Published in Oncogene on April 21, 2005
Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics. Nucleic Acids Res (2007) 3.49
Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro. Proc Natl Acad Sci U S A (2005) 2.63
DNA architecture: from G to Z. Curr Opin Struct Biol (2006) 1.97
Preferential binding of a G-quadruplex ligand to human chromosome ends. Nucleic Acids Res (2005) 1.53
Structural insights into G-quadruplexes: towards new anticancer drugs. Future Med Chem (2010) 1.44
Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action. Proc Natl Acad Sci U S A (2007) 1.29
A G-quadruplex structure within the 5'-UTR of TRF2 mRNA represses translation in human cells. Nucleic Acids Res (2010) 1.13
Telomerase and its potential for therapeutic intervention. Br J Pharmacol (2007) 1.11
G-quadruplex preferentially forms at the very 3' end of vertebrate telomeric DNA. Nucleic Acids Res (2007) 1.05
HTLV-1 propels untransformed CD4 lymphocytes into the cell cycle while protecting CD8 cells from death. J Clin Invest (2006) 1.03
The G-quadruplex ligand telomestatin impairs binding of topoisomerase IIIalpha to G-quadruplex-forming oligonucleotides and uncaps telomeres in ALT cells. PLoS One (2009) 1.00
Quadruplex ligands may act as molecular chaperones for tetramolecular quadruplex formation. Nucleic Acids Res (2007) 0.97
Triarylpyridines: a versatile small molecule scaffold for G-quadruplex recognition. Chem Commun (Camb) (2008) 0.97
A platinum-quinacridine hybrid as a G-quadruplex ligand. J Biol Inorg Chem (2007) 0.95
Diarylethynyl amides that recognize the parallel conformation of genomic promoter DNA G-quadruplexes. J Am Chem Soc (2008) 0.94
Mix and measure fluorescence screening for selective quadruplex binders. Nucleic Acids Res (2008) 0.89
ATR contributes to telomere maintenance in human cells. Nucleic Acids Res (2010) 0.88
G-quadruplex formation enhances splicing efficiency of PAX9 intron 1. Hum Genet (2014) 0.87
Role of ATM in the telomere response to the G-quadruplex ligand 360A. Nucleic Acids Res (2008) 0.87
G-quadruplexes: from guanine gels to chemotherapeutics. Mol Biotechnol (2011) 0.87
G-quadruplex recognition by bis-indole carboxamides. Chem Commun (Camb) (2008) 0.87
Rad51 and DNA-PKcs are involved in the generation of specific telomere aberrations induced by the quadruplex ligand 360A that impair mitotic cell progression and lead to cell death. Cell Mol Life Sci (2011) 0.85
Overexpression of Bcl-2 is associated with apoptotic resistance to the G-quadruplex ligand 12459 but is not sufficient to confer resistance to long-term senescence. Nucleic Acids Res (2005) 0.83
Bisquinolinium compounds induce quadruplex-specific transcriptome changes in HeLa S3 cell lines. BMC Res Notes (2012) 0.82
Radiation-induced upregulation of telomerase activity escapes PI3-kinase inhibition in two malignant glioma cell lines. Int J Oncol (2013) 0.81
A preclinical mouse model of glioma with an alternative mechanism of telomere maintenance (ALT). Int J Cancer (2014) 0.80
G-register exchange dynamics in guanine quadruplexes. Nucleic Acids Res (2016) 0.78
The biological activity of G-quadruplex DNA binding papaverine-derived ligand in breast cancer cells. Invest New Drugs (2008) 0.77
Highly fluorescent guanosine mimics for folding and energy transfer studies. Nucleic Acids Res (2011) 0.77
Induction of senescence in cancer cells by the G-quadruplex stabilizer, BMVC4, is independent of its telomerase inhibitory activity. Br J Pharmacol (2012) 0.77
Highly efficient radiosensitization of human glioblastoma and lung cancer cells by a G-quadruplex DNA binding compound. Sci Rep (2015) 0.77
Lead Exposure Induces Telomere Instability in Human Cells. PLoS One (2013) 0.77
5' to 3' Unfolding Directionality of DNA Secondary Structures by Replication Protein A: G-QUADRUPLEXES AND DUPLEXES. J Biol Chem (2016) 0.76
A comparative study of the interactions of cationic hetarenes with quadruplex-DNA forming oligonucleotide sequences of the insulin-linked polymorphic region (ILPR). Beilstein J Org Chem (2014) 0.76
Mechanism of the antiproliferative activity of some naphthalene diimide G-quadruplex ligands. Mol Pharmacol (2012) 0.76
RHPS4 G-quadruplex ligand induces anti-proliferative effects in brain tumor cells. PLoS One (2014) 0.76
Small-molecule selectively recognizes human telomeric G-quadruplex DNA and regulates its conformational switch. Biophys J (2009) 0.76
The nickel(II) complex of guanidinium phenyl porphyrin, a specific G-quadruplex ligand, targets telomeres and leads to POT1 mislocalization in culture cells. J Biol Inorg Chem (2015) 0.75
Human telomeric DNA: G-quadruplex, i-motif and Watson-Crick double helix. Nucleic Acids Res (2002) 2.35
The yeast Pif1 helicase prevents genomic instability caused by G-quadruplex-forming CEB1 sequences in vivo. PLoS Genet (2009) 2.32
Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression. Proc Natl Acad Sci U S A (2011) 2.10
The effect of chemical modifications on the thermal stability of different G-quadruplex-forming oligonucleotides. Nucleic Acids Res (2005) 2.04
Targeting telomeres and telomerase. Biochimie (2007) 2.02
Natural and pharmacological regulation of telomerase. Nucleic Acids Res (2002) 1.92
A novel small molecule that alters shelterin integrity and triggers a DNA-damage response at telomeres. J Am Chem Soc (2008) 1.91
DNA duplex-quadruplex exchange as the basis for a nanomolecular machine. Proc Natl Acad Sci U S A (2003) 1.79
Telomestatin-induced telomere uncapping is modulated by POT1 through G-overhang extension in HT1080 human tumor cells. J Biol Chem (2006) 1.74
How long is too long? Effects of loop size on G-quadruplex stability. Nucleic Acids Res (2010) 1.74
Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathways. J Cell Sci (2003) 1.72
The G-quadruplex ligand telomestatin inhibits POT1 binding to telomeric sequences in vitro and induces GFP-POT1 dissociation from telomeres in human cells. Cancer Res (2006) 1.62
Variations in the colchicine-binding domain provide insight into the structural switch of tubulin. Proc Natl Acad Sci U S A (2009) 1.59
Preferential binding of a G-quadruplex ligand to human chromosome ends. Nucleic Acids Res (2005) 1.53
Stabilization of the c-myc gene promoter quadruplex by specific ligands' inhibitors of telomerase. Biochem Biophys Res Commun (2004) 1.52
Radiation-induced H2AX phosphorylation and neural precursor apoptosis in the developing brain of mice. Radiat Res (2006) 1.43
Human replication protein A unfolds telomeric G-quadruplexes. Nucleic Acids Res (2006) 1.43
Fluorescence-based melting assays for studying quadruplex ligands. Methods (2007) 1.38
Telomerase downregulation induced by the G-quadruplex ligand 12459 in A549 cells is mediated by hTERT RNA alternative splicing. Nucleic Acids Res (2004) 1.38
Cellular and behavioral effects of cranial irradiation of the subventricular zone in adult mice. PLoS One (2009) 1.38
G-quadruplex structures in TP53 intron 3: role in alternative splicing and in production of p53 mRNA isoforms. Carcinogenesis (2010) 1.34
Highly efficient G-quadruplex recognition by bisquinolinium compounds. J Am Chem Soc (2007) 1.34
Guanines are a quartet's best friend: impact of base substitutions on the kinetics and stability of tetramolecular quadruplexes. Nucleic Acids Res (2007) 1.31
Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action. Proc Natl Acad Sci U S A (2007) 1.29
Interaction of telomestatin with the telomeric single-strand overhang. J Biol Chem (2004) 1.27
Preclinical antitumor activity of cabazitaxel, a semisynthetic taxane active in taxane-resistant tumors. Clin Cancer Res (2013) 1.25
Exon array analyses across the NCI-60 reveal potential regulation of TOP1 by transcription pausing at guanosine quartets in the first intron. Cancer Res (2010) 1.24
Predicting and understanding the stability of G-quadruplexes. Bioinformatics (2009) 1.23
Activation of Gbetagamma signaling downstream of Wnt-11/Xfz7 regulates Cdc42 activity during Xenopus gastrulation. Dev Biol (2003) 1.19
Stability of telomeric G-quadruplexes. Nucleic Acids Res (2010) 1.16
DNA nanomachines and nanostructures involving quadruplexes. Org Biomol Chem (2006) 1.16
Selective recognition of G-qQuadruplex telomeric DNA by a bis(quinacridine) macrocycle. J Am Chem Soc (2003) 1.15
Topoisomerase IIIalpha is required for normal proliferation and telomere stability in alternative lengthening of telomeres. EMBO J (2008) 1.15
Sequence effects in single-base loops for quadruplexes. Biochimie (2008) 1.13
A G-quadruplex structure within the 5'-UTR of TRF2 mRNA represses translation in human cells. Nucleic Acids Res (2010) 1.13
Radiation-induced mitotic catastrophe in PARG-deficient cells. J Cell Sci (2009) 1.12
Neural stem cells from mouse forebrain are contained in a population distinct from the 'side population'. J Neurochem (2006) 1.12
Ku counteracts mobilization of PARP1 and MRN in chromatin damaged with DNA double-strand breaks. Nucleic Acids Res (2011) 1.12
Quartets in G-major. The First International Meeting on Quadruplex DNA. EMBO Rep (2007) 1.11
TRF2/RAP1 and DNA-PK mediate a double protection against joining at telomeric ends. EMBO J (2010) 1.11
Interaction of human telomeric DNA with N-methyl mesoporphyrin IX. Nucleic Acids Res (2012) 1.11
Unusual DNA conformations: implications for telomeres. Curr Med Chem Anticancer Agents (2002) 1.10
Vascular-derived TGF-β increases in the stem cell niche and perturbs neurogenesis during aging and following irradiation in the adult mouse brain. EMBO Mol Med (2013) 1.10
Alternative lengthening of telomeres in human glioma stem cells. Stem Cells (2011) 1.10
Selective interaction of ethidium derivatives with quadruplexes: an equilibrium dialysis and electrospray ionization mass spectrometry analysis. Biochemistry (2003) 1.07
Exclusive platination of loop adenines in the human telomeric G-quadruplex. Org Biomol Chem (2009) 1.07
Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells. Org Biomol Chem (2012) 1.05
Human POT1 is required for efficient telomere C-rich strand replication in the absence of WRN. Genes Dev (2009) 1.05
Thioflavin T as a fluorescence light-up probe for G4 formation. Nucleic Acids Res (2014) 1.03
Sequence variant (CTAGGG)n in the human telomere favors a G-quadruplex structure containing a G.C.G.C tetrad. Nucleic Acids Res (2009) 1.02
Clinical relevance of tumor cells with stem-like properties in pediatric brain tumors. PLoS One (2011) 1.02
Length-dependent energetics of (CTG)n and (CAG)n trinucleotide repeats. Nucleic Acids Res (2005) 1.01
The G-quadruplex ligand telomestatin impairs binding of topoisomerase IIIalpha to G-quadruplex-forming oligonucleotides and uncaps telomeres in ALT cells. PLoS One (2009) 1.00
Interactions of cryptolepine and neocryptolepine with unusual DNA structures. Biochimie (2003) 0.99
Formation of pearl-necklace monomorphic G-quadruplexes in the human CEB25 minisatellite. J Am Chem Soc (2012) 0.98
The telomerase activity of adult mouse testis resides in the spermatogonial alpha6-integrin-positive side population enriched in germinal stem cells. Endocrinology (2005) 0.98
The importance of metal geometry in the recognition of G-quadruplex-DNA by metal-terpyridine complexes. Org Biomol Chem (2007) 0.97
Detection of telomerase inhibitors based on g-quadruplex ligands by a modified telomeric repeat amplification protocol assay. Cancer Res (2002) 0.97
Quadruplex ligands may act as molecular chaperones for tetramolecular quadruplex formation. Nucleic Acids Res (2007) 0.97
Stability of intramolecular quadruplexes: sequence effects in the central loop. Nucleic Acids Res (2009) 0.97
G-quartets direct assembly of HIV-1 nucleocapsid protein along single-stranded DNA. Nucleic Acids Res (2003) 0.94
Lack of a p21waf1/cip -dependent G1/S checkpoint in neural stem and progenitor cells after DNA damage in vivo. Stem Cells (2012) 0.94
G-quadruplex recognition by quinacridines: a SAR, NMR, and biological study. ChemMedChem (2007) 0.94
Disruption of Adult Neurogenesis in the Olfactory Bulb Affects Social Interaction but not Maternal Behavior. Front Behav Neurosci (2010) 0.93
Fanconi DNA repair pathway is required for survival and long-term maintenance of neural progenitors. EMBO J (2008) 0.93
Engineering bisquinolinium/thiazole orange conjugates for fluorescent sensing of G-quadruplex DNA. Angew Chem Int Ed Engl (2009) 0.93
Topology of a DNA G-quadruplex structure formed in the HIV-1 promoter: a potential target for anti-HIV drug development. J Am Chem Soc (2014) 0.93
G-Quadruplex formation interferes with P1 helix formation in the RNA component of telomerase hTERC. Chembiochem (2008) 0.92
Persistent oxidative stress after ionizing radiation is involved in inherited radiosensitivity. Free Radic Biol Med (2003) 0.92
Endothelial cell-derived bone morphogenetic proteins control proliferation of neural stem/progenitor cells. Mol Cell Neurosci (2008) 0.91
Resistance to the short term antiproliferative activity of the G-quadruplex ligand 12459 is associated with telomerase overexpression and telomere capping alteration. J Biol Chem (2003) 0.90
Amyloid-beta peptide triggers Fas-independent apoptosis and differentiation of neural progenitor cells. Neurobiol Dis (2005) 0.90