on pulmonary inflammation and host defense. J Immunol (2008) 1.11
Airway fibroblasts exhibit a synthetic phenotype in severe asthma. J Allergy Clin Immunol (2005) 1.10
Toll-like receptor 2 down-regulation in established mouse allergic lungs contributes to decreased mycoplasma clearance. Am J Respir Crit Care Med (2008) 1.08
Human lung project: evaluating variance of gene expression in the human lung. Am J Respir Cell Mol Biol (2006) 1.07
Genetic etiology of isolated low HDL syndrome: incidence and heterogeneity of efflux defects. Arterioscler Thromb Vasc Biol (2007) 1.06
Mycoplasma pneumoniae infection and environmental tobacco smoke inhibit lung glutathione adaptive responses and increase oxidative stress. Infect Immun (2008) 1.05
Inhibition of c-Jun N-terminal kinase limits lipopolysaccharide-induced pulmonary neutrophil influx. Am J Respir Crit Care Med (2005) 1.04
A deficient TLR2 signaling promotes airway mucin production in Mycoplasma pneumoniae-infected allergic mice. Am J Physiol Lung Cell Mol Physiol (2006) 1.02
Myeloid differentiation protein-2-dependent and -independent neutrophil accumulation during Escherichia coli pneumonia. Am J Respir Cell Mol Biol (2008) 1.02
Aging adversely affects the cigarette smoke-induced glutathione adaptive response in the lung. Am J Respir Crit Care Med (2010) 1.01
SPTLC1 binds ABCA1 to negatively regulate trafficking and cholesterol efflux activity of the transporter. Biochemistry (2008) 1.01
IL-13 dampens human airway epithelial innate immunity through induction of IL-1 receptor-associated kinase M. J Allergy Clin Immunol (2011) 1.00
Human alveolar epithelial cell injury induced by cigarette smoke. PLoS One (2011) 1.00
Risk factors for coronary artery disease in patients with elevated high-density lipoprotein cholesterol. Am J Cardiol (2006) 1.00
Regulation of lipopolysaccharide-induced lung inflammation by plasminogen activator Inhibitor-1 through a JNK-mediated pathway. J Immunol (2005) 1.00
Role of β-catenin-regulated CCN matricellular proteins in epithelial repair after inflammatory lung injury. Am J Physiol Lung Cell Mol Physiol (2013) 0.99
ATP-binding cassette transporter A1 contains a novel C-terminal VFVNFA motif that is required for its cholesterol efflux and ApoA-I binding activities. J Biol Chem (2004) 0.99
Activation of signaling pathways by putative scavenger receptor class A (SR-A) ligands requires CD14 but not SR-A. Biochem Biophys Res Commun (2003) 0.99
Surfactant protein A is defective in abrogating inflammation in asthma. Am J Physiol Lung Cell Mol Physiol (2011) 0.98
Nuclear hormone receptors and cholesterol trafficking: the orphans find a new home. J Mol Med (Berl) (2002) 0.98
Local injection of bevacizumab (Avastin) and angiolytic KTP laser treatment of recurrent respiratory papillomatosis of the vocal folds: a prospective study. Ann Otol Rhinol Laryngol (2011) 0.97
Cigarette smoke modulates PGE(2) and host defence against Moraxella catarrhalis infection in human airway epithelial cells. Respirology (2011) 0.97
Purification of ATP-binding cassette transporter A1 and associated binding proteins reveals the importance of beta1-syntrophin in cholesterol efflux. J Biol Chem (2005) 0.97
Overexpression of matrix metalloproteinase-7 in pulmonary fibrosis. Chest (2002) 0.96
Interleukin-1 receptor-associated kinase M (IRAK-M) promotes human rhinovirus infection in lung epithelial cells via the autophagic pathway. Virology (2013) 0.95
Role of the E1A Rb-binding domain in repression of the NF-kappa B-dependent defense against tumor necrosis factor-alpha. Proc Natl Acad Sci U S A (2002) 0.95