Published in J Immunol on August 15, 2002
Endothelium-derived Toll-like receptor-4 is the key molecule in LPS-induced neutrophil sequestration into lungs. J Clin Invest (2003) 2.89
Transcriptional profiling of lipopolysaccharide-induced acute lung injury. Infect Immun (2004) 1.97
Toll-like receptor 4 mediates neutrophil sequestration and lung injury induced by endotoxin and hyperinflation. Crit Care Med (2010) 1.87
Mice that exclusively express TLR4 on endothelial cells can efficiently clear a lethal systemic Gram-negative bacterial infection. J Clin Invest (2009) 1.70
Both TRIF- and MyD88-dependent signaling contribute to host defense against pulmonary Klebsiella infection. J Immunol (2009) 1.48
Distinct roles of pattern recognition receptors CD14 and Toll-like receptor 4 in acute lung injury. Infect Immun (2005) 1.39
TLR4 activation of TRPC6-dependent calcium signaling mediates endotoxin-induced lung vascular permeability and inflammation. J Exp Med (2012) 1.24
Mammalian Toll-like receptors: to immunity and beyond. Clin Exp Immunol (2005) 1.23
Toll-like receptor and tumour necrosis factor dependent endotoxin-induced acute lung injury. Int J Exp Pathol (2007) 1.15
Mitigation of chlorine gas lung injury in rats by postexposure administration of sodium nitrite. Am J Physiol Lung Cell Mol Physiol (2010) 1.06
Pattern recognition receptor-dependent mechanisms of acute lung injury. Mol Med (2009) 1.04
TLR2, TLR4 and the MYD88 signaling pathway are crucial for neutrophil migration in acute kidney injury induced by sepsis. PLoS One (2012) 1.03
Myeloid differentiation protein-2-dependent and -independent neutrophil accumulation during Escherichia coli pneumonia. Am J Respir Cell Mol Biol (2008) 1.02
Role of Toll-like receptors 2 and 4 in the induction of cyclooxygenase-2 in vascular smooth muscle. Proc Natl Acad Sci U S A (2005) 0.99
Association of Toll-like receptor signaling and reactive oxygen species: a potential therapeutic target for posttrauma acute lung injury. Mediators Inflamm (2010) 0.92
Absence of Fer protein tyrosine kinase exacerbates endotoxin induced intestinal epithelial barrier dysfunction in vivo. Gut (2005) 0.91
Role of TLR-4 in liver macrophage and endothelial cell responsiveness during acute endotoxemia. Exp Mol Pathol (2007) 0.90
Small interference RNA targeting TLR4 gene effectively attenuates pulmonary inflammation in a rat model. J Biomed Biotechnol (2012) 0.86
Fas-activated serine/threonine phosphoprotein promotes immune-mediated pulmonary inflammation. J Immunol (2010) 0.86
Use of low-molecular-weight heparin to decrease mortality in mice after intracardiac injection of tumor cells. Comp Med (2009) 0.80
In vivo imaging approaches in animal models of rheumatoid arthritis. Arthritis Res Ther (2003) 0.80
TRAF1 regulates recruitment of lymphocytes and, to a lesser extent, neutrophils, myeloid dendritic cells and monocytes to the lung airways following lipopolysaccharide inhalation. Immunology (2007) 0.79
Leukotriene B4-loaded microspheres: a new therapeutic strategy to modulate cell activation. BMC Immunol (2008) 0.78
Enhancement of methacholine-evoked tracheal contraction induced by bacterial lipopolysaccharides depends on epithelium and tumor necrosis factor. J Allergy (Cairo) (2012) 0.78
Lactobacillus plantarum CECT 7315/7316 intake modulates the acute and chronic innate inflammatory response. Eur J Nutr (2014) 0.77
Characterization and differentiation of equine experimental local and early systemic inflammation by expression responses of inflammation-related genes in peripheral blood leukocytes. BMC Vet Res (2016) 0.75
Deletion of Nlrp3 Augments Survival during Polymicrobial Sepsis by Decreasing Autophagy and Enhancing Phagocytosis. J Immunol (2016) 0.75
Penehyclidine ameliorates acute lung injury by inhibiting Toll-like receptor 2/4 expression and nuclear factor-κB activation. Exp Ther Med (2016) 0.75
Downregulation of Lung Toll-Like Receptor 4 Could Effectively Attenuate Liver Transplantation-Induced Pulmonary Damage at the Early Stage of Reperfusion. Mediators Inflamm (2015) 0.75
A Role for Neutrophils in Viral Respiratory Disease. Front Immunol (2017) 0.75
Barrier protective activities of phloroglucinol on lipopolysaccharide (LPS)-induced barrier disruption in human endothelial cells. Inflammation (2012) 0.75
Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood. Nat Med (2007) 8.58
Neutrophil recruitment and function in health and inflammation. Nat Rev Immunol (2013) 7.10
Intravascular danger signals guide neutrophils to sites of sterile inflammation. Science (2010) 5.84
Intraluminal crawling of neutrophils to emigration sites: a molecularly distinct process from adhesion in the recruitment cascade. J Exp Med (2006) 3.38
Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo. Nat Med (2012) 3.38
A novel mechanism of rapid nuclear neutrophil extracellular trap formation in response to Staphylococcus aureus. J Immunol (2010) 3.20
Metabolic profiling of serum samples by 1H nuclear magnetic resonance spectroscopy as a potential diagnostic approach for septic shock. Crit Care Med (2014) 2.97
Endothelium-derived Toll-like receptor-4 is the key molecule in LPS-induced neutrophil sequestration into lungs. J Clin Invest (2003) 2.89
PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophils. Nat Immunol (2008) 2.88
The neutrophil in vascular inflammation. Nat Med (2011) 2.84
Enhanced S-nitroso-albumin formation from inhaled NO during ischemia/reperfusion. Circ Res (2004) 2.75
An intracellular signaling hierarchy determines direction of migration in opposing chemotactic gradients. J Cell Biol (2002) 2.48
Functional innervation of hepatic iNKT cells is immunosuppressive following stroke. Science (2011) 2.44
Platelets express functional Toll-like receptor-4. Blood (2005) 2.37
TNF-alpha-secreting monocytes are recruited into the brain of cholestatic mice. Hepatology (2006) 2.23
Intravascular neutrophil extracellular traps capture bacteria from the bloodstream during sepsis. Cell Host Microbe (2012) 2.17
NETosis: how vital is it? Blood (2013) 2.11
An intravascular immune response to Borrelia burgdorferi involves Kupffer cells and iNKT cells. Nat Immunol (2010) 2.03
Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis. J Clin Invest (2013) 2.03
Platelets contribute to the pathogenesis of experimental autoimmune encephalomyelitis. Circ Res (2012) 1.85
Interaction of CD44 and hyaluronan is the dominant mechanism for neutrophil sequestration in inflamed liver sinusoids. J Exp Med (2008) 1.84
The physiology of leukocyte recruitment: an in vivo perspective. J Immunol (2008) 1.84
Immune surveillance by the liver. Nat Immunol (2013) 1.79
LSP1 is an endothelial gatekeeper of leukocyte transendothelial migration. J Exp Med (2005) 1.72
Mice that exclusively express TLR4 on endothelial cells can efficiently clear a lethal systemic Gram-negative bacterial infection. J Clin Invest (2009) 1.70
TLR4 contributes to disease-inducing mechanisms resulting in central nervous system autoimmune disease. J Immunol (2004) 1.70
Real-time imaging of trapping and urease-dependent transmigration of Cryptococcus neoformans in mouse brain. J Clin Invest (2010) 1.67
Immune surveillance in the central nervous system. Nat Neurosci (2012) 1.63
IVIg therapy in brain inflammation: etiology-dependent differential effects on leucocyte recruitment. Brain (2004) 1.61
Targeting adhesion molecules as a potential mechanism of action for intravenous immunoglobulin. Circulation (2005) 1.60
Intravascular immunity: the host-pathogen encounter in blood vessels. Nat Rev Immunol (2009) 1.60
Toll gates and traffic arteries: from endothelial TLR2 to atherosclerosis. Circ Res (2004) 1.59
Real-time high resolution 3D imaging of the lyme disease spirochete adhering to and escaping from the vasculature of a living host. PLoS Pathog (2008) 1.59
PI3K accelerates, but is not required for, neutrophil chemotaxis to fMLP. J Cell Sci (2008) 1.54
Endothelial paxillin and focal adhesion kinase (FAK) play a critical role in neutrophil transmigration. Eur J Immunol (2012) 1.53
Role of CD44 and hyaluronan in neutrophil recruitment. J Immunol (2004) 1.53
Measuring chemotaxis and chemokinesis: the under-agarose cell migration assay. Sci STKE (2003) 1.50
Essential role for neutrophil recruitment to the liver in concanavalin A-induced hepatitis. J Immunol (2004) 1.49
Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14- and TNF-dependent mechanisms. J Leukoc Biol (2004) 1.49
A requirement for microglial TLR4 in leukocyte recruitment into brain in response to lipopolysaccharide. J Immunol (2006) 1.49
Nucleation of platelets with blood-borne pathogens on Kupffer cells precedes other innate immunity and contributes to bacterial clearance. Nat Immunol (2013) 1.46
Leukocyte migration is regulated by L-selectin endoproteolytic release. Immunity (2003) 1.42
Intrahepatic myeloid-cell aggregates enable local proliferation of CD8(+) T cells and successful immunotherapy against chronic viral liver infection. Nat Immunol (2013) 1.37
Molecular mechanisms of leukocyte recruitment: organ-specific mechanisms of action. Thromb Haemost (2003) 1.36
Immune cell Toll-like receptor 4 is required for cardiac myocyte impairment during endotoxemia. Circ Res (2004) 1.35
Depletion of Ly6G/Gr-1 leukocytes after spinal cord injury in mice alters wound healing and worsens neurological outcome. J Neurosci (2009) 1.35
Molecular mechanisms involved in vascular interactions of the Lyme disease pathogen in a living host. PLoS Pathog (2008) 1.34
The role of TLR2 in vivo following challenge with Staphylococcus aureus and prototypic ligands. J Immunol (2006) 1.34
Neutrophils recruited to sites of infection protect from virus challenge by releasing neutrophil extracellular traps. Cell Host Microbe (2013) 1.33
Leukocyte PI3Kgamma and PI3Kdelta have temporally distinct roles for leukocyte recruitment in vivo. Blood (2007) 1.33
Modulating leukocyte recruitment in inflammation. J Allergy Clin Immunol (2007) 1.30
Neutrophils promote liver metastasis via Mac-1-mediated interactions with circulating tumor cells. Cancer Res (2012) 1.30
Persistence of apoptotic cells without autoimmune disease or inflammation in CD14-/- mice. J Cell Biol (2004) 1.29
Toll-like receptor 2 ligands on the staphylococcal cell wall downregulate superantigen-induced T cell activation and prevent toxic shock syndrome. Nat Med (2009) 1.29
In silico and in vivo approach to elucidate the inflammatory complexity of CD14-deficient mice. Mol Med (2006) 1.25
Overlapping roles of P-selectin and alpha 4 integrin to recruit leukocytes to the central nervous system in experimental autoimmune encephalomyelitis. J Immunol (2002) 1.25
Chemokines: sirens of neutrophil recruitment-but is it just one song? Immunity (2010) 1.24
Anti-adhesive effect of nitric oxide on Plasmodium falciparum cytoadherence under flow. Am J Pathol (2003) 1.23
Rules of recruitment for Th1 and Th2 lymphocytes in inflamed liver: a role for alpha-4 integrin and vascular adhesion protein-1. Immunity (2005) 1.23
Role of endothelial TLR4 for neutrophil recruitment into central nervous system microvessels in systemic inflammation. J Immunol (2009) 1.23
Vav1 is essential for mechanotactic crawling and migration of neutrophils out of the inflamed microvasculature. J Immunol (2009) 1.23
Antibodies against neutrophil LY6G do not inhibit leukocyte recruitment in mice in vivo. Blood (2013) 1.23
CD14-deficient mice are protected against lipopolysaccharide-induced cardiac inflammation and left ventricular dysfunction. Circulation (2002) 1.22
Neutrophil mobilization via plerixafor-mediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow. J Exp Med (2013) 1.21
Macrophages eliminate circulating tumor cells after monoclonal antibody therapy. J Clin Invest (2014) 1.21
Rod-Shaped monocytes patrol the brain vasculature and give rise to perivascular macrophages under the influence of proinflammatory cytokines and angiopoietin-2. J Neurosci (2008) 1.20
The use of spinning-disk confocal microscopy for the intravital analysis of platelet dynamics in response to systemic and local inflammation. PLoS One (2011) 1.17
Endothelial LSP1 is involved in endothelial dome formation, minimizing vascular permeability changes during neutrophil transmigration in vivo. Blood (2010) 1.15
Cytotoxic CD4+ T cells use granulysin to kill Cryptococcus neoformans, and activation of this pathway is defective in HIV patients. Blood (2006) 1.15
Fundamentally different roles for LFA-1, Mac-1 and alpha4-integrin in neutrophil chemotaxis. J Cell Sci (2005) 1.15
Pivotal role of the alpha(2A)-adrenoceptor in producing inflammation and organ injury in a rat model of sepsis. PLoS One (2009) 1.13
Milk fat globule epidermal growth factor-factor VIII is down-regulated in sepsis via the lipopolysaccharide-CD14 pathway. J Immunol (2009) 1.12
Leukocyte adhesion in the liver: distinct adhesion paradigm from other organs. J Hepatol (2007) 1.12
Signaling through CD14 attenuates the inflammatory response to Borrelia burgdorferi, the agent of Lyme disease. J Immunol (2005) 1.11
Molecular regulators of leucocyte chemotaxis during inflammation. Cardiovasc Res (2010) 1.11
Integrin-induced PIP5K1C kinase polarization regulates neutrophil polarization, directionality, and in vivo infiltration. Immunity (2010) 1.10
P-selectin can support both Th1 and Th2 lymphocyte rolling in the intestinal microvasculature. Am J Pathol (2005) 1.09
Use of CD44 by CD4+ Th1 and Th2 lymphocytes to roll and adhere. Blood (2006) 1.09
Neutrophil-active chemokines in in vivo imaging of neutrophil trafficking. Eur J Immunol (2012) 1.08
Reevaluation of P-selectin and alpha 4 integrin as targets for the treatment of experimental autoimmune encephalomyelitis. J Immunol (2006) 1.06
Cellular and molecular choreography of neutrophil recruitment to sites of sterile inflammation. J Mol Med (Berl) (2011) 1.05
Vascular binding of a pathogen under shear force through mechanistically distinct sequential interactions with host macromolecules. Mol Microbiol (2012) 1.05
Endothelial domes encapsulate adherent neutrophils and minimize increases in vascular permeability in paracellular and transcellular emigration. PLoS One (2008) 1.05
Injection of lipopolysaccharide induces the migration of splenic neutrophils to the T cell area of the white pulp: role of CD14 and CXC chemokines. J Leukoc Biol (2007) 1.04
Selective down-regulation of neutrophil Mac-1 in endotoxemic hepatic microcirculation via IL-10. J Immunol (2009) 1.04
Profound differences in leukocyte-endothelial cell responses to lipopolysaccharide versus lipoteichoic acid. J Immunol (2002) 1.03
Inducible nitric oxide synthase (iNOS) in endotoxemia: chimeric mice reveal different cellular sources in various tissues. FASEB J (2002) 1.03
Loss of CD34 leads to exacerbated autoimmune arthritis through increased vascular permeability. J Immunol (2009) 1.03
Multichannel fluorescence spinning disk microscopy reveals early endogenous CD4 T cell recruitment in contact sensitivity via complement. J Immunol (2008) 1.03
Mast cell-expressed complement receptor, not TLR2, is the main detector of zymosan in peritonitis. Eur J Immunol (2007) 1.03
Local coordination verses systemic disregulation: complexities in leukocyte recruitment revealed by local and systemic activation of TLR4 in vivo. J Leukoc Biol (2005) 1.01
Influence of CD14 on ligand interactions between lipopolysaccharide and its receptor complex. J Immunol (2005) 1.01
Different domains of Pseudomonas aeruginosa exoenzyme S activate distinct TLRs. J Immunol (2004) 1.01
Bone marrow-derived mast cells accumulate in the central nervous system during inflammation but are dispensable for experimental autoimmune encephalomyelitis pathogenesis. J Immunol (2009) 1.01
Activation of human and mouse Kupffer cells by lipopolysaccharide is mediated by CD14. Am J Physiol Gastrointest Liver Physiol (2002) 1.01
Varying importance of soluble and membrane CD14 in endothelial detection of lipopolysaccharide. J Immunol (2008) 1.00
Cellular and molecular mechanisms underlying LPS-associated myocyte impairment. Am J Physiol Heart Circ Physiol (2005) 1.00
A critical temporal window for selectin-dependent CD4+ lymphocyte homing and initiation of late-phase inflammation in contact sensitivity. J Exp Med (2004) 0.99
Mast cells regulate the magnitude and the cytokine microenvironment of the contact hypersensitivity response. Am J Pathol (2008) 0.97
The role of selectins and integrins in adenovirus vector-induced neutrophil recruitment to the liver. Eur J Immunol (2002) 0.97