Published in J Biol Chem on March 24, 2005
Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosis. PLoS One (2011) 1.38
The role of Cdk5 in neuroendocrine thyroid cancer. Cancer Cell (2013) 1.30
A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling. J Biol Chem (2010) 1.23
A novel LZAP-binding protein, NLBP, inhibits cell invasion. J Biol Chem (2010) 1.17
Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity. EMBO J (2010) 1.14
Tumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activation. Cell Res (2009) 1.04
Identification of LZAP as a new candidate tumor suppressor in hepatocellular carcinoma. PLoS One (2011) 0.89
Bypass of hexavalent chromium-induced growth arrest by a protein tyrosine phosphatase inhibitor: enhanced survival and mutagenesis. Mutat Res (2008) 0.88
LZAP inhibits p38 MAPK (p38) phosphorylation and activity by facilitating p38 association with the wild-type p53 induced phosphatase 1 (WIP1). PLoS One (2011) 0.86
Tumor suppressor Lzap regulates cell cycle progression, doming, and zebrafish epiboly. Dev Dyn (2011) 0.84
Ubiquitin-fold modifier 1 acts as a positive regulator of breast cancer. Front Endocrinol (Lausanne) (2015) 0.84
PAK4-6 in cancer and neuronal development. Cell Logist (2012) 0.83
Ionizing radiation potentiates dihydroartemisinin-induced apoptosis of A549 cells via a caspase-8-dependent pathway. PLoS One (2013) 0.82
A functional variant of IC53 correlates with the late onset of colorectal cancer. Mol Med (2011) 0.81
Expression of TIP-1 confers radioresistance of malignant glioma cells. PLoS One (2012) 0.81
CDK5RAP3 is a novel repressor of p14ARF in hepatocellular carcinoma cells. PLoS One (2012) 0.81
ERK1/2 signaling plays an important role in topoisomerase II poison-induced G2/M checkpoint activation. PLoS One (2012) 0.81
Caspase-mediated cleavage of C53/LZAP protein causes abnormal microtubule bundling and rupture of the nuclear envelope. Cell Res (2013) 0.78
Isolation and characterization of the TIGA genes, whose transcripts are induced by growth arrest. Nucleic Acids Res (2006) 0.76
Network Topologies Decoding Cervical Cancer. PLoS One (2015) 0.76
Cdk5r1 Overexpression Induces Primary β-Cell Proliferation. J Diabetes Res (2015) 0.76
LZAP is a novel Wip1 binding partner and positive regulator of its phosphatase activity in vitro. Cell Cycle (2016) 0.76
Loss of LZAP inactivates p53 and regulates sensitivity of cells to DNA damage in a p53-dependent manner. Oncogenesis (2017) 0.75
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat Genet (2004) 14.31
Regulation of mammalian autophagy in physiology and pathophysiology. Physiol Rev (2010) 6.35
Complex inhibitory effects of nitric oxide on autophagy. Mol Cell (2011) 2.36
PDTD: a web-accessible protein database for drug target identification. BMC Bioinformatics (2008) 2.35
Cytoprotective roles for autophagy. Curr Opin Cell Biol (2010) 1.81
Mammalian macroautophagy at a glance. J Cell Sci (2009) 1.78
PharmMapper server: a web server for potential drug target identification using pharmacophore mapping approach. Nucleic Acids Res (2010) 1.50
Structural basis for the regulation of cysteine-protease activity by a new class of protease inhibitors in Plasmodium. Structure (2011) 1.46
[6]-Gingerol suppresses colon cancer growth by targeting leukotriene A4 hydrolase. Cancer Res (2009) 1.26
A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling. J Biol Chem (2010) 1.23
Ubiquitin ligase Hrd1 enhances the degradation and suppresses the toxicity of polyglutamine-expanded huntingtin. Exp Cell Res (2006) 1.12
Insulin-like growth factor-1 receptor (IGF-1R) kinase inhibitors in cancer therapy: advances and perspectives. Curr Pharm Des (2012) 1.11
Transcriptional regulation of the Ufm1 conjugation system in response to disturbance of the endoplasmic reticulum homeostasis and inhibition of vesicle trafficking. PLoS One (2012) 1.05
Mechanics of channel gating of the nicotinic acetylcholine receptor. PLoS Comput Biol (2008) 1.05
Tumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activation. Cell Res (2009) 1.04
Huntingtin interacts with the cue domain of gp78 and inhibits gp78 binding to ubiquitin and p97/VCP. PLoS One (2010) 1.02
ChemMapper: a versatile web server for exploring pharmacology and chemical structure association based on molecular 3D similarity method. Bioinformatics (2013) 0.99
An improved sequence based prediction protocol for DNA-binding proteins using SVM and comprehensive feature analysis. BMC Bioinformatics (2013) 0.99
Mammalian CHORD-containing protein 1 is a novel heat shock protein 90-interacting protein. FEBS Lett (2005) 0.98
Deleterious and protective properties of an aggregate-prone protein with a polyalanine expansion. Hum Mol Genet (2005) 0.97
Free energy landscape for the binding process of Huperzine A to acetylcholinesterase. Proc Natl Acad Sci U S A (2013) 0.93
eNOS protects prostate cancer cells from TRAIL-induced apoptosis. Cancer Lett (2004) 0.92
Discovery of pteridin-7(8H)-one-based irreversible inhibitors targeting the epidermal growth factor receptor (EGFR) kinase T790M/L858R mutant. J Med Chem (2013) 0.90
SHAFTS: a hybrid approach for 3D molecular similarity calculation. 1. Method and assessment of virtual screening. J Chem Inf Model (2011) 0.89
Proteasome inhibition induces both pro- and anti-cell death pathways in prostate cancer cells. Cancer Lett (2006) 0.89
Autophagic activity in neuronal cell death. Neurosci Bull (2015) 0.86
Discovery and SAR of thiazolidine-2,4-dione analogues as insulin-like growth factor-1 receptor (IGF-1R) inhibitors via hierarchical virtual screening. J Med Chem (2010) 0.85
Myc inhibition impairs autophagosome formation. Hum Mol Genet (2013) 0.85
Investigation of the catalytic mechanism of Sir2 enzyme with QM/MM approach: SN1 vs SN2? J Phys Chem B (2010) 0.85
SHAFTS: a hybrid approach for 3D molecular similarity calculation. 2. Prospective case study in the discovery of diverse p90 ribosomal S6 protein kinase 2 inhibitors to suppress cell migration. J Med Chem (2011) 0.85
Design and synthesis of small molecular dual inhibitor of falcipain-2 and dihydrofolate reductase as antimalarial agent. Bioorg Med Chem Lett (2011) 0.84
A highly selective space-folded photo-induced electron transfer fluorescent probe for carbonic anhydrase isozymes IX and its applications for biological imaging. Chem Commun (Camb) (2011) 0.84
Apoptosis in the skeletal muscle of untreated children with juvenile dermatomyositis: impact of duration of untreated disease. Clin Immunol (2007) 0.84
Trefoil factor 3 peptide regulates migration via a Twist-dependent pathway in gastric cell. Biochem Biophys Res Commun (2013) 0.84
New aromatic substituted pyrazoles as selective inhibitors of human adipocyte fatty acid-binding protein. Bioorg Med Chem Lett (2011) 0.84
Computational methods for drug design and discovery: focus on China. Trends Pharmacol Sci (2013) 0.84
Ponatinib efficiently kills imatinib-resistant chronic eosinophilic leukemia cells harboring gatekeeper mutant T674I FIP1L1-PDGFRα: roles of Mcl-1 and β-catenin. Mol Cancer (2014) 0.84
Design and synthesis of small molecule RhoA inhibitors: a new promising therapy for cardiovascular diseases? J Med Chem (2011) 0.83
Hypothermia inhibits Fas-mediated apoptosis of primary mouse hepatocytes in culture. Cell Transplant (2004) 0.83
Discovery of diverse human dihydroorotate dehydrogenase inhibitors as immunosuppressive agents by structure-based virtual screening. J Med Chem (2012) 0.82
A new fluorescent chemodosimeter for Hg2+: selectivity, sensitivity, and resistance to Cys and GSH. Org Lett (2010) 0.82
alpha Pix enhances mutant huntingtin aggregation. J Neurol Sci (2009) 0.82
Jacarelhyperol A induced apoptosis in leukaemia cancer cell through inhibition the activity of Bcl-2 proteins. BMC Cancer (2014) 0.82
Bioactive conformational generation of small molecules: a comparative analysis between force-field and multiple empirical criteria based methods. BMC Bioinformatics (2010) 0.80
Discovering potent inhibitors against the beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Helicobacter pylori: structure-based design, synthesis, bioassay, and crystal structure determination. J Med Chem (2009) 0.80
Discovery of novel selective inhibitors for EGFR-T790M/L858R. Bioorg Med Chem Lett (2011) 0.80
Cyndi: a multi-objective evolution algorithm based method for bioactive molecular conformational generation. BMC Bioinformatics (2009) 0.80
Fluorescent chemodosimeter for Cys/Hcy with a large absorption shift and imaging in living cells. Org Biomol Chem (2010) 0.80
TMEM16A protein attenuates lipopolysaccharide-mediated inflammatory response of human lung epithelial cell line A549. Exp Lung Res (2014) 0.79
A novel, customizable and optimizable parameter method using spherical harmonics for molecular shape similarity comparisons. J Mol Model (2011) 0.79
Acenaphtho[1,2-b]pyrrole-based selective fibroblast growth factor receptors 1 (FGFR1) inhibitors: design, synthesis, and biological activity. J Med Chem (2011) 0.79
An improved PMF scoring function for universally predicting the interactions of a ligand with protein, DNA, and RNA. J Chem Inf Model (2008) 0.79
Quality of life evaluation in juveniles with disorders of sexual development. Pediatr Surg Int (2012) 0.79
Structure-activity study on a series of α-glutamic acid scaffold based compounds as new ADAMTS inhibitors. Bioorg Med Chem Lett (2011) 0.78
Natural products as a gold mine for selective matrix metalloproteinases inhibitors. Bioorg Med Chem (2012) 0.78
Novel selective and potent inhibitors of malaria parasite dihydroorotate dehydrogenase: discovery and optimization of dihydrothiophenone derivatives. J Med Chem (2013) 0.78
Optical Cu2+ probe bearing an 8-hydroxyquinoline subunit: high sensitivity and large fluorescence enhancement. Talanta (2012) 0.78
Imaging of lysosomal pH changes with a fluorescent sensor containing a novel lysosome-locating group. Chem Commun (Camb) (2012) 0.78
An improved adaptive genetic algorithm for protein-ligand docking. J Comput Aided Mol Des (2008) 0.78
Pyrimido[4,5-d]pyrimidin-4(1H)-one derivatives as selective inhibitors of EGFR threonine790 to methionine790 (T790M) mutants. Angew Chem Int Ed Engl (2013) 0.78
Caspase-mediated cleavage of C53/LZAP protein causes abnormal microtubule bundling and rupture of the nuclear envelope. Cell Res (2013) 0.78
Design, synthesis, X-ray crystallographic analysis, and biological evaluation of thiazole derivatives as potent and selective inhibitors of human dihydroorotate dehydrogenase. J Med Chem (2015) 0.78
Substituted indolin-2-ones as p90 ribosomal S6 protein kinase 2 (RSK2) inhibitors: Molecular docking simulation and structure-activity relationship analysis. Bioorg Med Chem (2013) 0.77
HL005--a new selective PPARγ antagonist specifically inhibits the proliferation of MCF-7. J Steroid Biochem Mol Biol (2011) 0.77
Synthesis of glucoconjugates of oleanolic acid as inhibitors of glycogen phosphorylase. Carbohydr Res (2009) 0.77
2-amido-3-(1H-indol-3-yl)-N-substituted-propanamides as a new class of falcipain-2 inhibitors. 1. Design, synthesis, biological evaluation and binding model studies. Molecules (2009) 0.77
Optimizing energy potential for protein fold recognition with parametric evaluation function. J Comput Biol (2009) 0.76
PTID: an integrated web resource and computational tool for agrochemical discovery. Bioinformatics (2012) 0.76
A simple Calpha-SC potential with higher accuracy for protein fold recognition. Biochem Biophys Res Commun (2009) 0.76
New thiazole carboxamides as potent inhibitors of Akt kinases. Bioorg Med Chem Lett (2011) 0.76
Catalytic asymmetric construction of quaternary α-amino acid containing pyrrolidines through 1,3-dipolar cycloaddition of azomethine ylides to α-aminoacrylates. Chemistry (2013) 0.76
Screening and chromatographic assessing of a novel IgG biomimetic ligand. Biomed Chromatogr (2006) 0.76
Discovery of natural estrogen receptor modulators with structure-based virtual screening. Bioorg Med Chem Lett (2013) 0.76
A generic force field for protein coarse-grained molecular dynamics simulation. Int J Mol Sci (2012) 0.76
Predicting the Drug Safety for Traditional Chinese Medicine through a Comparative Analysis of Withdrawn Drugs Using Pharmacological Network. Evid Based Complement Alternat Med (2013) 0.76
Discovery of new potent inhibitors for carbonic anhydrase IX by structure-based virtual screening. Bioorg Med Chem Lett (2013) 0.76
Benzamide derivatives as dual-action hypoglycemic agents that inhibit glycogen phosphorylase and activate glucokinase. Bioorg Med Chem (2009) 0.76
Optimization of heterocyclic substituted benzenesulfonamides as novel carbonic anhydrase IX inhibitors and their structure activity relationship. Eur J Med Chem (2013) 0.75
Discrimination of colon cancer stem cells using noncanonical amino acid. Chem Commun (Camb) (2012) 0.75
Discovery of non-peptide inhibitors of Plasmepsin II by structure-based virtual screening. Bioorg Med Chem Lett (2013) 0.75
A fluorescence turn-on sensor for Hg2+ with a simple receptor available in sulphide-rich environments. J Fluoresc (2012) 0.75
2-(3,4-dihydro-4-oxothieno[2,3-d]pyrimidin-2-ylthio) acetamides as a new class of falcipain-2 inhibitors. 3. design, synthesis and biological evaluation. Molecules (2009) 0.75
A new diaryl urea compound, D181, induces cell cycle arrest in the G1 and M phases by targeting receptor tyrosine kinases and the microtubule skeleton. Invest New Drugs (2010) 0.75
[Sonographic diagnosis of carotid body tumor]. Zhonghua Zhong Liu Za Zhi (2002) 0.75
Synthesis, activity evaluation, and docking analysis of barbituric acid aryl hydrazone derivatives as RSK2 inhibitors. J Enzyme Inhib Med Chem (2012) 0.75
[Clinical application of cardiopulmonary resuscitation with abdominal lifting and compression in emergency treatment]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue (2017) 0.75
Rational design of a highly selective fluorescent sensor for l-histidine detection in aqueous solution. Dalton Trans (2015) 0.75
Synthesis of derivatives of methyl rosmarinate and their inhibitory activities against matrix metalloproteinase-1 (MMP-1). Eur J Med Chem (2012) 0.75
Enhanced field emission and photocatalytic performance of MoS₂ titania nanoheterojunctions via two synthetic approaches. Dalton Trans (2015) 0.75
[Treatment of severe displaced proximal humeral fractures with titanium elastic nails in older children]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi (2014) 0.75
Discovering benzamide derivatives as glycogen phosphorylase inhibitors and their binding site at the enzyme. Bioorg Med Chem (2007) 0.75
Highly selective and anions controlled fluorescent sensor for Hg(2+) in aqueous environment. J Fluoresc (2008) 0.75
Identification of inhibitors against p90 ribosomal S6 kinase 2 (RSK2) through structure-based virtual screening with the inhibitor-constrained refined homology model. J Chem Inf Model (2011) 0.75
SimG: an alignment based method for evaluating the similarity of small molecules and binding sites. J Chem Inf Model (2013) 0.75