A novel adjuvant-allergen complex, CBP-rFel d 1, induces up-regulation of CD86 expression and enhances cytokine release by human dendritic cells in vitro.

PubWeight™: 0.86‹?›

🔗 View Article (PMC 1782568)

Published in Immunology on October 01, 2004

Authors

Theresa N Andersson1, Gunilla J Ekman, Hans Grönlund, Eva Buentke, Tove L J Eriksson, Annika Scheynius, Marianne Van Hage-Hamsten, Guro Gafvelin

Author Affiliations

1: Department of Medicine, Clinical Immunology and Allergy Unit, Karolinska Institutet and University Hospital, Stockholm, Sweden.

Articles cited by this

Dendritic cells and the control of immunity. Nature (1998) 56.54

Chemical coupling of peptides and proteins to polysaccharides by means of cyanogen halides. Nature (1967) 16.97

CD28/B7 system of T cell costimulation. Annu Rev Immunol (1996) 10.48

Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products. J Exp Med (1995) 9.79

Proliferating dendritic cell progenitors in human blood. J Exp Med (1994) 7.67

Origin, maturation and antigen presenting function of dendritic cells. Curr Opin Immunol (1997) 5.21

A revised nomenclature for allergy. An EAACI position statement from the EAACI nomenclature task force. Allergy (2001) 5.07

Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity? Trends Immunol (2002) 4.64

Oral gene delivery with chitosan--DNA nanoparticles generates immunologic protection in a murine model of peanut allergy. Nat Med (1999) 3.36

Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation. J Clin Invest (1999) 3.32

Efficient major histocompatibility complex class I presentation of exogenous antigen upon phagocytosis by macrophages. Proc Natl Acad Sci U S A (1993) 3.27

Allergen immunotherapy: therapeutic vaccines for allergic diseases. A WHO position paper. J Allergy Clin Immunol (1998) 3.27

To respond or not to respond: T cells in allergic asthma. Nat Rev Immunol (2003) 3.14

Sensitisation, asthma, and a modified Th2 response in children exposed to cat allergen: a population-based cross-sectional study. Lancet (2001) 3.06

Viral-induced T helper type 1 responses enhance allergic disease by effects on lung dendritic cells. Nat Immunol (2004) 2.96

Aluminium hydroxide adjuvant initiates strong antigen-specific Th2 responses in the absence of IL-4- or IL-13-mediated signaling. J Immunol (1999) 2.53

Allergen-specific immunotherapy with a monophosphoryl lipid A-adjuvanted vaccine: reduced seasonally boosted immunoglobulin E production and inhibition of basophil histamine release by therapy-induced blocking antibodies. Clin Exp Allergy (2003) 2.08

Adjuvants--a classification and review of their modes of action. Vaccine (1997) 1.86

Some interfaces of dendritic cell biology. APMIS (2003) 1.79

Macrophagic myofasciitis lesions assess long-term persistence of vaccine-derived aluminium hydroxide in muscle. Brain (2001) 1.67

The future of antigen-specific immunotherapy of allergy. Nat Rev Immunol (2002) 1.41

What's the difference between CD80 and CD86? Trends Immunol (2003) 1.29

The instructive role of dendritic cells on T-cell responses. Arthritis Res (2002) 1.26

Th2 polarization by Der p 1--pulsed monocyte-derived dendritic cells is due to the allergic status of the donors. Blood (2001) 1.25

ICOS and CD28 reversely regulate IL-10 on re-activation of human effector T cells with mature dendritic cells. Eur J Immunol (2002) 1.19

Immunologic changes associated with allergen immunotherapy. J Allergy Clin Immunol (1998) 1.17

Chemically modified antigen preferentially elicits induction of Th1-like cytokine synthesis patterns in vivo. J Exp Med (1993) 1.10

Formation of disulfide bonds and homodimers of the major cat allergen Fel d 1 equivalent to the natural allergen by expression in Escherichia coli. J Biol Chem (2003) 1.04

CD154 plays a central role in regulating dendritic cell activation during infections that induce Th1 or Th2 responses. J Immunol (2003) 1.01

Costimulation through CD86 is involved in airway antigen-presenting cell and T cell responses to allergen in atopic asthmatics. J Immunol (1998) 0.98

The allergenic yeast Malassezia furfur induces maturation of human dendritic cells. Clin Exp Allergy (2001) 0.95

Langerhans-like dendritic cells generated from cord blood progenitors internalize pollen allergens by macropinocytosis, and part of the molecules are processed and can activate autologous naive T lymphocytes. J Allergy Clin Immunol (2000) 0.90

Aluminium-induced granulomas after inaccurate intradermal hyposensitization injections of aluminium-adsorbed depot preparations. Allergy (2000) 0.89

Particulate adjuvants can induce macrophage survival, DNA synthesis, and a synergistic proliferative response to GM-CSF and CSF-1. J Leukoc Biol (2000) 0.88

Allergy immunotherapy and inhibition of Th2 immune responses: a sufficient strategy? Curr Opin Immunol (2002) 0.87

Side effects during immunotherapy with purified grass pollen extracts. Allergy (1982) 0.82

Carbohydrate-based particles: a new adjuvant for allergen-specific immunotherapy. Immunology (2002) 0.81

CpG motifs as possible adjuvants for the treatment of allergic diseases. Int Arch Allergy Immunol (2002) 0.81

Uptake of the yeast Malassezia furfur and its allergenic components by human immature CD1a+ dendritic cells. Clin Exp Allergy (2000) 0.81

Articles by these authors

Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis. Nat Biotechnol (2013) 5.89

Differential DNA methylation in purified human blood cells: implications for cell lineage and studies on disease susceptibility. PLoS One (2012) 5.03

MicroRNAs: novel regulators involved in the pathogenesis of psoriasis? PLoS One (2007) 3.96

Exosomes with immune modulatory features are present in human breast milk. J Immunol (2007) 3.47

Tumor imaging using a picomolar affinity HER2 binding affibody molecule. Cancer Res (2006) 2.46

Allergic disease and sensitization in Steiner school children. J Allergy Clin Immunol (2005) 2.44

Selenocysteine in proteins-properties and biotechnological use. Biochim Biophys Acta (2005) 2.23

Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL Consensus Report. J Allergy Clin Immunol (2006) 2.00

Intralymphatic immunotherapy for cat allergy induces tolerance after only 3 injections. J Allergy Clin Immunol (2012) 1.88

Prenatal farm exposure is related to the expression of receptors of the innate immunity and to atopic sensitization in school-age children. J Allergy Clin Immunol (2006) 1.84

Haplotypes of G protein-coupled receptor 154 are associated with childhood allergy and asthma. Am J Respir Crit Care Med (2005) 1.78

IgE-mediated and T cell-mediated autoimmunity against manganese superoxide dismutase in atopic dermatitis. J Allergy Clin Immunol (2005) 1.74

Peptide immunotherapy in allergic asthma generates IL-10-dependent immunological tolerance associated with linked epitope suppression. J Exp Med (2009) 1.73

Microarrayed allergen molecules: diagnostic gatekeepers for allergy treatment. FASEB J (2002) 1.66

Affibody molecules for epidermal growth factor receptor targeting in vivo: aspects of dimerization and labeling chemistry. J Nucl Med (2009) 1.54

Class A scavenger receptors regulate tolerance against apoptotic cells, and autoantibodies against these receptors are predictive of systemic lupus. J Exp Med (2007) 1.53

The importance of an endotoxin-free environment during the production of nanoparticles used in medical applications. Nano Lett (2006) 1.52

Low salivary cortisol levels in infants of families with an anthroposophic lifestyle. Psychoneuroendocrinology (2010) 1.48

Toxicology of engineered nanomaterials: focus on biocompatibility, biodistribution and biodegradation. Biochim Biophys Acta (2010) 1.48

Cat IgA, representative of new carbohydrate cross-reactive allergens. J Allergy Clin Immunol (2007) 1.34

Expression and regulation of the pattern recognition receptors Toll-like receptor-2 and Toll-like receptor-4 in the human placenta. Immunology (2002) 1.33

Malassezia fungi are specialized to live on skin and associated with dandruff, eczema, and other skin diseases. PLoS Pathog (2012) 1.24

Exosomes containing glycoprotein 350 released by EBV-transformed B cells selectively target B cells through CD21 and block EBV infection in vitro. J Immunol (2010) 1.24

Molecular fingerprinting of the fecal microbiota of children raised according to different lifestyles. Appl Environ Microbiol (2007) 1.23

Directed evolution to low nanomolar affinity of a tumor-targeting epidermal growth factor receptor-binding affibody molecule. J Mol Biol (2008) 1.19

Mesoporous silica particles induce size dependent effects on human dendritic cells. Nano Lett (2007) 1.18

Phosphatidylserine targets single-walled carbon nanotubes to professional phagocytes in vitro and in vivo. PLoS One (2009) 1.16

Efficient internalization of silica-coated iron oxide nanoparticles of different sizes by primary human macrophages and dendritic cells. Toxicol Appl Pharmacol (2011) 1.16

A hypoallergenic cat vaccine based on Fel d 1-derived peptides fused to hepatitis B PreS. J Allergy Clin Immunol (2011) 1.15

Genomic insights into the atopic eczema-associated skin commensal yeast Malassezia sympodialis. MBio (2013) 1.15

Biological and genetic interaction between tenascin C and neuropeptide S receptor 1 in allergic diseases. Hum Mol Genet (2008) 1.14

Low levels of IgM antibodies to phosphorylcholine predict cardiovascular disease in 60-year old men: effects on uptake of oxidized LDL in macrophages as a potential mechanism. J Autoimmun (2009) 1.13

Atopic eczema/dermatitis syndrome and Malassezia. Int Arch Allergy Immunol (2002) 1.12

Natural killer and dendritic cell contact in lesional atopic dermatitis skin--Malassezia-influenced cell interaction. J Invest Dermatol (2002) 1.12

The crystal structure of the major cat allergen Fel d 1, a member of the secretoglobin family. J Biol Chem (2003) 1.11

Low levels of IgM antibodies against phosphorylcholine-A potential risk marker for ischemic stroke in men. Atherosclerosis (2008) 1.10

Impaired allergy diagnostics among parasite-infected patients caused by IgE antibodies to the carbohydrate epitope galactose-α 1,3-galactose. J Allergy Clin Immunol (2011) 1.09

Exosomes from human macrophages and dendritic cells contain enzymes for leukotriene biosynthesis and promote granulocyte migration. J Allergy Clin Immunol (2010) 1.07

The carbohydrate galactose-alpha-1,3-galactose is a major IgE-binding epitope on cat IgA. J Allergy Clin Immunol (2009) 1.07

Exploiting the 21st amino acid-purifying and labeling proteins by selenolate targeting. Nat Methods (2004) 1.06

Global expression profiling in atopic eczema reveals reciprocal expression of inflammatory and lipid genes. PLoS One (2008) 1.06

B cell-derived exosomes can present allergen peptides and activate allergen-specific T cells to proliferate and produce TH2-like cytokines. J Allergy Clin Immunol (2007) 1.05

Nanovesicles from Malassezia sympodialis and host exosomes induce cytokine responses--novel mechanisms for host-microbe interactions in atopic eczema. PLoS One (2011) 1.02

Crystal structure of the dog lipocalin allergen Can f 2: implications for cross-reactivity to the cat allergen Fel d 4. J Mol Biol (2010) 1.02

Gene expression profiling of immune-competent human cells exposed to engineered zinc oxide or titanium dioxide nanoparticles. PLoS One (2013) 1.02

The prevalence of Malassezia yeasts in patients with atopic dermatitis, seborrhoeic dermatitis and healthy controls. Acta Derm Venereol (2005) 1.02

Different types of in vitro generated human monocyte-derived dendritic cells release exosomes with distinct phenotypes. Immunology (2007) 0.98

Malassezia sympodialis thioredoxin-specific T cells are highly cross-reactive to human thioredoxin in atopic dermatitis. J Allergy Clin Immunol (2011) 0.98

Sensitization to the yeast Malassezia sympodialis is specific for extrinsic and intrinsic atopic eczema. J Invest Dermatol (2006) 0.98

Dexamethasone-induced apoptosis in acute lymphoblastic leukemia involves differential regulation of Bcl-2 family members. Haematologica (2007) 0.97

Neonatal immune responses to microbial stimuli: is there an influence of maternal allergy? J Allergy Clin Immunol (2005) 0.96

Exposure to a farming environment has allergen-specific protective effects on TH2-dependent isotype switching in response to common inhalants. J Allergy Clin Immunol (2006) 0.96

Truncated thioredoxin (Trx80) exerts unique mitogenic cytokine effects via a mechanism independent of thiol oxido-reductase activity. FEBS Lett (2003) 0.95

An anthroposophic lifestyle and intestinal microflora in infancy. Pediatr Allergy Immunol (2002) 0.93

Structural characterization of the tetrameric form of the major cat allergen Fel d 1. J Mol Biol (2007) 0.93

Allergens as immunomodulatory proteins: the cat dander protein Fel d 1 enhances TLR activation by lipid ligands. J Immunol (2013) 0.93

In vitro evolution of allergy vaccine candidates, with maintained structure, but reduced B cell and T cell activation capacity. PLoS One (2011) 0.92

TLR2/MyD88-dependent and -independent activation of mast cell IgE responses by the skin commensal yeast Malassezia sympodialis. J Immunol (2009) 0.92

Dendritic cells and fungi. APMIS (2003) 0.92

IL-18 skews the invariant NKT-cell population via autoreactive activation in atopic eczema. Eur J Immunol (2009) 0.92

Cytokine and antibody responses in birch-pollen-allergic patients treated with genetically modified derivatives of the major birch pollen allergen Bet v 1. Int Arch Allergy Immunol (2005) 0.91

Allergic asthmatics show divergent lipid mediator profiles from healthy controls both at baseline and following birch pollen provocation. PLoS One (2012) 0.91

A polymorphism in CD14 modifies the effect of farm milk consumption on allergic diseases and CD14 gene expression. J Allergy Clin Immunol (2007) 0.91

Elevated peripheral allergen-specific T cell response is crucial for a positive atopy patch test reaction. Int Arch Allergy Immunol (2009) 0.90

Effects of subtoxic concentrations of TiO2 and ZnO nanoparticles on human lymphocytes, dendritic cells and exosome production. Toxicol Appl Pharmacol (2012) 0.90

The major cat allergen, Fel d 1, in diagnosis and therapy. Int Arch Allergy Immunol (2009) 0.89

The inflammatory cytokine IL-18 induces self-reactive innate antibody responses regulated by natural killer T cells. Proc Natl Acad Sci U S A (2011) 0.89

Truncated thioredoxin (Trx80) induces differentiation of human CD14+ monocytes into a novel cell type (TAMs) via activation of the MAP kinases p38, ERK, and JNK. Blood (2004) 0.88

Analysis of the cross-reactivity and of the 1.5 A crystal structure of the Malassezia sympodialis Mala s 6 allergen, a member of the cyclophilin pan-allergen family. Biochem J (2006) 0.88

Microvilli structures on B lymphocytes: inducible functional domains? Int Immunol (2004) 0.87

Problematic severe asthma: a proposed approach to identifying children who are severely resistant to therapy. Pediatr Allergy Immunol (2010) 0.87

Identification of (1-->6)-beta-D-glucan as the major carbohydrate component of the Malassezia sympodialis cell wall. Carbohydr Res (2009) 0.87

Interference in immunoassays by human IgM with specificity for the carbohydrate moiety of animal proteins. J Immunol Methods (2006) 0.87

Allergic disease and atopic sensitization in children in relation to measles vaccination and measles infection. Pediatrics (2009) 0.86

Production, crystallization and preliminary crystallographic study of the major cat allergen Fel d 1. Acta Crystallogr D Biol Crystallogr (2003) 0.86

Covalent coupling of vitamin D3 to the major cat allergen Fel d 1 improves the effects of allergen-specific immunotherapy in a mouse model for cat allergy. Int Arch Allergy Immunol (2011) 0.86

Human cytomegalovirus-derived protein UL18 alters the phenotype and function of monocyte-derived dendritic cells. J Leukoc Biol (2007) 0.86

Hypoallergens for allergen-specific immunotherapy by directed molecular evolution of mite group 2 allergens. J Biol Chem (2006) 0.86

Rule-based models of the interplay between genetic and environmental factors in childhood allergy. PLoS One (2013) 0.85

Cloning, expression and characterization of two new IgE-binding proteins from the yeast Malassezia sympodialis with sequence similarities to heat shock proteins and manganese superoxide dismutase. Eur J Biochem (2004) 0.85

Positive atopy patch test reaction to Malassezia furfur in atopic dermatitis correlates with a T helper 2-like peripheral blood mononuclear cells response. J Invest Dermatol (2002) 0.85

DNA methylation in the Neuropeptide S Receptor 1 (NPSR1) promoter in relation to asthma and environmental factors. PLoS One (2013) 0.84

Non-proteolytic aeroallergens from mites, cat and dog exert adjuvant-like activation of bronchial epithelial cells. Int Arch Allergy Immunol (2010) 0.84

Comparisons between salivary cortisol levels in six-months-olds and their parents. Psychoneuroendocrinology (2008) 0.84

Adjuvant properties of mesoporous silica particles tune the development of effector T cells. Small (2012) 0.83

Human immunoglobulin A (IgA)-specific ligands from combinatorial engineering of protein A. Eur J Biochem (2002) 0.83

Severe childhood asthma and allergy to furry animals: refined assessment using molecular-based allergy diagnostics. Pediatr Allergy Immunol (2014) 0.83

Zymosan suppresses leukotriene C₄ synthase activity in differentiating monocytes: antagonism by aspirin and protein kinase inhibitors. FASEB J (2011) 0.82

Cloning and characterisation of two IgE-binding proteins, homologous to tropomyosin and alpha-tubulin, from the mite Lepidoglyphus destructor. Int Arch Allergy Immunol (2003) 0.82

Interaction between retinoid acid receptor-related orphan receptor alpha (RORA) and neuropeptide S receptor 1 (NPSR1) in asthma. PLoS One (2013) 0.82

Salivary cortisol levels and allergy in children: the ALADDIN birth cohort. J Allergy Clin Immunol (2011) 0.82

Toll-like receptor-2 expression in normal and pathologic human placenta. Hum Pathol (2007) 0.82

Structural changes and allergenic properties of β-lactoglobulin upon exposure to high-intensity ultrasound. Mol Nutr Food Res (2012) 0.82

The role of sensitization to Malassezia sympodialis in atopic eczema. Chem Immunol Allergy (2006) 0.81

Carbohydrate-based particles: a new adjuvant for allergen-specific immunotherapy. Immunology (2002) 0.81

The expression of BAFF, APRIL and TWEAK is altered in eczema skin but not in the circulation of atopic and seborrheic eczema patients. PLoS One (2011) 0.81