Published in J Neurosci on April 20, 2005
Cellular and molecular mechanisms of pain. Cell (2009) 9.36
TRPA1 mediates formalin-induced pain. Proc Natl Acad Sci U S A (2007) 5.27
Pungent products from garlic activate the sensory ion channel TRPA1. Proc Natl Acad Sci U S A (2005) 4.20
4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1. Proc Natl Acad Sci U S A (2007) 4.10
TRPA1 acts as a cold sensor in vitro and in vivo. Proc Natl Acad Sci U S A (2009) 3.46
Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stress. J Neurosci (2008) 3.30
TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury. J Clin Invest (2005) 3.05
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TRPA1 is a major oxidant sensor in murine airway sensory neurons. J Clin Invest (2008) 2.55
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Temporal dynamics of neuronal activation by Channelrhodopsin-2 and TRPA1 determine behavioral output in Drosophila larvae. J Neurophysiol (2009) 2.30
Transient receptor potential TRPA1 channel desensitization in sensory neurons is agonist dependent and regulated by TRPV1-directed internalization. J Physiol (2007) 2.26
Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents. J Clin Invest (2008) 2.20
The micromachinery of mechanotransduction in hair cells. Annu Rev Neurosci (2007) 2.17
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The nociceptor ion channel TRPA1 is potentiated and inactivated by permeating calcium ions. J Biol Chem (2008) 2.03
Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases. FASEB J (2008) 1.93
Nociceptive signals induce trafficking of TRPA1 to the plasma membrane. Neuron (2009) 1.93
TRP channels and lipids: from Drosophila to mammalian physiology. J Physiol (2006) 1.90
Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs. J Physiol (2008) 1.85
How cold is it? TRPM8 and TRPA1 in the molecular logic of cold sensation. Mol Pain (2005) 1.84
The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli. Gastroenterology (2009) 1.78
The functions of TRPA1 and TRPV1: moving away from sensory nerves. Br J Pharmacol (2012) 1.69
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TRPA1 contributes to cold hypersensitivity. J Neurosci (2010) 1.68
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Contribution of TRPV1-TRPA1 interaction to the single channel properties of the TRPA1 channel. J Biol Chem (2010) 1.63
Genetic predictors for acute experimental cold and heat pain sensitivity in humans. J Med Genet (2006) 1.62
Cox-dependent fatty acid metabolites cause pain through activation of the irritant receptor TRPA1. Proc Natl Acad Sci U S A (2008) 1.59
TRPA1-mediated responses in trigeminal sensory neurons: interaction between TRPA1 and TRPV1. Eur J Neurosci (2009) 1.53
TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells. Proc Natl Acad Sci U S A (2009) 1.52
The varitint-waddler (Va) deafness mutation in TRPML3 generates constitutive, inward rectifying currents and causes cell degeneration. Proc Natl Acad Sci U S A (2007) 1.51
Mammalian somatosensory mechanotransduction. Curr Opin Neurobiol (2009) 1.51
TRP channels in lower urinary tract dysfunction. Br J Pharmacol (2014) 1.48
TRPA1 underlies a sensing mechanism for O2. Nat Chem Biol (2011) 1.47
Roles of transient receptor potential channels in pain. Brain Res Rev (2008) 1.44
Pharmacological blockade of TRPA1 inhibits mechanical firing in nociceptors. Mol Pain (2009) 1.42
The ion channel TRPA1 is required for chronic itch. J Neurosci (2013) 1.41
TRPA1: A gatekeeper for inflammation. Annu Rev Physiol (2012) 1.36
TRP channels and Ca2+ signaling. Cell Calcium (2006) 1.35
Pore dilation occurs in TRPA1 but not in TRPM8 channels. Mol Pain (2009) 1.34
Cutaneous nociception evoked by 15-delta PGJ2 via activation of ion channel TRPA1. Mol Pain (2008) 1.33
Irritating channels: the case of TRPA1. J Physiol (2010) 1.32
Modulation of the transient receptor potential channel TRPA1 by phosphatidylinositol 4,5-biphosphate manipulators. Pflugers Arch (2008) 1.31
TRPA1 and cold transduction: an unresolved issue? J Gen Physiol (2009) 1.30
Intracellular alkalization causes pain sensation through activation of TRPA1 in mice. J Clin Invest (2008) 1.27
The roles of iPLA2, TRPM8 and TRPA1 in chemically induced cold hypersensitivity. Mol Pain (2010) 1.25
The physiology of mechanoelectrical transduction channels in hearing. Physiol Rev (2014) 1.23
TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats. Mol Pain (2010) 1.22
Differential ATF3 expression in dorsal root ganglion neurons reveals the profile of primary afferents engaged by diverse noxious chemical stimuli. Pain (2010) 1.22
Transient receptor potential channel ankyrin-1 is not a cold sensor for autonomic thermoregulation in rodents. J Neurosci (2014) 1.21
Species differences and molecular determinant of TRPA1 cold sensitivity. Nat Commun (2013) 1.20
A TRPA1-dependent mechanism for the pungent sensation of weak acids. J Gen Physiol (2011) 1.19
Transient Receptor Potential Vanilloid 1 is essential for cisplatin-induced heat hyperalgesia in mice. Mol Pain (2010) 1.19
The contribution of TRPM8 and TRPA1 channels to cold allodynia and neuropathic pain. PLoS One (2009) 1.18
Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn2+. Proc Natl Acad Sci U S A (2009) 1.18
Temperature sensing across species. Pflugers Arch (2007) 1.16
Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs. Pflugers Arch (2009) 1.16
Transient receptor potential ankyrin 1 (TRPA1) receptor is involved in chronic arthritis: in vivo study using TRPA1-deficient mice. Arthritis Res Ther (2016) 1.15
Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling. EMBO J (2012) 1.15
Transient receptor potential channels in the vasculature. Physiol Rev (2015) 1.14
Agonist-induced changes in Ca(2+) permeation through the nociceptor cation channel TRPA1. Biophys J (2010) 1.12
The molecular and cellular basis of cold sensation. ACS Chem Neurosci (2012) 1.11
TRPA1 contributes to specific mechanically activated currents and sensory neuron mechanical hypersensitivity. J Physiol (2011) 1.11
Molecular and cellular limits to somatosensory specificity. Mol Pain (2008) 1.09
Primary afferents with TRPM8 and TRPA1 profiles target distinct subpopulations of rat superficial dorsal horn neurones. Br J Pharmacol (2009) 1.09
Transient receptor potential ankyrin receptor 1 is a novel target for pro-tussive agents. Br J Pharmacol (2009) 1.08
What is the hair cell transduction channel? J Physiol (2006) 1.08
Mechano-electrical transduction: new insights into old ideas. J Membr Biol (2006) 1.07
TRP channels in neurogastroenterology: opportunities for therapeutic intervention. Br J Pharmacol (2011) 1.07
Intrinsic properties and mechanisms of spontaneous firing in mouse cerebellar unipolar brush cells. J Physiol (2007) 1.07
Desensitization of cold- and menthol-sensitive rat dorsal root ganglion neurones by inflammatory mediators. Exp Brain Res (2006) 1.06
Properties and therapeutic potential of transient receptor potential channels with putative roles in adversity: focus on TRPC5, TRPM2 and TRPA1. Curr Drug Targets (2011) 1.06
Scraping through the ice: uncovering the role of TRPM8 in cold transduction. Am J Physiol Regul Integr Comp Physiol (2011) 1.06
Chemokines as pain mediators and modulators. Curr Opin Anaesthesiol (2008) 1.04
How does morphology relate to function in sensory arbors? Trends Neurosci (2011) 1.03
What's new in ion transports in the cochlea? Pflugers Arch (2006) 1.03
TRPA1 mediates the noxious effects of natural sesquiterpene deterrents. J Biol Chem (2008) 1.03
Methyl p-hydroxybenzoate causes pain sensation through activation of TRPA1 channels. Br J Pharmacol (2007) 1.02
Inhibition of transient receptor potential A1 channel by phosphatidylinositol-4,5-bisphosphate. Am J Physiol Cell Physiol (2008) 1.00
Emerging concepts for the role of TRP channels in the cardiovascular system. J Physiol (2010) 1.00
TRP channels and analgesia. Life Sci (2012) 0.99
TRPA1 contributes to the acute inflammatory response and mediates carrageenan-induced paw edema in the mouse. Sci Rep (2012) 0.99
Polymodal ligand sensitivity of TRPA1 and its modes of interactions. J Gen Physiol (2009) 0.98
Localized TRPA1 channel Ca2+ signals stimulated by reactive oxygen species promote cerebral artery dilation. Sci Signal (2015) 0.97
Inflammation reduces mechanical thresholds in a population of transient receptor potential channel A1-expressing nociceptors in the rat. Eur J Neurosci (2008) 0.95
TRPA1-mediated accumulation of aminoglycosides in mouse cochlear outer hair cells. J Assoc Res Otolaryngol (2011) 0.94
A tarantula-venom peptide antagonizes the TRPA1 nociceptor ion channel by binding to the S1-S4 gating domain. Curr Biol (2014) 0.93
Developmental regulation of human embryonic stem cell-derived neurons by calcium entry via transient receptor potential channels. Stem Cells (2009) 0.93
Activation characteristics of transient receptor potential ankyrin 1 and its role in nociception. Am J Physiol Cell Physiol (2011) 0.93
The emerging role of TRP channels in mechanisms of temperature and pain sensation. Curr Neuropharmacol (2006) 0.93
Transient receptor potential V1 regulates activation and modulation of transient receptor potential A1 by Ca2+. Neuroscience (2010) 0.93
Expression of transient receptor potential ankyrin 1 (TRPA1) and its role in insulin release from rat pancreatic beta cells. PLoS One (2012) 0.93
Warmth suppresses and desensitizes damage-sensing ion channel TRPA1. Mol Pain (2012) 0.93
ThermoTRP channels in nociceptors: taking a lead from capsaicin receptor TRPV1. Curr Neuropharmacol (2008) 0.93
The C-terminal basic residues contribute to the chemical- and voltage-dependent activation of TRPA1. Biochem J (2011) 0.92
TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells. Nature (2004) 4.50
Lighting up the senses: FM1-43 loading of sensory cells through nonselective ion channels. J Neurosci (2003) 4.28
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Proliferation of functional hair cells in vivo in the absence of the retinoblastoma protein. Science (2005) 2.81
Acute myocardial infarction: a national analysis of the weekend effect over time. J Am Coll Cardiol (2015) 2.20
TRPC5 is a regulator of hippocampal neurite length and growth cone morphology. Nat Neurosci (2003) 1.95
Utilization of mechanical ventilation for asthma exacerbations: analysis of a national database. Respir Care (2013) 1.62
Effect of Joint National Committee VII report on hospitalizations for hypertensive emergencies in the United States. Am J Cardiol (2011) 1.58
The varitint-waddler (Va) deafness mutation in TRPML3 generates constitutive, inward rectifying currents and causes cell degeneration. Proc Natl Acad Sci U S A (2007) 1.51
Incidence and outcomes of Clostridium difficile-associated disease in hematopoietic cell transplant recipients. Int J Hematol (2014) 1.51
Assessing the credibility of the "YouTube approach" to health information on acute myocardial infarction. Clin Cardiol (2012) 1.26
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Mutant sodium channel for tumor therapy. Mol Ther (2009) 1.22
Trends in survival after in-hospital cardiac arrest. N Engl J Med (2013) 1.21
Transient expression of the conserved zinc finger gene INSM1 in progenitors and nascent neurons throughout embryonic and adult neurogenesis. J Comp Neurol (2008) 1.11
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Insm1 promotes the transition of olfactory progenitors from apical and proliferative to basal, terminally dividing and neuronogenic. Neural Dev (2011) 0.98
Chronic kidney disease and end-stage renal disease predict higher risk of mortality in patients with primary upper gastrointestinal bleeding. Am J Nephrol (2012) 0.97
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Concurrent and long-term impact of intimate partner violence on employment stability. J Interpers Violence (2010) 0.84
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TRPML2 and the evolution of mucolipins. Adv Exp Med Biol (2011) 0.82
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Administrative databases and trends in in-hospital deaths in pulmonary embolism. Arch Intern Med (2012) 0.75
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