Published in Biochim Biophys Acta on February 11, 2010
Mitochondria and cancer. Nat Rev Cancer (2012) 4.81
Mitochondrial retrograde signaling at the crossroads of tumor bioenergetics, genetics and epigenetics. Mitochondrion (2013) 1.17
Mitochondrial retrograde signaling induces epithelial-mesenchymal transition and generates breast cancer stem cells. Oncogene (2013) 0.98
Heterogeneous nuclear ribonucleoprotein A2 participates in the replication of Japanese encephalitis virus through an interaction with viral proteins and RNA. J Virol (2011) 0.97
Mitochondria Retrograde Signaling and the UPR mt: Where Are We in Mammals? Int J Mol Sci (2015) 0.87
The emergence of the mitochondrial genome as a partial regulator of nuclear function is providing new insights into the genetic mechanisms underlying age-related complex disease. Hum Genet (2013) 0.83
Silencing of IkBβ mRNA causes disruption of mitochondrial retrograde signaling and suppression of tumor growth in vivo. Carcinogenesis (2012) 0.81
Nitric oxide and calcium participate in the fine regulation of mitochondrial biogenesis in follicular thyroid carcinoma cells. J Biol Chem (2011) 0.80
Enhanced osteoclastogenesis by mitochondrial retrograde signaling through transcriptional activation of the cathepsin K gene. Ann N Y Acad Sci (2015) 0.78
HNRNPA1 interacts with a 5'-flanking distal element of interleukin-6 and upregulates its basal transcription. Genes Immun (2013) 0.77
Roles of Mitochondrial DNA Changes on Cancer Initiation and Progression. Cell Biol (Henderson, NV) (2012) 0.77
Calcineurin/nuclear factor-κB signaling mediates isoflurane-induced hippocampal neuroinflammation and subsequent cognitive impairment in aged rats. Mol Med Rep (2016) 0.76
Mitochondrial dysfunction and mitochondrial dynamics-The cancer connection. Biochim Biophys Acta (2017) 0.76
Calcium channel regulator Mid1 links TORC2-mediated changes in mitochondrial respiration to autophagy. J Cell Biol (2016) 0.75
HnRNPA2 is a novel histone acetyltransferase that mediates mitochondrial stress-induced nuclear gene expression. Cell Discov (2016) 0.75
Defining the momiome: Promiscuous information transfer by mobile mitochondria and the mitochondrial genome. Semin Cancer Biol (2017) 0.75
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res (1983) 124.30
Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science (2009) 49.82
The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab (2008) 18.87
A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu Rev Genet (2005) 16.79
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature (2006) 15.69
A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell (1998) 13.56
hnRNP proteins and the biogenesis of mRNA. Annu Rev Biochem (1993) 11.44
Genetic pathways that regulate ageing in model organisms. Nature (2000) 8.19
Decoding of cytosolic calcium oscillations in the mitochondria. Cell (1995) 7.31
Microdomains with high Ca2+ close to IP3-sensitive channels that are sensed by neighboring mitochondria. Science (1993) 6.29
FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin. Nature (1992) 5.75
Mitochondrial signaling: the retrograde response. Mol Cell (2004) 4.21
TDP-43 binds heterogeneous nuclear ribonucleoprotein A/B through its C-terminal tail: an important region for the inhibition of cystic fibrosis transmembrane conductance regulator exon 9 splicing. J Biol Chem (2005) 3.99
A mitochondrial specific stress response in mammalian cells. EMBO J (2002) 3.95
hnRNP K: an HDM2 target and transcriptional coactivator of p53 in response to DNA damage. Cell (2005) 3.18
Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redox-mediated mechanism. J Cell Biol (2006) 2.68
Retrograde Ca2+ signaling in C2C12 skeletal myocytes in response to mitochondrial genetic and metabolic stress: a novel mode of inter-organelle crosstalk. EMBO J (1999) 2.62
Mitochondria-to-nucleus stress signaling induces phenotypic changes, tumor progression and cell invasion. EMBO J (2001) 2.30
CIITA is a transcriptional coactivator that is recruited to MHC class II promoters by multiple synergistic interactions with an enhanceosome complex. Genes Dev (2000) 2.19
Detection of mitochondrial DNA mutations in primary breast cancer and fine-needle aspirates. Cancer Res (2001) 1.98
Mitochondrial stress-induced calcium signaling, phenotypic changes and invasive behavior in human lung carcinoma A549 cells. Oncogene (2002) 1.95
Positive contribution of pathogenic mutations in the mitochondrial genome to the promotion of cancer by prevention from apoptosis. Cancer Res (2005) 1.90
Oxidative stress induces degradation of mitochondrial DNA. Nucleic Acids Res (2009) 1.73
Mitochondria to nucleus stress signaling: a distinctive mechanism of NFkappaB/Rel activation through calcineurin-mediated inactivation of IkappaBbeta. J Cell Biol (2003) 1.69
The tumor metabolome. Anticancer Res (2003) 1.68
Energy metabolism of tumor cells. Requirement for a form of hexokinase with a propensity for mitochondrial binding. J Biol Chem (1981) 1.63
Small interfering RNA-mediated reduction in heterogeneous nuclear ribonucleoparticule A1/A2 proteins induces apoptosis in human cancer cells but not in normal mortal cell lines. Cancer Res (2003) 1.62
CREB activation induced by mitochondrial dysfunction is a new signaling pathway that impairs cell proliferation. EMBO J (2002) 1.55
Calcineurin functions in Ca(2+)-activated cell death in mammalian cells. J Cell Biol (1995) 1.55
Lack of oxidative phosphorylation and low mitochondrial membrane potential decrease susceptibility to apoptosis and do not modulate the protective effect of Bcl-x(L) in osteosarcoma cells. J Biol Chem (2000) 1.55
mtDNA depletion myopathy: elucidation of the tissue specificity in the mitochondrial thymidine kinase (TK2) deficiency. Mol Genet Metab (2003) 1.52
Decrease of mitochondrial DNA content and energy metabolism in renal cell carcinoma. Carcinogenesis (2004) 1.50
The calcium cycle of mitochondria. FEBS Lett (1979) 1.48
Differential effects of constitutively active phosphatidylinositol 3-kinase on glucose transport, glycogen synthase activity, and DNA synthesis in 3T3-L1 adipocytes. Mol Cell Biol (1997) 1.44
RTG-dependent mitochondria to nucleus signaling is negatively regulated by the seven WD-repeat protein Lst8p. EMBO J (2001) 1.27
Mitochondrial DNA depletion in prostate epithelial cells promotes anoikis resistance and invasion through activation of PI3K/Akt2. Cell Death Differ (2008) 1.22
Nuclear genes involved in mitochondria-to-nucleus communication in breast cancer cells. Mol Cancer (2002) 1.16
Activation of a novel calcineurin-mediated insulin-like growth factor-1 receptor pathway, altered metabolism, and tumor cell invasion in cells subjected to mitochondrial respiratory stress. J Biol Chem (2007) 1.16
The insulin receptor: structure, function, and signaling. Am J Physiol (1994) 1.16
Dioxin-mediated tumor progression through activation of mitochondria-to-nucleus stress signaling. Proc Natl Acad Sci U S A (2008) 1.15
Suppression by cathepsin L inhibitors of the invasion of amnion membranes by murine cancer cells. Cancer Res (1989) 1.11
A distinctive physiological role for IkappaBbeta in the propagation of mitochondrial respiratory stress signaling. J Biol Chem (2008) 1.10
hnRNP A2, a potential ssDNA/RNA molecular adapter at the telomere. Nucleic Acids Res (2005) 1.06
Heterogeneous nuclear ribonucleoprotein A2 is a common transcriptional coactivator in the nuclear transcription response to mitochondrial respiratory stress. Mol Biol Cell (2009) 1.04
The microtubule-associated protein tumor overexpressed gene binds to the RNA trafficking protein heterogeneous nuclear ribonucleoprotein A2. Mol Biol Cell (2005) 1.03
Mechanism of mitochondrial stress-induced resistance to apoptosis in mitochondrial DNA-depleted C2C12 myocytes. Cell Death Differ (2005) 1.03
Nuclear Akt interacts with B23/NPM and protects it from proteolytic cleavage, enhancing cell survival. Proc Natl Acad Sci U S A (2008) 1.02
A role for the serine/threonine kinase, Akt, in insulin-stimulated glucose uptake. Biochem Soc Trans (1997) 1.02
Skeletal muscle gene expression profiling in mitochondrial disorders. FASEB J (2005) 0.98
Distinct nuclear gene expression profiles in cells with mtDNA depletion and homoplasmic A3243G mutation. Mutat Res (2005) 0.95
Heterogeneous nuclear ribonucleoprotein A2 interacts with protein kinase CK2. Biochem Biophys Res Commun (1999) 0.94
Expression and regulation of the human GLUT4/muscle-fat facilitative glucose transporter gene in transgenic mice. J Biol Chem (1992) 0.94
Hypoxic coordinate regulation of mitochondrial enzymes in mammalian cells. Science (1984) 0.92
Hypoxia-mediated mitochondrial stress in RAW264.7 cells induces osteoclast-like TRAP-positive cells. Ann N Y Acad Sci (2007) 0.88
Inhibitory role for calcineurin in stimulus-secretion coupling revealed by FK506 and cyclosporin A in pituitary corticotrope tumor cells. Biochem Biophys Res Commun (1993) 0.86
Heterogeneous nuclear ribonucleoprotein A2 is a SET-binding protein and a PP2A inhibitor. Oncogene (2006) 0.85
Expression of hnRNP A2/B1 proteins in human cancer cell lines. Int J Oncol (2000) 0.84
Proteomic analysis of SET-binding proteins. Proteomics (2007) 0.82
Mitochondrial DNA mutations in disease and ageing. Novartis Found Symp (2001) 0.81
Mitochondrial signaling: the retrograde response. Mol Cell (2004) 4.21
Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction. J Neurosci (2006) 3.00
Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain. J Biol Chem (2008) 2.53
Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells. J Cell Biol (2003) 2.32
SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor. EMBO J (2003) 2.16
Changes in the middle region of Sup35 profoundly alter the nature of epigenetic inheritance for the yeast prion [PSI+]. Proc Natl Acad Sci U S A (2002) 2.15
Mitochondrial stress-induced calcium signaling, phenotypic changes and invasive behavior in human lung carcinoma A549 cells. Oncogene (2002) 1.95
Mitochondria to nucleus stress signaling: a distinctive mechanism of NFkappaB/Rel activation through calcineurin-mediated inactivation of IkappaBbeta. J Cell Biol (2003) 1.69
Protein kinase A-mediated phosphorylation modulates cytochrome c oxidase function and augments hypoxia and myocardial ischemia-related injury. J Biol Chem (2005) 1.66
Modeling kinetic rate variation in third generation DNA sequencing data to detect putative modifications to DNA bases. Genome Res (2012) 1.59
Mitochondrial tRNA(Phe) mutation as a cause of end-stage renal disease in childhood. Pediatr Nephrol (2012) 1.56
Smoke carcinogens cause bone loss through the aryl hydrocarbon receptor and induction of Cyp1 enzymes. Proc Natl Acad Sci U S A (2013) 1.54
Cytochrome c oxidase dysfunction in oxidative stress. Free Radic Biol Med (2012) 1.52
Phosphorylation enhances mitochondrial targeting of GSTA4-4 through increased affinity for binding to cytoplasmic Hsp70. J Biol Chem (2003) 1.51
Bimodal targeting of microsomal CYP2E1 to mitochondria through activation of an N-terminal chimeric signal by cAMP-mediated phosphorylation. J Biol Chem (2002) 1.45
Cytochrome c-mediated oxidation of hydroethidine and mito-hydroethidine in mitochondria: identification of homo- and heterodimers. Free Radic Biol Med (2007) 1.34
Negative regulation of prolactin receptor stability and signaling mediated by SCF(beta-TrCP) E3 ubiquitin ligase. Mol Cell Biol (2004) 1.34
Multiple isoforms of mitochondrial glutathione S-transferases and their differential induction under oxidative stress. Biochem J (2002) 1.32
Doxorubicin inactivates myocardial cytochrome c oxidase in rats: cardioprotection by Mito-Q. Biophys J (2009) 1.28
Elevated mitochondrial cytochrome P450 2E1 and glutathione S-transferase A4-4 in streptozotocin-induced diabetic rats: tissue-specific variations and roles in oxidative stress. Diabetes (2004) 1.26
Competitive and noncompetitive inhibition of myocardial cytochrome C oxidase in sepsis. Shock (2004) 1.20
Mutations in FBXL4, encoding a mitochondrial protein, cause early-onset mitochondrial encephalomyopathy. Am J Hum Genet (2013) 1.18
Mitochondrial retrograde signaling at the crossroads of tumor bioenergetics, genetics and epigenetics. Mitochondrion (2013) 1.17
Activation of a novel calcineurin-mediated insulin-like growth factor-1 receptor pathway, altered metabolism, and tumor cell invasion in cells subjected to mitochondrial respiratory stress. J Biol Chem (2007) 1.16
Dioxin-mediated tumor progression through activation of mitochondria-to-nucleus stress signaling. Proc Natl Acad Sci U S A (2008) 1.15
Leucine-rich pentatricopeptide-repeat containing protein regulates mitochondrial transcription. Biochemistry (2010) 1.13
Role of nuclear-encoded subunit Vb in the assembly and stability of cytochrome c oxidase complex: implications in mitochondrial dysfunction and ROS production. Biochem J (2009) 1.13
Site specific phosphorylation of cytochrome c oxidase subunits I, IVi1 and Vb in rabbit hearts subjected to ischemia/reperfusion. FEBS Lett (2007) 1.11
Induction of homologue of Slimb ubiquitin ligase receptor by mitogen signaling. J Biol Chem (2002) 1.11
A distinctive physiological role for IkappaBbeta in the propagation of mitochondrial respiratory stress signaling. J Biol Chem (2008) 1.10
Oncogene-mediated inhibition of glycogen synthase kinase 3 beta impairs degradation of prolactin receptor. Cancer Res (2008) 1.06
Mitochondria-targeted cytochrome P450 2E1 induces oxidative damage and augments alcohol-mediated oxidative stress. J Biol Chem (2010) 1.05
Heterogeneous nuclear ribonucleoprotein A2 is a common transcriptional coactivator in the nuclear transcription response to mitochondrial respiratory stress. Mol Biol Cell (2009) 1.04
Modulation of mitochondrial metabolic function by phorbol 12-myristate 13-acetate through increased mitochondrial translocation of protein kinase Calpha in C2C12 myocytes. Biochem Pharmacol (2006) 1.02
Inhibition of HOS expression and activities by Wnt pathway. Oncogene (2002) 1.00
Activation of Akt is essential for the propagation of mitochondrial respiratory stress signaling and activation of the transcriptional coactivator heterogeneous ribonucleoprotein A2. Mol Biol Cell (2010) 1.00
High-dose continuous renal replacement therapy for neonatal hyperammonemia. Pediatr Nephrol (2013) 1.00
Bimodal protein targeting through activation of cryptic mitochondrial targeting signals by an inducible cytosolic endoprotease. Mol Cell (2008) 0.99
Knock-in mouse lines expressing either mitochondrial or microsomal CYP1A1: differing responses to dietary benzo[a]pyrene as proof of principle. Mol Pharmacol (2008) 0.98
Impaired mitochondrial respiratory functions and oxidative stress in streptozotocin-induced diabetic rats. Int J Mol Sci (2011) 0.95
Role of mitochondrial reactive oxygen species in osteoclast differentiation. Ann N Y Acad Sci (2010) 0.95
Differences in activity of cytochrome C oxidase in brain between sleep and wakefulness. Sleep (2005) 0.95
beta1-Adrenoreceptor activation contributes to ischemia-reperfusion damage as well as playing a role in ischemic preconditioning. Am J Physiol Heart Circ Physiol (2007) 0.94
Mitochondrial respiratory chain disease discrimination by retrospective cohort analysis of blood metabolites. Mol Genet Metab (2013) 0.93
Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors. J Clin Invest (2016) 0.93
Adaptive changes in the expression of nuclear and mitochondrial encoded subunits of cytochrome c oxidase and the catalytic activity during hypoxia. Eur J Biochem (2003) 0.93
Mutation in the mitochondrial tRNA(Val) causes mitochondrial encephalopathy, lactic acidosis and stroke-like episodes. Mitochondrion (2011) 0.92
Role of protein kinase C-mediated protein phosphorylation in mitochondrial translocation of mouse CYP1A1, which contains a non-canonical targeting signal. J Biol Chem (2006) 0.91
Transcriptional requirements of the distal heavy-strand promoter of mtDNA. Proc Natl Acad Sci U S A (2012) 0.89
Transcription termination at the mouse mitochondrial H-strand promoter distal site requires an A/T rich sequence motif and sequence specific DNA binding proteins. Eur J Biochem (2003) 0.89
A novel mechanism for coupling cellular intermediary metabolism to cytosolic Ca2+ signaling via CD38/ADP-ribosyl cyclase, a putative intracellular NAD+ sensor. FASEB J (2002) 0.89
Mitochondrial targeting of cytochrome P450 (CYP) 1B1 and its role in polycyclic aromatic hydrocarbon-induced mitochondrial dysfunction. J Biol Chem (2014) 0.89
Hypoxia-mediated mitochondrial stress in RAW264.7 cells induces osteoclast-like TRAP-positive cells. Ann N Y Acad Sci (2007) 0.88
Human liver mitochondrial cytochrome P450 2D6--individual variations and implications in drug metabolism. FEBS J (2009) 0.88
Triggering ubiquitination of IFNAR1 protects tissues from inflammatory injury. EMBO Mol Med (2014) 0.87
Bimodal targeting of microsomal cytochrome P450s to mitochondria: implications in drug metabolism and toxicity. Expert Opin Drug Metab Toxicol (2010) 0.87
Oxidative stress induced mitochondrial protein kinase A mediates cytochrome c oxidase dysfunction. PLoS One (2013) 0.86
Identification of genetic variants of human cytochrome P450 2D6 with impaired mitochondrial targeting. Mol Genet Metab (2010) 0.84
Complex management of a patient with a contiguous Xp11.4 gene deletion involving ornithine transcarbamylase: a role for detailed molecular analysis in complex presentations of classical diseases. Mol Genet Metab (2008) 0.84
Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by mitochondrion-targeted cytochrome P450 2D6: implications in Parkinson disease. J Biol Chem (2012) 0.84
Mitochondrial targeting of cytochrome P450 proteins containing NH2-terminal chimeric signals involves an unusual TOM20/TOM22 bypass mechanism. J Biol Chem (2009) 0.83
Mitochondrial genetic diseases. Curr Opin Pediatr (2010) 0.83
Additive effects of mitochondrion-targeted cytochrome CYP2E1 and alcohol toxicity on cytochrome c oxidase function and stability of respirosome complexes. J Biol Chem (2012) 0.82
Human cytochrome P450 2E1 mutations that alter mitochondrial targeting efficiency and susceptibility to ethanol-induced toxicity in cellular models. J Biol Chem (2013) 0.82
Improving surveillance for hyperammonemia in the newborn. Mol Genet Metab (2013) 0.81
Silencing of IkBβ mRNA causes disruption of mitochondrial retrograde signaling and suppression of tumor growth in vivo. Carcinogenesis (2012) 0.81
The effects of smoke carcinogens on bone. Curr Osteoporos Rep (2011) 0.78
Retracted An unusual TOM20/TOM22 bypass mechanism for the mitochondrial targeting of cytochrome P450 proteins containing N-terminal chimeric signals. J Biol Chem (2008) 0.76
Newborn screening by sequence and the road ahead. Clin Chem (2013) 0.75
Mitochondrial dysfunction in myocardium obtained from clinically normal dogs, clinically normal anesthetized dogs, and dogs with dilated cardiomyopathy. Am J Vet Res (2012) 0.75
Increased C3-carnitine in a healthy premature infant. Clin Chem (2008) 0.75
The value of the metabolic autopsy in the pediatric hospital setting. J Pediatr (2006) 0.75
An unusual TOM20/TOM22 bypass mechanism for the mitochondrial targeting of cytochrome P450 proteins containing N-terminal chimeric signals. J Biol Chem (2008) 0.75
Cell signaling. Ann N Y Acad Sci (2010) 0.75