Published in Nucleic Acids Res on July 28, 2005
5'-UTR RNA G-quadruplexes: translation regulation and targeting. Nucleic Acids Res (2012) 2.36
A novel small molecule that alters shelterin integrity and triggers a DNA-damage response at telomeres. J Am Chem Soc (2008) 1.91
Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway. Genes Dev (2005) 1.84
How long is too long? Effects of loop size on G-quadruplex stability. Nucleic Acids Res (2010) 1.74
Folding and unfolding pathways of the human telomeric G-quadruplex. J Mol Biol (2014) 1.73
G-quadruplex structures are stable and detectable in human genomic DNA. Nat Commun (2013) 1.72
Structural insights into G-quadruplexes: towards new anticancer drugs. Future Med Chem (2010) 1.44
G-quadruplexes and their regulatory roles in biology. Nucleic Acids Res (2015) 1.43
Inhibition of translation in living eukaryotic cells by an RNA G-quadruplex motif. RNA (2008) 1.34
Arrangements of human telomere DNA quadruplex in physiologically relevant K+ solutions. Nucleic Acids Res (2009) 1.27
A G-quadruplex structure within the 5'-UTR of TRF2 mRNA represses translation in human cells. Nucleic Acids Res (2010) 1.13
The tail of the telomere. J Am Chem Soc (2008) 1.07
Selective RNA versus DNA G-quadruplex targeting by in situ click chemistry. Angew Chem Int Ed Engl (2012) 1.07
Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells. Org Biomol Chem (2012) 1.05
G-quadruplex preferentially forms at the very 3' end of vertebrate telomeric DNA. Nucleic Acids Res (2007) 1.05
Structure and stability of higher-order human telomeric quadruplexes. J Am Chem Soc (2011) 1.02
G-quadruplex formation in human telomeric (TTAGGG)4 sequence with complementary strand in close vicinity under molecularly crowded condition. Nucleic Acids Res (2007) 0.99
Quadruplex ligands may act as molecular chaperones for tetramolecular quadruplex formation. Nucleic Acids Res (2007) 0.97
Polyethylene glycol binding alters human telomere G-quadruplex structure by conformational selection. Nucleic Acids Res (2013) 0.97
An integrated molecular dynamics (MD) and experimental study of higher order human telomeric quadruplexes. Biopolymers (2010) 0.88
ATR contributes to telomere maintenance in human cells. Nucleic Acids Res (2010) 0.88
G-quadruplex formation enhances splicing efficiency of PAX9 intron 1. Hum Genet (2014) 0.87
Role of ATM in the telomere response to the G-quadruplex ligand 360A. Nucleic Acids Res (2008) 0.87
A dual-site simultaneous binding mode in the interaction between parallel-stranded G-quadruplex [d(TGGGGT)]4 and cyanine dye 2,2'-diethyl-9-methyl-selenacarbocyanine bromide. Nucleic Acids Res (2012) 0.86
Rad51 and DNA-PKcs are involved in the generation of specific telomere aberrations induced by the quadruplex ligand 360A that impair mitotic cell progression and lead to cell death. Cell Mol Life Sci (2011) 0.85
End-stacking of copper cationic porphyrins on parallel-stranded guanine quadruplexes. J Biol Inorg Chem (2007) 0.84
Bisquinolinium compounds induce quadruplex-specific transcriptome changes in HeLa S3 cell lines. BMC Res Notes (2012) 0.82
Evaluation of human telomeric g-quadruplexes: the influence of overhanging sequences on quadruplex stability and folding. J Nucleic Acids (2010) 0.82
A preclinical mouse model of glioma with an alternative mechanism of telomere maintenance (ALT). Int J Cancer (2014) 0.80
Impact of G-quadruplex structures and intronic polymorphisms rs17878362 and rs1642785 on basal and ionizing radiation-induced expression of alternative p53 transcripts. Carcinogenesis (2014) 0.80
DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential. Nat Rev Mol Cell Biol (2017) 0.78
Highly efficient radiosensitization of human glioblastoma and lung cancer cells by a G-quadruplex DNA binding compound. Sci Rep (2015) 0.77
G-quadruplex DNA and ligand interaction in living cells using NMR spectroscopy. Chem Sci (2015) 0.77
Synthesis and g-quadruplex-binding properties of defined acridine oligomers. J Nucleic Acids (2010) 0.76
Targeting human telomeric G-quadruplex DNA and inhibition of telomerase activity with [(dmb)2Ru(obip)Ru(dmb)2](4+). PLoS One (2013) 0.76
Structure and stability of human telomeric G-quadruplex with preclinical 9-amino acridines. PLoS One (2013) 0.76
Alternative DNA structures: G4 DNA in cells: itae missa est? Nat Chem Biol (2012) 0.76
Bis-indole derivatives with antitumor activity turn out to be specific ligands of human telomeric G-quadruplex. Front Chem (2014) 0.75
Excited state proton transfer of natural flavonoids and their chromophores in duplex and tetraplex DNAs. J Phys Chem B (2014) 0.75
Human Telomeric G-Quadruplex Structures and G-Quadruplex-Interactive Compounds. Methods Mol Biol (2017) 0.75
Insights into the structure-activity relationships of chiral 1,2-diaminophenylalkane platinum(II) anticancer derivatives. J Biol Inorg Chem (2015) 0.75
Initial sequencing and analysis of the human genome. Nature (2001) 212.86
A survey of telomerase activity in human cancer. Eur J Cancer (1997) 10.84
Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription. Proc Natl Acad Sci U S A (2002) 9.60
Crystal structure of parallel quadruplexes from human telomeric DNA. Nature (2002) 8.90
Solution structure of the human telomeric repeat d[AG3(T2AG3)3] G-tetraplex. Structure (1993) 6.05
In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronuclei. Proc Natl Acad Sci U S A (2001) 3.97
Intracellular transcription of G-rich DNAs induces formation of G-loops, novel structures containing G4 DNA. Genes Dev (2004) 3.36
Telomere maintenance as a target for anticancer drug discovery. Nat Rev Drug Discov (2002) 3.32
Sequence and structural selectivity of nucleic acid binding ligands. Biochemistry (1999) 2.54
New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin. Oncogene (2002) 2.46
Human telomeric DNA: G-quadruplex, i-motif and Watson-Crick double helix. Nucleic Acids Res (2002) 2.35
The structure of telomeric DNA. Curr Opin Struct Biol (2003) 2.32
Telomestatin, a novel telomerase inhibitor from Streptomyces anulatus. J Am Chem Soc (2001) 2.05
Natural and pharmacological regulation of telomerase. Nucleic Acids Res (2002) 1.92
The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function. Cancer Res (2005) 1.84
Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex. J Am Chem Soc (2002) 1.82
Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands. Proc Natl Acad Sci U S A (2002) 1.75
Stabilization of the c-myc gene promoter quadruplex by specific ligands' inhibitors of telomerase. Biochem Biophys Res Commun (2004) 1.52
Structural competition involving G-quadruplex DNA and its complement. Biochemistry (2003) 1.39
Apoptosis related to telomere instability and cell cycle alterations in human glioma cells treated by new highly selective G-quadruplex ligands. Oncogene (2005) 1.36
A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity. Mol Pharmacol (2002) 1.33
Duplex dissociation of telomere DNAs induced by molecular crowding. J Am Chem Soc (2004) 1.29
Detection of quadruplex DNA structures in human telomeres by a fluorescent carbazole derivative. Anal Chem (2004) 1.28
Interaction of telomestatin with the telomeric single-strand overhang. J Biol Chem (2004) 1.27
Activity of a novel G-quadruplex-interactive telomerase inhibitor, telomestatin (SOT-095), against human leukemia cells: involvement of ATM-dependent DNA damage response pathways. Oncogene (2003) 1.26
Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma. Mol Cancer Ther (2003) 1.26
Allosteric, chiral-selective drug binding to DNA. Proc Natl Acad Sci U S A (2000) 1.22
A G-quadruplex telomere targeting agent produces p16-associated senescence and chromosomal fusions in human prostate cancer cells. Mol Cancer Ther (2004) 1.11
Selective interaction of ethidium derivatives with quadruplexes: an equilibrium dialysis and electrospray ionization mass spectrometry analysis. Biochemistry (2003) 1.07
Energetics of strand-displacement reactions in triple helices: a spectroscopic study. J Mol Biol (1999) 1.04
Interactions of cryptolepine and neocryptolepine with unusual DNA structures. Biochimie (2003) 0.99
Targeting human telomerase for cancer therapeutics. Cytotechnology (2004) 0.79
Highly efficient CRISPR/Cas9-mediated knock-in in zebrafish by homology-independent DNA repair. Genome Res (2013) 2.60
Human telomeric DNA: G-quadruplex, i-motif and Watson-Crick double helix. Nucleic Acids Res (2002) 2.35
The yeast Pif1 helicase prevents genomic instability caused by G-quadruplex-forming CEB1 sequences in vivo. PLoS Genet (2009) 2.32
Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression. Proc Natl Acad Sci U S A (2011) 2.10
Mouse differentiating spermatogonia can generate germinal stem cells in vivo. Nat Cell Biol (2008) 2.05
The effect of chemical modifications on the thermal stability of different G-quadruplex-forming oligonucleotides. Nucleic Acids Res (2005) 2.04
Targeting telomeres and telomerase. Biochimie (2007) 2.02
Flow cytometric characterization of viable meiotic and postmeiotic cells by Hoechst 33342 in mouse spermatogenesis. Cytometry A (2005) 1.97
Natural and pharmacological regulation of telomerase. Nucleic Acids Res (2002) 1.92
A novel small molecule that alters shelterin integrity and triggers a DNA-damage response at telomeres. J Am Chem Soc (2008) 1.91
Kinetics of tetramolecular quadruplexes. Nucleic Acids Res (2005) 1.80
Mutations of DNAI1 in primary ciliary dyskinesia: evidence of founder effect in a common mutation. Am J Respir Crit Care Med (2006) 1.80
Common fragile sites: mechanisms of instability revisited. Trends Genet (2011) 1.80
DNA duplex-quadruplex exchange as the basis for a nanomolecular machine. Proc Natl Acad Sci U S A (2003) 1.79
Telomestatin-induced telomere uncapping is modulated by POT1 through G-overhang extension in HT1080 human tumor cells. J Biol Chem (2006) 1.74
How long is too long? Effects of loop size on G-quadruplex stability. Nucleic Acids Res (2010) 1.74
'Side Population' cells in adult mouse testis express Bcrp1 gene and are enriched in spermatogonia and germinal stem cells. Development (2003) 1.72
Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathways. J Cell Sci (2003) 1.72
Establishment of human colon cancer cell lines from fresh tumors versus xenografts: comparison of success rate and cell line features. Cancer Res (2007) 1.69
The G-quadruplex ligand telomestatin inhibits POT1 binding to telomeric sequences in vitro and induces GFP-POT1 dissociation from telomeres in human cells. Cancer Res (2006) 1.62
Oxidative stress induces an ATM-independent senescence pathway through p38 MAPK-mediated lamin B1 accumulation. EMBO J (2012) 1.60
Variations in the colchicine-binding domain provide insight into the structural switch of tubulin. Proc Natl Acad Sci U S A (2009) 1.59
Molecular structure of double-minute chromosomes bearing amplified copies of the epidermal growth factor receptor gene in gliomas. Proc Natl Acad Sci U S A (2004) 1.56
Stabilization of the c-myc gene promoter quadruplex by specific ligands' inhibitors of telomerase. Biochem Biophys Res Commun (2004) 1.52
Cancer translocations in human cells induced by zinc finger and TALE nucleases. Genome Res (2013) 1.44
Radiation-induced H2AX phosphorylation and neural precursor apoptosis in the developing brain of mice. Radiat Res (2006) 1.43
Human replication protein A unfolds telomeric G-quadruplexes. Nucleic Acids Res (2006) 1.43
Fluorescence-based melting assays for studying quadruplex ligands. Methods (2007) 1.38
Cellular and behavioral effects of cranial irradiation of the subventricular zone in adult mice. PLoS One (2009) 1.38
Telomerase downregulation induced by the G-quadruplex ligand 12459 in A549 cells is mediated by hTERT RNA alternative splicing. Nucleic Acids Res (2004) 1.38
Apoptosis related to telomere instability and cell cycle alterations in human glioma cells treated by new highly selective G-quadruplex ligands. Oncogene (2005) 1.36
G-quadruplex structures in TP53 intron 3: role in alternative splicing and in production of p53 mRNA isoforms. Carcinogenesis (2010) 1.34
Highly efficient G-quadruplex recognition by bisquinolinium compounds. J Am Chem Soc (2007) 1.34
Premature condensation induces breaks at the interface of early and late replicating chromosome bands bearing common fragile sites. Proc Natl Acad Sci U S A (2005) 1.31
Common fragile site profiling in epithelial and erythroid cells reveals that most recurrent cancer deletions lie in fragile sites hosting large genes. Cell Rep (2013) 1.31
Guanines are a quartet's best friend: impact of base substitutions on the kinetics and stability of tetramolecular quadruplexes. Nucleic Acids Res (2007) 1.31
Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action. Proc Natl Acad Sci U S A (2007) 1.29
Interaction of telomestatin with the telomeric single-strand overhang. J Biol Chem (2004) 1.27
Preclinical antitumor activity of cabazitaxel, a semisynthetic taxane active in taxane-resistant tumors. Clin Cancer Res (2013) 1.25
Exon array analyses across the NCI-60 reveal potential regulation of TOP1 by transcription pausing at guanosine quartets in the first intron. Cancer Res (2010) 1.24
Predicting and understanding the stability of G-quadruplexes. Bioinformatics (2009) 1.23
Activation of Gbetagamma signaling downstream of Wnt-11/Xfz7 regulates Cdc42 activity during Xenopus gastrulation. Dev Biol (2003) 1.19
Characterization of Spo11-dependent and independent phospho-H2AX foci during meiotic prophase I in the male mouse. J Cell Sci (2007) 1.18
Stability of telomeric G-quadruplexes. Nucleic Acids Res (2010) 1.16
DNA nanomachines and nanostructures involving quadruplexes. Org Biomol Chem (2006) 1.16
Selective recognition of G-qQuadruplex telomeric DNA by a bis(quinacridine) macrocycle. J Am Chem Soc (2003) 1.15
Topoisomerase IIIalpha is required for normal proliferation and telomere stability in alternative lengthening of telomeres. EMBO J (2008) 1.15
Molecular profiling of common fragile sites in human fibroblasts. Nat Struct Mol Biol (2011) 1.14
Sequence effects in single-base loops for quadruplexes. Biochimie (2008) 1.13
A G-quadruplex structure within the 5'-UTR of TRF2 mRNA represses translation in human cells. Nucleic Acids Res (2010) 1.13
Radiation-induced mitotic catastrophe in PARG-deficient cells. J Cell Sci (2009) 1.12
Neural stem cells from mouse forebrain are contained in a population distinct from the 'side population'. J Neurochem (2006) 1.12
Ku counteracts mobilization of PARP1 and MRN in chromatin damaged with DNA double-strand breaks. Nucleic Acids Res (2011) 1.12
Quartets in G-major. The First International Meeting on Quadruplex DNA. EMBO Rep (2007) 1.11
TRF2/RAP1 and DNA-PK mediate a double protection against joining at telomeric ends. EMBO J (2010) 1.11
Interaction of human telomeric DNA with N-methyl mesoporphyrin IX. Nucleic Acids Res (2012) 1.11
Unusual DNA conformations: implications for telomeres. Curr Med Chem Anticancer Agents (2002) 1.10
Vascular-derived TGF-β increases in the stem cell niche and perturbs neurogenesis during aging and following irradiation in the adult mouse brain. EMBO Mol Med (2013) 1.10
Alternative lengthening of telomeres in human glioma stem cells. Stem Cells (2011) 1.10
Selective interaction of ethidium derivatives with quadruplexes: an equilibrium dialysis and electrospray ionization mass spectrometry analysis. Biochemistry (2003) 1.07
Exclusive platination of loop adenines in the human telomeric G-quadruplex. Org Biomol Chem (2009) 1.07
Phase II study of lonidamine and diazepam in the treatment of recurrent glioblastoma multiforme. J Neurooncol (2003) 1.06
Genetic alterations associated with acquired temozolomide resistance in SNB-19, a human glioma cell line. Mol Cancer Ther (2006) 1.06
Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells. Org Biomol Chem (2012) 1.05
Human POT1 is required for efficient telomere C-rich strand replication in the absence of WRN. Genes Dev (2009) 1.05
Segmental duplications in euchromatic regions of human chromosome 5: a source of evolutionary instability and transcriptional innovation. Genome Res (2003) 1.04
Thioflavin T as a fluorescence light-up probe for G4 formation. Nucleic Acids Res (2014) 1.03
Sequence variant (CTAGGG)n in the human telomere favors a G-quadruplex structure containing a G.C.G.C tetrad. Nucleic Acids Res (2009) 1.02
Clinical relevance of tumor cells with stem-like properties in pediatric brain tumors. PLoS One (2011) 1.02
Length-dependent energetics of (CTG)n and (CAG)n trinucleotide repeats. Nucleic Acids Res (2005) 1.01
Hormone escape is associated with genomic instability in a human prostate cancer model. Int J Cancer (2009) 1.00
The G-quadruplex ligand telomestatin impairs binding of topoisomerase IIIalpha to G-quadruplex-forming oligonucleotides and uncaps telomeres in ALT cells. PLoS One (2009) 1.00
Interactions of cryptolepine and neocryptolepine with unusual DNA structures. Biochimie (2003) 0.99