Published in Proc Natl Acad Sci U S A on April 21, 2005
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Different electrostatic potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response. Mol Cell Biol (2007) 2.38
Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase. Cancer Cell (2010) 1.95
Molecular mechanisms of ultraviolet radiation-induced DNA damage and repair. J Nucleic Acids (2010) 1.91
Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response. DNA Repair (Amst) (2009) 1.89
MiR-322/424 and -503 are induced during muscle differentiation and promote cell cycle quiescence and differentiation by down-regulation of Cdc25A. Mol Biol Cell (2010) 1.89
Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP. Mol Cell Biol (2006) 1.82
Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression. J Cell Biol (2008) 1.81
The NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and Therapy. Genes Cancer (2010) 1.80
Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/β-TrCP axis. Mol Cell Biol (2012) 1.28
SAG/ROC-SCF beta-TrCP E3 ubiquitin ligase promotes pro-caspase-3 degradation as a mechanism of apoptosis protection. Neoplasia (2006) 1.24
Coupled activation and degradation of eEF2K regulates protein synthesis in response to genotoxic stress. Sci Signal (2012) 1.23
The multiple layers of ubiquitin-dependent cell cycle control. Chem Rev (2009) 1.22
SCF ubiquitin ligases in the maintenance of genome stability. Trends Biochem Sci (2011) 1.21
Casein kinase 1 functions as both penultimate and ultimate kinase in regulating Cdc25A destruction. Oncogene (2010) 1.16
Ubiquitin and SUMO systems in the regulation of mitotic checkpoints. Trends Biochem Sci (2006) 1.15
Eastern chimpanzees, but not bonobos, represent a simian immunodeficiency virus reservoir. J Virol (2012) 1.13
The extracellular signal-regulated kinase-mitogen-activated protein kinase pathway phosphorylates and targets Cdc25A for SCF beta-TrCP-dependent degradation for cell cycle arrest. Mol Biol Cell (2009) 0.99
Mechanism of degradation of CPEB during Xenopus oocyte maturation. Proc Natl Acad Sci U S A (2007) 0.99
beta-TrCP inhibition reduces prostate cancer cell growth via upregulation of the aryl hydrocarbon receptor. PLoS One (2010) 0.99
Novel insights into the molecular mechanisms governing Mdm2 ubiquitination and destruction. Oncotarget (2010) 0.98
MAPK pathway activation delays G2/M progression by destabilizing Cdc25B. J Biol Chem (2009) 0.92
Chronic inflammation and cancer: potential chemoprevention through nuclear factor kappa B and p53 mutual antagonism. J Inflamm (Lond) (2014) 0.92
A C-terminal fragment of Cyclin E, generated by caspase-mediated cleavage, is degraded in the absence of a recognizable phosphodegron. J Biol Chem (2008) 0.91
DNA damage induces the accumulation of Tiam1 by blocking β-TrCP-dependent degradation. J Biol Chem (2014) 0.90
Unscheduled expression of CDC25B in S-phase leads to replicative stress and DNA damage. Mol Cancer (2010) 0.87
Tripartite degrons confer diversity and specificity on regulated protein degradation in the ubiquitin-proteasome system. Nat Commun (2016) 0.86
Interaction and co-localization of JC virus large T antigen and the F-box protein β-transducin-repeat containing protein. Virology (2010) 0.85
Network architecture of signaling from uncoupled helicase-polymerase to cell cycle checkpoints and trans-lesion DNA synthesis. Cell Cycle (2009) 0.82
RB in breast cancer: differential effects in estrogen receptor-positive and estrogen receptor-negative disease. Cell Cycle (2010) 0.82
Pro-apoptotic role of Cdc25A: activation of cyclin B1/Cdc2 by the Cdc25A C-terminal domain. J Biol Chem (2010) 0.82
Ras regulates SCF(β-TrCP) protein activity and specificity via its effector protein NORE1A. J Biol Chem (2014) 0.81
Crumbs promotes expanded recognition and degradation by the SCF(Slimb/β-TrCP) ubiquitin ligase. Proc Natl Acad Sci U S A (2014) 0.81
Proteasome-dependent degradation of transcription factor activating enhancer-binding protein 4 (TFAP4) controls mitotic division. J Biol Chem (2014) 0.81
DNA Damage Regulates Translation through β-TRCP Targeting of CReP. PLoS Genet (2015) 0.79
Deubiquitinase USP47/UBP64E Regulates β-Catenin Ubiquitination and Degradation and Plays a Positive Role in Wnt Signaling. Mol Cell Biol (2015) 0.79
Cdc25 phosphatases: differential regulation by ubiquitin-mediated proteolysis. Cell Cycle (2010) 0.77
The human COP9 signalosome protects ubiquitin-conjugating enzyme 3 (UBC3/Cdc34) from beta-transducin repeat-containing protein (betaTrCP)-mediated degradation. J Biol Chem (2010) 0.77
Cycle on Wheels: Is APP Key to the AppBp1 Pathway? Austin Alzheimers Parkinsons Dis (2014) 0.76
Ubiquitination-mediated degradation of cell cycle-related proteins by F-box proteins. Int J Biochem Cell Biol (2016) 0.76
The transmembrane domain of HIV-1 Vpu is sufficient to confer anti-tetherin activity to SIVcpz and SIVgor Vpu proteins: cytoplasmic determinants of Vpu function. Retrovirology (2013) 0.76
Chk1 Inhibition of the Replication Factor Drf1 Guarantees Cell-Cycle Elongation at the Xenopus laevis Mid-blastula Transition. Dev Cell (2017) 0.75
Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell (2002) 10.34
Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat Cell Biol (2004) 9.80
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PEST sequences and regulation by proteolysis. Trends Biochem Sci (1996) 8.90
The SCF ubiquitin ligase: insights into a molecular machine. Nat Rev Mol Cell Biol (2004) 8.21
The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature (2001) 6.73
The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro. Genes Dev (1999) 6.56
Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase. Mol Cell (2003) 5.31
Identification of the receptor component of the IkappaBalpha-ubiquitin ligase. Nature (1998) 4.89
Rapid destruction of human Cdc25A in response to DNA damage. Science (2000) 4.74
Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex. Nature (2000) 4.52
M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP. Proc Natl Acad Sci U S A (2004) 4.13
Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints. Proc Natl Acad Sci U S A (2002) 4.06
Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. Cancer Cell (2003) 3.58
Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage. Nature (2003) 3.54
Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase. Dev Cell (2003) 3.53
An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin. EMBO J (1999) 3.42
A ubiquitin ligase complex essential for the NF-kappaB, Wnt/Wingless, and Hedgehog signaling pathways. Genes Dev (1999) 3.38
SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase. Genes Dev (2003) 3.35
The many faces of beta-TrCP E3 ubiquitin ligases: reflections in the magic mirror of cancer. Oncogene (2004) 2.94
Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability. EMBO J (2002) 2.39
Regulating mammalian checkpoints through Cdc25 inactivation. EMBO Rep (2003) 2.21
Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome. Proc Natl Acad Sci U S A (2004) 2.05
Dual mode of degradation of Cdc25 A phosphatase. EMBO J (2002) 1.95
The cdc25B phosphatase is essential for the G2/M phase transition in human cells. J Cell Sci (1998) 1.92
Human Cdc25 A inactivation in response to S phase inhibition and its role in preventing premature mitosis. EMBO Rep (2000) 1.72
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Chk1 is activated transiently and targets Cdc25A for degradation at the Xenopus midblastula transition. EMBO J (2002) 1.58
IkappaBalpha ubiquitination is catalyzed by an SCF-like complex containing Skp1, cullin-1, and two F-box/WD40-repeat proteins, betaTrCP1 and betaTrCP2. Biochem Biophys Res Commun (1999) 1.56
SCF(beta)(-TrCP) ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase. EMBO J (2000) 1.55
Pseudosubstrate regulation of the SCF(beta-TrCP) ubiquitin ligase by hnRNP-U. Genes Dev (2002) 1.51
A maternal form of the phosphatase Cdc25A regulates early embryonic cell cycles in Xenopus laevis. Dev Biol (1999) 1.36
A dual-specificity phosphatase Cdc25B is an unstable protein and triggers p34(cdc2)/cyclin B activation in hamster BHK21 cells arrested with hydroxyurea. J Cell Biol (1997) 1.20
Cytoplasmic occurrence of the Chk1/Cdc25 pathway and regulation of Chk1 in Xenopus oocytes. Dev Biol (2001) 1.19
Hyperphosphorylation of the N-terminal domain of Cdc25 regulates activity toward cyclin B1/Cdc2 but not cyclin A/Cdk2. J Biol Chem (1997) 1.16
Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism. EMBO J (2004) 1.15
HIV-1 Vpu sequesters beta-transducin repeat-containing protein (betaTrCP) in the cytoplasm and provokes the accumulation of beta-catenin and other SCFbetaTrCP substrates. J Biol Chem (2003) 1.14
Phosphorylation of human CDC25B phosphatase by CDK1-cyclin A triggers its proteasome-dependent degradation. J Biol Chem (1997) 1.09
Regulation of the discs large tumor suppressor by a phosphorylation-dependent interaction with the beta-TrCP ubiquitin ligase receptor. J Biol Chem (2003) 1.04
Facilitation of stress-induced phosphorylation of beta-amyloid precursor protein family members by X11-like/Mint2 protein. J Biol Chem (2004) 1.03
Isolation of a cDNA encoding the X enopus homologue of mammalian Cdc25A that can induce meiotic maturation of oocytes. Gene (1996) 0.85
Molecular biology. Untangling checkpoints. Science (2002) 0.84
Chk1 is activated transiently and targets Cdc25A for degradation at the Xenopus midblastula transition. EMBO J (2002) 1.58
Regulation of Chk1 kinase by autoinhibition and ATR-mediated phosphorylation. Mol Biol Cell (2004) 1.46
A direct link of the Mos-MAPK pathway to Erp1/Emi2 in meiotic arrest of Xenopus laevis eggs. Nature (2007) 1.41
Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism. EMBO J (2004) 1.15
Mechanism for inactivation of the mitotic inhibitory kinase Wee1 at M phase. Proc Natl Acad Sci U S A (2007) 1.13
The existence of two distinct Wee1 isoforms in Xenopus: implications for the developmental regulation of the cell cycle. EMBO J (2002) 1.12
The Polo-like kinase Plx1 interacts with and inhibits Myt1 after fertilization of Xenopus eggs. EMBO J (2005) 1.11
Erp1/Emi2 is essential for the meiosis I to meiosis II transition in Xenopus oocytes. Dev Biol (2006) 1.09
Emi2 inhibition of the anaphase-promoting complex/cyclosome absolutely requires Emi2 binding via the C-terminal RL tail. Mol Biol Cell (2010) 1.01
The extracellular signal-regulated kinase-mitogen-activated protein kinase pathway phosphorylates and targets Cdc25A for SCF beta-TrCP-dependent degradation for cell cycle arrest. Mol Biol Cell (2009) 0.99
Mechanism of degradation of CPEB during Xenopus oocyte maturation. Proc Natl Acad Sci U S A (2007) 0.99
FoxM1-driven cell division is required for neuronal differentiation in early Xenopus embryos. Development (2008) 0.91
Dynamic regulation of Emi2 by Emi2-bound Cdk1/Plk1/CK1 and PP2A-B56 in meiotic arrest of Xenopus eggs. Dev Cell (2011) 0.89
Syk and Lyn mediate distinct Syk phosphorylation events in FcɛRI-signal transduction: implications for regulation of IgE-mediated degranulation. Mol Immunol (2010) 0.87
The C-terminal seven amino acids in the cytoplasmic retention signal region of cyclin B2 are required for normal bipolar spindle formation in Xenopus oocytes and embryos. Mol Cancer Res (2003) 0.83
Expression of cell-cycle regulators during Xenopus oogenesis. Gene Expr Patterns (2003) 0.80
Requirement for both EDEN and AUUUA motifs in translational arrest of Mos mRNA upon fertilization of Xenopus eggs. Dev Biol (2002) 0.80
Mr 25 000 protein, a substrate for protein serine/threonine kinases, is identified as a part of Xenopus laevis vitellogenin B1. Dev Growth Differ (2003) 0.78
Cross-centre replication of suppressed burrowing behaviour as an ethologically relevant pain outcome measure in the rat: a prospective multicentre study. Pain (2016) 0.77
[Regulation of the cell cycle and checkpoint by SCF(beta-TrCP)]. Tanpakushitsu Kakusan Koso (2006) 0.75
Cross-centre replication of suppressed burrowing behaviour as an ethologically relevant pain outcome measure in the rat: a prospective multicentre study. Pain (2016) 0.75
Temporal and spatial expression patterns of Cdc25 phosphatase isoforms during early Xenopus development. Int J Dev Biol (2011) 0.75
The RRASK motif in Xenopus cyclin B2 is required for the substrate recognition of Cdc25C by the cyclin B-Cdc2 complex. J Biol Chem (2003) 0.75