Published in J Virol on April 01, 2005
Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5alpha restriction factor. Proc Natl Acad Sci U S A (2006) 6.82
Species-specific variation in the B30.2(SPRY) domain of TRIM5alpha determines the potency of human immunodeficiency virus restriction. J Virol (2005) 4.64
Species-specific activity of SIV Nef and HIV-1 Vpu in overcoming restriction by tetherin/BST2. PLoS Pathog (2009) 4.24
The B30.2(SPRY) domain of the retroviral restriction factor TRIM5alpha exhibits lineage-specific length and sequence variation in primates. J Virol (2005) 3.63
TRIM5alpha selectively binds a restriction-sensitive retroviral capsid. Retrovirology (2005) 3.39
Acute loss of intestinal CD4+ T cells is not predictive of simian immunodeficiency virus virulence. J Immunol (2007) 3.24
Retroviral restriction factor TRIM5alpha is a trimer. J Virol (2005) 2.52
Structural basis for PRYSPRY-mediated tripartite motif (TRIM) protein function. Proc Natl Acad Sci U S A (2007) 2.49
Restriction of human immunodeficiency virus type 1 by TRIM-CypA occurs with rapid kinetics and independently of cytoplasmic bodies, ubiquitin, and proteasome activity. J Virol (2005) 2.47
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Cyclophilin A, TRIM5, and resistance to human immunodeficiency virus type 1 infection. J Virol (2006) 2.31
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All three variable regions of the TRIM5alpha B30.2 domain can contribute to the specificity of retrovirus restriction. J Virol (2006) 2.26
Independent genesis of chimeric TRIM5-cyclophilin proteins in two primate species. Proc Natl Acad Sci U S A (2008) 2.23
Cyclophilin A is required for TRIM5{alpha}-mediated resistance to HIV-1 in Old World monkey cells. Proc Natl Acad Sci U S A (2005) 2.21
The human TRIM5alpha restriction factor mediates accelerated uncoating of the N-tropic murine leukemia virus capsid. J Virol (2006) 2.17
Balancing selection and the evolution of functional polymorphism in Old World monkey TRIM5alpha. Proc Natl Acad Sci U S A (2006) 2.16
Proteasomal degradation of TRIM5alpha during retrovirus restriction. PLoS Pathog (2008) 1.96
Structural and functional insights into the B30.2/SPRY domain. EMBO J (2006) 1.82
Cyclophilin A and TRIM5alpha independently regulate human immunodeficiency virus type 1 infectivity in human cells. J Virol (2006) 1.77
Comparative requirements for the restriction of retrovirus infection by TRIM5alpha and TRIMCyp. Virology (2007) 1.75
Accelerating next-generation vaccine development for global disease prevention. Science (2013) 1.73
Restriction of feline immunodeficiency virus by Ref1, Lv1, and primate TRIM5alpha proteins. J Virol (2005) 1.71
Genetic association of the antiviral restriction factor TRIM5alpha with human immunodeficiency virus type 1 infection. J Virol (2006) 1.62
Modulation of retroviral restriction and proteasome inhibitor-resistant turnover by changes in the TRIM5alpha B-box 2 domain. J Virol (2007) 1.60
Molecular evolution of the antiretroviral TRIM5 gene. Immunogenetics (2009) 1.55
An active TRIM5 protein in rabbits indicates a common antiviral ancestor for mammalian TRIM5 proteins. J Virol (2007) 1.54
Evolution of a cytoplasmic tripartite motif (TRIM) protein in cows that restricts retroviral infection. Proc Natl Acad Sci U S A (2006) 1.53
A human TRIM5alpha B30.2/SPRY domain mutant gains the ability to restrict and prematurely uncoat B-tropic murine leukemia virus. Virology (2008) 1.52
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Functional replacement of the RING, B-box 2, and coiled-coil domains of tripartite motif 5alpha (TRIM5alpha) by heterologous TRIM domains. J Virol (2006) 1.38
Two surface-exposed elements of the B30.2/SPRY domain as potency determinants of N-tropic murine leukemia virus restriction by human TRIM5alpha. J Virol (2006) 1.29
Identification of a genomic reservoir for new TRIM genes in primate genomes. PLoS Genet (2011) 1.20
Restriction of foamy viruses by primate Trim5alpha. J Virol (2008) 1.19
TRIM5alpha disrupts the structure of assembled HIV-1 capsid complexes in vitro. J Virol (2010) 1.15
Interfering residues narrow the spectrum of MLV restriction by human TRIM5alpha. PLoS Pathog (2007) 1.11
Implication of TRIM alpha and TRIMCyp in interferon-induced anti-retroviral restriction activities. Retrovirology (2008) 1.11
Determinants of the higher order association of the restriction factor TRIM5alpha and other tripartite motif (TRIM) proteins. J Biol Chem (2011) 1.10
Control of viral infectivity by tripartite motif proteins. Hum Gene Ther (2005) 1.10
p62/sequestosome-1 associates with and sustains the expression of retroviral restriction factor TRIM5alpha. J Virol (2010) 1.08
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Structural insight into HIV-1 capsid recognition by rhesus TRIM5α. Proc Natl Acad Sci U S A (2012) 1.03
Identification of postentry restrictions to Mason-Pfizer monkey virus infection in New World monkey cells. J Virol (2008) 1.03
SUMO-interacting motifs of human TRIM5α are important for antiviral activity. PLoS Pathog (2011) 0.98
An invariant surface patch on the TRIM5alpha PRYSPRY domain is required for retroviral restriction but dispensable for capsid binding. J Virol (2009) 0.98
The specificity of TRIM5 alpha-mediated restriction is influenced by its coiled-coil domain. J Virol (2010) 0.98
Recent insights into the mechanism and consequences of TRIM5α retroviral restriction. AIDS Res Hum Retroviruses (2011) 0.98
Role of TRIM5α RING domain E3 ubiquitin ligase activity in capsid disassembly, reverse transcription blockade, and restriction of simian immunodeficiency virus. J Virol (2011) 0.98
Species-specific inhibition of foamy viruses from South American monkeys by New World Monkey TRIM5{alpha} proteins. J Virol (2010) 0.97
Antiretroviral activity of ancestral TRIM5alpha. J Virol (2007) 0.97
Restriction of HIV-1 replication in monocytes is abolished by Vpx of SIVsmmPBj. PLoS One (2009) 0.96
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Trafficking of some old world primate TRIM5α proteins through the nucleus. Retrovirology (2011) 0.92
The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome. PLoS One (2012) 0.90
A phenotypic recessive, post-entry block in rabbit cells that results in aberrant trafficking of HIV-1. Traffic (2006) 0.89
Human TRIM5alpha mediated restriction of different HIV-1 subtypes and Lv2 sensitive and insensitive HIV-2 variants. Retrovirology (2006) 0.88
Contribution of SUMO-interacting motifs and SUMOylation to the antiretroviral properties of TRIM5α. Virology (2012) 0.88
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Primate TRIM5 proteins form hexagonal nets on HIV-1 capsids. Elife (2016) 0.87
Evidence for selection at HIV host susceptibility genes in a West Central African human population. BMC Evol Biol (2012) 0.87
Unique spectrum of activity of prosimian TRIM5alpha against exogenous and endogenous retroviruses. J Virol (2011) 0.87
Adaptation of the human immunodeficiency virus type 1 envelope glycoproteins to new world monkey receptors. J Virol (2007) 0.86
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Functional evidence for the involvement of microtubules and dynein motor complexes in TRIM5α-mediated restriction of retroviruses. J Virol (2014) 0.85
Intracellular immunity to HIV-1: newly defined retroviral battles inside infected cells. Retrovirology (2005) 0.85
Host cell species-specific effect of cyclosporine A on simian immunodeficiency virus replication. Retrovirology (2012) 0.84
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Homology-based identification of capsid determinants that protect HIV1 from human TRIM5α restriction. J Biol Chem (2010) 0.84
Birth, decay, and reconstruction of an ancient TRIMCyp gene fusion in primate genomes. Proc Natl Acad Sci U S A (2013) 0.84
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Phylogeny-directed search for murine leukemia virus-like retroviruses in vertebrate genomes and in patients suffering from myalgic encephalomyelitis/chronic fatigue syndrome and prostate cancer. Adv Virol (2011) 0.83
Characterization of a core fragment of the rhesus monkey TRIM5α protein. BMC Biochem (2011) 0.83
Virus-specific effects of TRIM5α(rh) RING domain functions on restriction of retroviruses. J Virol (2013) 0.83
Hsp70 interacts with the retroviral restriction factor TRIM5alpha and assists the folding of TRIM5alpha. J Biol Chem (2010) 0.82
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Porcine endogenous retroviruses PERV A and A/C recombinant are insensitive to a range of divergent mammalian TRIM5alpha proteins including human TRIM5alpha. J Gen Virol (2009) 0.81
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Cytoplasmic body component TRIM5{alpha} requires lipid-enriched microdomains for efficient HIV-1 restriction. J Biol Chem (2010) 0.79
TRIM5 Retroviral Restriction Activity Correlates with the Ability To Induce Innate Immune Signaling. J Virol (2015) 0.79
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