Published in Genes Dev on March 15, 2005
Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase. Nat Protoc (2009) 4.50
Selective activation of p53-mediated tumour suppression in high-grade tumours. Nature (2010) 2.51
A map of human cancer signaling. Mol Syst Biol (2007) 2.50
Analysis of orthologous gene expression between human pulmonary adenocarcinoma and a carcinogen-induced murine model. Am J Pathol (2005) 2.39
Nuclear factor I/B is an oncogene in small cell lung cancer. Genes Dev (2011) 2.29
miRNA-34 prevents cancer initiation and progression in a therapeutically resistant K-ras and p53-induced mouse model of lung adenocarcinoma. Cancer Res (2012) 2.13
A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression. Genes Dev (2006) 2.05
Reduced cell proliferation by IKK2 depletion in a mouse lung-cancer model. Nat Cell Biol (2012) 1.87
Requirement of the NF-kappaB subunit p65/RelA for K-Ras-induced lung tumorigenesis. Cancer Res (2010) 1.78
Epigenetic regulation of the tumor suppressor gene TCF21 on 6q23-q24 in lung and head and neck cancer. Proc Natl Acad Sci U S A (2006) 1.75
The comparative pathology of genetically engineered mouse models for neuroendocrine carcinomas of the lung. J Thorac Oncol (2015) 1.68
Targeting EGFR signalling in chronic lung disease: therapeutic challenges and opportunities. Eur Respir J (2014) 1.59
Deletion of XPC leads to lung tumors in mice and is associated with early events in human lung carcinogenesis. Proc Natl Acad Sci U S A (2005) 1.47
How genetically engineered mouse tumor models provide insights into human cancers. J Clin Oncol (2011) 1.43
Muscarinic receptors and ligands in cancer. Am J Physiol Cell Physiol (2008) 1.42
Urinary volatile compounds as biomarkers for lung cancer: a proof of principle study using odor signatures in mouse models of lung cancer. PLoS One (2010) 1.31
A dual role for the immune response in a mouse model of inflammation-associated lung cancer. J Clin Invest (2011) 1.25
Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis. EMBO J (2008) 1.25
Targeted deletion of the genes encoding NTH1 and NEIL1 DNA N-glycosylases reveals the existence of novel carcinogenic oxidative damage to DNA. DNA Repair (Amst) (2009) 1.24
Protein kinase Czeta represses the interleukin-6 promoter and impairs tumorigenesis in vivo. Mol Cell Biol (2008) 1.23
Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression. PLoS One (2009) 1.22
The atypical PKCs in inflammation: NF-κB and beyond. Immunol Rev (2012) 1.17
Mutually exclusive inactivation of DMP1 and ARF/p53 in lung cancer. Cancer Cell (2007) 1.17
Conditional deletion of Pten causes bronchiolar hyperplasia. Am J Respir Cell Mol Biol (2007) 1.11
Dachshund binds p53 to block the growth of lung adenocarcinoma cells. Cancer Res (2013) 1.07
Harnessing preclinical mouse models to inform human clinical cancer trials. J Clin Invest (2006) 1.06
Deregulated expression of hnRNP A/B proteins in human non-small cell lung cancer: parallel assessment of protein and mRNA levels in paired tumour/non-tumour tissues. BMC Cancer (2010) 1.05
The mouse pathology ontology, MPATH; structure and applications. J Biomed Semantics (2013) 1.05
Evolving concepts in lung carcinogenesis. Semin Respir Crit Care Med (2011) 1.03
Transdifferentiation of lung adenocarcinoma in mice with Lkb1 deficiency to squamous cell carcinoma. Nat Commun (2014) 1.02
Cyclin E transgenic mice: discovery tools for lung cancer biology, therapy, and prevention. Cancer Prev Res (Phila) (2010) 0.99
TPL2 kinase is a suppressor of lung carcinogenesis. Proc Natl Acad Sci U S A (2013) 0.99
Pulmonary inflammation and tumor induction in lung tumor susceptible A/J and resistant C57BL/6J mice exposed to welding fume. Part Fibre Toxicol (2008) 0.98
The rexinoid LG100268 and the synthetic triterpenoid CDDO-methyl amide are more potent than erlotinib for prevention of mouse lung carcinogenesis. Mol Cancer Ther (2008) 0.98
Loss of transforming growth factor beta type II receptor increases aggressive tumor behavior and reduces survival in lung adenocarcinoma and squamous cell carcinoma. Clin Cancer Res (2012) 0.97
Alveolar type II cells possess the capability of initiating lung tumor development. PLoS One (2012) 0.96
Stat1 phosphorylation determines Ras oncogenicity by regulating p27 kip1. PLoS One (2008) 0.95
Osteopontin induces growth of metastatic tumors in a preclinical model of non-small lung cancer. J Exp Clin Cancer Res (2012) 0.95
Colony-stimulating factor 1 potentiates lung cancer bone metastasis. Lab Invest (2014) 0.94
A comprehensive analysis of gene expression evolution between humans and mice. Evol Bioinform Online (2009) 0.92
Gprc5a deletion enhances the transformed phenotype in normal and malignant lung epithelial cells by eliciting persistent Stat3 signaling induced by autocrine leukemia inhibitory factor. Cancer Res (2010) 0.91
Role of DMP1 and its future in lung cancer diagnostics. Expert Rev Mol Diagn (2008) 0.91
Mutation of the LXCXE binding cleft of pRb facilitates transformation by ras in vitro but does not promote tumorigenesis in vivo. PLoS One (2013) 0.87
Nicotine stimulates PPARbeta/delta expression in human lung carcinoma cells through activation of PI3K/mTOR and suppression of AP-2alpha. Cancer Res (2009) 0.87
KSHV viral cyclin interferes with T-cell development and induces lymphoma through Cdk6 and Notch activation in vivo. Cell Cycle (2014) 0.87
Kinase domain activation of FGFR2 yields high-grade lung adenocarcinoma sensitive to a Pan-FGFR inhibitor in a mouse model of NSCLC. Cancer Res (2014) 0.87
Activin upregulation by NF-κB is required to maintain mesenchymal features of cancer stem-like cells in non-small cell lung cancer. Cancer Res (2014) 0.86
Flavonoids from each of the six structural groups reactivate BRM, a possible cofactor for the anticancer effects of flavonoids. Carcinogenesis (2014) 0.86
Emerging roles of DMP1 in lung cancer. Cancer Res (2008) 0.86
Protein expression and promoter methylation of the candidate biomarker TCF21 in gastric cancer. J Cancer Res Clin Oncol (2014) 0.86
Lung cancer stem cells: Molecular features and therapeutic targets. Mol Aspects Med (2013) 0.85
Role of PTEN in basal cell derived lung carcinogenesis. Mol Carcinog (2013) 0.84
NSCLC metastasis: going with ELMO3. Oncotarget (2014) 0.84
Differential transcriptomic analysis of spontaneous lung tumors in B6C3F1 mice: comparison to human non-small cell lung cancer. Toxicol Pathol (2012) 0.84
Adult lung stem cells and their contribution to lung tumourigenesis. Open Biol (2012) 0.83
Overview of the molecular carcinogenesis of mouse lung tumor models of human lung cancer. Toxicol Pathol (2007) 0.82
Signal transduction involving the dmp1 transcription factor and its alteration in human cancer. Clin Med Oncol (2008) 0.82
Expression of C4.4A, a structural uPAR homolog, reflects squamous epithelial differentiation in the adult mouse and during embryogenesis. J Histochem Cytochem (2011) 0.81
A review of the molecular mechanisms of chemically induced neoplasia in rat and mouse models in National Toxicology Program bioassays and their relevance to human cancer. Toxicol Pathol (2009) 0.81
Pulmonary tumors associated with the JC virus T-antigen in a transgenic mouse model. Oncol Rep (2013) 0.81
Lineage factors and differentiation states in lung cancer progression. Oncogene (2015) 0.81
Lung cancer stem cell: new insights on experimental models and preclinical data. J Oncol (2010) 0.80
Proceedings of the 2014 National Toxicology Program Satellite Symposium. Toxicol Pathol (2014) 0.79
Screening for tumor suppressors: Loss of ephrin receptor A2 cooperates with oncogenic KRas in promoting lung adenocarcinoma. Proc Natl Acad Sci U S A (2015) 0.79
E-cadherin controls bronchiolar progenitor cells and onset of preneoplastic lesions in mice. Neoplasia (2012) 0.79
Systems toxicology approaches enable mechanistic comparison of spontaneous and cigarette smoke-related lung tumor development in the A/J mouse model. Interdiscip Toxicol (2014) 0.78
A translational approach to lung cancer research: From EGFRs to Wnt and cancer stem cells. Ann Thorac Cardiovasc Surg (2009) 0.78
How do K-RAS-activated cells evade cellular defense mechanisms? Oncogene (2015) 0.78
Genetic alterations in K-ras and p53 cancer genes in lung neoplasms from B6C3F1 mice exposed to cumene. Toxicol Pathol (2008) 0.78
Regulation of cytokine-induced prostanoid and nitric oxide synthesis by extracellular signal–regulated kinase 1/2 in lung epithelial cells. Exp Lung Res (2010) 0.78
Conditional expression of oncogenic C-RAF in mouse pulmonary epithelial cells reveals differential tumorigenesis and induction of autophagy leading to tumor regression. Neoplasia (2011) 0.78
Matrix metalloproteinases and genetic mouse models in cancer research: a mini-review. Tumour Biol (2014) 0.78
Comparative pathobiology of environmentally induced lung cancers in humans and rodents. Toxicol Pathol (2014) 0.77
The LIM-domain only protein 4 contributes to lung epithelial cell proliferation but is not essential for tumor progression. Respir Res (2015) 0.77
Intracellular signals of lung cancer cells as possible therapeutic targets. Cancer Sci (2015) 0.77
AKT1E17K Is Oncogenic in Mouse Lung and Cooperates with Chemical Carcinogens in Inducing Lung Cancer. PLoS One (2016) 0.77
Effective Capture of Circulating Tumor Cells from a Transgenic Mouse Lung Cancer Model Using Dendrimer Surfaces Immobilized with Anti-EGFR. Anal Chem (2015) 0.77
Ablation of Liver X receptors α and β leads to spontaneous peripheral squamous cell lung cancer in mice. Proc Natl Acad Sci U S A (2016) 0.77
Loss of the SWI/SNF ATPase subunits BRM and BRG1 drives lung cancer development. Oncoscience (2016) 0.75
Insight into the relationship between the cell culture model, cell trafficking and siRNA silencing efficiency. Biochem Biophys Res Commun (2016) 0.75
Loss of adipose triglyceride lipase is associated with human cancer and induces mouse pulmonary neoplasia. Oncotarget (2016) 0.75
Analysis of lung tumor initiation and progression in transgenic mice for Cre-inducible overexpression of Cul4A gene. Thorac Cancer (2015) 0.75
MDM2 knockdown mediated by a triazine-modified dendrimer in the treatment of non-small cell lung cancer. Oncotarget (2016) 0.75
Kruppel-like factor 5 is not required for K-RasG12D lung tumorigenesis, but represses ABCG2 expression and is associated with better disease-specific survival. Am J Pathol (2010) 0.75
Expression of B-RAF V600E in type II pneumocytes causes abnormalities in alveolar formation, airspace enlargement and tumor formation in mice. PLoS One (2011) 0.75
Mouse Modeling of Obese Lung Disease. Insights and Caveats. Am J Respir Cell Mol Biol (2016) 0.75
Coal dust alters beta-naphthoflavone-induced aryl hydrocarbon receptor nuclear translocation in alveolar type II cells. Part Fibre Toxicol (2009) 0.75
C4.4A gene ablation is compatible with normal epidermal development and causes modest overt phenotypes. Sci Rep (2016) 0.75
Respiratory Homeostasis and Exploitation of the Immune System for Lung Cancer Vaccines. US Oncol (2009) 0.75
Fraction of MHCII and EpCAM expression characterizes distal lung epithelial cells for alveolar type 2 cell isolation. Respir Res (2017) 0.75
Small-cell lung cancer: what we know, what we need to know and the path forward. Nat Rev Cancer (2017) 0.75
Sex-related differences of urethane and sodium valproate effects on Ki-67 expression in urethane-induced lung tumors of mice. Exp Ther Med (2017) 0.75
Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis. Cancer Cell (2006) 4.15
The European dimension for the mouse genome mutagenesis program. Nat Genet (2004) 3.84
High-throughput retroviral tagging to identify components of specific signaling pathways in cancer. Nat Genet (2002) 3.81
Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer. Proc Natl Acad Sci U S A (2007) 3.58
Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model. Cancer Cell (2003) 3.31
p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a. Nature (2007) 3.26
Large-scale mutagenesis in p19(ARF)- and p53-deficient mice identifies cancer genes and their collaborative networks. Cell (2008) 3.25
Cell of origin of small cell lung cancer: inactivation of Trp53 and Rb1 in distinct cell types of adult mouse lung. Cancer Cell (2011) 2.63
Conditional mouse models of sporadic cancer. Nat Rev Cancer (2002) 2.47
Pim-1 regulates cardiomyocyte survival downstream of Akt. Nat Med (2007) 2.39
Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors. Mol Cell Biol (2004) 2.31
A functional role for tumor cell heterogeneity in a mouse model of small cell lung cancer. Cancer Cell (2011) 2.29
For better or for worse: the role of Pim oncogenes in tumorigenesis. Nat Rev Cancer (2010) 2.26
Targeted biallelic inactivation of Pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis. Cancer Res (2005) 2.19
Chromatin position effects assayed by thousands of reporters integrated in parallel. Cell (2013) 2.16
Toxicity of ligand-dependent Cre recombinases and generation of a conditional Cre deleter mouse allowing mosaic recombination in peripheral tissues. Physiol Genomics (2007) 2.15
Retroviral insertional mutagenesis: tagging cancer pathways. Adv Cancer Res (2003) 2.07
High-throughput insertional mutagenesis screens in mice to identify oncogenic networks. Nat Rev Cancer (2009) 2.06
Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis. Nat Genet (2011) 2.02
A high-throughput splinkerette-PCR method for the isolation and sequencing of retroviral insertion sites. Nat Protoc (2009) 1.95
Identification of oncogenes collaborating with p27Kip1 loss by insertional mutagenesis and high-throughput insertion site analysis. Proc Natl Acad Sci U S A (2002) 1.85
The comparative pathology of genetically engineered mouse models for neuroendocrine carcinomas of the lung. J Thorac Oncol (2015) 1.68
Unique and overlapping functions of pRb and p107 in the control of proliferation and differentiation in epidermis. Development (2004) 1.65
PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum. Development (2002) 1.64
NCAM-induced focal adhesion assembly: a functional switch upon loss of E-cadherin. EMBO J (2008) 1.62
Cell of origin of lung cancer. Mol Oncol (2010) 1.54
Oncogene addiction: sometimes a temporary slavery. Cancer Cell (2004) 1.54
Immune response in lung cancer mouse model mimics human anti-Hu reactivity. J Neuroimmunol (2009) 1.47
Noninvasive imaging of spontaneous retinoblastoma pathway-dependent tumors in mice. Cancer Res (2002) 1.46
Knockout mouse models to study Wnt signal transduction. Trends Genet (2006) 1.46
Mouse models of prostate adenocarcinoma with the capacity to monitor spontaneous carcinogenesis by bioluminescence or fluorescence. Cancer Res (2007) 1.33
Multiple cells-of-origin of mutant K-Ras-induced mouse lung adenocarcinoma. Proc Natl Acad Sci U S A (2014) 1.30
Loss of p27(Kip1) but not p21(Cip1) decreases survival and synergizes with MYC in murine lymphomagenesis. EMBO J (2002) 1.26
The generation of a conditional reporter that enables bioluminescence imaging of Cre/loxP-dependent tumorigenesis in mice. Cancer Res (2003) 1.19
Mouse models for lung cancer. Mol Oncol (2013) 1.18
Rapid target gene validation in complex cancer mouse models using re-derived embryonic stem cells. EMBO Mol Med (2014) 1.17
Tumor formation in mice with somatic inactivation of the retinoblastoma gene in interphotoreceptor retinol binding protein-expressing cells. Oncogene (2002) 1.16
A conditional mouse model for malignant mesothelioma. Cancer Cell (2008) 1.14
DCC expression by neurons regulates synaptic plasticity in the adult brain. Cell Rep (2013) 1.13
Deleted in colorectal carcinoma suppresses metastasis in p53-deficient mammary tumours. Nature (2012) 1.08
Rb and p107 are required for normal cerebellar development and granule cell survival but not for Purkinje cell persistence. Development (2003) 1.07
Novel candidate cancer genes identified by a large-scale cross-species comparative oncogenomics approach. Cancer Res (2010) 1.03
Insertional mutagenesis in mice deficient for p15Ink4b, p16Ink4a, p21Cip1, and p27Kip1 reveals cancer gene interactions and correlations with tumor phenotypes. Cancer Res (2010) 1.02
Lack of Rb and p53 delays cerebellar development and predisposes to large cell anaplastic medulloblastoma through amplification of N-Myc and Ptch2. Cancer Res (2006) 0.97
An inducible mouse model of melanoma expressing a defined tumor antigen. Cancer Res (2006) 0.96
Computational identification of insertional mutagenesis targets for cancer gene discovery. Nucleic Acids Res (2011) 0.92
Rapid validation of cancer genes in chimeras derived from established genetically engineered mouse models. Bioessays (2011) 0.89
Frat is dispensable for canonical Wnt signaling in mammals. Genes Dev (2005) 0.87
Cross-species oncogenomics in cancer gene identification. Cell (2006) 0.87
Cancer biology: can less be more for p53? Nature (2006) 0.87
Synergy of Nf2 and p53 mutations in development of malignant tumours of neural crest origin. Oncogene (2004) 0.85
Re-evaluating the role of Frat in Wnt-signal transduction. Cell Cycle (2005) 0.85
TXR1-mediated thrombospondin repression: a novel mechanism of resistance to taxanes? Genes Dev (2006) 0.84
Tobacco: deadly in any form or disguise. Lancet (2006) 0.83
Frat2 mediates the oncogenic activation of Rac by MLL fusions. Blood (2012) 0.82
Improved pregnancy and birth rates with routine application of nonsurgical embryo transfer. Transgenic Res (2014) 0.82
Proviral activation of the tumor suppressor E2a contributes to T cell lymphomagenesis in EmuMyc transgenic mice. Oncogene (2002) 0.82
Drugging drug resistance. Cell (2010) 0.82
Cancer: two in one. Nature (2005) 0.81
Characterization and functional analysis of the murine Frat2 gene. J Biol Chem (2004) 0.81
Cancer: The blind spot of p53. Nature (2010) 0.79
Mouse lung neuroendocrine carcinomas: distinct morphologies, same transcription factors. Exp Lung Res (2005) 0.79
Controlling gene expression in the urothelium using transgenic mice with inducible bladder specific Cre-lox recombination. J Urol (2002) 0.78
Tumour suppressors: timing will tell. Nature (2003) 0.77
Kras and Hras--what is the difference? Nat Genet (2008) 0.77
Mouse models of cancer. Mol Oncol (2013) 0.76
Jump-starting cancer gene discovery. Nat Biotechnol (2009) 0.75
Break the loop, escape the cycle? EMBO J (2013) 0.75
Targeted anticancer therapies: mouse models help uncover the mechanisms of tumor escape. Cancer Cell (2008) 0.75
Corrigendum: using TRIP for genome-wide position effect analysis in cultured cells. Nat Protoc (2015) 0.75
Curbing tobacco's toll starts with the professionals: World No Tobacco Day. Lancet (2005) 0.75