Published in J Am Chem Soc on November 26, 2008
Quantitative visualization of DNA G-quadruplex structures in human cells. Nat Chem (2013) 4.61
Targeting G-quadruplexes in gene promoters: a novel anticancer strategy? Nat Rev Drug Discov (2011) 3.54
Small-molecule-induced DNA damage identifies alternative DNA structures in human genes. Nat Chem Biol (2012) 2.41
High-throughput sequencing of DNA G-quadruplex structures in the human genome. Nat Biotechnol (2015) 1.86
G-quadruplex nucleic acids as therapeutic targets. Curr Opin Chem Biol (2009) 1.74
G-quadruplex structures are stable and detectable in human genomic DNA. Nat Commun (2013) 1.72
DNA helicases involved in DNA repair and their roles in cancer. Nat Rev Cancer (2013) 1.58
Visualization and selective chemical targeting of RNA G-quadruplex structures in the cytoplasm of human cells. Nat Chem (2013) 1.48
A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands. Nat Chem (2011) 1.43
Small-molecule-mediated G-quadruplex isolation from human cells. Nat Chem (2010) 1.26
Small molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex. Org Biomol Chem (2010) 1.11
G-quadruplexes regulate Epstein-Barr virus-encoded nuclear antigen 1 mRNA translation. Nat Chem Biol (2014) 1.07
Selective RNA versus DNA G-quadruplex targeting by in situ click chemistry. Angew Chem Int Ed Engl (2012) 1.07
Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells. Org Biomol Chem (2012) 1.05
The G-quadruplex ligand telomestatin impairs binding of topoisomerase IIIalpha to G-quadruplex-forming oligonucleotides and uncaps telomeres in ALT cells. PLoS One (2009) 1.00
Specialization among iron-sulfur cluster helicases to resolve G-quadruplex DNA structures that threaten genomic stability. J Biol Chem (2013) 0.99
G-quadruplex DNA as a molecular target for induced synthetic lethality in cancer cells. J Am Chem Soc (2013) 0.98
G-quadruplex structures mark human regulatory chromatin. Nat Genet (2016) 0.95
Elevated levels of G-quadruplex formation in human stomach and liver cancer tissues. PLoS One (2014) 0.92
Insights into the mechanism of a G-quadruplex-unwinding DEAH-box helicase. Nucleic Acids Res (2015) 0.91
Experimental approaches to identify cellular G-quadruplex structures and functions. Methods (2012) 0.91
G-quadruplexes significantly stimulate Pif1 helicase-catalyzed duplex DNA unwinding. J Biol Chem (2015) 0.91
Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds. Mol Cell (2015) 0.88
Controlled-folding of a small molecule modulates DNA G-quadruplex recognition. Chem Commun (Camb) (2008) 0.86
The interactions between a small molecule and G-quadruplexes are visualized by fluorescence lifetime imaging microscopy. Nat Commun (2015) 0.86
Mechanistic insight into ligand binding to G-quadruplex DNA. Nucleic Acids Res (2014) 0.86
DNA damage signaling induced by the G-quadruplex ligand 12459 is modulated by PPM1D/WIP1 phosphatase. Nucleic Acids Res (2013) 0.85
Targeted Detection of G-Quadruplexes in Cellular RNAs. Angew Chem Int Ed Engl (2015) 0.82
Directly lighting up RNA G-quadruplexes from test tubes to living human cells. Nucleic Acids Res (2015) 0.82
Crystal structure of a DNA/Ba2+ G-quadruplex containing a water-mediated C-tetrad. Nucleic Acids Res (2014) 0.80
Native electrospray mass spectrometry of DNA G-quadruplexes in potassium solution. J Am Soc Mass Spectrom (2014) 0.79
Molecular engineering of G-quadruplex ligands based on solvent effect of polyethylene glycol. Nucleic Acids Res (2012) 0.78
Ruthenium Complex "Light Switches" that are Selective for Different G-Quadruplex Structures. Chemistry (2015) 0.77
rG4-seq reveals widespread formation of G-quadruplex structures in the human transcriptome. Nat Methods (2016) 0.76
Mechanism of the antiproliferative activity of some naphthalene diimide G-quadruplex ligands. Mol Pharmacol (2012) 0.76
Alternative DNA structures: G4 DNA in cells: itae missa est? Nat Chem Biol (2012) 0.76
Conformation-sensitive nucleoside analogues as topology-specific fluorescence turn-on probes for DNA and RNA G-quadruplexes. Nucleic Acids Res (2015) 0.76
A small molecule inhibitor of Pot1 binding to telomeric DNA. Biochemistry (2012) 0.75
PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA. Nat Commun (2017) 0.75
Reprogramming the mechanism of action of chlorambucil by coupling to a G-quadruplex ligand. J Am Chem Soc (2014) 0.75
Downregulation of oncogenic RAS and c-Myc expression in MOLT-4 leukaemia cells by a salicylaldehyde semicarbazone copper(II) complex. Sci Rep (2016) 0.75
Loop flexibility in human telomeric quadruplex small-molecule complexes. Nucleic Acids Res (2015) 0.75
Bis-indole derivatives with antitumor activity turn out to be specific ligands of human telomeric G-quadruplex. Front Chem (2014) 0.75
Data on secondary structures and ligand interactions of G-rich oligonucleotides that defy the classical formula for G4 motifs. Data Brief (2017) 0.75
Light-mediated in cell downregulation of G-quadruplex-containing genes using a photo-caged ligand. Chem Commun (Camb) (2013) 0.75
A Dual-Specific Targeting Approach Based on the Simultaneous Recognition of Duplex and Quadruplex Motifs. Sci Rep (2017) 0.75
Study of 2-aminoquinolin-4(1H)-one under Mannich and retro-Mannich reaction. PLoS One (2017) 0.75
RNA G-quadruplexes in biology: Principles and molecular mechanisms. J Mol Biol (2017) 0.75
Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev (2005) 15.19
Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem (2004) 14.93
A DNA damage checkpoint response in telomere-initiated senescence. Nature (2003) 12.55
Switching and signaling at the telomere. Cell (2001) 11.25
How shelterin protects mammalian telomeres. Annu Rev Genet (2008) 11.20
Pot1, the putative telomere end-binding protein in fission yeast and humans. Science (2001) 6.95
Inhibition of telomerase by G-quartet DNA structures. Nature (1991) 5.38
The POT1-TPP1 telomere complex is a telomerase processivity factor. Nature (2007) 5.08
Living on a break: cellular senescence as a DNA-damage response. Nat Rev Cancer (2008) 4.63
Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins. J Biol Chem (2004) 2.76
Inhibition of human telomerase by a G-quadruplex-interactive compound. J Med Chem (1997) 2.66
A hitchhiker's guide to G-quadruplex ligands. Org Biomol Chem (2007) 2.27
Targeting telomeres and telomerase. Biochimie (2007) 2.02
Trisubstituted isoalloxazines as a new class of G-quadruplex binding ligands: small molecule regulation of c-kit oncogene expression. J Am Chem Soc (2007) 1.87
Telomestatin-induced telomere uncapping is modulated by POT1 through G-overhang extension in HT1080 human tumor cells. J Biol Chem (2006) 1.74
Fluorescence resonance energy transfer as a probe for G-quartet formation by a telomeric repeat. Chembiochem (2001) 1.70
The G-quadruplex ligand telomestatin inhibits POT1 binding to telomeric sequences in vitro and induces GFP-POT1 dissociation from telomeres in human cells. Cancer Res (2006) 1.62
Preferential binding of a G-quadruplex ligand to human chromosome ends. Nucleic Acids Res (2005) 1.53
Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action. Proc Natl Acad Sci U S A (2007) 1.29
Oxazole-based peptide macrocycles: a new class of G-quadruplex binding ligands. J Am Chem Soc (2006) 1.20
Ligand-driven G-quadruplex conformational switching by using an unusual mode of interaction. Angew Chem Int Ed Engl (2007) 1.15
Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands. J Am Chem Soc (2007) 1.10
Exploring the differential recognition of DNA G-quadruplex targets by small molecules using dynamic combinatorial chemistry. Angew Chem Int Ed Engl (2008) 1.03
Selective recognition of a DNA G-quadruplex by an engineered antibody. Biochemistry (2008) 1.02
Tetramethylpyridiniumporphyrazines--a new class of G-quadruplex inducing and stabilising ligands. Chem Commun (Camb) (2006) 1.02
A platinum supramolecular square as an effective G-quadruplex binder and telomerase inhibitor. J Am Chem Soc (2008) 1.01
Triarylpyridines: a versatile small molecule scaffold for G-quadruplex recognition. Chem Commun (Camb) (2008) 0.97
Accurate whole human genome sequencing using reversible terminator chemistry. Nature (2008) 90.20
Prevalence of quadruplexes in the human genome. Nucleic Acids Res (2005) 7.79
G-quadruplexes in promoters throughout the human genome. Nucleic Acids Res (2006) 5.84
Quantitative sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution. Science (2012) 5.17
Quantitative visualization of DNA G-quadruplex structures in human cells. Nat Chem (2013) 4.61
An RNA G-quadruplex in the 5' UTR of the NRAS proto-oncogene modulates translation. Nat Chem Biol (2007) 4.11
Putative DNA quadruplex formation within the human c-kit oncogene. J Am Chem Soc (2005) 3.28
Loop-length-dependent folding of G-quadruplexes. J Am Chem Soc (2004) 3.16
Studies on the structure and dynamics of the human telomeric G quadruplex by single-molecule fluorescence resonance energy transfer. Proc Natl Acad Sci U S A (2003) 2.82
LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans. Nat Struct Mol Biol (2009) 2.79
A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene. Biochemistry (2006) 2.62
Small-molecule-induced DNA damage identifies alternative DNA structures in human genes. Nat Chem Biol (2012) 2.41
5'-UTR RNA G-quadruplexes: translation regulation and targeting. Nucleic Acids Res (2012) 2.36
G-quadruplexes: the beginning and end of UTRs. Nucleic Acids Res (2008) 2.18
Protter: interactive protein feature visualization and integration with experimental proteomic data. Bioinformatics (2013) 2.17
Targeting telomeres and telomerase. Biochimie (2007) 2.02
Genome-wide distribution of 5-formylcytosine in embryonic stem cells is associated with transcription and depends on thymine DNA glycosylase. Genome Biol (2012) 1.94
FANCJ is a structure-specific DNA helicase associated with the maintenance of genomic G/C tracts. J Biol Chem (2008) 1.93
Natural and pharmacological regulation of telomerase. Nucleic Acids Res (2002) 1.92
Template-assisted fabrication of salt-independent catalytic tubular microengines. ACS Nano (2010) 1.90
Trisubstituted isoalloxazines as a new class of G-quadruplex binding ligands: small molecule regulation of c-kit oncogene expression. J Am Chem Soc (2007) 1.87
The transcription factor FOXM1 is a cellular target of the natural product thiostrepton. Nat Chem (2011) 1.82
Thymosin beta4 is an essential paracrine factor of embryonic endothelial progenitor cell-mediated cardioprotection. Circulation (2008) 1.77
A sequence-independent study of the influence of short loop lengths on the stability and topology of intramolecular DNA G-quadruplexes. Biochemistry (2007) 1.75
Telomestatin-induced telomere uncapping is modulated by POT1 through G-overhang extension in HT1080 human tumor cells. J Biol Chem (2006) 1.74
Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathways. J Cell Sci (2003) 1.72
G-quadruplex structures are stable and detectable in human genomic DNA. Nat Commun (2013) 1.72
Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians. Hepatology (2010) 1.65
The G-quadruplex ligand telomestatin inhibits POT1 binding to telomeric sequences in vitro and induces GFP-POT1 dissociation from telomeres in human cells. Cancer Res (2006) 1.62
Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice. Proc Natl Acad Sci U S A (2010) 1.60
Ultrasensitive coincidence fluorescence detection of single DNA molecules. Anal Chem (2003) 1.60
Oxidative bisulfite sequencing of 5-methylcytosine and 5-hydroxymethylcytosine. Nat Protoc (2013) 1.54
Preferential binding of a G-quadruplex ligand to human chromosome ends. Nucleic Acids Res (2005) 1.53
Stabilization of the c-myc gene promoter quadruplex by specific ligands' inhibitors of telomerase. Biochem Biophys Res Commun (2004) 1.52
Kinetics of unfolding the human telomeric DNA quadruplex using a PNA trap. J Am Chem Soc (2003) 1.51
A screen for hydroxymethylcytosine and formylcytosine binding proteins suggests functions in transcription and chromatin regulation. Genome Biol (2013) 1.50
FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA. Nucleic Acids Res (2011) 1.45
A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands. Nat Chem (2011) 1.43
A proton-fuelled DNA nanomachine. Angew Chem Int Ed Engl (2003) 1.42
A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics. J Am Chem Soc (2009) 1.40
Telomerase downregulation induced by the G-quadruplex ligand 12459 in A549 cells is mediated by hTERT RNA alternative splicing. Nucleic Acids Res (2004) 1.38
Formation of an interlocked quadruplex dimer by d(GGGT). J Am Chem Soc (2004) 1.37
Apoptosis related to telomere instability and cell cycle alterations in human glioma cells treated by new highly selective G-quadruplex ligands. Oncogene (2005) 1.36
An Interspecies Regulatory Network Inferred from Simultaneous RNA-seq of Candida albicans Invading Innate Immune Cells. Front Microbiol (2012) 1.35
Genome-wide mapping of FOXM1 binding reveals co-binding with estrogen receptor alpha in breast cancer cells. Genome Biol (2013) 1.31
Interaction of telomestatin with the telomeric single-strand overhang. J Biol Chem (2004) 1.27
Small-molecule-mediated G-quadruplex isolation from human cells. Nat Chem (2010) 1.26
Preclinical antitumor activity of cabazitaxel, a semisynthetic taxane active in taxane-resistant tumors. Clin Cancer Res (2013) 1.25
Single-molecule conformational analysis of G-quadruplex formation in the promoter DNA duplex of the proto-oncogene c-kit. J Am Chem Soc (2007) 1.25
Oxazole-based peptide macrocycles: a new class of G-quadruplex binding ligands. J Am Chem Soc (2006) 1.20
Activation of Gbetagamma signaling downstream of Wnt-11/Xfz7 regulates Cdc42 activity during Xenopus gastrulation. Dev Biol (2003) 1.19
Identification of a new RNA.RNA interaction site for human telomerase RNA (hTR): structural implications for hTR accumulation and a dyskeratosis congenita point mutation. Nucleic Acids Res (2003) 1.19
Determination of the fraction and stoichiometry of femtomolar levels of biomolecular complexes in an excess of monomer using single-molecule, two-color coincidence detection. Anal Chem (2006) 1.17
G-quadruplex-specific peptide-hemicyanine ligands by partial combinatorial selection. J Am Chem Soc (2003) 1.16
Single-molecule analysis of human telomerase monomer. Nat Chem Biol (2008) 1.16
Genome-wide analysis of a G-quadruplex-specific single-chain antibody that regulates gene expression. Nucleic Acids Res (2009) 1.15
Motion-based DNA detection using catalytic nanomotors. Nat Commun (2010) 1.15
Topoisomerase IIIalpha is required for normal proliferation and telomere stability in alternative lengthening of telomeres. EMBO J (2008) 1.15
Ligand-driven G-quadruplex conformational switching by using an unusual mode of interaction. Angew Chem Int Ed Engl (2007) 1.15
Rudimentary G-quadruplex-based telomere capping in Saccharomyces cerevisiae. Nat Struct Mol Biol (2011) 1.14
A G-quadruplex structure within the 5'-UTR of TRF2 mRNA represses translation in human cells. Nucleic Acids Res (2010) 1.13
A non-canonical DNA structure is a binding motif for the transcription factor SP1 in vitro. Nucleic Acids Res (2011) 1.12
Small molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex. Org Biomol Chem (2010) 1.11
An intramolecular G-quadruplex structure is required for binding of telomeric repeat-containing RNA to the telomeric protein TRF2. J Am Chem Soc (2012) 1.11
The BCL-2 5' untranslated region contains an RNA G-quadruplex-forming motif that modulates protein expression. Biochemistry (2010) 1.11
Treatment of focal degenerative cartilage defects with polymer-based autologous chondrocyte grafts: four-year clinical results. Arthritis Res Ther (2009) 1.10
Molecule by molecule direct and quantitative counting of antibody-protein complexes in solution. Anal Chem (2004) 1.10
Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands. J Am Chem Soc (2007) 1.10
Rapid delivery of drug carriers propelled and navigated by catalytic nanoshuttles. Small (2010) 1.10
Binding interactions between long noncoding RNA HOTAIR and PRC2 proteins. Biochemistry (2013) 1.09
Structural analysis of the catalytic core of human telomerase RNA by FRET and molecular modeling. Biochemistry (2006) 1.08
A LIN28-dependent structural change in pre-let-7g directly inhibits dicer processing. Biochemistry (2011) 1.08
DNA molecular motor driven micromechanical cantilever arrays. J Am Chem Soc (2005) 1.07
Selective interaction of ethidium derivatives with quadruplexes: an equilibrium dialysis and electrospray ionization mass spectrometry analysis. Biochemistry (2003) 1.07
Selective RNA versus DNA G-quadruplex targeting by in situ click chemistry. Angew Chem Int Ed Engl (2012) 1.07
A reversible pH-driven DNA nanoswitch array. J Am Chem Soc (2006) 1.07
Distinct functions of maternal and somatic Pat1 protein paralogs. RNA (2010) 1.06
Minimum length requirement of the alignment domain of human telomerase RNA to sustain catalytic activity in vitro. Nucleic Acids Res (2002) 1.05
Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells. Org Biomol Chem (2012) 1.05
Human POT1 is required for efficient telomere C-rich strand replication in the absence of WRN. Genes Dev (2009) 1.05
G-quadruplex-binding benzo[a]phenoxazines down-regulate c-KIT expression in human gastric carcinoma cells. J Am Chem Soc (2011) 1.05
A sequence-independent analysis of the loop length dependence of intramolecular RNA G-quadruplex stability and topology. Biochemistry (2011) 1.04
Measuring single-molecule nucleic acid dynamics in solution by two-color filtered ratiometric fluorescence correlation spectroscopy. Proc Natl Acad Sci U S A (2004) 1.04
The kinetics and folding pathways of intramolecular G-quadruplex nucleic acids. J Am Chem Soc (2012) 1.03
Exploring the differential recognition of DNA G-quadruplex targets by small molecules using dynamic combinatorial chemistry. Angew Chem Int Ed Engl (2008) 1.03
Selective recognition of a DNA G-quadruplex by an engineered antibody. Biochemistry (2008) 1.02
Sequence variant (CTAGGG)n in the human telomere favors a G-quadruplex structure containing a G.C.G.C tetrad. Nucleic Acids Res (2009) 1.02
Tetramethylpyridiniumporphyrazines--a new class of G-quadruplex inducing and stabilising ligands. Chem Commun (Camb) (2006) 1.02
Exploring the recognition of quadruplex DNA by an engineered Cys2-His2 zinc finger protein. Biochemistry (2006) 1.02
Relative contribution of NF-kappaB and AP-1 in the modulation by curcumin and pyrrolidine dithiocarbamate of the UVB-induced cytokine expression by keratinocytes. Cytokine (2002) 1.01
The G-quadruplex ligand telomestatin impairs binding of topoisomerase IIIalpha to G-quadruplex-forming oligonucleotides and uncaps telomeres in ALT cells. PLoS One (2009) 1.00
A PNA4 quadruplex. J Am Chem Soc (2004) 1.00
An RNA hairpin to G-quadruplex conformational transition. J Am Chem Soc (2012) 1.00
Interactions of cryptolepine and neocryptolepine with unusual DNA structures. Biochimie (2003) 0.99
G-quadruplex DNA as a molecular target for induced synthetic lethality in cancer cells. J Am Chem Soc (2013) 0.98
Inhibition of human telomerase activity by an engineered zinc finger protein that binds G-quadruplexes. Biochemistry (2004) 0.98