Published in Nature on October 13, 2004
TRP channels. Annu Rev Biochem (2007) 8.09
TRP channel activation by reversible covalent modification. Proc Natl Acad Sci U S A (2006) 5.41
The Drosophila ortholog of vertebrate TRPA1 regulates thermotaxis. Genes Dev (2005) 3.89
Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor. Proc Natl Acad Sci U S A (2006) 3.24
The Concise Guide to PHARMACOLOGY 2013/14: ion channels. Br J Pharmacol (2013) 3.03
The aminoglycoside antibiotic dihydrostreptomycin rapidly enters mouse outer hair cells through the mechano-electrical transducer channels. J Physiol (2005) 2.87
Neurosensory mechanotransduction. Nat Rev Mol Cell Biol (2009) 2.73
Making an effort to listen: mechanical amplification in the ear. Neuron (2008) 2.73
International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacol Rev (2010) 2.66
HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity. Mol Pain (2008) 2.32
The micromachinery of mechanotransduction in hair cells. Annu Rev Neurosci (2007) 2.17
Molecular mechanisms of mechanotransduction in mammalian sensory neurons. Nat Rev Neurosci (2011) 2.12
TRPA1 modulates mechanotransduction in cutaneous sensory neurons. J Neurosci (2009) 2.07
Different contributions of ASIC channels 1a, 2, and 3 in gastrointestinal mechanosensory function. Gut (2005) 1.96
TRP channels and lipids: from Drosophila to mammalian physiology. J Physiol (2006) 1.90
Mice with altered KCNQ4 K+ channels implicate sensory outer hair cells in human progressive deafness. EMBO J (2006) 1.88
Stretch-activated ion channels: what are they? Physiology (Bethesda) (2010) 1.85
The mechanosensitive nature of TRPV channels. Pflugers Arch (2005) 1.84
How cold is it? TRPM8 and TRPA1 in the molecular logic of cold sensation. Mol Pain (2005) 1.84
Revisiting TRPC1 and TRPC6 mechanosensitivity. Pflugers Arch (2007) 1.81
Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells. J Neurosci (2006) 1.75
A single N-terminal cysteine in TRPV1 determines activation by pungent compounds from onion and garlic. Nat Neurosci (2008) 1.71
A primer on ankyrin repeat function in TRP channels and beyond. Mol Biosyst (2008) 1.70
The functions of TRPA1 and TRPV1: moving away from sensory nerves. Br J Pharmacol (2012) 1.69
The transient receptor potential channel TRPA1: from gene to pathophysiology. Pflugers Arch (2012) 1.63
Function and pharmacology of TRPM cation channels. Naunyn Schmiedebergs Arch Pharmacol (2005) 1.57
The role of transient receptor potential cation channels in Ca2+ signaling. Cold Spring Harb Perspect Biol (2010) 1.56
TRP channels: a TR(I)P through a world of multifunctional cation channels. Pflugers Arch (2005) 1.54
TRPV1: contribution to retinal ganglion cell apoptosis and increased intracellular Ca2+ with exposure to hydrostatic pressure. Invest Ophthalmol Vis Sci (2008) 1.54
TRPA1-mediated responses in trigeminal sensory neurons: interaction between TRPA1 and TRPV1. Eur J Neurosci (2009) 1.53
Endothelium-dependent cerebral artery dilation mediated by TRPA1 and Ca2+-Activated K+ channels. Circ Res (2009) 1.53
Mammalian somatosensory mechanotransduction. Curr Opin Neurobiol (2009) 1.51
Mechanosensitive ion channels and the peptide inhibitor GsMTx-4: history, properties, mechanisms and pharmacology. Toxicon (2006) 1.49
Zebrafish TRPA1 channels are required for chemosensation but not for thermosensation or mechanosensory hair cell function. J Neurosci (2008) 1.48
Roles of transient receptor potential channels in pain. Brain Res Rev (2008) 1.44
Uptake of fluorescent gentamicin by vertebrate sensory cells in vivo. Hear Res (2006) 1.39
Gap-junction channels dysfunction in deafness and hearing loss. Antioxid Redox Signal (2009) 1.39
The thermo-TRP ion channel family: properties and therapeutic implications. Br J Pharmacol (2012) 1.39
High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain. PLoS One (2007) 1.38
Regulation of TRP channels by PIP(2). Pflugers Arch (2006) 1.37
Cytoplasmic and intra-nuclear binding of gentamicin does not require endocytosis. Hear Res (2005) 1.37
Polycystins: polymodal receptor/ion-channel cellular sensors. Pflugers Arch (2005) 1.37
TRP channels and Ca2+ signaling. Cell Calcium (2006) 1.35
Imaging hair cell transduction at the speed of sound: dynamic behavior of mammalian stereocilia. Proc Natl Acad Sci U S A (2006) 1.35
Species-specific pharmacology of Trichloro(sulfanyl)ethyl benzamides as transient receptor potential ankyrin 1 (TRPA1) antagonists. Mol Pain (2007) 1.34
Modulation of the transient receptor potential channel TRPA1 by phosphatidylinositol 4,5-biphosphate manipulators. Pflugers Arch (2008) 1.31
Phosphoinositide regulation of non-canonical transient receptor potential channels. Cell Calcium (2009) 1.29
Xenopus TRPN1 (NOMPC) localizes to microtubule-based cilia in epithelial cells, including inner-ear hair cells. Proc Natl Acad Sci U S A (2005) 1.28
Ionic basis of a mechanotransduction current in adult rat dorsal root ganglion neurons. Mol Pain (2006) 1.27
Whirlin complexes with p55 at the stereocilia tip during hair cell development. Proc Natl Acad Sci U S A (2006) 1.26
Probing a moving target with a plastic unfolding intermediate of an ankyrin-repeat protein. Proc Natl Acad Sci U S A (2007) 1.25
TRPA1 mediates mechanical currents in the plasma membrane of mouse sensory neurons. PLoS One (2010) 1.25
TRP channels and mechanosensory transduction: insights into the arterial myogenic response. Pflugers Arch (2008) 1.24
The physiology of mechanoelectrical transduction channels in hearing. Physiol Rev (2014) 1.23
TRPV1 regulators mediate gentamicin penetration of cultured kidney cells. Hear Res (2005) 1.21
Stepwise unfolding of ankyrin repeats in a single protein revealed by atomic force microscopy. Biophys J (2005) 1.20
Contribution of TRPV1 to microglia-derived IL-6 and NFkappaB translocation with elevated hydrostatic pressure. Invest Ophthalmol Vis Sci (2008) 1.20
Developmental acquisition of voltage-dependent conductances and sensory signaling in hair cells of the embryonic mouse inner ear. J Neurosci (2004) 1.19
Potassium ion movement in the inner ear: insights from genetic disease and mouse models. Physiology (Bethesda) (2009) 1.18
Dominant-negative inhibition of M-like potassium conductances in hair cells of the mouse inner ear. J Neurosci (2007) 1.16
Mutations in OTOGL, encoding the inner ear protein otogelin-like, cause moderate sensorineural hearing loss. Am J Hum Genet (2012) 1.15
TRPC1 contributes to light-touch sensation and mechanical responses in low-threshold cutaneous sensory neurons. J Neurophysiol (2011) 1.13
FM1-43 is a permeant blocker of mechanosensitive ion channels in sensory neurons and inhibits behavioural responses to mechanical stimuli. Mol Pain (2007) 1.12
TRPA1 contributes to specific mechanically activated currents and sensory neuron mechanical hypersensitivity. J Physiol (2011) 1.11
Drosophila TRP channels. Pflugers Arch (2005) 1.10
Molecular and cellular limits to somatosensory specificity. Mol Pain (2008) 1.09
Cells, molecules and morphogenesis: the making of the vertebrate ear. Brain Res (2006) 1.09
What is the hair cell transduction channel? J Physiol (2006) 1.08
Shifting transition states in the unfolding of a large ankyrin repeat protein. Proc Natl Acad Sci U S A (2008) 1.08
Progression of inner ear pathology in Ames waltzer mice and the role of protocadherin 15 in hair cell development. J Assoc Res Otolaryngol (2006) 1.08
Mechano-electrical transduction: new insights into old ideas. J Membr Biol (2006) 1.07
Properties and therapeutic potential of transient receptor potential channels with putative roles in adversity: focus on TRPC5, TRPM2 and TRPA1. Curr Drug Targets (2011) 1.06
Dynamic expression of the osmosensory channel trpv4 in multiple developing organs in zebrafish. Gene Expr Patterns (2006) 1.05
The varitint-waddler mouse phenotypes and the TRPML3 ion channel mutation: cause and consequence. Pflugers Arch (2008) 1.04
Mechanical properties and consequences of stereocilia and extracellular links in vestibular hair bundles. Biophys J (2006) 1.04
Electrophilic components of diesel exhaust particles (DEP) activate transient receptor potential ankyrin-1 (TRPA1): a probable mechanism of acute pulmonary toxicity for DEP. Chem Res Toxicol (2011) 1.04
Activation of TRPA1 on dural afferents: a potential mechanism of headache pain. Pain (2012) 1.03
A preliminary and comparative evaluation of a novel Ad5 [E1-, E2b-] recombinant-based vaccine used to induce cell mediated immune responses. Immunol Lett (2008) 1.02
The Role of TRP Proteins in Mast Cells. Front Immunol (2012) 1.02
Recruitment of dynamic endothelial Ca2+ signals by the TRPA1 channel activator AITC in rat cerebral arteries. Microcirculation (2013) 1.02
Ion channel gene expression in the inner ear. J Assoc Res Otolaryngol (2007) 1.01
TRP channels and analgesia. Life Sci (2012) 0.99
Mechanical unfolding of an ankyrin repeat protein. Biophys J (2010) 0.99
TRPA1 channels: molecular sentinels of cellular stress and tissue damage. J Physiol (2016) 0.98
Intact Adelta-fibers up-regulate transient receptor potential A1 and contribute to cold hypersensitivity in neuropathic rats. Neuroscience (2008) 0.98
trpm7 regulation of in vivo cation homeostasis and kidney function involves stanniocalcin 1 and fgf23. Endocrinology (2010) 0.96
Behavioral evidence of thermal hyperalgesia and mechanical allodynia induced by intradermal cinnamaldehyde in rats. Neurosci Lett (2010) 0.95
Inflammation reduces mechanical thresholds in a population of transient receptor potential channel A1-expressing nociceptors in the rat. Eur J Neurosci (2008) 0.95
An in vitro model system to study gene therapy in the human inner ear. Gene Ther (2007) 0.94
TRPA1-mediated accumulation of aminoglycosides in mouse cochlear outer hair cells. J Assoc Res Otolaryngol (2011) 0.94
Activation characteristics of transient receptor potential ankyrin 1 and its role in nociception. Am J Physiol Cell Physiol (2011) 0.93
The emerging role of TRP channels in mechanisms of temperature and pain sensation. Curr Neuropharmacol (2006) 0.93
ThermoTRP channels in nociceptors: taking a lead from capsaicin receptor TRPV1. Curr Neuropharmacol (2008) 0.93
The C-terminal basic residues contribute to the chemical- and voltage-dependent activation of TRPA1. Biochem J (2011) 0.92
TRP_2, a lipid/trafficking domain that mediates diacylglycerol-induced vesicle fusion. J Biol Chem (2008) 0.92
TRPA1 channels in the vasculature. Br J Pharmacol (2012) 0.92
TRP channels as candidates for hearing and balance abnormalities in vertebrates. Biochim Biophys Acta (2007) 0.92
A tingling sanshool derivative excites primary sensory neurons and elicits nocifensive behavior in rats. J Neurophysiol (2011) 0.91
Hypoxia-inducible factor-1α (HIF1α) switches on transient receptor potential ankyrin repeat 1 (TRPA1) gene expression via a hypoxia response element-like motif to modulate cytokine release. J Biol Chem (2012) 0.91
Transient receptor potential ion channels in primary sensory neurons as targets for novel analgesics. Br J Pharmacol (2014) 0.91
ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing. Genet Med (2013) 22.73
TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. Neuron (2006) 8.57
The genome of the sea urchin Strongylocentrotus purpuratus. Science (2006) 6.41
Insertional mutagenesis in zebrafish rapidly identifies genes essential for early vertebrate development. Nat Genet (2002) 5.43
Loss-of-function mutations in FGFR1 cause autosomal dominant Kallmann syndrome. Nat Genet (2003) 4.44
Lighting up the senses: FM1-43 loading of sensory cells through nonselective ion channels. J Neurosci (2003) 4.28
A multipotent progenitor domain guides pancreatic organogenesis. Dev Cell (2007) 4.13
Exploring concordance and discordance for return of incidental findings from clinical sequencing. Genet Med (2012) 4.04
Nociceptor and hair cell transducer properties of TRPA1, a channel for pain and hearing. J Neurosci (2005) 3.99
A public resource facilitating clinical use of genomes. Proc Natl Acad Sci U S A (2012) 3.72
Assuring the quality of next-generation sequencing in clinical laboratory practice. Nat Biotechnol (2012) 3.62
TRPA1 acts as a cold sensor in vitro and in vivo. Proc Natl Acad Sci U S A (2009) 3.46
Tlx3 and Tlx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fates. Nat Neurosci (2004) 3.26
Phased whole-genome genetic risk in a family quartet using a major allele reference sequence. PLoS Genet (2011) 3.20
An ion channel essential for sensing chemical damage. J Neurosci (2007) 3.03
Proliferation of functional hair cells in vivo in the absence of the retinoblastoma protein. Science (2005) 2.81
Implications of hypertrophic cardiomyopathy transmitted by sperm donation. JAMA (2009) 2.77
Filter-based hybridization capture of subgenomes enables resequencing and copy-number detection. Nat Methods (2009) 2.71
GJB2 mutations and degree of hearing loss: a multicenter study. Am J Hum Genet (2005) 2.63
TMC1 and TMC2 are components of the mechanotransduction channel in hair cells of the mammalian inner ear. Neuron (2013) 2.54
Salivary gland branching morphogenesis. Differentiation (2006) 2.46
Differential distribution of stem cells in the auditory and vestibular organs of the inner ear. J Assoc Res Otolaryngol (2006) 2.41
The micromachinery of mechanotransduction in hair cells. Annu Rev Neurosci (2007) 2.17
Mechanotransduction in mouse inner ear hair cells requires transmembrane channel-like genes. J Clin Invest (2011) 2.17
Adenovirus infection triggers a rapid, MyD88-regulated transcriptome response critical to acute-phase and adaptive immune responses in vivo. J Virol (2006) 2.16
Shared genetic causes of cardiac hypertrophy in children and adults. N Engl J Med (2008) 2.12
Fast adaptation in vestibular hair cells requires myosin-1c activity. Neuron (2005) 2.11
Processes and preliminary outputs for identification of actionable genes as incidental findings in genomic sequence data in the Clinical Sequencing Exploratory Research Consortium. Genet Med (2013) 2.08
The GeneInsight Suite: a platform to support laboratory and provider use of DNA-based genetic testing. Hum Mutat (2011) 2.08
Communicating new knowledge on previously reported genetic variants. Genet Med (2012) 2.02
Understanding the rhythm of breathing: so near, yet so far. Annu Rev Physiol (2012) 2.01
FGFR2b signaling regulates ex vivo submandibular gland epithelial cell proliferation and branching morphogenesis. Development (2005) 1.98
TRPC5 is a regulator of hippocampal neurite length and growth cone morphology. Nat Neurosci (2003) 1.95
An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge. Genome Biol (2014) 1.95
Role of the extracellular matrix in morphogenesis. Curr Opin Biotechnol (2003) 1.93
The very large G-protein-coupled receptor VLGR1: a component of the ankle link complex required for the normal development of auditory hair bundles. J Neurosci (2006) 1.93
Burden of rare sarcomere gene variants in the Framingham and Jackson Heart Study cohorts. Am J Hum Genet (2012) 1.90
Tonotopic gradient in the developmental acquisition of sensory transduction in outer hair cells of the mouse cochlea. J Neurophysiol (2009) 1.89
Efficacy of an adeno-associated virus 8-pseudotyped vector in glycogen storage disease type II. Mol Ther (2005) 1.88
Evasion of immune responses to introduced human acid alpha-glucosidase by liver-restricted expression in glycogen storage disease type II. Mol Ther (2005) 1.87
Persistence of high sustained antibodies to enzyme replacement therapy despite extensive immunomodulatory therapy in an infant with Pompe disease: need for agents to target antibody-secreting plasma cells. Mol Genet Metab (2012) 1.79
Essential role of retinoblastoma protein in mammalian hair cell development and hearing. Proc Natl Acad Sci U S A (2006) 1.78
The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli. Gastroenterology (2009) 1.78
Developmental acquisition of sensory transduction in hair cells of the mouse inner ear. Nat Neurosci (2003) 1.78
Adenovirus vector-induced innate inflammatory mediators, MAPK signaling, as well as adaptive immune responses are dependent upon both TLR2 and TLR9 in vivo. J Immunol (2008) 1.76
Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells. J Neurosci (2006) 1.75
Disease boundaries in the retina of patients with Usher syndrome caused by MYO7A gene mutations. Invest Ophthalmol Vis Sci (2008) 1.69
TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3. Nat Neurosci (2011) 1.67
Adenovirus vector induced innate immune responses: impact upon efficacy and toxicity in gene therapy and vaccine applications. Virus Res (2007) 1.64
The MedSeq Project: a randomized trial of integrating whole genome sequencing into clinical medicine. Trials (2014) 1.62
Self-organization and branching morphogenesis of primary salivary epithelial cells. Tissue Eng (2007) 1.52
The varitint-waddler (Va) deafness mutation in TRPML3 generates constitutive, inward rectifying currents and causes cell degeneration. Proc Natl Acad Sci U S A (2007) 1.51
MT2-MMP-dependent release of collagen IV NC1 domains regulates submandibular gland branching morphogenesis. Dev Cell (2009) 1.46
High-throughput detection of mutations responsible for childhood hearing loss using resequencing microarrays. BMC Biotechnol (2010) 1.45
Vascular defects and sensorineural deafness in a mouse model of Norrie disease. J Neurosci (2002) 1.44
Myosin-I isozymes in neonatal rodent auditory and vestibular epithelia. J Assoc Res Otolaryngol (2002) 1.42
A differential developmental pattern of spinal interneuron apoptosis during synaptogenesis: insights from genetic analyses of the protocadherin-gamma gene cluster. Development (2008) 1.41
Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis. Development (2007) 1.40
A mouse model for nonsyndromic deafness (DFNB12) links hearing loss to defects in tip links of mechanosensory hair cells. Proc Natl Acad Sci U S A (2009) 1.39
Genome-wide SNP genotyping identifies the Stereocilin (STRC) gene as a major contributor to pediatric bilateral sensorineural hearing impairment. Am J Med Genet A (2011) 1.39
Towards a Universal Clinical Genomics Database: the 2012 International Standards for Cytogenomic Arrays Consortium Meeting. Hum Mutat (2013) 1.38
New approaches to molecular diagnosis. JAMA (2013) 1.36
Differential interactions of FGFs with heparan sulfate control gradient formation and branching morphogenesis. Sci Signal (2009) 1.34
Laminin alpha5 is necessary for submandibular gland epithelial morphogenesis and influences FGFR expression through beta1 integrin signaling. Dev Biol (2007) 1.33
Gipc3 mutations associated with audiogenic seizures and sensorineural hearing loss in mouse and human. Nat Commun (2011) 1.33
Sensory transduction and adaptation in inner and outer hair cells of the mouse auditory system. J Neurophysiol (2007) 1.33
Genetic testing for dilated cardiomyopathy in clinical practice. J Card Fail (2012) 1.32
A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development. Development (2006) 1.32
Nephrotic syndrome complicating alpha-glucosidase replacement therapy for Pompe disease. Pediatrics (2004) 1.31
Development, maturation, and necessity of transcription factors in the mouse suprachiasmatic nucleus. J Neurosci (2011) 1.30
Parasympathetic stimulation improves epithelial organ regeneration. Nat Commun (2013) 1.30
Inherited cardiomyopathies: molecular genetics and clinical genetic testing in the postgenomic era. J Mol Diagn (2012) 1.28
Transient pretreatment with glucocorticoid ablates innate toxicity of systemically delivered adenoviral vectors without reducing efficacy. Mol Ther (2009) 1.27
A common single nucleotide polymorphism in endoplasmic reticulum aminopeptidase 2 induces a specificity switch that leads to altered antigen processing. J Immunol (2012) 1.27
Development and validation of a computational method for assessment of missense variants in hypertrophic cardiomyopathy. Am J Hum Genet (2011) 1.25
Role of PI 3-kinase and PIP3 in submandibular gland branching morphogenesis. Dev Biol (2003) 1.24
Diverse roles of E-cadherin in the morphogenesis of the submandibular gland: insights into the formation of acinar and ductal structures. Dev Dyn (2008) 1.23
Use and interpretation of genetic tests in cardiovascular genetics. Heart (2010) 1.23
Adenoviral infection induces a multi-faceted innate cellular immune response that is mediated by the toll-like receptor pathway in A549 cells. Virology (2006) 1.23
A multicenter study of the frequency and distribution of GJB2 and GJB6 mutations in a large North American cohort. Genet Med (2007) 1.23
Mutant sodium channel for tumor therapy. Mol Ther (2009) 1.22
Overcoming pre-existing adenovirus immunity by genetic engineering of adenovirus-based vectors. Expert Opin Biol Ther (2009) 1.22
Developmental acquisition of voltage-dependent conductances and sensory signaling in hair cells of the embryonic mouse inner ear. J Neurosci (2004) 1.19
Multiple innate inflammatory responses induced after systemic adenovirus vector delivery depend on a functional complement system. Mol Ther (2006) 1.18
A novel custom resequencing array for dilated cardiomyopathy. Genet Med (2010) 1.18
Laminin alpha5 is required for dental epithelium growth and polarity and the development of tooth bud and shape. J Biol Chem (2005) 1.17
Sound strategies for hearing restoration. Science (2014) 1.16
Ecrg4 expression and its product augurin in the choroid plexus: impact on fetal brain development, cerebrospinal fluid homeostasis and neuroprogenitor cell response to CNS injury. Fluids Barriers CNS (2011) 1.16
Development and regeneration of sensory transduction in auditory hair cells requires functional interaction between cadherin-23 and protocadherin-15. J Neurosci (2010) 1.15
Translational profiling of hypocretin neurons identifies candidate molecules for sleep regulation. Genes Dev (2013) 1.15
Specific heparan sulfate structures modulate FGF10-mediated submandibular gland epithelial morphogenesis and differentiation. J Biol Chem (2008) 1.14
A systematic approach to the reporting of medically relevant findings from whole genome sequencing. BMC Med Genet (2014) 1.14
Usability of a novel clinician interface for genetic results. J Biomed Inform (2012) 1.13
Identification of molecular compartments and genetic circuitry in the developing mammalian kidney. Development (2012) 1.13
Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses. Proc Natl Acad Sci U S A (2013) 1.11