Published in RNA on January 01, 2006
What recent ribosome structures have revealed about the mechanism of translation. Nature (2009) 4.01
The hybrid state of tRNA binding is an authentic translation elongation intermediate. Nat Struct Mol Biol (2006) 2.32
Quality control by the ribosome following peptide bond formation. Nature (2008) 2.15
Structure and dynamics of a processive Brownian motor: the translating ribosome. Annu Rev Biochem (2010) 1.84
RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA. J Am Chem Soc (2010) 1.60
A gripping tale of ribosomal frameshifting: extragenic suppressors of frameshift mutations spotlight P-site realignment. Microbiol Mol Biol Rev (2009) 1.50
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Two distinct components of release factor function uncovered by nucleophile partitioning analysis. Mol Cell (2007) 1.41
The Fic protein Doc uses an inverted substrate to phosphorylate and inactivate EF-Tu. Nat Chem Biol (2013) 1.33
pH-sensitivity of the ribosomal peptidyl transfer reaction dependent on the identity of the A-site aminoacyl-tRNA. Proc Natl Acad Sci U S A (2010) 1.23
rRNA mutants in the yeast peptidyltransferase center reveal allosteric information networks and mechanisms of drug resistance. Nucleic Acids Res (2008) 1.08
A structural view on the mechanism of the ribosome-catalyzed peptide bond formation. Biochim Biophys Acta (2009) 1.08
The 2'-OH group of the peptidyl-tRNA stabilizes an active conformation of the ribosomal PTC. EMBO J (2011) 1.04
Visualization of codon-dependent conformational rearrangements during translation termination. Nat Struct Mol Biol (2010) 0.99
Rapid peptide bond formation on isolated 50S ribosomal subunits. EMBO Rep (2006) 0.98
Further in vitro exploration fails to support the allosteric three-site model. J Biol Chem (2012) 0.97
Molecular dynamics simulations suggest that RNA three-way junctions can act as flexible RNA structural elements in the ribosome. Nucleic Acids Res (2010) 0.97
The transition state for formation of the peptide bond in the ribosome. Proc Natl Acad Sci U S A (2006) 0.97
The transition state for peptide bond formation reveals the ribosome as a water trap. Proc Natl Acad Sci U S A (2010) 0.93
Insights into the molecular determinants of EF-G catalyzed translocation. RNA (2011) 0.93
In vitro experimental system for analysis of transcription-translation coupling. Nucleic Acids Res (2011) 0.91
The role of SmpB and the ribosomal decoding center in licensing tmRNA entry into stalled ribosomes. RNA (2011) 0.90
Eukaryotic release factor 3 is required for multiple turnovers of peptide release catalysis by eukaryotic release factor 1. J Biol Chem (2013) 0.89
Large facilities and the evolving ribosome, the cellular machine for genetic-code translation. J R Soc Interface (2009) 0.88
Modulating the activity of the peptidyl transferase center of the ribosome. RNA (2008) 0.87
Distinct roles for release factor 1 and release factor 2 in translational quality control. J Biol Chem (2014) 0.83
An unusual mechanism for EF-Tu activation during tmRNA-mediated ribosome rescue. RNA (2013) 0.81
Peptidyl-CCA deacylation on the ribosome promoted by induced fit and the O3'-hydroxyl group of A76 of the unacylated A-site tRNA. RNA (2008) 0.79
Binding of Macrolide Antibiotics Leads to Ribosomal Selection against Specific Substrates Based on Their Charge and Size. Cell Rep (2016) 0.78
Activities of the peptidyl transferase center of ribosomes lacking protein L27. RNA (2015) 0.78
Exploring the mechanism of protein synthesis with modified substrates and novel intermediate mimics. Blood Cells Mol Dis (2006) 0.77
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Kinetic and thermodynamic studies of peptidyltransferase in ribosomes from the extreme thermophile Thermus thermophilus. RNA (2008) 0.76
Induced-fit of the peptidyl-transferase center of the ribosome and conformational freedom of the esterified amino acids. RNA (2016) 0.75
Translational roles of the C75 2'OH in an in vitro tRNA transcript at the ribosomal A, P and E sites. Sci Rep (2017) 0.75
The structural basis of ribosome activity in peptide bond synthesis. Science (2000) 18.82
X-ray crystal structures of 70S ribosome functional complexes. Science (1999) 10.51
Transfer RNA shields specific nucleotides in 16S ribosomal RNA from attack by chemical probes. Cell (1986) 4.65
An induced-fit mechanism to promote peptide bond formation and exclude hydrolysis of peptidyl-tRNA. Nature (2005) 3.18
The active site of the ribosome is composed of two layers of conserved nucleotides with distinct roles in peptide bond formation and peptide release. Cell (2004) 3.18
Substrate-assisted catalysis of peptide bond formation by the ribosome. Nat Struct Mol Biol (2004) 2.53
The ribosome as an entropy trap. Proc Natl Acad Sci U S A (2004) 2.40
A pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits. Nat Struct Biol (2002) 2.36
Interaction of translation initiation factor 3 with the 30S ribosomal subunit. Mol Cell (2001) 2.34
Base-pairing between 23S rRNA and tRNA in the ribosomal A site. Mol Cell (1999) 2.19
Important contribution to catalysis of peptide bond formation by a single ionizing group within the ribosome. Mol Cell (2002) 1.91
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Interaction of translation initiation factor IF1 with the E. coli ribosomal A site. J Mol Biol (2000) 1.31
pH-dependent conformational flexibility within the ribosomal peptidyl transferase center. RNA (2001) 1.29
The G2447A mutation does not affect ionization of a ribosomal group taking part in peptide bond formation. RNA (2003) 1.13
Kinetic isotope effect analysis of the ribosomal peptidyl transferase reaction. Biochemistry (2005) 1.09
Uncovering the enzymatic pKa of the ribosomal peptidyl transferase reaction utilizing a fluorinated puromycin derivative. Biochemistry (2005) 1.06
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Puromycin-rRNA interaction sites at the peptidyl transferase center. RNA (2000) 0.94
Exploration of the conserved A+C wobble pair within the ribosomal peptidyl transferase center using affinity purified mutant ribosomes. Nucleic Acids Res (2004) 0.93
Puromycin oligonucleotides reveal steric restrictions for ribosome entry and multiple modes of translation inhibition. RNA (2002) 0.89
The distribution and query systems of the RCSB Protein Data Bank. Nucleic Acids Res (2004) 7.03
miRNA-mediated gene silencing by translational repression followed by mRNA deadenylation and decay. Science (2012) 4.44
A parsimonious model for gene regulation by miRNAs. Science (2011) 3.79
Visualization of the hybrid state of tRNA binding promoted by spontaneous ratcheting of the ribosome. Mol Cell (2008) 3.58
An active role for tRNA in decoding beyond codon:anticodon pairing. Science (2005) 3.49
Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin. Nat Chem Biol (2010) 3.44
Distinct argonaute-mediated 22G-RNA pathways direct genome surveillance in the C. elegans germline. Mol Cell (2009) 3.43
The active site of the ribosome is composed of two layers of conserved nucleotides with distinct roles in peptide bond formation and peptide release. Cell (2004) 3.18
Hypusine-containing protein eIF5A promotes translation elongation. Nature (2009) 2.99
Fidelity at the molecular level: lessons from protein synthesis. Cell (2009) 2.65
Substrate-assisted catalysis of peptide bond formation by the ribosome. Nat Struct Mol Biol (2004) 2.53
The hybrid state of tRNA binding is an authentic translation elongation intermediate. Nat Struct Mol Biol (2006) 2.32
Dom34:Hbs1 promotes subunit dissociation and peptidyl-tRNA drop-off to initiate no-go decay. Science (2010) 2.19
Quality control by the ribosome following peptide bond formation. Nature (2008) 2.15
A genomewide screen for components of the RNAi pathway in Drosophila cultured cells. Proc Natl Acad Sci U S A (2006) 2.04
Translation drives mRNA quality control. Nat Struct Mol Biol (2012) 1.97
Structural basis of highly conserved ribosome recycling in eukaryotes and archaea. Nature (2012) 1.86
Stop codon recognition by release factors induces structural rearrangement of the ribosomal decoding center that is productive for peptide release. Mol Cell (2007) 1.80
Kinetic analysis reveals the ordered coupling of translation termination and ribosome recycling in yeast. Proc Natl Acad Sci U S A (2011) 1.78
The elongation, termination, and recycling phases of translation in eukaryotes. Cold Spring Harb Perspect Biol (2012) 1.73
Sequential rounds of RNA-dependent RNA transcription drive endogenous small-RNA biogenesis in the ERGO-1/Argonaute pathway. Proc Natl Acad Sci U S A (2010) 1.72
Ribosomal proteins S12 and S13 function as control elements for translocation of the mRNA:tRNA complex. Mol Cell (2003) 1.71
CapSeq and CIP-TAP identify Pol II start sites and reveal capped small RNAs as C. elegans piRNA precursors. Cell (2012) 1.61
Peptide release on the ribosome: mechanism and implications for translational control. Annu Rev Microbiol (2008) 1.48
Mutational analysis of S12 protein and implications for the accuracy of decoding by the ribosome. J Mol Biol (2007) 1.45
Structural characterization of mRNA-tRNA translocation intermediates. Proc Natl Acad Sci U S A (2012) 1.42
Nevirapine plus efavirenz plus didanosine: a simple, safe, and effective once-daily regimen for patients with HIV infection. J Natl Med Assoc (2003) 1.41
Two distinct components of release factor function uncovered by nucleophile partitioning analysis. Mol Cell (2007) 1.41
Allosteric regulation of Argonaute proteins by miRNAs. Nat Struct Mol Biol (2010) 1.40
Affinity purification of in vivo-assembled ribosomes for in vitro biochemical analysis. Methods (2005) 1.37
Analysis of Dom34 and its function in no-go decay. Mol Biol Cell (2009) 1.37
Mutational analysis reveals two independent molecular requirements during transfer RNA selection on the ribosome. Nat Struct Mol Biol (2006) 1.33
Hyperaccurate and error-prone ribosomes exploit distinct mechanisms during tRNA selection. Mol Cell (2010) 1.32
Multiple effects of S13 in modulating the strength of intersubunit interactions in the ribosome during translation. J Mol Biol (2005) 1.31
EFG-independent translocation of the mRNA:tRNA complex is promoted by modification of the ribosome with thiol-specific reagents. J Mol Biol (2002) 1.24
Ribosomal biogenesis genes play an essential and p53-independent role in zebrafish pancreas development. Development (2012) 1.22
Recognition of aminoacyl-tRNA: a common molecular mechanism revealed by cryo-EM. EMBO J (2008) 1.21
Peptide release on the ribosome depends critically on the 2' OH of the peptidyl-tRNA substrate. RNA (2008) 1.19
An expanded seed sequence definition accounts for full regulation of the hid 3' UTR by bantam miRNA. RNA (2009) 1.17
Transformation of aminoacyl tRNAs for the in vitro selection of "drug-like" molecules. Chem Biol (2004) 1.13
RNA chaperone activity of large ribosomal subunit proteins from Escherichia coli. RNA (2004) 1.11
Fidelity in protein synthesis. Curr Biol (2005) 1.09
Structural insights into cognate versus near-cognate discrimination during decoding. EMBO J (2011) 1.07
RNA-based regulation in the plant circadian clock. Trends Plant Sci (2011) 1.05
The 2'-OH group of the peptidyl-tRNA stabilizes an active conformation of the ribosomal PTC. EMBO J (2011) 1.04
A primary role for release factor 3 in quality control during translation elongation in Escherichia coli. Cell (2011) 1.01
Osmolytes stimulate the reconstitution of functional 50S ribosomes from in vitro transcripts of Escherichia coli 23S rRNA. RNA (2002) 1.00
Visualization of codon-dependent conformational rearrangements during translation termination. Nat Struct Mol Biol (2010) 0.99
Regulation of Argonaute slicer activity by guide RNA 3' end interactions with the N-terminal lobe. J Biol Chem (2013) 0.98
Further in vitro exploration fails to support the allosteric three-site model. J Biol Chem (2012) 0.97
Distinct response of yeast ribosomes to a miscoding event during translation. RNA (2011) 0.96
Recommendations on bioanalytical method stability implications of co-administered and co-formulated drugs by Global CRO Council for Bioanalysis (GCC). Bioanalysis (2012) 0.94
Helix 69 is key for uniformity during substrate selection on the ribosome. J Biol Chem (2011) 0.91
Kinetic basis for global loss of fidelity arising from mismatches in the P-site codon:anticodon helix. RNA (2010) 0.90
The role of SmpB and the ribosomal decoding center in licensing tmRNA entry into stalled ribosomes. RNA (2011) 0.90
Dom34-Hbs1 mediated dissociation of inactive 80S ribosomes promotes restart of translation after stress. EMBO J (2014) 0.89
Isolation of antibiotic resistance mutations in the rRNA by using an in vitro selection system. Proc Natl Acad Sci U S A (2004) 0.89
Infection frequently triggers thrombotic microangiopathy in patients with preexisting risk factors: a single-institution experience. J Clin Apher (2010) 0.89
Eukaryotic release factor 3 is required for multiple turnovers of peptide release catalysis by eukaryotic release factor 1. J Biol Chem (2013) 0.89
Functional elucidation of a key contact between tRNA and the large ribosomal subunit rRNA during decoding. RNA (2010) 0.88
Ribosomal translocation: sparsomycin pushes the button. Curr Biol (2003) 0.88
RF3:GTP promotes rapid dissociation of the class 1 termination factor. RNA (2014) 0.87
Wobble during decoding: more than third-position promiscuity. Nat Struct Mol Biol (2004) 0.85
Inhibition of eukaryotic translation elongation by the antitumor natural product Mycalamide B. RNA (2011) 0.85
The psychosocial aspects of donating blood stem cells: the sibling donor perspective. J Clin Apher (2003) 0.85
Sitagliptin, sitagliptin and metformin, or sitagliptin and amitriptyline attenuate streptozotocin-nicotinamide induced diabetic neuropathy in rats. J Biomed Res (2012) 0.84
Extracorporeal photopheresis improves nephrogenic fibrosing dermopathy/nephrogenic systemic fibrosis: three case reports and review of literature. J Clin Apher (2008) 0.82
Epicardial adipose tissue thickness as a predictor of impaired microvascular function in patients with non-obstructive coronary artery disease. J Nucl Cardiol (2013) 0.82
In vitro transcription from plasmid or PCR-amplified DNA. Methods Enzymol (2013) 0.81
Dynamic organization of transcription compartments is dependent on functional nuclear architecture. Biophys J (2012) 0.81
Efficient asymmetric synthesis of chiral hydroxy-gamma-butyrolactones. Org Lett (2009) 0.80
Early results of cataract surgery at mechi eye care centre in Nepal. Community Eye Health (2002) 0.80
Structural analysis of RNA backbone using in-line probing. Methods Enzymol (2013) 0.79
Direct early identification of Mycobacterium tuberculosis by PCR-restriction fragment length polymorphism analysis from clinical samples. Jpn J Infect Dis (2010) 0.79
Peliosis hepatis presenting as hemoperitoneum. Indian J Med Sci (2008) 0.79
Recommendations on biomarker bioanalytical method validation by GCC. Bioanalysis (2012) 0.79
Biochemistry. Getting past polyproline pauses. Science (2013) 0.79
Polysome analysis of mammalian cells. Methods Enzymol (2013) 0.78
An artificial molecular switch that mimics the visual pigment and completes its photocycle in picoseconds. Proc Natl Acad Sci U S A (2008) 0.78
Recommendations on the interpretation of the new European Medicines Agency Guideline on Bioanalytical Method Validation by Global CRO Council for Bioanalysis (GCC). Bioanalysis (2012) 0.78
Ribosomal translocation: LepA does it backwards. Curr Biol (2007) 0.78
High affinity ligands for the alpha7 nicotinic receptor that show no cross-reactivity with the 5-HT3 receptor. Bioorg Med Chem Lett (2005) 0.78
A Role for the 2' OH of peptidyl-tRNA substrate in peptide release on the ribosome revealed through RF-mediated rescue. Chem Biol (2012) 0.77
Toll like receptor 2 and 4 polymorphisms in malaria endemic populations of India. Hum Immunol (2012) 0.76
Genotyping-by-Sequencing Analysis for Determining Population Structure of Finger Millet Germplasm of Diverse Origins. Plant Genome (2016) 0.76
Another burst of smoke: atomic resolution structures of RF3 bound to the ribosome. RNA (2012) 0.75
Clinical audit of health promotion of vitamin D in one general practice. Asia Pac Fam Med (2012) 0.75
Northern blotting. Methods Enzymol (2013) 0.75
Current surgical management of basal cell carcinoma: a half-way technology? Skinmed (2014) 0.75
Cardioprotective activity of alcoholic extract of Tinospora cordifolia (Willd.) Miers in calcium chloride-induced cardiac arrhythmia in rats. J Biomed Res (2011) 0.75
Bilosomes: A Novel Approach to Meet the Challenges in Oral Immunization. Recent Pat Drug Deliv Formul (2015) 0.75
The survive and thrive program: encouraging coaching, mentoring, and peer learning among new local health officials. J Public Health Manag Pract (2010) 0.75
Corrigendum: Rapid generation of hypomorphic mutations. Nat Commun (2017) 0.75
Anti-Aging Effects of Probiotics. J Drugs Dermatol (2016) 0.75
Synthesis and Characterization of Fatty Acid Grafted Chitosan Polymer and their Nanomicelles for Non-Viral Gene Delivery Applications. Bioconjug Chem (2017) 0.75
Catalase and sodium fluoride mediated rehabilitation of enamel bleached with 37% hydrogen peroxide. J Indian Soc Pedod Prev Dent (2015) 0.75