Published in Nat Methods on September 29, 2004
Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide. Proc Natl Acad Sci U S A (2007) 2.11
Site-specific antibody-drug conjugates: the nexus of bioorthogonal chemistry, protein engineering, and drug development. Bioconjug Chem (2015) 1.58
Semisynthesis and characterization of mammalian thioredoxin reductase. Biochemistry (2006) 1.28
Cell death by SecTRAPs: thioredoxin reductase as a prooxidant killer of cells. PLoS One (2008) 1.24
Molecularly defined antibody conjugation through a selenocysteine interface. Biochemistry (2009) 1.23
An engineered selenocysteine defines a unique class of antibody derivatives. Proc Natl Acad Sci U S A (2008) 1.21
Probing the role of the proximal heme ligand in cytochrome P450cam by recombinant incorporation of selenocysteine. Proc Natl Acad Sci U S A (2009) 1.01
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Rewiring translation for elongation factor Tu-dependent selenocysteine incorporation. Angew Chem Int Ed Engl (2012) 0.92
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TrxR1 as a Potent Regulator of the Nrf2-Keap1 Response System. Antioxid Redox Signal (2015) 0.90
The selenium-independent inherent pro-oxidant NADPH oxidase activity of mammalian thioredoxin reductase and its selenium-dependent direct peroxidase activities. J Biol Chem (2010) 0.90
(77)Se enrichment of proteins expands the biological NMR toolbox. J Mol Biol (2012) 0.89
Titration and conditional knockdown of the prfB gene in Escherichia coli: effects on growth and overproduction of the recombinant mammalian selenoprotein thioredoxin reductase. Appl Environ Microbiol (2006) 0.86
Wobble decoding by the Escherichia coli selenocysteine insertion machinery. Nucleic Acids Res (2013) 0.83
Combining [11C]-AnxA5 PET imaging with serum biomarkers for improved detection in live mice of modest cell death in human solid tumor xenografts. PLoS One (2012) 0.82
Redox activation of Fe(III)-thiosemicarbazones and Fe(III)-bleomycin by thioredoxin reductase: specificity of enzymatic redox centers and analysis of reactive species formation by ESR spin trapping. Free Radic Biol Med (2013) 0.81
Targeting Thioredoxin Reductase by Parthenolide Contributes to Inducing Apoptosis of HeLa Cells. J Biol Chem (2016) 0.81
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Preclinical PET imaging of EGFR levels: pairing a targeting with a non-targeting Sel-tagged Affibody-based tracer to estimate the specific uptake. EJNMMI Res (2016) 0.75
Vascular endothelial growth factor B controls endothelial fatty acid uptake. Nature (2010) 3.40
Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration. Toxicol Lett (2006) 3.06
Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes. Nature (2012) 2.83
Binding of blood proteins to carbon nanotubes reduces cytotoxicity. Proc Natl Acad Sci U S A (2011) 2.66
Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target. PLoS Med (2007) 2.39
Selenocysteine in proteins-properties and biotechnological use. Biochim Biophys Acta (2005) 2.23
Acute toxicological effects of copper nanoparticles in vivo. Toxicol Lett (2005) 2.04
Cellular uptake, intracellular trafficking, and cytotoxicity of nanomaterials. Small (2011) 2.00
Active sites of thioredoxin reductases: why selenoproteins? Proc Natl Acad Sci U S A (2003) 1.69
Inhibition of thioredoxin reductase but not of glutathione reductase by the major classes of alkylating and platinum-containing anticancer compounds. Free Radic Biol Med (2005) 1.58
Time-dependent translocation and potential impairment on central nervous system by intranasally instilled TiO(2) nanoparticles. Toxicology (2008) 1.56
Understanding the toxicity of carbon nanotubes. Acc Chem Res (2012) 1.51
Surface chemistry and aspect ratio mediated cellular uptake of Au nanorods. Biomaterials (2010) 1.48
Cinnabar is not converted into methylmercury by human intestinal bacteria. J Ethnopharmacol (2011) 1.45
Regulation of the mammalian selenoprotein thioredoxin reductase 1 in relation to cellular phenotype, growth, and signaling events. Antioxid Redox Signal (2004) 1.45
Mesoporous silica-coated gold nanorods as a light-mediated multifunctional theranostic platform for cancer treatment. Adv Mater (2012) 1.44
Selective targeting of gold nanorods at the mitochondria of cancer cells: implications for cancer therapy. Nano Lett (2010) 1.40
The triggering of apoptosis in macrophages by pristine graphene through the MAPK and TGF-beta signaling pathways. Biomaterials (2011) 1.37
Crystal structure and catalysis of the selenoprotein thioredoxin reductase 1. J Biol Chem (2008) 1.28
Potential neurological lesion after nasal instillation of TiO(2) nanoparticles in the anatase and rutile crystal phases. Toxicol Lett (2008) 1.27
Potent angiogenesis inhibition by the particulate form of fullerene derivatives. ACS Nano (2010) 1.25
Metallofullerene nanoparticles circumvent tumor resistance to cisplatin by reactivating endocytosis. Proc Natl Acad Sci U S A (2010) 1.25
Cell death by SecTRAPs: thioredoxin reductase as a prooxidant killer of cells. PLoS One (2008) 1.24
On the selection of a tracer for PET imaging of HER2-expressing tumors: direct comparison of a 124I-labeled affibody molecule and trastuzumab in a murine xenograft model. J Nucl Med (2009) 1.23
The scavenging of reactive oxygen species and the potential for cell protection by functionalized fullerene materials. Biomaterials (2008) 1.19
Assessment of production conditions for efficient use of Escherichia coli in high-yield heterologous recombinant selenoprotein synthesis. Appl Environ Microbiol (2004) 1.18
Rapid induction of cell death by selenium-compromised thioredoxin reductase 1 but not by the fully active enzyme containing selenocysteine. J Biol Chem (2003) 1.18
Ultrahigh reactivity provokes nanotoxicity: explanation of oral toxicity of nano-copper particles. Toxicol Lett (2007) 1.14
The mammalian cytosolic selenoenzyme thioredoxin reductase reduces ubiquinone. A novel mechanism for defense against oxidative stress. J Biol Chem (2002) 1.13
Circumventing tumor resistance to chemotherapy by nanotechnology. Methods Mol Biol (2010) 1.12
High levels of thioredoxin reductase 1 modulate drug-specific cytotoxic efficacy. Free Radic Biol Med (2009) 1.12
Interactions of quinones with thioredoxin reductase: a challenge to the antioxidant role of the mammalian selenoprotein. J Biol Chem (2003) 1.12
Near-infrared light-mediated nanoplatforms for cancer thermo-chemotherapy and optical imaging. Adv Mater (2013) 1.12
Gold nanorods based platforms for light-mediated theranostics. Theranostics (2013) 1.11
Inhibition of tumor growth by endohedral metallofullerenol nanoparticles optimized as reactive oxygen species scavenger. Mol Pharmacol (2008) 1.11
Multiwall carbon nanotubes mediate macrophage activation and promote pulmonary fibrosis through TGF-β/Smad signaling pathway. Small (2013) 1.07
Interactions of nitroaromatic compounds with the mammalian selenoprotein thioredoxin reductase and the relation to induction of apoptosis in human cancer cells. J Biol Chem (2005) 1.06
Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis. J Med Chem (2009) 1.05
Near infrared laser-induced targeted cancer therapy using thermoresponsive polymer encapsulated gold nanorods. J Am Chem Soc (2014) 1.05
Cytotoxic potential of silver nanoparticles. Yonsei Med J (2014) 1.04
Quantitative analysis of metal impurities in carbon nanotubes: efficacy of different pretreatment protocols for ICPMS spectroscopy. Anal Chem (2008) 1.04
Evidence for intriguingly complex transcription of human thioredoxin reductase 1. Free Radic Biol Med (2004) 1.04
Antioxidative function and biodistribution of [Gd@C82(OH)22]n nanoparticles in tumor-bearing mice. Biochem Pharmacol (2006) 1.03
Radiolabelled receptor-tyrosine-kinase targeting drugs for patient stratification and monitoring of therapy response: prospects and pitfalls. Lancet Oncol (2010) 1.03
Molecular mechanism of pancreatic tumor metastasis inhibition by Gd@C82(OH)22 and its implication for de novo design of nanomedicine. Proc Natl Acad Sci U S A (2012) 1.03
Substrate and inhibitor specificities differ between human cytosolic and mitochondrial thioredoxin reductases: Implications for development of specific inhibitors. Free Radic Biol Med (2010) 1.02
The effect of Gd@C82(OH)22 nanoparticles on the release of Th1/Th2 cytokines and induction of TNF-alpha mediated cellular immunity. Biomaterials (2009) 1.02
Cisplatin and oxaliplatin toxicity: importance of cochlear kinetics as a determinant for ototoxicity. J Natl Cancer Inst (2008) 1.02
Overexpression of enzymatically active human cytosolic and mitochondrial thioredoxin reductase in HEK-293 cells. Effect on cell growth and differentiation. J Biol Chem (2004) 1.01
Radiolabelled proteins for positron emission tomography: Pros and cons of labelling methods. Biochim Biophys Acta (2010) 1.01
Potato gene Y-1 is an N gene homolog that confers cell death upon infection with potato virus Y. Mol Plant Microbe Interact (2002) 1.01
Controlling assembly of paired gold clusters within apoferritin nanoreactor for in vivo kidney targeting and biomedical imaging. J Am Chem Soc (2011) 1.00
Fate and toxicity of metallic and metal-containing nanoparticles for biomedical applications. Small (2011) 1.00
The translocation of fullerenic nanoparticles into lysosome via the pathway of clathrin-mediated endocytosis. Nanotechnology (2008) 0.99
Anti-tumor activity of paclitaxel through dual-targeting carrier of cyclic RGD and transferrin conjugated hyperbranched copolymer nanoparticles. Biomaterials (2011) 0.97
Biopharmaceutics and therapeutic potential of engineered nanomaterials. Curr Drug Metab (2008) 0.97
Induction of cell membrane protrusions by the N-terminal glutaredoxin domain of a rare splice variant of human thioredoxin reductase 1. J Biol Chem (2007) 0.97
Surface-engineered gold nanorods: promising DNA vaccine adjuvant for HIV-1 treatment. Nano Lett (2012) 0.96
Bismuth sulfide nanorods as a precision nanomedicine for in vivo multimodal imaging-guided photothermal therapy of tumor. ACS Nano (2015) 0.96
Selenoprotein TRXR-1 and GSR-1 are essential for removal of old cuticle during molting in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2011) 0.96
Hepatocyte DNA replication in growing liver requires either glutathione or a single allele of txnrd1. Free Radic Biol Med (2011) 0.96
Endoplasmic reticulum stress induced by zinc oxide nanoparticles is an earlier biomarker for nanotoxicological evaluation. ACS Nano (2014) 0.96
Mitochondrial peroxiredoxin 3 is rapidly oxidized in cells treated with isothiocyanates. Free Radic Biol Med (2008) 0.95
Highly active dimeric and low-activity tetrameric forms of selenium-containing rat thioredoxin reductase 1. Free Radic Biol Med (2008) 0.94
p53-dependent inhibition of TrxR1 contributes to the tumor-specific induction of apoptosis by RITA. Cell Cycle (2009) 0.94
Noble metal targeting of thioredoxin reductase--covalent complexes with thioredoxin and thioredoxin-related protein of 14 kDa triggered by cisplatin. Free Radic Biol Med (2010) 0.93
Applications of functionalized fullerenes in tumor theranostics. Theranostics (2012) 0.93
Fullerene nanoparticles selectively enter oxidation-damaged cerebral microvessel endothelial cells and inhibit JNK-related apoptosis. ACS Nano (2009) 0.93
Structural characterization of the tetrameric form of the major cat allergen Fel d 1. J Mol Biol (2007) 0.93
Nano-bio effects: interaction of nanomaterials with cells. Nanoscale (2013) 0.92
Selective activation of oxidized PTP1B by the thioredoxin system modulates PDGF-β receptor tyrosine kinase signaling. Proc Natl Acad Sci U S A (2013) 0.91
Allergic asthmatics show divergent lipid mediator profiles from healthy controls both at baseline and following birch pollen provocation. PLoS One (2012) 0.91
Potential health impact on mice after nasal instillation of nano-sized copper particles and their translocation in mice. J Nanosci Nanotechnol (2009) 0.91
The 19S Deubiquitinase inhibitor b-AP15 is enriched in cells and elicits rapid commitment to cell death. Mol Pharmacol (2014) 0.90
The selenium-independent inherent pro-oxidant NADPH oxidase activity of mammalian thioredoxin reductase and its selenium-dependent direct peroxidase activities. J Biol Chem (2010) 0.90
Immunostimulatory properties and enhanced TNF- alpha mediated cellular immunity for tumor therapy by C60(OH)20 nanoparticles. Nanotechnology (2009) 0.90
Synthesis and preclinical evaluation of [(11)C]PAQ as a PET imaging tracer for VEGFR-2. Eur J Nucl Med Mol Imaging (2009) 0.90
The interactions between pristine graphene and macrophages and the production of cytokines/chemokines via TLR- and NF-κB-related signaling pathways. Biomaterials (2012) 0.89
Biochemical discrimination between selenium and sulfur 1: a single residue provides selenium specificity to human selenocysteine lyase. PLoS One (2012) 0.89
The major cat allergen, Fel d 1, in diagnosis and therapy. Int Arch Allergy Immunol (2009) 0.89
Au@Pt nanostructures as oxidase and peroxidase mimetics for use in immunoassays. Biomaterials (2010) 0.88
Full assessment of fate and physiological behavior of quantum dots utilizing Caenorhabditis elegans as a model organism. Nano Lett (2011) 0.88
Thioredoxin reductase inhibition elicits Nrf2-mediated responses in Clara cells: implications for oxidant-induced lung injury. Antioxid Redox Signal (2012) 0.88
Multilevel regulation of 2-Cys peroxiredoxin reaction cycle by S-nitrosylation. J Biol Chem (2013) 0.87
Tagging recombinant proteins with a Sel-tag for purification, labeling with electrophilic compounds or radiolabeling with 11C. Nat Protoc (2006) 0.87
Revealing the binding structure of the protein corona on gold nanorods using synchrotron radiation-based techniques: understanding the reduced damage in cell membranes. J Am Chem Soc (2013) 0.87
Expression of selenocysteine-containing glutathione S-transferase in Escherichia coli. Biochem Biophys Res Commun (2004) 0.87
Changes in Regional Cerebral Oxidative Metabolism Induced by Tactile Learning and Recognition in Man. Eur J Neurosci (1989) 0.87
Blood cadmium, mercury, and lead in children: an international comparison of cities in six European countries, and China, Ecuador, and Morocco. Environ Int (2012) 0.87
Brief Report: alterations in cerebral blood flow as assessed by PET/CT in adults with autism spectrum disorder with normal IQ. J Autism Dev Disord (2012) 0.86
Titration and conditional knockdown of the prfB gene in Escherichia coli: effects on growth and overproduction of the recombinant mammalian selenoprotein thioredoxin reductase. Appl Environ Microbiol (2006) 0.86
Covalent coupling of vitamin D3 to the major cat allergen Fel d 1 improves the effects of allergen-specific immunotherapy in a mouse model for cat allergy. Int Arch Allergy Immunol (2011) 0.86
Pyrroloquinoline quinone modulates the kinetic parameters of the mammalian selenoprotein thioredoxin reductase 1 and is an inhibitor of glutathione reductase. Biochem Pharmacol (2011) 0.86
Fullerene derivatives protect endothelial cells against NO-induced damage. Nanotechnology (2009) 0.86
A novel adjuvant-allergen complex, CBP-rFel d 1, induces up-regulation of CD86 expression and enhances cytokine release by human dendritic cells in vitro. Immunology (2004) 0.86
Morphologically virus-like fullerenol nanoparticles act as the dual-functional nanoadjuvant for HIV-1 vaccine. Adv Mater (2013) 0.86