Published in Proc Natl Acad Sci U S A on July 31, 2002
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Large-scale identification of disease genes involved in acute myeloid leukemia. J Virol (2004) 1.02
Insertional mutagenesis in mice deficient for p15Ink4b, p16Ink4a, p21Cip1, and p27Kip1 reveals cancer gene interactions and correlations with tumor phenotypes. Cancer Res (2010) 1.02
The ubiquitously expressed bZIP inhibitor, JDP2, suppresses the transcription of its homologue immediate early gene counterpart, ATF3. Nucleic Acids Res (2009) 1.02
Evidence for a p27 tumor suppressive function independent of its role regulating cell proliferation in the prostate. Proc Natl Acad Sci U S A (2004) 0.98
Suppression of cell-cycle progression by Jun dimerization protein-2 (JDP2) involves downregulation of cyclin-A2. Oncogene (2010) 0.95
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Genetic screening reveals an essential role of p27kip1 in restriction of breast cancer progression. Cancer Res (2007) 0.92
The AP-1 repressor protein, JDP2, potentiates hepatocellular carcinoma in mice. Mol Cancer (2010) 0.92
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Retroviruses hijack chromatin loops to drive oncogene expression and highlight the chromatin architecture around proto-oncogenic loci. PLoS One (2015) 0.79
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Role of c-Myb in the survival of pre B-cell acute lymphoblastic leukemia and leukemogenesis. Am J Hematol (2012) 0.76
Interferon-γ-induced p27KIP1 binds to and targets MYC for proteasome-mediated degradation. Oncotarget (2016) 0.75
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MYC Modulation around the CDK2/p27/SKP2 Axis. Genes (Basel) (2017) 0.75
The miR-106a~363(Xpcl1) miRNA cluster induces murine T cell lymphoma despite transcriptional activation of the p27(Kip1) cell cycle inhibitor. Oncotarget (2017) 0.75
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Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis. Cancer Cell (2006) 4.15
Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation. Mol Cell (2003) 3.91
The European dimension for the mouse genome mutagenesis program. Nat Genet (2004) 3.84
High-throughput retroviral tagging to identify components of specific signaling pathways in cancer. Nat Genet (2002) 3.81
Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer. Proc Natl Acad Sci U S A (2007) 3.58
Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model. Cancer Cell (2003) 3.31
p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a. Nature (2007) 3.26
Large-scale mutagenesis in p19(ARF)- and p53-deficient mice identifies cancer genes and their collaborative networks. Cell (2008) 3.25
Cyclin E in normal and neoplastic cell cycles. Oncogene (2005) 3.16
Kinase-independent function of cyclin E. Mol Cell (2007) 3.03
Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype. Genes Dev (2007) 3.00
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Selective activation of p53-mediated tumour suppression in high-grade tumours. Nature (2010) 2.51
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A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size. Curr Biol (2004) 2.45
Pim-1 regulates cardiomyocyte survival downstream of Akt. Nat Med (2007) 2.39
Ubiquitin-independent degradation of cell-cycle inhibitors by the REGgamma proteasome. Mol Cell (2007) 2.38
Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors. Mol Cell Biol (2004) 2.31
A functional role for tumor cell heterogeneity in a mouse model of small cell lung cancer. Cancer Cell (2011) 2.29
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Targeted biallelic inactivation of Pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis. Cancer Res (2005) 2.19
Chromatin position effects assayed by thousands of reporters integrated in parallel. Cell (2013) 2.16
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Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis. Nat Genet (2011) 2.02
A high-throughput splinkerette-PCR method for the isolation and sequencing of retroviral insertion sites. Nat Protoc (2009) 1.95
Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma. J Cell Biol (2004) 1.88
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Werner syndrome protein limits MYC-induced cellular senescence. Genes Dev (2003) 1.84
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The comparative pathology of genetically engineered mouse models for neuroendocrine carcinomas of the lung. J Thorac Oncol (2015) 1.68
Unique and overlapping functions of pRb and p107 in the control of proliferation and differentiation in epidermis. Development (2004) 1.65
PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum. Development (2002) 1.64
Fbw7/hCDC4 dimerization regulates its substrate interactions. Cell Div (2007) 1.64
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Notch activation induces endothelial cell cycle arrest and participates in contact inhibition: role of p21Cip1 repression. Mol Cell Biol (2004) 1.61
A mouse model for cyclin E-dependent genetic instability and tumorigenesis. Cancer Cell (2005) 1.59
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Noninvasive imaging of spontaneous retinoblastoma pathway-dependent tumors in mice. Cancer Res (2002) 1.46
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N-acetylation and ubiquitin-independent proteasomal degradation of p21(Cip1). Mol Cell (2004) 1.45
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Mutations in WNT10A are present in more than half of isolated hypodontia cases. J Med Genet (2012) 1.37
Isoform- and cell cycle-dependent substrate degradation by the Fbw7 ubiquitin ligase. J Cell Biol (2008) 1.35
Mouse models of prostate adenocarcinoma with the capacity to monitor spontaneous carcinogenesis by bioluminescence or fluorescence. Cancer Res (2007) 1.33
Multiple cells-of-origin of mutant K-Ras-induced mouse lung adenocarcinoma. Proc Natl Acad Sci U S A (2014) 1.30
Loss of p27(Kip1) but not p21(Cip1) decreases survival and synergizes with MYC in murine lymphomagenesis. EMBO J (2002) 1.26
Cyclin E phosphorylation regulates cell proliferation in hematopoietic and epithelial lineages in vivo. Genes Dev (2008) 1.25
The generation of a conditional reporter that enables bioluminescence imaging of Cre/loxP-dependent tumorigenesis in mice. Cancer Res (2003) 1.19
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Fbw7 and p53 cooperatively suppress advanced and chromosomally unstable intestinal cancer. Mol Cell Biol (2012) 1.17
Rapid target gene validation in complex cancer mouse models using re-derived embryonic stem cells. EMBO Mol Med (2014) 1.17
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Tumor formation in mice with somatic inactivation of the retinoblastoma gene in interphotoreceptor retinol binding protein-expressing cells. Oncogene (2002) 1.16
Ras activity regulates cyclin E degradation by the Fbw7 pathway. Proc Natl Acad Sci U S A (2005) 1.15
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Validation of MdmX as a therapeutic target for reactivating p53 in tumors. Genes Dev (2011) 1.11
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Fbw7 dimerization determines the specificity and robustness of substrate degradation. Genes Dev (2013) 1.05
Novel candidate cancer genes identified by a large-scale cross-species comparative oncogenomics approach. Cancer Res (2010) 1.03
Insertional mutagenesis in mice deficient for p15Ink4b, p16Ink4a, p21Cip1, and p27Kip1 reveals cancer gene interactions and correlations with tumor phenotypes. Cancer Res (2010) 1.02
Lack of Rb and p53 delays cerebellar development and predisposes to large cell anaplastic medulloblastoma through amplification of N-Myc and Ptch2. Cancer Res (2006) 0.97
An inducible mouse model of melanoma expressing a defined tumor antigen. Cancer Res (2006) 0.96
Nucleolar targeting of the fbw7 ubiquitin ligase by a pseudosubstrate and glycogen synthase kinase 3. Mol Cell Biol (2011) 0.94
Proliferative reactive gliosis is compatible with glial metabolic support and neuronal function. BMC Neurosci (2011) 0.93
A mechanism misregulating p27 in tumors discovered in a functional genomic screen. PLoS Genet (2007) 0.92
Computational identification of insertional mutagenesis targets for cancer gene discovery. Nucleic Acids Res (2011) 0.92
Fbw7 repression by hes5 creates a feedback loop that modulates Notch-mediated intestinal and neural stem cell fate decisions. PLoS Biol (2013) 0.91
Rapid validation of cancer genes in chimeras derived from established genetically engineered mouse models. Bioessays (2011) 0.89
Essential role for Cdk2 inhibitory phosphorylation during replication stress revealed by a human Cdk2 knockin mutation. Proc Natl Acad Sci U S A (2013) 0.88
Frat is dispensable for canonical Wnt signaling in mammals. Genes Dev (2005) 0.87
Cross-species oncogenomics in cancer gene identification. Cell (2006) 0.87
Cancer biology: can less be more for p53? Nature (2006) 0.87
Analysis of gene expression, copy number and palindrome formation with a Dt40 enriched cDNA microarray. Subcell Biochem (2006) 0.86
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Hypoxia-inducible factor 1 is activated by dysregulated cyclin E during mammary epithelial morphogenesis. Mol Cell Biol (2011) 0.85
Re-evaluating the role of Frat in Wnt-signal transduction. Cell Cycle (2005) 0.85
Zcchc8 is a glycogen synthase kinase-3 substrate that interacts with RNA-binding proteins. Biochem Biophys Res Commun (2005) 0.84
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Frat2 mediates the oncogenic activation of Rac by MLL fusions. Blood (2012) 0.82