Published in Blood on March 10, 2005
The JAK-STAT pathway at twenty. Immunity (2012) 4.41
Hepatic gene expression during treatment with peginterferon and ribavirin: Identifying molecular pathways for treatment response. Hepatology (2007) 3.87
Interferon-stimulated genes: a complex web of host defenses. Annu Rev Immunol (2014) 3.47
Targeting signal transducer and activator of transcription signaling pathway in leukemias. J Clin Oncol (2009) 1.40
Biology and significance of the JAK/STAT signalling pathways. Growth Factors (2012) 1.29
Stat1 and SUMO modification. Blood (2006) 1.12
Cytokine-induced paracrystals prolong the activity of signal transducers and activators of transcription (STAT) and provide a model for the regulation of protein solubility by small ubiquitin-like modifier (SUMO). J Biol Chem (2011) 1.11
Targeting the PIAS1 SUMO ligase pathway to control inflammation. Trends Pharmacol Sci (2008) 1.10
Retracted PRMT1-mediated arginine methylation of PIAS1 regulates STAT1 signaling. Genes Dev (2009) 0.96
Modulation of inducible nitric oxide synthase expression by sumoylation. J Neuroinflammation (2009) 0.91
Epstein-Barr virus latent membrane protein 1 (LMP1) C-terminal-activating region 3 contributes to LMP1-mediated cellular migration via its interaction with Ubc9. J Virol (2011) 0.90
Gene expression profiling in monocytes and SNP association suggest the importance of the STAT1 gene for osteoporosis in both Chinese and Caucasians. J Bone Miner Res (2010) 0.90
Interpreting mixed signals: the cell's cytokine conundrum. Curr Opin Immunol (2011) 0.88
Novel role and mechanism of protein inhibitor of activated STAT1 in spatial learning. EMBO J (2010) 0.88
MDA5 is SUMOylated by PIAS2β in the upregulation of type I interferon signaling. Mol Immunol (2010) 0.85
Sumoylation coordinates the repression of inflammatory and anti-viral gene-expression programs during innate sensing. Nat Immunol (2015) 0.83
Adenovirus sequesters phosphorylated STAT1 at viral replication centers and inhibits STAT dephosphorylation. J Virol (2011) 0.83
Structure-function analysis indicates that sumoylation modulates DNA-binding activity of STAT1. BMC Biochem (2012) 0.80
SUMOylation-disrupting WAS mutation converts WASp from a transcriptional activator to a repressor of NF-κB response genes in T cells. Blood (2015) 0.79
Computational models of the JAK1/2-STAT1 signaling. JAKSTAT (2013) 0.78
Multiple Functions of Protein Inhibitor of Activated STAT1 in Regulating Endothelial Cell Proliferation and Inflammation. Arterioscler Thromb Vasc Biol (2016) 0.75
S100A6 Regulates Endothelial Cell Cycle Progression by Attenuating Antiproliferative Signal Transducers and Activators of Transcription 1 Signaling. Arterioscler Thromb Vasc Biol (2016) 0.75
RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation. Nat Cell Biol (2008) 5.90
PIAS proteins modulate transcription factors by functioning as SUMO-1 ligases. Mol Cell Biol (2002) 3.25
PDSM, a motif for phosphorylation-dependent SUMO modification. Proc Natl Acad Sci U S A (2005) 3.01
Circadian clock control by SUMOylation of BMAL1. Science (2005) 2.30
The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling. Nat Struct Mol Biol (2011) 2.20
The Janus kinases (Jaks). Genome Biol (2004) 2.18
Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1. Mol Cell Biol (2003) 2.17
The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction. J Biol Chem (2002) 2.14
PIAS proteins: pleiotropic interactors associated with SUMO. Cell Mol Life Sci (2009) 1.94
Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1. Mol Cell Biol (2002) 1.92
Involvement of proteasome in the dynamic assembly of the androgen receptor transcription complex. J Biol Chem (2002) 1.90
Acetylation of androgen receptor enhances coactivator binding and promotes prostate cancer cell growth. Mol Cell Biol (2003) 1.89
Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture. Dis Model Mech (2011) 1.87
Coregulator recruitment and histone modifications in transcriptional regulation by the androgen receptor. Mol Endocrinol (2004) 1.86
Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain. Mol Biol Cell (2003) 1.79
Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II. EMBO J (2002) 1.65
Tudor staphylococcal nuclease is an evolutionarily conserved component of the programmed cell death degradome. Nat Cell Biol (2009) 1.60
The nuclear receptor interaction domain of GRIP1 is modulated by covalent attachment of SUMO-1. J Biol Chem (2002) 1.57
A two-base deletion -439delGC in the melanocortin-4 receptor promoter associated with early-onset obesity. Horm Res (2006) 1.52
Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis without affecting in vitro sumoylation and trans-repression function. Mol Cell Biol (2002) 1.48
The multifunctional human p100 protein 'hooks' methylated ligands. Nat Struct Mol Biol (2007) 1.46
STATs as critical mediators of signal transduction and transcription: lessons learned from STAT5. Cytokine Growth Factor Rev (2004) 1.41
Sumo-1 function is dispensable in normal mouse development. Mol Cell Biol (2008) 1.37
Tudor and nuclease-like domains containing protein p100 function as coactivators for signal transducer and activator of transcription 5. Mol Endocrinol (2003) 1.36
Small ubiquitin-related modifier-1 (SUMO-1) modification of the glucocorticoid receptor. Biochem J (2002) 1.33
SUMO-specific protease 1 (SENP1) reverses the hormone-augmented SUMOylation of androgen receptor and modulates gene responses in prostate cancer cells. Mol Endocrinol (2008) 1.32
Transcriptional co-activator protein p100 interacts with snRNP proteins and facilitates the assembly of the spliceosome. Nucleic Acids Res (2007) 1.31
The transcriptional co-activator protein p100 recruits histone acetyltransferase activity to STAT6 and mediates interaction between the CREB-binding protein and STAT6. J Biol Chem (2005) 1.31
Glucocorticoid receptor activates poised FKBP51 locus through long-distance interactions. Mol Endocrinol (2010) 1.31
PIAS proteins promote SUMO-1 conjugation to STAT1. Blood (2003) 1.29
hZimp10 is an androgen receptor co-activator and forms a complex with SUMO-1 at replication foci. EMBO J (2003) 1.28
PME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma. Cancer Res (2009) 1.27
Long-range activation of FKBP51 transcription by the androgen receptor via distal intronic enhancers. Nucleic Acids Res (2009) 1.26
Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F. Nat Struct Mol Biol (2012) 1.25
Inhibition of androgen receptor (AR) function by the reproductive orphan nuclear receptor DAX-1. Mol Endocrinol (2002) 1.23
SUMO-1 promotes association of SNURF (RNF4) with PML nuclear bodies. Exp Cell Res (2004) 1.21
Cell model of catecholaminergic polymorphic ventricular tachycardia reveals early and delayed afterdepolarizations. PLoS One (2012) 1.19
Pim-1 kinase inhibits STAT5-dependent transcription via its interactions with SOCS1 and SOCS3. Blood (2004) 1.19
Expression of androgen receptor coregulators in prostate cancer. Clin Cancer Res (2004) 1.17
SUMOylation attenuates the function of PGC-1alpha. J Biol Chem (2009) 1.14
Steroid up-regulation of FKBP51 and its role in hormone signaling. Curr Opin Pharmacol (2011) 1.12
Pattern of somatic androgen receptor gene mutations in patients with hormone-refractory prostate cancer. Lab Invest (2002) 1.06
Comparative analysis of targeted differentiation of human induced pluripotent stem cells (hiPSCs) and human embryonic stem cells reveals variability associated with incomplete transgene silencing in retrovirally derived hiPSC lines. Stem Cells Transl Med (2013) 1.06
TRIM37 defective in mulibrey nanism is a novel RING finger ubiquitin E3 ligase. Exp Cell Res (2005) 1.05
Genome-wide RNA interference in Drosophila cells identifies G protein-coupled receptor kinase 2 as a conserved regulator of NF-kappaB signaling. J Immunol (2010) 1.05
Dynamic SUMOylation is linked to the activity cycles of androgen receptor in the cell nucleus. Mol Cell Biol (2012) 1.04
Androgen receptor-interacting protein 3 and other PIAS proteins cooperate with glucocorticoid receptor-interacting protein 1 in steroid receptor-dependent signaling. J Biol Chem (2002) 1.04
Tudor-SN interacts with and co-localizes with G3BP in stress granules under stress conditions. FEBS Lett (2010) 1.03
SUMOylation modulates the transcription repressor function of RIP140. J Biol Chem (2008) 1.02
p100 increases AT1R expression through interaction with AT1R 3'-UTR. Nucleic Acids Res (2008) 1.02
MAPK-induced Ser727 phosphorylation promotes SUMOylation of STAT1. Biochem J (2008) 1.00
Effects of triaryl phosphates on mouse and human nuclear receptors. Biochem Pharmacol (2004) 1.00
M-CSF induced differentiation of myeloid precursor cells involves activation of PKC-delta and expression of Pkare. J Leukoc Biol (2003) 0.97
Binding of SH2-B family members within a potential negative regulatory region maintains JAK2 in an active state. Mol Cell Biol (2006) 0.97
ZNF451 is a novel PML body- and SUMO-associated transcriptional coregulator. J Mol Biol (2008) 0.96
SUMOylation regulates the chromatin occupancy and anti-proliferative gene programs of glucocorticoid receptor. Nucleic Acids Res (2013) 0.96
Proto-oncogene PIM-1 is a novel estrogen receptor target associating with high grade breast tumors. Mol Cell Endocrinol (2012) 0.96
Characterization of RNA helicase A as component of STAT6-dependent enhanceosome. Nucleic Acids Res (2006) 0.95
Androgen receptor amplification is reflected in the transcriptional responses of Vertebral-Cancer of the Prostate cells. Mol Cell Endocrinol (2010) 0.95
Small carboxyl-terminal domain phosphatase 2 attenuates androgen-dependent transcription. EMBO J (2006) 0.94
JAK Kinases in Health and Disease: An Update. Open Rheumatol J (2012) 0.94
Tudor staphylococcal nuclease (Tudor-SN) participates in small ribonucleoprotein (snRNP) assembly via interacting with symmetrically dimethylated Sm proteins. J Biol Chem (2012) 0.92
Monocyte anergy is present in patients with severe acute pancreatitis and is significantly alleviated by granulocyte-macrophage colony-stimulating factor and interferon-gamma in vitro. Pancreas (2005) 0.91
Inhibition of small ubiquitin-related modifier-1 expression by luteinizing hormone receptor stimulation is linked to induction of progesterone receptor during ovulation in mouse granulosa cells. Endocrinology (2003) 0.91
Novel ATPase of SNF2-like protein family interacts with androgen receptor and modulates androgen-dependent transcription. Mol Biol Cell (2002) 0.91
SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling. Sci STKE (2005) 0.90
Functional interaction of AIRE with PIAS1 in transcriptional regulation. Mol Immunol (2008) 0.89
Androgen receptor mutations in high-grade prostate cancer before hormonal therapy. Lab Invest (2003) 0.89
Down-regulation of estrogen receptor beta and transcriptional coregulator SNURF/RNF4 in testicular germ cell cancer. Eur Urol (2003) 0.89
SUMOylation can regulate the activity of ETS-like transcription factor 4. Biochim Biophys Acta (2010) 0.88
Histone H2B ubiquitin ligases RNF20 and RNF40 in androgen signaling and prostate cancer cell growth. Mol Cell Endocrinol (2011) 0.88
Interleukins 1α and 1β as regulators of steroidogenesis in human NCI-H295R adrenocortical cells. Steroids (2011) 0.87
Cooperative coactivation of estrogen receptor alpha in ZR-75 human breast cancer cells by SNURF and TATA-binding protein. J Biol Chem (2001) 0.87
Small nuclear RING finger protein stimulates the rat luteinizing hormone-beta promoter by interacting with Sp1 and steroidogenic factor-1 and protects from androgen suppression. Mol Endocrinol (2004) 0.87
Attenuation of androgen receptor-dependent transcription by the serine/threonine kinase Pim-1. Lab Invest (2003) 0.87
Eye transformer is a negative regulator of Drosophila JAK/STAT signaling. FASEB J (2010) 0.87
Protein inhibitor of activated STAT3 (PIAS3) protein promotes SUMOylation and nuclear sequestration of the intracellular domain of ErbB4 protein. J Biol Chem (2012) 0.87
Ets transcription factors regulate AIRE gene promoter. Biochem Biophys Res Commun (2006) 0.86
Prostaglandin 15d-PGJ(2) inhibits androgen receptor signaling in prostate cancer cells. Mol Endocrinol (2012) 0.86
Expression of the E3 SUMO-1 ligases PIASx and PIAS1 during spermatogenesis in the rat. Gene Expr Patterns (2003) 0.86
p38 Mitogen-activated protein kinase regulates interleukin-4-induced gene expression by stimulating STAT6-mediated transcription. J Biol Chem (2002) 0.86
Th17 cells in multiple sclerosis express higher levels of JAK2, which increases their surface expression of IFN-γR2. J Immunol (2012) 0.86
Histone demethylase GASC1--a potential prognostic and predictive marker in invasive breast cancer. BMC Cancer (2012) 0.84
PTB-associated splicing factor (PSF) functions as a repressor of STAT6-mediated Ig epsilon gene transcription by recruitment of HDAC1. J Biol Chem (2010) 0.84
PQBP-1 transgenic mice show a late-onset motor neuron disease-like phenotype. Hum Mol Genet (2003) 0.84
Not4 enhances JAK/STAT pathway-dependent gene expression in Drosophila and in human cells. FASEB J (2011) 0.84
Nuclear mobility and activity of FOXA1 with androgen receptor are regulated by SUMOylation. Mol Endocrinol (2014) 0.83
Androgen receptor regulates nuclear trafficking and nuclear domain residency of corepressor HDAC7 in a ligand-dependent fashion. Exp Cell Res (2006) 0.83
Analysis of Jak2 catalytic function by peptide microarrays: the role of the JH2 domain and V617F mutation. PLoS One (2011) 0.83
Effects of hyperactive Janus kinase 2 signaling in mammary epithelial cells. Biochem Biophys Res Commun (2002) 0.83
Defense of zebrafish embryos against Streptococcus pneumoniae infection is dependent on the phagocytic activity of leukocytes. Dev Comp Immunol (2011) 0.82
Oestrogen receptors and small nuclear ring finger protein 4 (RNF4) in malignant ovarian germ cell tumours. Mol Cell Endocrinol (2009) 0.82
Sumoylation of Drosophila transcription factor STAT92E. J Innate Immun (2010) 0.82
Biochemical characterization of androgen receptor-interacting protein 4. Biochem J (2006) 0.82
TWIST overexpression predicts biochemical recurrence-free survival in prostate cancer patients treated with radical prostatectomy. Scand J Urol (2014) 0.82
Molecular basis of Stat1 and PU.1 cooperation in cytokine-induced Fcgamma receptor I promoter activation. Int Immunol (2004) 0.82
PU.1 is required for transcriptional activation of the Stat6 response element in the Igepsilon promoter. Eur J Immunol (2003) 0.82