Published in Biochemistry on March 15, 2005
The interaction between C75 of tRNA and the A loop of the ribosome stimulates peptidyl transferase activity. RNA (2006) 1.53
A two-step chemical mechanism for ribosome-catalysed peptide bond formation. Nature (2011) 0.99
Rapid peptide bond formation on isolated 50S ribosomal subunits. EMBO Rep (2006) 0.98
Inaccuracies in selected ion monitoring determination of isotope ratios obviated by profile acquisition: nucleotide 18O/16O measurements. Anal Biochem (2007) 0.98
An uncharged amine in the transition state of the ribosomal peptidyl transfer reaction. Chem Biol (2008) 0.97
Different substrate-dependent transition states in the active site of the ribosome. Nature (2011) 0.96
The transition state for peptide bond formation reveals the ribosome as a water trap. Proc Natl Acad Sci U S A (2010) 0.93
Transition states of uncatalyzed hydrolysis and aminolysis reactions of a ribosomal P-site substrate determined by kinetic isotope effects. Biochemistry (2010) 0.88
The chemical versatility of RNA. Philos Trans R Soc Lond B Biol Sci (2011) 0.87
Synthesis of isotopically labeled P-site substrates for the ribosomal peptidyl transferase reaction. J Org Chem (2007) 0.86
Toward ribosomal RNA catalytic activity in the absence of protein. J Mol Evol (2007) 0.84
The nature of the dietary protein impacts the tissue-to-diet 15N discrimination factors in laboratory rats. PLoS One (2011) 0.82
Heavy atom labeled nucleotides for measurement of kinetic isotope effects. Biochim Biophys Acta (2015) 0.78
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Crystal structure of a self-splicing group I intron with both exons. Nature (2004) 3.92
Structural basis of ligand binding by a c-di-GMP riboswitch. Nat Struct Mol Biol (2009) 3.28
An induced-fit mechanism to promote peptide bond formation and exclude hydrolysis of peptidyl-tRNA. Nature (2005) 3.18
Structural investigation of the GlmS ribozyme bound to Its catalytic cofactor. Chem Biol (2006) 2.60
Substrate-assisted catalysis of peptide bond formation by the ribosome. Nat Struct Mol Biol (2004) 2.53
Structural insights into the roles of water and the 2' hydroxyl of the P site tRNA in the peptidyl transferase reaction. Mol Cell (2005) 2.49
A pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits. Nat Struct Biol (2002) 2.36
Structural evidence for a two-metal-ion mechanism of group I intron splicing. Science (2005) 2.05
Important contribution to catalysis of peptide bond formation by a single ionizing group within the ribosome. Mol Cell (2002) 1.91
Computational and theoretical methods to explore the relation between enzyme dynamics and catalysis. Chem Rev (2006) 1.74
Transition state structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli and its similarity to transition state analogues. Biochemistry (2005) 1.73
Catalytic strategies of self-cleaving ribozymes. Acc Chem Res (2008) 1.67
Exclusive interaction of the 15.5 kD protein with the terminal box C/D motif of a methylation guide snoRNP. Chem Biol (2002) 1.58
Crystal structure of a group I intron splicing intermediate. RNA (2004) 1.52
Competencies: a cure for pre-med curriculum. Science (2011) 1.47
Structural basis of cooperative ligand binding by the glycine riboswitch. Chem Biol (2011) 1.43
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Chemical basis of glycine riboswitch cooperativity. RNA (2007) 1.32
Structural basis of differential ligand recognition by two classes of bis-(3'-5')-cyclic dimeric guanosine monophosphate-binding riboswitches. Proc Natl Acad Sci U S A (2011) 1.28
Structural and chemical basis for glucosamine 6-phosphate binding and activation of the glmS ribozyme. Biochemistry (2009) 1.25
Ionization of a critical adenosine residue in the neurospora Varkud Satellite ribozyme active site. Biochemistry (2003) 1.24
IBI series winner. Student-directed discovery of the plant microbiome and its products. Science (2012) 1.24
Eukaryotic resistance to fluoride toxicity mediated by a widespread family of fluoride export proteins. Proc Natl Acad Sci U S A (2013) 1.22
RNA splicing: group I intron crystal structures reveal the basis of splice site selection and metal ion catalysis. Curr Opin Struct Biol (2006) 1.20
Molecular basis for RNA kink-turn recognition by the h15.5K small RNP protein. RNA (2005) 1.17
Differential analogue binding by two classes of c-di-GMP riboswitches. J Am Chem Soc (2011) 1.07
Uncovering the enzymatic pKa of the ribosomal peptidyl transferase reaction utilizing a fluorinated puromycin derivative. Biochemistry (2005) 1.06
Identification of an active site ligand for a group I ribozyme catalytic metal ion. Biochemistry (2002) 1.05
Identification of a tertiary interaction important for cooperative ligand binding by the glycine riboswitch. RNA (2010) 1.04
Biodegradation of polyester polyurethane by endophytic fungi. Appl Environ Microbiol (2011) 1.04
The 2'-OH group of the peptidyl-tRNA stabilizes an active conformation of the ribosomal PTC. EMBO J (2011) 1.04
Bioactive endophytes warrant intensified exploration and conservation. PLoS One (2008) 1.03
Participation of the tRNA A76 hydroxyl groups throughout translation. Biochemistry (2006) 1.01
Structural metals in the group I intron: a ribozyme with a multiple metal ion core. J Mol Biol (2007) 1.00
Human immunodeficiency virus-reverse transcriptase inhibition and hepatitis C virus RNA-dependent RNA polymerase inhibition activities of fullerene derivatives. Bioorg Med Chem Lett (2005) 1.00
A two-step chemical mechanism for ribosome-catalysed peptide bond formation. Nature (2011) 0.99
A relaxed active site after exon ligation by the group I intron. Proc Natl Acad Sci U S A (2008) 0.98
Catalytic importance of a protonated adenosine in the hairpin ribozyme active site. Biochemistry (2010) 0.98
Comparative analysis of hairpin ribozyme structures and interference data. Nucleic Acids Res (2002) 0.97
An uncharged amine in the transition state of the ribosomal peptidyl transfer reaction. Chem Biol (2008) 0.97
Assessment of scaffold hopping efficiency by use of molecular interaction fingerprints. J Med Chem (2008) 0.96
glmS Riboswitch binding to the glucosamine-6-phosphate α-anomer shifts the pKa toward neutrality. Biochemistry (2011) 0.96
pK(a) perturbation in genomic Hepatitis Delta Virus ribozyme catalysis evidenced by nucleotide analogue interference mapping. Biochemistry (2002) 0.94
Exploration of the conserved A+C wobble pair within the ribosomal peptidyl transferase center using affinity purified mutant ribosomes. Nucleic Acids Res (2004) 0.93
205Tl NMR methods for the characterization of monovalent cation binding to nucleic acids. J Am Chem Soc (2005) 0.92
Isolation, identification, and biological evaluation of HIF-1-modulating compounds from Brazilian green propolis. Bioorg Med Chem (2011) 0.92
Genomic analysis of the hydrocarbon-producing, cellulolytic, endophytic fungus Ascocoryne sarcoides. PLoS Genet (2012) 0.91
Riboswitch effectors as protein enzyme cofactors. RNA (2008) 0.91
Bacterial toxin RelE: a highly efficient ribonuclease with exquisite substrate specificity using atypical catalytic residues. Biochemistry (2013) 0.89
Crystallization and characterization of the thallium form of the Oxytricha nova G-quadruplex. Nucleic Acids Res (2006) 0.89
Transition states of uncatalyzed hydrolysis and aminolysis reactions of a ribosomal P-site substrate determined by kinetic isotope effects. Biochemistry (2010) 0.88
Nucleotide analog interference mapping. Methods Enzymol (2009) 0.87
Regiospecificity of the peptidyl tRNA ester within the ribosomal P site. J Am Chem Soc (2006) 0.87
The chemical versatility of RNA. Philos Trans R Soc Lond B Biol Sci (2011) 0.87
Fluorine substituted adenosines as probes of nucleobase protonation in functional RNAs. J Am Chem Soc (2008) 0.87
Synthesis of isotopically labeled P-site substrates for the ribosomal peptidyl transferase reaction. J Org Chem (2007) 0.86
Interactions of the c-di-GMP riboswitch with its second messenger ligand. Biochem Soc Trans (2011) 0.86
Synthesis of the ribosomal P-site substrate CCA-pcb. Org Lett (2006) 0.85
Identification of A-minor tertiary interactions within a bacterial group I intron active site by 3-deazaadenosine interference mapping. Biochemistry (2002) 0.85
Evidence against stabilization of the transition state oxyanion by a pKa-perturbed RNA base in the peptidyl transferase center. Proc Natl Acad Sci U S A (2002) 0.85
Volatile organic compound production by organisms in the genus Ascocoryne and a re-evaluation of myco-diesel production by NRRL 50072. Microbiology (2010) 0.85
Identification of c-di-GMP derivatives resistant to an EAL domain phosphodiesterase. Biochemistry (2013) 0.85
Toward ribosomal RNA catalytic activity in the absence of protein. J Mol Evol (2007) 0.84
Transition state chirality and role of the vicinal hydroxyl in the ribosomal peptidyl transferase reaction. Biochemistry (2008) 0.83
Plasticity of the RNA kink turn structural motif. RNA (2010) 0.83
Probing RNA structure and function by nucleotide analog interference mapping. Curr Protoc Nucleic Acid Chem (2004) 0.83
Respiratory chain inhibition by fullerene derivatives: hydrogen peroxide production caused by fullerene derivatives and a respiratory chain system. Bioorg Med Chem (2003) 0.81
Solid phase synthesis and binding affinity of peptidyl transferase transition state mimics containing 2'-OH at P-site position A76. Nucleic Acids Res (2004) 0.80
A new class of high-contrast Fe(II) selective fluorescent probes based on spirocyclized scaffolds for visualization of intracellular labile iron delivered by transferrin. Org Biomol Chem (2014) 0.80
Development of a hypoxia-selective near-infrared fluorescent probe for non-invasive tumor imaging. Chem Pharm Bull (Tokyo) (2012) 0.79
Nuclease-Resistant c-di-AMP Derivatives That Differentially Recognize RNA and Protein Receptors. Biochemistry (2016) 0.79
Quantitation of free energy profiles in RNA-ligand interactions by nucleotide analog interference mapping. RNA (2003) 0.79
Structural and biochemical characterization of linear dinucleotide analogues bound to the c-di-GMP-I aptamer. Biochemistry (2011) 0.79
Biosynthesis and genomic analysis of medium-chain hydrocarbon production by the endophytic fungal isolate Nigrograna mackinnonii E5202H. Appl Microbiol Biotechnol (2015) 0.79
Minimal transition state charge stabilization of the oxyanion during peptide bond formation by the ribosome. Biochemistry (2011) 0.79
FRET-based imaging of transbilayer movement of pepducin in living cells by novel intracellular bioreductively activatable fluorescent probes. Org Biomol Chem (2013) 0.79
The bacterial second messenger c-di-GMP: probing interactions with protein and RNA binding partners using cyclic dinucleotide analogs. Org Biomol Chem (2012) 0.79
Multiple, novel biologically active endophytic actinomycetes isolated from upper Amazonian rainforests. Microb Ecol (2009) 0.78
Analysis of enzymatic transacylase Brønsted studies with application to the ribosome. Acc Chem Res (2011) 0.78
Xyolide, a bioactive nonenolide from an Amazonian endophytic fungus, Xylaria feejeensis. Tetrahedron Lett (2013) 0.77
Exploring the mechanism of protein synthesis with modified substrates and novel intermediate mimics. Blood Cells Mol Dis (2006) 0.77
Effect of hexasulfobutylated C(60) on the isolated aortic ring of guinea pig. Pharmacology (2002) 0.77
Biosynthesis of hydrocarbons and volatile organic compounds by fungi: bioengineering potential. Appl Microbiol Biotechnol (2015) 0.76
Ribonucleic general acid. Nat Chem Biol (2005) 0.76
HIS & HERS, magic magnesium and the ballet of protein synthesis. Curr Opin Chem Biol (2003) 0.76
3-(2-Oxo-2,3,4,5-tetra-hydro-furan-3-yl)-1-benzofuran-2-carbonitrile. Acta Crystallogr Sect E Struct Rep Online (2012) 0.75
7-Chloro-1,2-dihydro-furo[2,3-c]isoquinolin-5-amine. Acta Crystallogr Sect E Struct Rep Online (2010) 0.75
Substituting a copper atom modifies the melting of aluminum clusters. J Chem Phys (2008) 0.75
[Prognostic factors for mortality related to nutritional status in the hospitalized elderly]. Med Clin (Barc) (2004) 0.75
Fusaric acid induces a notochord malformation in zebrafish via copper chelation. Biometals (2015) 0.75
Facile one-pot synthesis of [1, 2, 3]triazolo[1, 5-a]pyridines from 2-acylpyridines by copper(II)-catalyzed oxidative N-N bond formation. Chemistry (2014) 0.75
Nitrate and phosphate transporters rescue fluoride toxicity in yeast. Chem Res Toxicol (2019) 0.75
Synthesis and evaluation of cyclic RGD-boron cluster conjugates to develop tumor-selective boron carriers for boron neutron capture therapy. Bioorg Med Chem (2011) 0.75
Pyrrolocin A, a 3-Decalinoyltetramic Acid with Selective Biological Activity, Isolated from Amazonian Cultures of the Novel Endophyte Diaporthales sp. E6927E. Nat Prod Commun (2015) 0.75