Published in Protein Sci on March 01, 2005
Structural basis of CXCR4 sulfotyrosine recognition by the chemokine SDF-1/CXCL12. Sci Signal (2008) 2.33
Recognition of a CXCR4 sulfotyrosine by the chemokine stromal cell-derived factor-1alpha (SDF-1alpha/CXCL12). J Mol Biol (2006) 1.63
Structural basis of the interaction between chemokine stromal cell-derived factor-1/CXCL12 and its G-protein-coupled receptor CXCR4. J Biol Chem (2009) 1.60
Structural and functional basis of CXCL12 (stromal cell-derived factor-1 alpha) binding to heparin. J Biol Chem (2007) 1.58
Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways. Proc Natl Acad Sci U S A (2011) 1.58
Chemokine oligomerization and interactions with receptors and glycosaminoglycans: the role of structural dynamics in function. Exp Cell Res (2011) 1.35
Stromal-derived factor-1 (CXCL12) regulates laminar position of Cajal-Retzius cells in normal and dysplastic brains. J Neurosci (2006) 1.28
Sequential tyrosine sulfation of CXCR4 by tyrosylprotein sulfotransferases. Biochemistry (2008) 1.20
Probing receptor binding activity of interleukin-8 dimer using a disulfide trap. Biochemistry (2006) 1.16
The novel CXCL12gamma isoform encodes an unstructured cationic domain which regulates bioactivity and interaction with both glycosaminoglycans and CXCR4. PLoS One (2007) 1.14
Monomeric structure of the cardioprotective chemokine SDF-1/CXCL12. Protein Sci (2009) 1.13
On-column refolding of recombinant chemokines for NMR studies and biological assays. Protein Expr Purif (2006) 1.05
Modulatory effects of heparin and short-length oligosaccharides of heparin on the metastasis and growth of LMD MDA-MB 231 breast cancer cells in vivo. Br J Cancer (2007) 1.03
A locked, dimeric CXCL12 variant effectively inhibits pulmonary metastasis of CXCR4-expressing melanoma cells due to enhanced serum stability. Mol Cancer Ther (2012) 1.02
Cation-independent mannose 6-phosphate receptor: a composite of distinct phosphomannosyl binding sites. J Biol Chem (2009) 1.02
Backbone dynamics of SDF-1alpha determined by NMR: interpretation in the presence of monomer-dimer equilibrium. Protein Sci (2006) 1.01
CXCL12 chemokine expression suppresses human pancreatic cancer growth and metastasis. PLoS One (2014) 0.99
The structural role of receptor tyrosine sulfation in chemokine recognition. Br J Pharmacol (2014) 0.98
Binding site identification and structure determination of protein-ligand complexes by NMR a semiautomated approach. Methods Enzymol (2011) 0.95
Secreted CXCL12 (SDF-1) forms dimers under physiological conditions. Biochem J (2012) 0.95
Structural determinants involved in the regulation of CXCL14/BRAK expression by the 26 S proteasome. J Mol Biol (2006) 0.93
Structure of the SCAN domain from the tumor suppressor protein MZF1. J Mol Biol (2006) 0.92
Heterologous quaternary structure of CXCL12 and its relationship to the CC chemokine family. Proteins (2010) 0.92
NMR analysis of the structure, dynamics, and unique oligomerization properties of the chemokine CCL27. J Biol Chem (2010) 0.92
The isolation of novel mesenchymal stromal cell chemotactic factors from the conditioned medium of tumor cells. Exp Cell Res (2008) 0.91
The dependence of chemokine-glycosaminoglycan interactions on chemokine oligomerization. Glycobiology (2015) 0.91
Multiple glycosaminoglycan-binding epitopes of monocyte chemoattractant protein-3/CCL7 enable it to function as a non-oligomerizing chemokine. J Biol Chem (2014) 0.89
Chemokines and chemokine receptors: update on utility and challenges for the clinician. Surgery (2014) 0.89
Effects of temperature and salt concentration on the structural stability of human lymphotactin: insights from molecular simulations. J Am Chem Soc (2006) 0.88
Chemokine signaling in development and disease. Development (2014) 0.88
The Anti-inflammatory Protein TSG-6 Regulates Chemokine Function by Inhibiting Chemokine/Glycosaminoglycan Interactions. J Biol Chem (2016) 0.87
Human macrophage inflammatory protein 3alpha: protein and peptide nuclear magnetic resonance solution structures, dimerization, dynamics, and anti-infective properties. Antimicrob Agents Chemother (2007) 0.87
Structural and functional studies of the potent anti-HIV chemokine variant P2-RANTES. Proteins (2010) 0.86
Sulfotyrosine recognition as marker for druggable sites in the extracellular space. Int J Mol Sci (2011) 0.85
Sulfopeptide probes of the CXCR4/CXCL12 interface reveal oligomer-specific contacts and chemokine allostery. ACS Chem Biol (2013) 0.85
Multiple signaling interactions coordinate collective cell migration of the posterior lateral line primordium. Cell Adh Migr (2009) 0.85
Microfluidic source-sink model reveals effects of biophysically distinct CXCL12 isoforms in breast cancer chemotaxis. Integr Biol (Camb) (2014) 0.84
Modulating the interaction of CXCR4 and CXCL12 by low-molecular-weight heparin inhibits hepatic metastasis of colon cancer. Invest New Drugs (2010) 0.84
Exploring platelet chemokine antimicrobial activity: nuclear magnetic resonance backbone dynamics of NAP-2 and TC-1. Antimicrob Agents Chemother (2011) 0.83
Structure-Based Identification of Novel Ligands Targeting Multiple Sites within a Chemokine-G-Protein-Coupled-Receptor Interface. J Med Chem (2016) 0.83
Fragment-based optimization of small molecule CXCL12 inhibitors for antagonizing the CXCL12/CXCR4 interaction. Curr Top Med Chem (2012) 0.82
Pancreatic Cancer Cell Migration and Metastasis Is Regulated by Chemokine-Biased Agonism and Bioenergetic Signaling. Cancer Res (2015) 0.82
Solution structure of Arabidopsis thaliana protein At5g39720.1, a member of the AIG2-like protein family. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.81
Characterization of the interactions of vMIP-II, and a dimeric variant of vMIP-II, with glycosaminoglycans. Biochemistry (2010) 0.80
Proline substitution of dimer interface β-strand residues as a strategy for the design of functional monomeric proteins. Biophys J (2013) 0.79
Transferring the C-terminus of the chemokine CCL21 to CCL19 confers enhanced heparin binding. Biochem Biophys Res Commun (2016) 0.77
The role of tyrosine sulfation in the dimerization of the CXCR4:SDF-1 complex. Protein Sci (2013) 0.77
New paradigms in chemokine receptor signal transduction: Moving beyond the two-site model. Biochem Pharmacol (2016) 0.77
Structural basis for chemokine recognition by a G protein-coupled receptor and implications for receptor activation. Sci Signal (2017) 0.76
SDF1 induction by acidosis from principal cells regulates intercalated cell subtype distribution. J Clin Invest (2015) 0.75
Analysis of the interaction between heparin and follistatin and heparin and follistatin-ligand complexes using surface plasmon resonance. Biochemistry (2012) 0.75
NMR in the Analysis of Functional Chemokine Interactions and Drug Discovery. Drug Discov Today Technol (2012) 0.75
Predicted molecular signaling guiding photoreceptor cell migration following transplantation into damaged retina. Sci Rep (2016) 0.75
Process of hepatic metastasis from pancreatic cancer: biology with clinical significance. J Cancer Res Clin Oncol (2015) 0.75
Structural perspectives on antimicrobial chemokines. Front Immunol (2012) 0.75
Enriching Traditional Protein-protein Interaction Networks with Alternative Conformations of Proteins. Sci Rep (2017) 0.75
CCR7 Sulfotyrosine Enhances CCL21 Binding. Int J Mol Sci (2017) 0.75
Glycosaminoglycan Interactions with Chemokines Add Complexity to a Complex System. Pharmaceuticals (Basel) (2017) 0.75
Involvement of chemokine receptors in breast cancer metastasis. Nature (2001) 26.07
Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature (1998) 11.41
The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature (1996) 11.21
Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature (1996) 10.67
The biology of chemokines and their receptors. Annu Rev Immunol (2000) 9.81
The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract. Nature (1998) 7.38
Backbone 1H and 15N resonance assignments of the N-terminal SH3 domain of drk in folded and unfolded states using enhanced-sensitivity pulsed field gradient NMR techniques. J Biomol NMR (1994) 6.06
Improved sensitivity of HSQC spectra of exchanging protons at short interscan delays using a new fast HSQC (FHSQC) detection scheme that avoids water saturation. J Magn Reson B (1995) 4.93
Solution structure and basis for functional activity of stromal cell-derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1. EMBO J (1997) 4.04
NF-kappaB promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4. J Biol Chem (2003) 3.98
Glycosaminoglycan binding and oligomerization are essential for the in vivo activity of certain chemokines. Proc Natl Acad Sci U S A (2003) 3.77
Guidance of primordial germ cell migration by the chemokine SDF-1. Cell (2002) 3.22
A zebrafish homologue of the chemokine receptor Cxcr4 is a germ-cell guidance receptor. Nature (2002) 3.15
Glycosaminoglycans mediate cell surface oligomerization of chemokines. Biochemistry (1997) 2.87
Stromal cell-derived factor-1alpha associates with heparan sulfates through the first beta-strand of the chemokine. J Biol Chem (1999) 2.32
Neutrophil activation by monomeric interleukin-8. Science (1994) 2.31
An optimized 3D NOESY-HSQC. J Magn Reson B (1996) 2.17
CXCR4: chemokine receptor extraordinaire. Immunol Rev (2000) 2.16
Molecular genetic analysis of a plant virus polyprotein cleavage site: a model. Virology (1989) 2.15
The chemokine SDF1/CXCL12 and its receptor CXCR4 regulate mouse germ cell migration and survival. Development (2003) 2.13
Monomeric monocyte chemoattractant protein-1 (MCP-1) binds and activates the MCP-1 receptor CCR2B. J Biol Chem (1998) 1.84
Impaired colonization of the gonads by primordial germ cells in mice lacking a chemokine, stromal cell-derived factor-1 (SDF-1). Proc Natl Acad Sci U S A (2003) 1.69
Identification of the glycosaminoglycan binding site of the CC chemokine, MCP-1: implications for structure and function in vivo. J Biol Chem (2004) 1.69
Crystal structure of chemically synthesized [N33A] stromal cell-derived factor 1alpha, a potent ligand for the HIV-1 "fusin" coreceptor. Proc Natl Acad Sci U S A (1998) 1.58
1H NMR solution structure of an active monomeric interleukin-8. Biochemistry (1995) 1.56
Determination of the monomer-dimer equilibrium of interleukin-8 reveals it is a monomer at physiological concentrations. Biochemistry (1994) 1.53
Characterization of the stromal cell-derived factor-1alpha-heparin complex. J Biol Chem (2000) 1.46
Identification and characterization of a glycosaminoglycan recognition element of the C chemokine lymphotactin. J Biol Chem (2004) 1.42
Interference with heparin binding and oligomerization creates a novel anti-inflammatory strategy targeting the chemokine system. J Immunol (2004) 1.39
Proton NMR assignments and solution conformation of RANTES, a chemokine of the C-C type. Biochemistry (1995) 1.38
Structural rearrangement of human lymphotactin, a C chemokine, under physiological solution conditions. J Biol Chem (2002) 1.36
CC chemokine MIP-1 beta can function as a monomer and depends on Phe13 for receptor binding. Biochemistry (2000) 1.33
Monomeric variants of IL-8: effects of side chain substitutions and solution conditions upon dimer formation. Protein Sci (1997) 1.20
Crystal structure of recombinant native SDF-1alpha with additional mutagenesis studies: an attempt at a more comprehensive interpretation of accumulated structure-activity relationship data. J Interferon Cytokine Res (2000) 1.15
Comparisons of Indefinite Self-Association Models. Chem Rev (1996) 1.11
Current evidence and future directions for targeting HIV entry: therapeutic and prophylactic strategies. JAMA (2000) 1.06
Solution studies of recombinant human stromal-cell-derived factor-1. Protein Expr Purif (2001) 1.05
Characterization of a Xenopus laevis CXC chemokine receptor 4: implications for hematopoietic cell development in the vertebrate embryo. Eur J Immunol (2000) 1.03
Optimal inhibition of X4 HIV isolates by the CXC chemokine stromal cell-derived factor 1 alpha requires interaction with cell surface heparan sulfate proteoglycans. J Biol Chem (2001) 1.02
Strategies for chemokine antagonists as therapeutics. Semin Immunol (2003) 0.98
Evaluation of SDF-1/CXCR4-induced Ca2+ signaling by fluorometric imaging plate reader (FLIPR) and flow cytometry. Cytometry A (2003) 0.97
The binding surface and affinity of monomeric and dimeric chemokine macrophage inflammatory protein 1 beta for various glycosaminoglycan disaccharides. J Biol Chem (2002) 0.94
Glycan and glycosaminoglycan binding properties of stromal cell-derived factor (SDF)-1alpha. Glycobiology (2000) 0.94
Effect of N-terminal truncation and solution conditions on chemokine dimer stability: nuclear magnetic resonance structural analysis of macrophage inflammatory protein 1 beta mutants. Biochemistry (1998) 0.92
Glycosaminoglycan disaccharide alters the dimer dissociation constant of the chemokine MIP-1 beta. Biochemistry (2004) 0.88
Developmental biology: Germ-cell attraction. Nature (2003) 0.84
Abscisic acid inhibits type 2C protein phosphatases via the PYR/PYL family of START proteins. Science (2009) 10.21
A gate-latch-lock mechanism for hormone signalling by abscisic acid receptors. Nature (2009) 3.63
Structural basis of CXCR4 sulfotyrosine recognition by the chemokine SDF-1/CXCL12. Sci Signal (2008) 2.33
Project management system for structural and functional proteomics: Sesame. J Struct Funct Genomics (2003) 2.19
Interconversion between two unrelated protein folds in the lymphotactin native state. Proc Natl Acad Sci U S A (2008) 2.17
Unfolding of the C-terminal domain of the J-protein Zuo1 releases autoinhibition and activates Pdr1-dependent transcription. J Mol Biol (2012) 2.04
Cdc42 regulates the Par-6 PDZ domain through an allosteric CRIB-PDZ transition. Mol Cell (2004) 1.95
Cell-free protein production and labeling protocol for NMR-based structural proteomics. Nat Methods (2004) 1.78
Structure of the N-WASP EVH1 domain-WIP complex: insight into the molecular basis of Wiskott-Aldrich Syndrome. Cell (2002) 1.70
Recognition of a CXCR4 sulfotyrosine by the chemokine stromal cell-derived factor-1alpha (SDF-1alpha/CXCL12). J Mol Biol (2006) 1.63
Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways. Proc Natl Acad Sci U S A (2011) 1.58
Altered dimer interface decreases stability in an amyloidogenic protein. J Biol Chem (2008) 1.50
Heterodimer formation of the myeloid zinc finger 1 SCAN domain and association with promyelocytic leukemia nuclear bodies. Leuk Res (2008) 1.48
Activation of dimeric ABA receptors elicits guard cell closure, ABA-regulated gene expression, and drought tolerance. Proc Natl Acad Sci U S A (2013) 1.47
Structural basis for selective activation of ABA receptors. Nat Struct Mol Biol (2010) 1.43
Identification and characterization of a glycosaminoglycan recognition element of the C chemokine lymphotactin. J Biol Chem (2004) 1.42
Solution structure of a ubiquitin-like domain from tubulin-binding cofactor B. J Biol Chem (2004) 1.40
Structural rearrangement of human lymphotactin, a C chemokine, under physiological solution conditions. J Biol Chem (2002) 1.36
The NMR solution structure of BeF(3)(-)-activated Spo0F reveals the conformational switch in a phosphorelay system. J Mol Biol (2003) 1.32
Structural and functional insights into core ABA signaling. Curr Opin Plant Biol (2010) 1.29
Comparison of cell-based and cell-free protocols for producing target proteins from the Arabidopsis thaliana genome for structural studies. Proteins (2005) 1.26
Structure-based ligand discovery for the protein-protein interface of chemokine receptor CXCR4. Proc Natl Acad Sci U S A (2012) 1.25
The CXC chemokine receptor 4 ligands ubiquitin and stromal cell-derived factor-1α function through distinct receptor interactions. J Biol Chem (2011) 1.23
The 1.6 A crystal structure of the catalytic domain of PlyB, a bacteriophage lysin active against Bacillus anthracis. J Mol Biol (2006) 1.23
Sequential tyrosine sulfation of CXCR4 by tyrosylprotein sulfotransferases. Biochemistry (2008) 1.20
Macromolecular structure determination by NMR spectroscopy. Methods Biochem Anal (2003) 1.16
Potent and selective activation of abscisic acid receptors in vivo by mutational stabilization of their agonist-bound conformation. Proc Natl Acad Sci U S A (2011) 1.14
Monomeric structure of the cardioprotective chemokine SDF-1/CXCL12. Protein Sci (2009) 1.13
Targeting SDF-1/CXCL12 with a ligand that prevents activation of CXCR4 through structure-based drug design. J Am Chem Soc (2010) 1.12
Orphan macrodomain protein (human C6orf130) is an O-acyl-ADP-ribose deacylase: solution structure and catalytic properties. J Biol Chem (2011) 1.12
An engineered second disulfide bond restricts lymphotactin/XCL1 to a chemokine-like conformation with XCR1 agonist activity. Biochemistry (2007) 1.11
Structure of the B3 domain from Arabidopsis thaliana protein At1g16640. Protein Sci (2005) 1.11
Solution structure of thioredoxin h1 from Arabidopsis thaliana. Protein Sci (2005) 1.07
On-column refolding of recombinant chemokines for NMR studies and biological assays. Protein Expr Purif (2006) 1.05
A locked, dimeric CXCL12 variant effectively inhibits pulmonary metastasis of CXCR4-expressing melanoma cells due to enhanced serum stability. Mol Cancer Ther (2012) 1.02
Distal interactions within the par3-VE-cadherin complex. Biochemistry (2010) 1.00
A novel zinc finger is required for Mcm10 homocomplex assembly. J Biol Chem (2003) 1.00
Multiple WASP-interacting protein recognition motifs are required for a functional interaction with N-WASP. J Biol Chem (2007) 1.00
Native-state interconversion of a metamorphic protein requires global unfolding. Biochemistry (2011) 0.97
Chapter 3. Lymphotactin structural dynamics. Methods Enzymol (2009) 0.97
Structures of proteins of biomedical interest from the Center for Eukaryotic Structural Genomics. J Struct Funct Genomics (2007) 0.96
Solution structure of CCL21 and identification of a putative CCR7 binding site. Biochemistry (2012) 0.96
Residues within a lipid-associated segment of the PECAM-1 cytoplasmic domain are susceptible to inducible, sequential phosphorylation. Blood (2011) 0.95
A single mutation promotes amyloidogenicity through a highly promiscuous dimer interface. Structure (2010) 0.95
The solution structure of ZNF593 from Homo sapiens reveals a zinc finger in a predominantly unstructured protein. Protein Sci (2008) 0.95
Diversity of polyproline recognition by EVH1 domains. Front Biosci (Landmark Ed) (2009) 0.95
Binding site identification and structure determination of protein-ligand complexes by NMR a semiautomated approach. Methods Enzymol (2011) 0.95
Use of a bacteriophage lysin to identify a novel target for antimicrobial development. PLoS One (2013) 0.93
Structural determinants involved in the regulation of CXCL14/BRAK expression by the 26 S proteasome. J Mol Biol (2006) 0.93
Structure of the SCAN domain from the tumor suppressor protein MZF1. J Mol Biol (2006) 0.92
Structural basis for recognition of phosphodiester-containing lysosomal enzymes by the cation-independent mannose 6-phosphate receptor. Proc Natl Acad Sci U S A (2010) 0.92
Production in two-liter beverage bottles of proteins for NMR structure determination labeled with either 15N- or 13C-15N. J Struct Funct Genomics (2004) 0.91
Conversion of the enzyme guanylate kinase into a mitotic-spindle orienting protein by a single mutation that inhibits GMP-induced closing. Proc Natl Acad Sci U S A (2011) 0.90
The first structure from the SOUL/HBP family of heme-binding proteins, murine P22HBP. J Biol Chem (2006) 0.89
Structures of two Arabidopsis thaliana major latex proteins represent novel helix-grip folds. Proteins (2009) 0.88
Tyrosine residues mediate fibril formation in a dynamic light chain dimer interface. J Biol Chem (2012) 0.88
Identification of the major ubiquitin-binding domain of the Pseudomonas aeruginosa ExoU A2 phospholipase. J Biol Chem (2013) 0.88
The Center for Eukaryotic Structural Genomics. J Struct Funct Genomics (2009) 0.87
Modulation of the CXC chemokine receptor 4 agonist activity of ubiquitin through C-terminal protein modification. Biochemistry (2013) 0.86
Electrostatic optimization of the conformational energy landscape in a metamorphic protein. Biochemistry (2012) 0.86
Structure of the hypothetical protein At3g17210 from Arabidopsis thaliana. J Biomol NMR (2004) 0.86
Structure of the lectin mannose 6-phosphate receptor homology (MRH) domain of glucosidase II, an enzyme that regulates glycoprotein folding quality control in the endoplasmic reticulum. J Biol Chem (2013) 0.86
Sulfotyrosine recognition as marker for druggable sites in the extracellular space. Int J Mol Sci (2011) 0.85
Sulfopeptide probes of the CXCR4/CXCL12 interface reveal oligomer-specific contacts and chemokine allostery. ACS Chem Biol (2013) 0.85