MGMT gene silencing and benefit from temozolomide in glioblastoma.

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🔗 View Article (PMID 15758010)

Published in N Engl J Med on March 10, 2005

Authors

Monika E Hegi1, Annie-Claire Diserens, Thierry Gorlia, Marie-France Hamou, Nicolas de Tribolet, Michael Weller, Johan M Kros, Johannes A Hainfellner, Warren Mason, Luigi Mariani, Jacoline E C Bromberg, Peter Hau, René O Mirimanoff, J Gregory Cairncross, Robert C Janzer, Roger Stupp

Author Affiliations

1: Laboratory of Tumor Biology and Genetics, Department of Neurosurgery, University Hospital Lausanne, Lausanne, Switzerland. monika.hegi@chuv.hospvd.ch

Associated clinical trials:

Comparison of Different Methods to Test MGMT Status in Glioblastoma Patients (ECOM) | NCT01345370

Proton Chemoradiotherapy for High-Risk Soft Tissue Sarcomas (SA02) | NCT00881595

Assessment of MGMT Promoter Methylation in Advanced Ewing Sarcoma Treated With Temozolomide and Irinotecan (MGMTLiberati) | NCT03542097

5FU/LV, Irinotecan, Temozolomide and Bevacizumab for MGMT Silenced, Microsatellite Stable Metastatic Colorectal Cancer. | NCT04689347

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