Published in J Med Chem on April 07, 2005
Targeted rescue of a destabilized mutant of p53 by an in silico screened drug. Proc Natl Acad Sci U S A (2008) 2.30
Beyond small-molecule SAR: using the dopamine D3 receptor crystal structure to guide drug design. Adv Pharmacol (2014) 0.95
Selectivity and activation of dopamine D3R from molecular dynamics. J Mol Model (2012) 0.80
Structural determinants of CX-4945 derivatives as protein kinase CK2 inhibitors: a computational study. Int J Mol Sci (2011) 0.79
Advances and challenges in the search for D2 and D3 dopamine receptor-selective compounds. Cell Signal (2017) 0.75
A new hominid from the Upper Miocene of Chad, Central Africa. Nature (2002) 6.85
Structure and function of an irreversible agonist-β(2) adrenoceptor complex. Nature (2011) 5.35
Macrovertebrate paleontology and the Pliocene habitat of Ardipithecus ramidus. Science (2009) 3.49
Both tadalafil and dexamethasone may reduce the incidence of high-altitude pulmonary edema: a randomized trial. Ann Intern Med (2006) 3.14
Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms. Blood (2014) 2.72
Stem cell characteristics of amniotic epithelial cells. Stem Cells (2005) 2.66
Clonal analysis of TET2 and JAK2 mutations suggests that TET2 can be a late event in the progression of myeloproliferative neoplasms. Blood (2010) 2.61
Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature (2013) 2.49
Geology and palaeontology of the Upper Miocene Toros-Menalla hominid locality, Chad. Nature (2002) 2.41
Cardiac magnetic resonance monitors reversible and irreversible myocardial injury in myocarditis. JACC Cardiovasc Imaging (2009) 2.08
Asa Issie, Aramis and the origin of Australopithecus. Nature (2006) 2.00
A new clinico-pathological classification system for mesial temporal sclerosis. Acta Neuropathol (2007) 1.77
Myeloproliferative neoplasm (MPN) symptom assessment form total symptom score: prospective international assessment of an abbreviated symptom burden scoring system among patients with MPNs. J Clin Oncol (2012) 1.58
Molecular and clinical features of the myeloproliferative neoplasm associated with JAK2 exon 12 mutations. Blood (2011) 1.56
Quinpramine is a novel compound effective in ameliorating brain autoimmune disease. Exp Neurol (2008) 1.44
Interactive SAR studies: rational discovery of super-potent and highly selective dopamine D3 receptor antagonists and partial agonists. J Med Chem (2002) 1.44
The influence of age at single-event multilevel surgery on outcome in children with cerebral palsy who walk with flexed knee gait. Dev Med Child Neurol (2011) 1.40
The structural evolution of dopamine D3 receptor ligands: structure-activity relationships and selected neuropharmacological aspects. Pharmacol Ther (2006) 1.33
The new framework for understanding placental mammal evolution. Bioessays (2009) 1.26
Transcription factors ETF, E2F, and SP-1 are involved in cytokine-independent proliferation of murine hepatocytes. Hepatology (2010) 1.25
Randomized comparison of reduced fat and reduced carbohydrate hypocaloric diets on intrahepatic fat in overweight and obese human subjects. Hepatology (2011) 1.23
Variability and homogeneity of cardiovascular magnetic resonance myocardial T2-mapping in volunteers compared to patients with edema. J Cardiovasc Magn Reson (2013) 1.21
Induction and inhibition of cytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures. Drug Metab Dispos (2004) 1.19
Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. J Med Chem (2009) 1.18
Towards a clinico-pathological classification of granule cell dispersion in human mesial temporal lobe epilepsies. Acta Neuropathol (2009) 1.17
Dental eruption in afrotherian mammals. BMC Biol (2008) 1.15
Conditional transgenic mouse models: from the basics to genome-wide sets of knockouts and current studies of tissue regeneration. Regen Med (2008) 1.14
Tricyclic antidepressants, quinacrine and a novel, synthetic chimera thereof clear prions by destabilizing detergent-resistant membrane compartments. J Neurochem (2006) 1.13
Recent advances in the search for D3- and D4-selective drugs: probes, models and candidates. Trends Pharmacol Sci (2011) 1.10
Activating mutations in STIM1 and ORAI1 cause overlapping syndromes of tubular myopathy and congenital miosis. Proc Natl Acad Sci U S A (2014) 1.10
Tracking of human cells in mice. Histochem Cell Biol (2008) 1.06
Rational Molecular Design and EPC Synthesis of a Type VI beta-Turn Inducing Peptide Mimetic This work was supported by the BMBF and the Fonds der Chemischen Industrie. EPC=enantiomerically pure compound. Angew Chem Int Ed Engl (2001) 1.06
Dopamine D2 and D3 receptors in human putamen, caudate nucleus, and globus pallidus. Synapse (2006) 1.05
Hepatocyte transplantation: clinical experience and potential for future use. Cell Transplant (2006) 1.05
Labeling and glycosylation of peptides using click chemistry: a general approach to (18)F-glycopeptides as effective imaging probes for positron emission tomography. Angew Chem Int Ed Engl (2010) 1.03
Negative regulation of RANKL-induced osteoclastic differentiation in RAW264.7 Cells by estrogen and phytoestrogens. J Biol Chem (2005) 1.02
Chirospecific synthesis of spirocyclic beta-lactams and their characterization as potent type II beta-turn inducing peptide mimetics. J Org Chem (2006) 1.01
Evaluation of lactam-bridged neurotensin analogues adjusting psi(Pro10) close to the experimentally derived bioactive conformation of NT(8-13). J Med Chem (2004) 1.01
Histidine 6.55 is a major determinant of ligand-biased signaling in dopamine D2L receptor. Mol Pharmacol (2010) 0.98
Structure-based design of Tet repressor to optimize a new inducer specificity. Biochemistry (2004) 0.97
Argyreia nervosa (Burm. f.): receptor profiling of lysergic acid amide and other potential psychedelic LSD-like compounds by computational and binding assay approaches. J Ethnopharmacol (2013) 0.96
Fancy bioisosteres: novel paracyclophane derivatives as super-affinity dopamine D3 receptor antagonists. J Med Chem (2006) 0.96
A chimeric ligand approach leading to potent antiprion active acridine derivatives: design, synthesis, and biological investigations. J Med Chem (2006) 0.96
Cardiorespiratory fitness and insulin sensitivity in overweight or obese subjects may be linked through intrahepatic lipid content. Diabetes (2010) 0.95
Functionally selective dopamine D₂, D₃ receptor partial agonists. J Med Chem (2014) 0.93
Arabidopsis amidase 1, a member of the amidase signature family. FEBS J (2007) 0.93
Comparison of a powered bone marrow biopsy device with a manual system: results of a prospective randomised controlled trial. J Clin Pathol (2012) 0.93
A gene regulation system with four distinct expression levels. J Gene Med (2006) 0.93
Class A G-protein-coupled receptor (GPCR) dimers and bivalent ligands. J Med Chem (2013) 0.92
Certain 1,4-disubstituted aromatic piperidines and piperazines with extreme selectivity for the dopamine D4 receptor interact with a common receptor microdomain. Mol Pharmacol (2004) 0.92
Subcellular localization and tissue specific expression of amidase 1 from Arabidopsis thaliana. Planta (2006) 0.91
Randomized crossover study to examine the necessity of an injection-to-meal interval in patients with type 2 diabetes and human insulin. Diabetes Care (2013) 0.91
Long-lasting improvements in liver fat and metabolism despite body weight regain after dietary weight loss. Diabetes Care (2013) 0.91
Cardiac magnetic resonance imaging during pulmonary hyperinflation in apnea divers. Med Sci Sports Exerc (2011) 0.90
Modeling the similarity and divergence of dopamine D2-like receptors and identification of validated ligand-receptor complexes. J Med Chem (2005) 0.90
Bivalent dopamine D2 receptor ligands: synthesis and binding properties. J Med Chem (2011) 0.89
Novel insights into GPCR-peptide interactions: mutations in extracellular loop 1, ligand backbone methylations and molecular modeling of neurotensin receptor 1. Bioorg Med Chem (2008) 0.89
In vitro affinities of various halogenated benzamide derivatives as potential radioligands for non-invasive quantification of D(2)-like dopamine receptors. Bioorg Med Chem (2007) 0.88
SCRF-DFT and NMR comparison of tetracycline and 5a,6-anhydrotetracycline in solution. J Phys Chem B (2006) 0.88
Structure-selectivity investigations of D2-like receptor ligands by CoMFA and CoMSIA guiding the discovery of D3 selective PET radioligands. J Med Chem (2007) 0.88
Muscarinic receptors as model targets and antitargets for structure-based ligand discovery. Mol Pharmacol (2013) 0.87
Functionally selective dopamine D2/D3 receptor agonists comprising an enyne moiety. J Med Chem (2013) 0.87
A comparative study of four intensive care outcome prediction models in cardiac surgery patients. J Cardiothorac Surg (2011) 0.87
18F-Labeled FAUC 346 and BP 897 derivatives as subtype-selective potential PET radioligands for the dopamine D3 receptor. ChemMedChem (2008) 0.87
Dopamine D3 receptor ligands: recent advances in the control of subtype selectivity and intrinsic activity. Biochim Biophys Acta (2006) 0.87
Active-state models of ternary GPCR complexes: determinants of selective receptor-G-protein coupling. PLoS One (2013) 0.87
Highly potent 5-aminotetrahydropyrazolopyridines: enantioselective dopamine D3 receptor binding, functional selectivity, and analysis of receptor-ligand interactions. J Med Chem (2011) 0.86
3,4,6-Tri-O-acetyl-2-deoxy-2-[18F]fluoroglucopyranosyl phenylthiosulfonate: a thiol-reactive agent for the chemoselective 18F-glycosylation of peptides. Bioconjug Chem (2007) 0.86
Functional characterization of a partial loss-of-function mutation of the epithelial sodium channel (ENaC) associated with atypical cystic fibrosis. Cell Physiol Biochem (2009) 0.86
Daily-Mean-SOFA, a new derivative to increase accuracy of mortality prediction in cardiac surgical intensive care units. Thorac Cardiovasc Surg (2012) 0.85
Gender-specific differences in left ventricular remodelling and fibrosis in hypertrophic cardiomyopathy: insights from cardiovascular magnetic resonance. Eur J Heart Fail (2008) 0.85
PIP3EA and PD-168077, two selective dopamine D4 receptor agonists, induce penile erection in male rats: site and mechanism of action in the brain. Eur J Neurosci (2006) 0.85
Molecular dynamics simulations of the effect of the G-protein and diffusible ligands on the β2-adrenergic receptor. J Mol Biol (2011) 0.85
Development of a metabolically stable neurotensin receptor 2 (NTS2) ligand. ChemMedChem (2012) 0.84
Pharmacophore-guided drug discovery investigations leading to bioactive 5-aminotetrahydropyrazolopyridines. Implications for the binding mode of heterocyclic dopamine D3 receptor agonists. J Med Chem (2005) 0.84
Discovery of highly potent and neurotensin receptor 2 selective neurotensin mimetics. J Med Chem (2011) 0.84
Determinants of quinolone versus trimethoprim-sulfamethoxazole use for outpatient urinary tract infection. Antimicrob Agents Chemother (2012) 0.84
Single lipoprotein apheresis session improves cardiac microvascular function in patients with elevated lipoprotein(a): detection by stress/rest perfusion magnetic resonance imaging. Ther Apher Dial (2009) 0.84
Peptide backbone modifications on the C-terminal hexapeptide of neurotensin. Bioorg Med Chem Lett (2008) 0.84