Activation and allosteric modulation of a muscarinic acetylcholine receptor.

Structural insights into µ-opioid receptor activation. Nature (2015) 1.77

DREADDs for Neuroscientists. Neuron (2016) 1.52

Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders. Nat Rev Drug Discov (2014) 1.51

Agonist-bound structure of the human P2Y12 receptor. Nature (2014) 1.36

High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875. Nature (2014) 1.19

Propagation of conformational changes during μ-opioid receptor activation. Nature (2015) 1.14

The role of protein dynamics in GPCR function: insights from the β2AR and rhodopsin. Curr Opin Cell Biol (2014) 1.13

GPCRdb: an information system for G protein-coupled receptors. Nucleic Acids Res (2015) 1.12

Explicit spatiotemporal simulation of receptor-G protein coupling in rod cell disk membranes. Biophys J (2014) 1.07

Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant. Nature (2014) 1.03

Differences in allosteric communication pipelines in the inactive and active states of a GPCR. Biophys J (2014) 1.02

Novel Allosteric Modulators of G Protein-coupled Receptors. J Biol Chem (2015) 1.02

From G Protein-coupled Receptor Structure Resolution to Rational Drug Design. J Biol Chem (2015) 0.99

Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies. Mol Pharmacol (2013) 0.98

Nanobodies and recombinant binders in cell biology. J Cell Biol (2015) 0.96

Molecular Determinants of CGS21680 Binding to the Human Adenosine A2A Receptor. Mol Pharmacol (2015) 0.96

Discovery and characterization of a G protein-biased agonist that inhibits β-arrestin recruitment to the D2 dopamine receptor. Mol Pharmacol (2014) 0.96

Structure and function of serotonin G protein-coupled receptors. Pharmacol Ther (2015) 0.94

A new mechanism of allostery in a G protein-coupled receptor dimer. Nat Chem Biol (2014) 0.93

Structural prerequisites for G-protein activation by the neurotensin receptor. Nat Commun (2015) 0.92

Buried ionizable networks are an ancient hallmark of G protein-coupled receptor activation. Proc Natl Acad Sci U S A (2015) 0.92

Allosteric coupling from G protein to the agonist-binding pocket in GPCRs. Nature (2016) 0.92

Crystal structures of the M1 and M4 muscarinic acetylcholine receptors. Nature (2016) 0.90

Accelerated molecular dynamics simulations of ligand binding to a muscarinic G-protein-coupled receptor. Q Rev Biophys (2015) 0.89

Allosteric modulation of β-arrestin-biased angiotensin II type 1 receptor signaling by membrane stretch. J Biol Chem (2014) 0.89

Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region. Nature (2016) 0.87

Engineering a minimal G protein to facilitate crystallisation of G protein-coupled receptors in their active conformation. Protein Eng Des Sel (2016) 0.87

Allosteric effects of sodium ion binding on activation of the m3 muscarinic g-protein-coupled receptor. Biophys J (2015) 0.87

A functional selectivity mechanism at the serotonin-2A GPCR involves ligand-dependent conformations of intracellular loop 2. J Am Chem Soc (2014) 0.86

Gaussian Accelerated Molecular Dynamics: Unconstrained Enhanced Sampling and Free Energy Calculation. J Chem Theory Comput (2015) 0.86

Allosteric and biased g protein-coupled receptor signaling regulation: potentials for new therapeutics. Front Endocrinol (Lausanne) (2014) 0.86

Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling. Cell (2016) 0.85

Nucleotides Acting at P2Y Receptors: Connecting Structure and Function. Mol Pharmacol (2015) 0.85

Conserved Residues Control Activation of Mammalian G Protein-Coupled Odorant Receptors. J Am Chem Soc (2015) 0.84

Superagonism at G protein-coupled receptors and beyond. Br J Pharmacol (2015) 0.84

Computational modeling of membrane proteins. Proteins (2014) 0.83

Structure-Based Sequence Alignment of the Transmembrane Domains of All Human GPCRs: Phylogenetic, Structural and Functional Implications. PLoS Comput Biol (2016) 0.83

Muscarinic acetylcholine receptor X-ray structures: potential implications for drug development. Curr Opin Pharmacol (2014) 0.83

Computational approaches to detect allosteric pathways in transmembrane molecular machines. Biochim Biophys Acta (2016) 0.83

Cardiac resynchronization therapy restores sympathovagal balance in the failing heart by differential remodeling of cholinergic signaling. Circ Res (2015) 0.83

Disruption of the Na+ ion binding site as a mechanism for positive allosteric modulation of the mu-opioid receptor. Proc Natl Acad Sci U S A (2014) 0.83

Molecular Insights into Metabotropic Glutamate Receptor Allosteric Modulation. Mol Pharmacol (2015) 0.83

Synthesis and biology of cyclic imine toxins, an emerging class of potent, globally distributed marine toxins. Nat Prod Rep (2015) 0.83

Single-molecule analysis of ligand efficacy in β2AR-G-protein activation. Nature (2017) 0.82

What can crystal structures of aminergic receptors tell us about designing subtype-selective ligands? Pharmacol Rev (2015) 0.82

Smoothened goes molecular: new pieces in the hedgehog signaling puzzle. J Biol Chem (2014) 0.82

Structural conservation among the rhodopsin-like and other G protein-coupled receptors. Sci Rep (2015) 0.82

Activation mechanism of endothelin ETB receptor by endothelin-1. Nature (2016) 0.82

Nanobodies as Probes for Protein Dynamics in Vitro and in Cells. J Biol Chem (2015) 0.81

Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor. J Biol Chem (2014) 0.81

Maltose neopentyl glycol-3 (MNG-3) analogues for membrane protein study. Analyst (2015) 0.81

Quantifying conformational changes in GPCRs: glimpse of a common functional mechanism. BMC Bioinformatics (2015) 0.81

Systematic comparison of molecular conformations of H+,K+-ATPase reveals an important contribution of the A-M2 linker for the luminal gating. J Biol Chem (2014) 0.81

Covalent agonists for studying G protein-coupled receptor activation. Proc Natl Acad Sci U S A (2014) 0.80

Identification of G protein-biased agonists that fail to recruit β-arrestin or promote internalization of the D1 dopamine receptor. ACS Chem Neurosci (2015) 0.80

G-protein coupled receptors: advances in simulation and drug discovery. Curr Opin Struct Biol (2016) 0.80

Discovery and SAR of muscarinic receptor subtype 1 (M1) allosteric activators from a molecular libraries high throughput screen. Part 1: 2,5-dibenzyl-2H-pyrazolo[4,3-c]quinolin-3(5H)-ones as positive allosteric modulators. Bioorg Med Chem Lett (2014) 0.80

Structural insights into ligand recognition and selectivity for classes A, B, and C GPCRs. Eur J Pharmacol (2015) 0.80

Optical probes based on G protein-coupled receptors - added work or added value? Br J Pharmacol (2015) 0.80

Structural dynamics and energetics underlying allosteric inactivation of the cannabinoid receptor CB1. Proc Natl Acad Sci U S A (2015) 0.79

Large-scale production and protein engineering of G protein-coupled receptors for structural studies. Front Pharmacol (2015) 0.79

Development of a highly selective allosteric antagonist radioligand for the type 1 cholecystokinin receptor and elucidation of its molecular basis of binding. Mol Pharmacol (2014) 0.79

Molecular mechanisms of bitopic ligand engagement with the M1 muscarinic acetylcholine receptor. J Biol Chem (2014) 0.79

Function-specific virtual screening for GPCR ligands using a combined scoring method. Sci Rep (2016) 0.78

ASD v3.0: unraveling allosteric regulation with structural mechanisms and biological networks. Nucleic Acids Res (2015) 0.78

Role of Structural Dynamics at the Receptor G Protein Interface for Signal Transduction. PLoS One (2015) 0.78

Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor. Cell Res (2016) 0.78

Selective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors – A Structural Perspective of Ligands and Mutants. Sci Rep (2015) 0.78

Structural Mechanisms of Voltage Sensing in G Protein-Coupled Receptors. Structure (2016) 0.78

The Dynamic Process of Drug-GPCR Binding at Either Orthosteric or Allosteric Sites Evaluated by Metadynamics. Methods Mol Biol (2015) 0.78

Novel Xylene-Linked Maltoside Amphiphiles (XMAs) for Membrane Protein Stabilisation. Chemistry (2015) 0.78

Crystallization scale preparation of a stable GPCR signaling complex between constitutively active rhodopsin and G-protein. PLoS One (2014) 0.78

Post-expression strategies for structural investigations of membrane proteins. Curr Opin Struct Biol (2015) 0.78

Graded activation and free energy landscapes of a muscarinic G-protein-coupled receptor. Proc Natl Acad Sci U S A (2016) 0.77

Recent Progress in Understanding the Conformational Mechanism of Heterotrimeric G Protein Activation. Biomol Ther (Seoul) (2017) 0.77

Investigation of the conformational dynamics of the apo A2A adenosine receptor. Protein Sci (2015) 0.77

Receptor, Ligand and Transducer Contributions to Dopamine D2 Receptor Functional Selectivity. PLoS One (2015) 0.77

Allosteric Activation of a G Protein-coupled Receptor with Cell-penetrating Receptor Mimetics. J Biol Chem (2015) 0.77

Visualization and ligand-induced modulation of dopamine receptor dimerization at the single molecule level. Sci Rep (2016) 0.77

Accelerated structure-based design of chemically diverse allosteric modulators of a muscarinic G protein-coupled receptor. Proc Natl Acad Sci U S A (2016) 0.77

Structural Insight into Specificity of Interactions between Nonconventional Three-finger Weak Toxin from Naja kaouthia (WTX) and Muscarinic Acetylcholine Receptors. J Biol Chem (2015) 0.77

The Role of Muscarinic Receptors in the Pathophysiology of Mood Disorders:A Potential Noveltreatment? Curr Neuropharmacol (2015) 0.76

On the different experimental manifestations of two-state 'induced-fit' binding of drugs to their cellular targets. Br J Pharmacol (2016) 0.76

The insect repellent N,N-diethyl-m-toluamide (DEET) induces angiogenesis via allosteric modulation of the M3 muscarinic receptor in endothelial cells. Sci Rep (2016) 0.76

Crucial role of the orexin-B C-terminus in the induction of OX1 receptor-mediated apoptosis: analysis by alanine scanning, molecular modelling and site-directed mutagenesis. Br J Pharmacol (2015) 0.76

In Silico and In Vitro Analysis of Bacoside A Aglycones and Its Derivatives as the Constituents Responsible for the Cognitive Effects of Bacopa monnieri. PLoS One (2015) 0.76

Structure and dynamics of a constitutively active neurotensin receptor. Sci Rep (2016) 0.76

'Partial' competition of heterobivalent ligand binding may be mistaken for allosteric interactions: a comparison of different target interaction models. Br J Pharmacol (2015) 0.76

Allosteric modulation in monomers and oligomers of a G protein-coupled receptor. Elife (2016) 0.76

Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40. Nat Struct Mol Biol (2017) 0.76

Prediction of consensus binding mode geometries for related chemical series of positive allosteric modulators of adenosine and muscarinic acetylcholine receptors. J Comput Chem (2017) 0.75

Structural insight to mutation effects uncover a common allosteric site in class C GPCRs. Bioinformatics (2016) 0.75

Computational Advances for the Development of Allosteric Modulators and Bitopic Ligands in G Protein-Coupled Receptors. AAPS J (2015) 0.75

Conserved Mechanism of Conformational Stability and Dynamics in G-Protein-Coupled Receptors. J Chem Theory Comput (2016) 0.75

A Novel Screening Approach for Optimal and Functional Fusion of T4 Lysozyme in GPCRs. Methods Enzymol (2015) 0.75

Allosteric communication pipelines in G-protein-coupled receptors. Curr Opin Pharmacol (2016) 0.75

Allosteric Modulation of GPCRs: New Insights and Potential Utility for Treatment of Schizophrenia and Other CNS Disorders. Neuron (2017) 0.75

A Novel Voltage Sensor in the Orthosteric Binding Site of the M2 Muscarinic Receptor. Biophys J (2016) 0.75

Molecular Insights into the Transmembrane Domain of the Thyrotropin Receptor. PLoS One (2015) 0.75

Binding of N-methylscopolamine to the extracellular domain of muscarinic acetylcholine receptors. Sci Rep (2017) 0.75

Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr (2004) 227.01

Phaser crystallographic software. J Appl Crystallogr (2007) 108.34

Crystal structure of the β2 adrenergic receptor-Gs protein complex. Nature (2011) 13.92

Towards automated crystallographic structure refinement with phenix.refine. Acta Crystallogr D Biol Crystallogr (2012) 11.31

Structure of a nanobody-stabilized active state of the β(2) adrenoceptor. Nature (2011) 9.61

Crystal structure of opsin in its G-protein-interacting conformation. Nature (2008) 8.61

Crystallizing membrane proteins using lipidic mesophases. Nat Protoc (2009) 6.36

A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein. Proc Natl Acad Sci U S A (2007) 6.04

Crystal structure of metarhodopsin II. Nature (2011) 5.05

Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development. Nat Rev Drug Discov (2007) 4.83

The dynamic process of β(2)-adrenergic receptor activation. Cell (2013) 4.09

Structure and dynamics of the M3 muscarinic acetylcholine receptor. Nature (2012) 3.83

Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist. Nature (2012) 3.83

Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6. J Biol Chem (2001) 3.49

Beta-lactamase inhibitors derived from single-domain antibody fragments elicited in the camelidae. Antimicrob Agents Chemother (2001) 2.24

Allosteric GPCR modulators: taking advantage of permissive receptor pharmacology. Trends Pharmacol Sci (2007) 2.10

Primary structure of porcine cardiac muscarinic acetylcholine receptor deduced from the cDNA sequence. FEBS Lett (1986) 2.03

Allosteric modulation of G protein-coupled receptors: a pharmacological perspective. Neuropharmacology (2010) 1.97

Stabilized G protein binding site in the structure of constitutively active metarhodopsin-II. Proc Natl Acad Sci U S A (2011) 1.96

Estimation of the affinities of allosteric ligands using radioligand binding and pharmacological null methods. Mol Pharmacol (1988) 1.91

Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody. Nature (2013) 1.68

Structure-function studies of allosteric agonism at M2 muscarinic acetylcholine receptors. Mol Pharmacol (2007) 1.51

Identification of orthosteric and allosteric site mutations in M2 muscarinic acetylcholine receptors that contribute to ligand-selective signaling bias. J Biol Chem (2010) 1.46

Activation and dynamic network of the M2 muscarinic receptor. Proc Natl Acad Sci U S A (2013) 1.41

Structural basis of G protein-coupled receptor-G protein interactions. Nat Chem Biol (2010) 1.27

Identification of a receptor/G-protein contact site critical for signaling specificity and G-protein activation. Proc Natl Acad Sci U S A (1995) 1.25

Rapid identification of functionally critical amino acids in a G protein-coupled receptor. Nat Methods (2007) 1.24

Allosteric modulation of muscarinic acetylcholine receptors. Curr Neuropharmacol (2007) 1.21

A Monod-Wyman-Changeux mechanism can explain G protein-coupled receptor (GPCR) allosteric modulation. J Biol Chem (2011) 1.13

Allosteric interactions with muscarinic acetylcholine receptors: complex role of the conserved tryptophan M2422Trp in a critical cluster of amino acids for baseline affinity, subtype selectivity, and cooperativity. Mol Pharmacol (2006) 1.12

Role of conserved threonine and tyrosine residues in acetylcholine binding and muscarinic receptor activation. A study with m3 muscarinic receptor point mutants. J Biol Chem (1992) 1.12

A comparison of the action of acetylcholine and acetylcholine mustard (chloroethylmethylaminoethyl acetate) on muscarinic and nicotinic receptors. J Pharmacol Exp Ther (1972) 1.10

Site-directed mutagenesis of the putative human muscarinic M2 receptor binding site. Eur J Pharmacol (1999) 1.10

Probe dependence in the allosteric modulation of a G protein-coupled receptor: implications for detection and validation of allosteric ligand effects. Mol Pharmacol (2011) 1.08

High-throughput screening for drug discovery. Nature (1996) 1.08

Structural basis of M3 muscarinic receptor dimer/oligomer formation. J Biol Chem (2011) 1.06

The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling. Nat Commun (2012) 1.05

Allosteric ligands for G protein-coupled receptors: a novel strategy with attractive therapeutic opportunities. Med Res Rev (2010) 1.04

Allosteric activators of muscarinic receptors as novel approaches for treatment of CNS disorders. Mol Biosyst (2010) 1.01

Purification of the muscarinic acetylcholine receptor from porcine atria. Proc Natl Acad Sci U S A (1984) 1.00

Acetylcholine mustard labels the binding site aspartate in muscarinic acetylcholine receptors. J Biol Chem (1994) 1.00

The third intracellular loop stabilizes the inactive state of the neuropeptide Y1 receptor. J Biol Chem (2008) 1.00

The structure of the third intracellular loop of the muscarinic acetylcholine receptor M2 subtype. FEBS Lett (2005) 0.95

Deletion analysis of the mouse m1 muscarinic acetylcholine receptor: effects on phosphoinositide metabolism and down-regulation. Biochemistry (1989) 0.94

Structure/activity relationships of M2 muscarinic allosteric modulators. Receptors Channels (2003) 0.87

Site-directed mutagenesis on the m2 muscarinic acetylcholine receptor: the significance of Tyr403 in the binding of agonists and functional coupling. Mol Pharmacol (1997) 0.87

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science (2007) 20.32

Crystal structure of the human beta2 adrenergic G-protein-coupled receptor. Nature (2007) 14.06

Crystal structure of the β2 adrenergic receptor-Gs protein complex. Nature (2011) 13.92

GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function. Science (2007) 11.74

Structure of a nanobody-stabilized active state of the β(2) adrenoceptor. Nature (2011) 9.61

Deconstructing the cadherin-catenin-actin complex. Cell (2005) 8.39

The structure and function of G-protein-coupled receptors. Nature (2009) 8.08

Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly. Cell (2005) 7.62

Functional selectivity and classical concepts of quantitative pharmacology. J Pharmacol Exp Ther (2006) 7.03

STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1. Cell (2009) 6.92

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders. Nat Rev Drug Discov (2009) 6.69

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist. Nature (2012) 6.18

Structure and function of an irreversible agonist-β(2) adrenoceptor complex. Nature (2011) 5.35

betaAR signaling required for diet-induced thermogenesis and obesity resistance. Science (2002) 4.47

Structural basis of Wnt recognition by Frizzled. Science (2012) 4.31

Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc Natl Acad Sci U S A (2010) 4.17

The dynamic process of β(2)-adrenergic receptor activation. Cell (2013) 4.09

Allosteric modulation of G protein-coupled receptors. Annu Rev Pharmacol Toxicol (2007) 4.02

Structure and dynamics of the M3 muscarinic acetylcholine receptor. Nature (2012) 3.83

Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist. Nature (2012) 3.83

Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system. Cell (2008) 3.72

Structure of the δ-opioid receptor bound to naltrindole. Nature (2012) 3.69

Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model. Science (2013) 3.59

Selective muscarinic receptor agonist xanomeline as a novel treatment approach for schizophrenia. Am J Psychiatry (2008) 3.51

Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis. Cell (2009) 3.46

Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation. Nat Struct Mol Biol (2005) 3.41

Signalling bias in new drug discovery: detection, quantification and therapeutic impact. Nat Rev Drug Discov (2012) 3.30

Conformational biosensors reveal GPCR signalling from endosomes. Nature (2013) 3.29

Engineered SIRPα variants as immunotherapeutic adjuvants to anticancer antibodies. Science (2013) 3.25

How a single T cell receptor recognizes both self and foreign MHC. Cell (2007) 3.20

Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor. Nature (2010) 3.19

Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase II. J Clin Invest (2003) 3.15

International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on terms and symbols in quantitative pharmacology. Pharmacol Rev (2003) 2.93

Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex. Science (2003) 2.87

Structure and mechanism of cadherins and catenins in cell-cell contacts. Annu Rev Cell Dev Biol (2007) 2.86

International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors. Pharmacol Rev (2002) 2.86

Structural basis for distinct ligand-binding and targeting properties of the receptors DC-SIGN and DC-SIGNR. Nat Struct Mol Biol (2004) 2.83

E-cadherin is under constitutive actomyosin-generated tension that is increased at cell-cell contacts upon externally applied stretch. Proc Natl Acad Sci U S A (2012) 2.82

A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo. Cell Metab (2006) 2.82

An epithelial tissue in Dictyostelium challenges the traditional origin of metazoan multicellularity. Bioessays (2012) 2.81

Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'. Nat Immunol (2007) 2.78

Sequential binding of agonists to the beta2 adrenoceptor. Kinetic evidence for intermediate conformational states. J Biol Chem (2003) 2.68

Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors. Science (2005) 2.64

Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation. Mol Cell (2003) 2.61

Molecular physiology of the WNK kinases. Annu Rev Physiol (2008) 2.58

Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors. Neuron (2007) 2.54

Conformational changes of p97 during nucleotide hydrolysis determined by small-angle X-Ray scattering. Structure (2005) 2.53

Structure-based discovery of beta2-adrenergic receptor ligands. Proc Natl Acad Sci U S A (2009) 2.48

Two-step binding mechanism for T-cell receptor recognition of peptide MHC. Nature (2002) 2.45

High-resolution crystal structure of human protease-activated receptor 1. Nature (2012) 2.44

Conformational changes in the G protein Gs induced by the β2 adrenergic receptor. Nature (2011) 2.43

Allosteric modulation of the cannabinoid CB1 receptor. Mol Pharmacol (2005) 2.42

Structural linkage between ligand discrimination and receptor activation by type I interferons. Cell (2011) 2.39

Conformational changes of the multifunction p97 AAA ATPase during its ATPase cycle. Nat Struct Biol (2002) 2.38

Structure and biochemistry of cadherins and catenins. Cold Spring Harb Perspect Biol (2009) 2.37

Improved structures of full-length p97, an AAA ATPase: implications for mechanisms of nucleotide-dependent conformational change. Structure (2008) 2.36

An extracellular interactome of immunoglobulin and LRR proteins reveals receptor-ligand networks. Cell (2013) 2.36

Munc18a controls SNARE assembly through its interaction with the syntaxin N-peptide. EMBO J (2008) 2.33

Structure of nerve growth factor complexed with the shared neurotrophin receptor p75. Science (2004) 2.32

Structure of a gammadelta T cell receptor in complex with the nonclassical MHC T22. Science (2005) 2.32

Biochemical and structural definition of the l-afadin- and actin-binding sites of alpha-catenin. J Biol Chem (2002) 2.31

Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway. Proc Natl Acad Sci U S A (2009) 2.30

Engineering GPCR signaling pathways with RASSLs. Nat Methods (2008) 2.29

Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase. Mol Cell (2006) 2.28

Structural biology of shared cytokine receptors. Annu Rev Immunol (2009) 2.27

Genetic deletion of the Nogo receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo. Proc Natl Acad Sci U S A (2005) 2.27

Planar cell polarity breaks bilateral symmetry by controlling ciliary positioning. Nature (2010) 2.23

The β-catenin destruction complex. Cold Spring Harb Perspect Biol (2013) 2.22

Antigen recognition determinants of gammadelta T cell receptors. Science (2005) 2.14

Novel receptor partners and function of receptor activity-modifying proteins. J Biol Chem (2002) 2.14

Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide. Nature (2013) 2.14

Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation. Mol Cell (2004) 2.13

Signaling conformations of the tall cytokine receptor gp130 when in complex with IL-6 and IL-6 receptor. Nat Struct Mol Biol (2005) 2.12

Structure of the measles virus hemagglutinin. Nat Struct Mol Biol (2007) 2.11