Published in J Biol Chem on August 01, 2013
The molecular mechanism of acute lung injury caused by Pseudomonas aeruginosa: from bacterial pathogenesis to host response. J Intensive Care (2014) 0.99
Association between Pseudomonas aeruginosa type III secretion, antibiotic resistance, and clinical outcome: a review. Crit Care (2014) 0.96
Manipulation of intestinal epithelial cell function by the cell contact-dependent type III secretion systems of Vibrio parahaemolyticus. Front Cell Infect Microbiol (2014) 0.95
Intoxication of host cells by the T3SS phospholipase ExoU: PI(4,5)P2-associated, cytoskeletal collapse and late phase membrane blebbing. PLoS One (2014) 0.80
Ubiquitin activates patatin-like phospholipases from multiple bacterial species. J Bacteriol (2014) 0.80
Chitinase 3-Like 1 (Chil1) Regulates Survival and Macrophage-Mediated Interleukin-1β and Tumor Necrosis Factor Alpha during Pseudomonas aeruginosa Pneumonia. Infect Immun (2016) 0.80
Mycobacterium tuberculosis alters the metalloprotease activity of the COP9 signalosome. MBio (2014) 0.78
Cooperative substrate-cofactor interactions and membrane localization of the bacterial PLA2 enzyme, ExoU. J Biol Chem (2017) 0.77
Lysine11-Linked Polyubiquitination of the AnkB F-Box Effector of Legionella pneumophila. Infect Immun (2015) 0.76
Bacterial Sphingomyelinases and Phospholipases as Virulence Factors. Microbiol Mol Biol Rev (2016) 0.76
Protein structure prediction on the Web: a case study using the Phyre server. Nat Protoc (2009) 32.64
Breaking the chains: structure and function of the deubiquitinases. Nat Rev Mol Cell Biol (2009) 8.85
Ubiquitin-binding domains. Nat Rev Mol Cell Biol (2005) 6.77
Ubiquitin-binding domains. Biochem J (2006) 5.32
Ubiquitin-binding domains - from structures to functions. Nat Rev Mol Cell Biol (2009) 4.62
ExoY, an adenylate cyclase secreted by the Pseudomonas aeruginosa type III system. Proc Natl Acad Sci U S A (1998) 4.04
Pseudomonas aeruginosa exoenzyme S: an adenosine diphosphate ribosyltransferase distinct from toxin A. Proc Natl Acad Sci U S A (1978) 3.84
The ubiquitin binding domain ZnF UBP recognizes the C-terminal diglycine motif of unanchored ubiquitin. Cell (2006) 3.46
Molecular motion of spin labeled side chains in alpha-helices: analysis by variation of side chain structure. Biochemistry (2001) 3.45
The mechanism of action of the Pseudomonas aeruginosa-encoded type III cytotoxin, ExoU. EMBO J (2003) 3.10
The N-terminal domain of Pseudomonas aeruginosa exoenzyme S is a GTPase-activating protein for Rho GTPases. J Biol Chem (1999) 2.78
Ubiquitin-binding proteins: decoders of ubiquitin-mediated cellular functions. Annu Rev Biochem (2012) 2.53
Integrating statistical pair potentials into protein complex prediction. Proteins (2007) 2.53
The eukaryotic host factor that activates exoenzyme S of Pseudomonas aeruginosa is a member of the 14-3-3 protein family. Proc Natl Acad Sci U S A (1993) 2.50
Accelerating protein docking in ZDOCK using an advanced 3D convolution library. PLoS One (2011) 2.33
Clinical significance of microbial infection and adaptation in cystic fibrosis. Clin Microbiol Rev (2011) 2.23
Structure of S5a bound to monoubiquitin provides a model for polyubiquitin recognition. J Mol Biol (2005) 2.22
Exploitation of eukaryotic ubiquitin signaling pathways by effectors translocated by bacterial type III and type IV secretion systems. PLoS Pathog (2007) 2.14
Clinical outcomes of type III Pseudomonas aeruginosa bacteremia. Crit Care Med (2012) 2.03
Functional domains and motifs of bacterial type III effector proteins and their roles in infection. FEMS Microbiol Rev (2011) 2.02
The Shigella flexneri effector OspI deamidates UBC13 to dampen the inflammatory response. Nature (2012) 1.99
In vivo phospholipase activity of the Pseudomonas aeruginosa cytotoxin ExoU and protection of mammalian cells with phospholipase A2 inhibitors. J Biol Chem (2003) 1.84
Host proteasomal degradation generates amino acids essential for intracellular bacterial growth. Science (2011) 1.69
Pseudomonas aeruginosa ExoT ADP-ribosylates CT10 regulator of kinase (Crk) proteins. J Biol Chem (2003) 1.60
Biochemical relationships between the 53-kilodalton (Exo53) and 49-kilodalton (ExoS) forms of exoenzyme S of Pseudomonas aeruginosa. J Bacteriol (1997) 1.30
Hijacking the host ubiquitin pathway: structural strategies of bacterial E3 ubiquitin ligases. Curr Opin Microbiol (2009) 1.23
A Pseudomonas aeruginosa toxin that hijacks the host ubiquitin proteolytic system. PLoS Pathog (2011) 1.22
Identification of superoxide dismutase as a cofactor for the pseudomonas type III toxin, ExoU. Biochemistry (2006) 1.18
Suppression of host innate immune response by Burkholderia pseudomallei through the virulence factor TssM. J Immunol (2010) 1.14
Ubiquitin and ubiquitin-modified proteins activate the Pseudomonas aeruginosa T3SS cytotoxin, ExoU. Mol Microbiol (2011) 1.13
Eukaryotic localization, activation and ubiquitinylation of a bacterial type III secreted toxin. Cell Microbiol (2006) 1.13
Pseudomonas aeruginosa exotoxin Y is a promiscuous cyclase that increases endothelial tau phosphorylation and permeability. J Biol Chem (2012) 1.08
Structural basis of cytotoxicity mediated by the type III secretion toxin ExoU from Pseudomonas aeruginosa. PLoS Pathog (2012) 1.00
Exploitation of the ubiquitin system by invading bacteria. Traffic (2010) 0.95
Five mechanisms of manipulation by bacterial effectors: a ubiquitous theme. PLoS Pathog (2012) 0.94
Activation of ExoU phospholipase activity requires specific C-terminal regions. J Bacteriol (2010) 0.92
Role of the membrane localization domain of the Pseudomonas aeruginosa effector protein ExoU in cytotoxicity. Infect Immun (2010) 0.91
The deubiquitinase activity of the Salmonella pathogenicity island 2 effector, SseL, prevents accumulation of cellular lipid droplets. Infect Immun (2011) 0.90
Structure of the type III secretion effector protein ExoU in complex with its chaperone SpcU. PLoS One (2012) 0.89
Induced conformational changes in the activation of the Pseudomonas aeruginosa type III toxin, ExoU. Biophys J (2011) 0.87
Phosphatidylinositol 4,5-bisphosphate is a novel coactivator of the Pseudomonas aeruginosa cytotoxin ExoU. Infect Immun (2013) 0.84
Bacterial effector-involved temporal and spatial regulation by hijack of the host ubiquitin pathway. Front Microbiol (2011) 0.80
Abscisic acid inhibits type 2C protein phosphatases via the PYR/PYL family of START proteins. Science (2009) 10.21
A gate-latch-lock mechanism for hormone signalling by abscisic acid receptors. Nature (2009) 3.63
The mechanism of action of the Pseudomonas aeruginosa-encoded type III cytotoxin, ExoU. EMBO J (2003) 3.10
Construction and characterization of a highly efficient Francisella shuttle plasmid. Appl Environ Microbiol (2004) 2.71
ExoU is a potent intracellular phospholipase. Mol Microbiol (2004) 2.71
Use of the Galleria mellonella caterpillar as a model host to study the role of the type III secretion system in Pseudomonas aeruginosa pathogenesis. Infect Immun (2003) 2.70
Structural basis of CXCR4 sulfotyrosine recognition by the chemokine SDF-1/CXCL12. Sci Signal (2008) 2.33
Project management system for structural and functional proteomics: Sesame. J Struct Funct Genomics (2003) 2.19
Interconversion between two unrelated protein folds in the lymphotactin native state. Proc Natl Acad Sci U S A (2008) 2.17
Unfolding of the C-terminal domain of the J-protein Zuo1 releases autoinhibition and activates Pdr1-dependent transcription. J Mol Biol (2012) 2.04
Cdc42 regulates the Par-6 PDZ domain through an allosteric CRIB-PDZ transition. Mol Cell (2004) 1.95
Crystal structure of the interferon-induced ubiquitin-like protein ISG15. J Biol Chem (2005) 1.93
Cell-free protein production and labeling protocol for NMR-based structural proteomics. Nat Methods (2004) 1.78
Methods and applications of site-directed spin labeling EPR spectroscopy. Methods Cell Biol (2008) 1.72
Structure of the N-WASP EVH1 domain-WIP complex: insight into the molecular basis of Wiskott-Aldrich Syndrome. Cell (2002) 1.70
Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer. J Biol Chem (2003) 1.68
Recognition of a CXCR4 sulfotyrosine by the chemokine stromal cell-derived factor-1alpha (SDF-1alpha/CXCL12). J Mol Biol (2006) 1.63
Peptide-membrane interactions and mechanisms of membrane destruction by amphipathic alpha-helical antimicrobial peptides. Biochim Biophys Acta (2006) 1.62
Serpin 2a is induced in activated macrophages and conjugates to a ubiquitin homolog. J Immunol (2002) 1.60
Elevated expression of ISG15 in tumor cells interferes with the ubiquitin/26S proteasome pathway. Cancer Res (2006) 1.59
Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways. Proc Natl Acad Sci U S A (2011) 1.58
The monomer-dimer equilibrium of stromal cell-derived factor-1 (CXCL 12) is altered by pH, phosphate, sulfate, and heparin. Protein Sci (2005) 1.57
Deubiquitinating function of adenovirus proteinase. J Virol (2002) 1.55
Protein interactions within the N-end rule ubiquitin ligation pathway. J Biol Chem (2003) 1.51
Altered dimer interface decreases stability in an amyloidogenic protein. J Biol Chem (2008) 1.50
Construction and characterization of an attenuated purine auxotroph in a Francisella tularensis live vaccine strain. Infect Immun (2006) 1.50
Identification of Francisella tularensis Himar1-based transposon mutants defective for replication in macrophages. Infect Immun (2007) 1.49
Heterodimer formation of the myeloid zinc finger 1 SCAN domain and association with promyelocytic leukemia nuclear bodies. Leuk Res (2008) 1.48
Activation of dimeric ABA receptors elicits guard cell closure, ABA-regulated gene expression, and drought tolerance. Proc Natl Acad Sci U S A (2013) 1.47
Structural basis for selective activation of ABA receptors. Nat Struct Mol Biol (2010) 1.43
Identification and characterization of a glycosaminoglycan recognition element of the C chemokine lymphotactin. J Biol Chem (2004) 1.42
Solution structure of a ubiquitin-like domain from tubulin-binding cofactor B. J Biol Chem (2004) 1.40
Acquisition and evolution of the exoU locus in Pseudomonas aeruginosa. J Bacteriol (2006) 1.40
A Francisella tularensis Schu S4 purine auxotroph is highly attenuated in mice but offers limited protection against homologous intranasal challenge. PLoS One (2008) 1.39
ISG15 Arg151 and the ISG15-conjugating enzyme UbE1L are important for innate immune control of Sindbis virus. J Virol (2008) 1.38
Structural rearrangement of human lymphotactin, a C chemokine, under physiological solution conditions. J Biol Chem (2002) 1.36
The NMR solution structure of BeF(3)(-)-activated Spo0F reveals the conformational switch in a phosphorelay system. J Mol Biol (2003) 1.32
Structural and functional insights into core ABA signaling. Curr Opin Plant Biol (2010) 1.29
Lys6-modified ubiquitin inhibits ubiquitin-dependent protein degradation. J Biol Chem (2005) 1.26
Nitric oxide inhibits H2O2-induced transferrin receptor-dependent apoptosis in endothelial cells: Role of ubiquitin-proteasome pathway. Proc Natl Acad Sci U S A (2003) 1.26
Identification, characterization and immunogenicity of an O-antigen capsular polysaccharide of Francisella tularensis. PLoS One (2010) 1.26
Comparison of cell-based and cell-free protocols for producing target proteins from the Arabidopsis thaliana genome for structural studies. Proteins (2005) 1.26
Deamidation, but not truncation, decreases the urea stability of a lens structural protein, betaB1-crystallin. Biochemistry (2002) 1.25
Structure-based ligand discovery for the protein-protein interface of chemokine receptor CXCR4. Proc Natl Acad Sci U S A (2012) 1.25
MdmX is a RING finger ubiquitin ligase capable of synergistically enhancing Mdm2 ubiquitination. J Biol Chem (2002) 1.24
Paradoxical cAMP-induced lung endothelial hyperpermeability revealed by Pseudomonas aeruginosa ExoY. Circ Res (2004) 1.24
The CXC chemokine receptor 4 ligands ubiquitin and stromal cell-derived factor-1α function through distinct receptor interactions. J Biol Chem (2011) 1.23
Characterization of phospholipase activity of the Pseudomonas aeruginosa type III cytotoxin, ExoU. J Bacteriol (2005) 1.23
Sequential tyrosine sulfation of CXCR4 by tyrosylprotein sulfotransferases. Biochemistry (2008) 1.20
Type IV pili in Francisella tularensis: roles of pilF and pilT in fiber assembly, host cell adherence, and virulence. Infect Immun (2008) 1.19
Identification of superoxide dismutase as a cofactor for the pseudomonas type III toxin, ExoU. Biochemistry (2006) 1.18
Macromolecular structure determination by NMR spectroscopy. Methods Biochem Anal (2003) 1.16
Potent and selective activation of abscisic acid receptors in vivo by mutational stabilization of their agonist-bound conformation. Proc Natl Acad Sci U S A (2011) 1.14
Ubiquitin and ubiquitin-modified proteins activate the Pseudomonas aeruginosa T3SS cytotoxin, ExoU. Mol Microbiol (2011) 1.13
Monomeric structure of the cardioprotective chemokine SDF-1/CXCL12. Protein Sci (2009) 1.13
Targeting SDF-1/CXCL12 with a ligand that prevents activation of CXCR4 through structure-based drug design. J Am Chem Soc (2010) 1.12
Orphan macrodomain protein (human C6orf130) is an O-acyl-ADP-ribose deacylase: solution structure and catalytic properties. J Biol Chem (2011) 1.12
Structure of the B3 domain from Arabidopsis thaliana protein At1g16640. Protein Sci (2005) 1.11
An engineered second disulfide bond restricts lymphotactin/XCL1 to a chemokine-like conformation with XCR1 agonist activity. Biochemistry (2007) 1.11
Solution structure of thioredoxin h1 from Arabidopsis thaliana. Protein Sci (2005) 1.07
Membrane binding, structure, and localization of cecropin-mellitin hybrid peptides: a site-directed spin-labeling study. Biophys J (2004) 1.06
On-column refolding of recombinant chemokines for NMR studies and biological assays. Protein Expr Purif (2006) 1.05
Pseudolipasin A is a specific inhibitor for phospholipase A2 activity of Pseudomonas aeruginosa cytotoxin ExoU. Infect Immun (2006) 1.04
Multi-Functional Characteristics of the Pseudomonas aeruginosa Type III Needle-Tip Protein, PcrV; Comparison to Orthologs in other Gram-negative Bacteria. Front Microbiol (2011) 1.03
ISG15 disrupts cytoskeletal architecture and promotes motility in human breast cancer cells. Exp Biol Med (Maywood) (2011) 1.03
A locked, dimeric CXCL12 variant effectively inhibits pulmonary metastasis of CXCR4-expressing melanoma cells due to enhanced serum stability. Mol Cancer Ther (2012) 1.02
Distal interactions within the par3-VE-cadherin complex. Biochemistry (2010) 1.00
A novel zinc finger is required for Mcm10 homocomplex assembly. J Biol Chem (2003) 1.00
Multiple WASP-interacting protein recognition motifs are required for a functional interaction with N-WASP. J Biol Chem (2007) 1.00
Pleiotropic effects of ATP.Mg2+ binding in the catalytic cycle of ubiquitin-activating enzyme. J Biol Chem (2006) 1.00
RANBP2 is an allosteric activator of the conventional kinesin-1 motor protein, KIF5B, in a minimal cell-free system. EMBO Rep (2009) 0.99
Membrane-anchoring and charge effects in the interaction of myelin basic protein with lipid bilayers studied by site-directed spin labeling. J Biol Chem (2003) 0.98