Published in Nature on April 28, 2005
The genetics of mammalian circadian order and disorder: implications for physiology and disease. Nat Rev Genet (2008) 7.65
Identification of SLEEPLESS, a sleep-promoting factor. Science (2008) 4.56
Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation. Science (2010) 3.60
About sleep's role in memory. Physiol Rev (2013) 3.35
Control of sleep and wakefulness. Physiol Rev (2012) 3.06
Genetic manipulation of genes and cells in the nervous system of the fruit fly. Neuron (2011) 2.54
Characterization of sleep in zebrafish and insomnia in hypocretin receptor mutants. PLoS Biol (2007) 2.34
A Drosophila model for age-associated changes in sleep:wake cycles. Proc Natl Acad Sci U S A (2006) 2.27
Genetics of sleep and sleep disorders. Cell (2011) 2.26
Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery. Pharmacol Rev (2011) 2.25
Modulation of GABAA receptor desensitization uncouples sleep onset and maintenance in Drosophila. Nat Neurosci (2008) 2.01
The genetic and molecular regulation of sleep: from fruit flies to humans. Nat Rev Neurosci (2009) 1.82
Two dopaminergic neurons signal to the dorsal fan-shaped body to promote wakefulness in Drosophila. Curr Biol (2012) 1.79
100 years of Drosophila research and its impact on vertebrate neuroscience: a history lesson for the future. Nat Rev Neurosci (2010) 1.76
A conserved behavioral state barrier impedes transitions between anesthetic-induced unconsciousness and wakefulness: evidence for neural inertia. PLoS One (2010) 1.72
Unearthing the phylogenetic roots of sleep. Curr Biol (2008) 1.71
A video method to study Drosophila sleep. Sleep (2008) 1.64
Conservation of sleep: insights from non-mammalian model systems. Trends Neurosci (2008) 1.62
Melatonin signaling controls circadian swimming behavior in marine zooplankton. Cell (2014) 1.59
Co-regulated transcriptional networks contribute to natural genetic variation in Drosophila sleep. Nat Genet (2009) 1.59
A genetic screen for sleep and circadian mutants reveals mechanisms underlying regulation of sleep in Drosophila. Sleep (2008) 1.45
The GABA(A) receptor RDL acts in peptidergic PDF neurons to promote sleep in Drosophila. Curr Biol (2009) 1.43
Sleep in Kcna2 knockout mice. BMC Biol (2007) 1.42
Sleep and wakefulness in Drosophila melanogaster. Ann N Y Acad Sci (2008) 1.39
Identification of a biomarker for sleep drive in flies and humans. Proc Natl Acad Sci U S A (2006) 1.32
Why we sleep: the temporal organization of recovery. PLoS Biol (2008) 1.31
SLEEPLESS, a Ly-6/neurotoxin family member, regulates the levels, localization and activity of Shaker. Nat Neurosci (2009) 1.27
Genetic analysis of sleep. Genes Dev (2010) 1.26
Neuronal machinery of sleep homeostasis in Drosophila. Neuron (2014) 1.25
The Drosophila fragile X mental retardation gene regulates sleep need. J Neurosci (2009) 1.25
A quantitative, theoretical framework for understanding mammalian sleep. Proc Natl Acad Sci U S A (2007) 1.24
insomniac and Cullin-3 regulate sleep and wakefulness in Drosophila. Neuron (2011) 1.23
What are microarrays teaching us about sleep? Trends Mol Med (2009) 1.22
The ecological relevance of sleep: the trade-off between sleep, memory and energy conservation. Philos Trans R Soc Lond B Biol Sci (2010) 1.20
Identifying sleep regulatory genes using a Drosophila model of insomnia. J Neurosci (2009) 1.18
Operation of a homeostatic sleep switch. Nature (2016) 1.16
Drosophila D1 dopamine receptor mediates caffeine-induced arousal. Proc Natl Acad Sci U S A (2008) 1.13
Detecting selective sweeps from pooled next-generation sequencing samples. Mol Biol Evol (2012) 1.13
Genome-wide association study of sleep in Drosophila melanogaster. BMC Genomics (2013) 1.11
Sleep and innate immunity. Front Biosci (Schol Ed) (2011) 1.11
Quantitative genetic analysis of sleep in Drosophila melanogaster. Genetics (2008) 1.09
Regulated RNA editing and functional epistasis in Shaker potassium channels. J Gen Physiol (2009) 1.07
Sleep triggered by an immune response in Drosophila is regulated by the circadian clock and requires the NFkappaB Relish. BMC Neurosci (2010) 1.07
Energy expenditure and aging. Ageing Res Rev (2009) 1.05
Drosophila aging 2006/2007. Exp Gerontol (2007) 1.05
Sleep deprivation specifically impairs short-term olfactory memory in Drosophila. Sleep (2009) 1.03
Re-patterning sleep architecture in Drosophila through gustatory perception and nutritional quality. PLoS Genet (2012) 1.02
Cul3 and the BTB adaptor insomniac are key regulators of sleep homeostasis and a dopamine arousal pathway in Drosophila. PLoS Genet (2012) 1.02
Circadian regulation of ion channels and their functions. J Neurochem (2009) 1.02
Understanding the neurogenetics of sleep: progress from Drosophila. Trends Genet (2009) 1.02
Modulation of the frequency response of Shaker potassium channels by the quiver peptide suggesting a novel extracellular interaction mechanism. J Neurogenet (2010) 1.01
Adenosine-to-inosine genetic recoding is required in the adult stage nervous system for coordinated behavior in Drosophila. J Biol Chem (2009) 0.99
The histone demethylase Dmel\Kdm4A controls genes required for life span and male-specific sex determination in Drosophila. Gene (2010) 0.98
Genetic and anatomical basis of the barrier separating wakefulness and anesthetic-induced unresponsiveness. PLoS Genet (2013) 0.96
Sleep, aging, and lifespan in Drosophila. BMC Neurosci (2010) 0.96
From genetics to structure to function: exploring sleep in Drosophila. Int Rev Neurobiol (2011) 0.95
Identification of Redeye, a new sleep-regulating protein whose expression is modulated by sleep amount. Elife (2014) 0.93
Deep conservation of genes required for both Drosphila melanogaster and Caenorhabditis elegans sleep includes a role for dopaminergic signaling. Sleep (2014) 0.93
A conserved long noncoding RNA affects sleep behavior in Drosophila. Genetics (2011) 0.92
Neuropathology in Drosophila membrane excitability mutants. Genetics (2005) 0.92
Call it Worm Sleep. Trends Neurosci (2015) 0.91
SLEEPLESS is a bifunctional regulator of excitability and cholinergic synaptic transmission. Curr Biol (2014) 0.91
Sleep interacts with aβ to modulate intrinsic neuronal excitability. Curr Biol (2015) 0.90
Sleep and plasticity. Pflugers Arch (2011) 0.90
Drosophila ATF-2 regulates sleep and locomotor activity in pacemaker neurons. Mol Cell Biol (2008) 0.90
WIDE AWAKE mediates the circadian timing of sleep onset. Neuron (2014) 0.90
Shaker-related potassium channels in the central medial nucleus of the thalamus are important molecular targets for arousal suppression by volatile general anesthetics. J Neurosci (2013) 0.89
Ion channels to inactivate neurons in Drosophila. Front Mol Neurosci (2009) 0.89
Genetic background has a major impact on differences in sleep resulting from environmental influences in Drosophila. Sleep (2012) 0.89
Plant neurobiology: from sensory biology, via plant communication, to social plant behavior. Cogn Process (2008) 0.88
Drosophila QVR/SSS modulates the activation and C-type inactivation kinetics of Shaker K(+) channels. J Neurosci (2011) 0.88
Altered regulation of sleep and feeding contributes to starvation resistance in Drosophila melanogaster. J Exp Biol (2014) 0.87
Hypocretin neuron-specific transcriptome profiling identifies the sleep modulator Kcnh4a. Elife (2015) 0.87
Sleeping together using social interactions to understand the role of sleep in plasticity. Adv Genet (2010) 0.87
An Adenosine-Mediated Glial-Neuronal Circuit for Homeostatic Sleep. J Neurosci (2016) 0.87
I(A) channels encoded by Kv1.4 and Kv4.2 regulate neuronal firing in the suprachiasmatic nucleus and circadian rhythms in locomotor activity. J Neurosci (2012) 0.86
Increased volatile anesthetic requirement in short-sleeping Drosophila mutants. Anesthesiology (2009) 0.85
Regulation of zebrafish sleep and arousal states: current and prospective approaches. Front Neural Circuits (2013) 0.84
Forward-genetics analysis of sleep in randomly mutagenized mice. Nature (2016) 0.83
A neuron-glia interaction involving GABA transaminase contributes to sleep loss in sleepless mutants. Mol Psychiatry (2014) 0.83
Small-molecule screen in adult Drosophila identifies VMAT as a regulator of sleep. J Neurosci (2013) 0.82
The NMDA Receptor Promotes Sleep in the Fruit Fly, Drosophila melanogaster. PLoS One (2015) 0.80
Shared genetic background for regulation of mood and sleep: association of GRIA3 with sleep duration in healthy Finnish women. Sleep (2011) 0.80
A new model to study sleep deprivation-induced seizure. Sleep (2015) 0.80
TARANIS Functions with Cyclin A and Cdk1 in a Novel Arousal Center to Control Sleep in Drosophila. Curr Biol (2015) 0.80
Regulation of Sleep by Insulin-like Peptide System in Drosophila melanogaster. Sleep (2015) 0.79
Modeling the genetic basis for human sleep disorders in Drosophila. Commun Integr Biol (2013) 0.79
Molecular mechanisms of age-related sleep loss in the fruit fly - a mini-review. Gerontology (2013) 0.78
Histamine-HisCl1 receptor axis regulates wake-promoting signals in Drosophila melanogaster. PLoS One (2013) 0.78
Approaches to unravel the genetics of sleep. Sleep Med Rev (2010) 0.78
Novel phenotype associated with a mutation in the KCNA1(Kv1.1) gene. Front Physiol (2015) 0.78
An emerging link between general anesthesia and sleep. Proc Natl Acad Sci U S A (2008) 0.78
Effects of light interruption on sleep and viability of Drosophila melanogaster. PLoS One (2014) 0.78
In vivo analysis of a gain-of-function mutation in the Drosophila eag-encoded K+ channel. Genetics (2006) 0.78
A Zebrafish Genetic Screen Identifies Neuromedin U as a Regulator of Sleep/Wake States. Neuron (2016) 0.77
The shaker potassium channel is no target for xenon anesthesia in short-sleeping Drosophila melanogaster mutants. ScientificWorldJournal (2012) 0.77
Day-night cycles and the sleep-promoting factor, Sleepless, affect stem cell activity in the Drosophila testis. Proc Natl Acad Sci U S A (2014) 0.76
To sleep, perchance to live. Sleeping is vital for health, cognitive function, memory and long life. EMBO Rep (2008) 0.76
Pushing the threshold: How NMDAR antagonists induce homeostasis through protein synthesis to remedy depression. Brain Res (2016) 0.76
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
The human connectome: A structural description of the human brain. PLoS Comput Biol (2005) 14.12
Local sleep and learning. Nature (2004) 7.67
Breakdown of cortical effective connectivity during sleep. Science (2005) 5.80
Consciousness and anesthesia. Science (2008) 4.91
Molecular and electrophysiological evidence for net synaptic potentiation in wake and depression in sleep. Nat Neurosci (2008) 4.36
The sleep slow oscillation as a traveling wave. J Neurosci (2004) 3.99
Local sleep in awake rats. Nature (2011) 3.83
Cortical firing and sleep homeostasis. Neuron (2009) 3.65
A theoretically based index of consciousness independent of sensory processing and behavior. Sci Transl Med (2013) 3.26
Stress response genes protect against lethal effects of sleep deprivation in Drosophila. Nature (2002) 3.15
Widespread changes in synaptic markers as a function of sleep and wakefulness in Drosophila. Science (2009) 3.07
Regional slow waves and spindles in human sleep. Neuron (2011) 3.05
Extensive and divergent effects of sleep and wakefulness on brain gene expression. Neuron (2004) 2.95
Arm immobilization causes cortical plastic changes and locally decreases sleep slow wave activity. Nat Neurosci (2006) 2.85
New insights into the classification and nomenclature of cortical GABAergic interneurons. Nat Rev Neurosci (2013) 2.65
Modeling sleep and wakefulness in the thalamocortical system. J Neurophysiol (2004) 2.56
Sleep homeostasis in Drosophila melanogaster. Sleep (2004) 2.44
Exploratory behavior, cortical BDNF expression, and sleep homeostasis. Sleep (2007) 2.39
Is sleep essential? PLoS Biol (2008) 2.33
Sleep homeostasis and cortical synchronization: III. A high-density EEG study of sleep slow waves in humans. Sleep (2007) 2.27
Reduced sleep spindle activity in schizophrenia patients. Am J Psychiatry (2007) 2.26
Triggering sleep slow waves by transcranial magnetic stimulation. Proc Natl Acad Sci U S A (2007) 2.26
Sleep homeostasis and cortical synchronization: I. Modeling the effects of synaptic strength on sleep slow waves. Sleep (2007) 2.16
Nervous wreck, an SH3 adaptor protein that interacts with Wsp, regulates synaptic growth in Drosophila. Neuron (2004) 2.12
Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation. Proc Natl Acad Sci U S A (2008) 2.09
Sleep and synaptic homeostasis: structural evidence in Drosophila. Science (2011) 2.07
International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels. Pharmacol Rev (2003) 2.05
Breakdown in cortical effective connectivity during midazolam-induced loss of consciousness. Proc Natl Acad Sci U S A (2010) 2.05
Source modeling sleep slow waves. Proc Natl Acad Sci U S A (2009) 2.05
Connectivity changes underlying spectral EEG changes during propofol-induced loss of consciousness. J Neurosci (2012) 2.04
Propofol anesthesia and sleep: a high-density EEG study. Sleep (2011) 1.95
Unresponsiveness ≠ unconsciousness. Anesthesiology (2012) 1.94
Recovery of cortical effective connectivity and recovery of consciousness in vegetative patients. Brain (2012) 1.80
Sleep-dependent improvement in visuomotor learning: a causal role for slow waves. Sleep (2009) 1.80
Electrophysiological correlates of rest and activity in Drosophila melanogaster. Curr Biol (2002) 1.80
Autophagy promotes synapse development in Drosophila. J Cell Biol (2009) 1.79
Sleep spindles in humans: insights from intracranial EEG and unit recordings. J Neurosci (2011) 1.78
Thalamic dysfunction in schizophrenia suggested by whole-night deficits in slow and fast spindles. Am J Psychiatry (2010) 1.74
Direct evidence for wake-related increases and sleep-related decreases in synaptic strength in rodent cortex. J Neurosci (2010) 1.74
Nervous wreck interacts with thickveins and the endocytic machinery to attenuate retrograde BMP signaling during synaptic growth. Neuron (2008) 1.69
Mapping of cortical activity in the first two decades of life: a high-density sleep electroencephalogram study. J Neurosci (2010) 1.69
Sleep homeostasis and cortical synchronization: II. A local field potential study of sleep slow waves in the rat. Sleep (2007) 1.67
Long-term homeostasis of extracellular glutamate in the rat cerebral cortex across sleep and waking states. J Neurosci (2009) 1.63
A proposal for a Decade of the Mind initiative. Science (2007) 1.61
Sleep and waking modulate spine turnover in the adolescent mouse cortex. Nat Neurosci (2011) 1.56
Integrated information in discrete dynamical systems: motivation and theoretical framework. PLoS Comput Biol (2008) 1.55
A causal role for brain-derived neurotrophic factor in the homeostatic regulation of sleep. J Neurosci (2008) 1.54
Drosophila Hyperkinetic mutants have reduced sleep and impaired memory. J Neurosci (2007) 1.54
Consensus paper: combining transcranial stimulation with neuroimaging. Brain Stimul (2009) 1.54
Neurodevelopmental outcome, psychological adjustment, and quality of life in adolescents with congenital heart disease. Dev Med Child Neurol (2013) 1.53
Dreaming and the brain: from phenomenology to neurophysiology. Trends Cogn Sci (2010) 1.52
Sleep and wakefulness modulate gene expression in Drosophila. J Neurochem (2005) 1.50
Sleep homeostasis in the rat is preserved during chronic sleep restriction. Proc Natl Acad Sci U S A (2010) 1.49
Models of neocortical layer 5b pyramidal cells capturing a wide range of dendritic and perisomatic active properties. PLoS Comput Biol (2011) 1.48
Reduced evoked gamma oscillations in the frontal cortex in schizophrenia patients: a TMS/EEG study. Am J Psychiatry (2008) 1.45
Migratory sleeplessness in the white-crowned sparrow (Zonotrichia leucophrys gambelii). PLoS Biol (2004) 1.44
TMS-induced cortical potentiation during wakefulness locally increases slow wave activity during sleep. PLoS One (2007) 1.44
Impaired slow wave sleep downscaling in encephalopathy with status epilepticus during sleep (ESES). Clin Neurophysiol (2011) 1.43
Neural dysfunction and neurodegeneration in Drosophila Na+/K+ ATPase alpha subunit mutants. J Neurosci (2003) 1.43
Sleep in Kcna2 knockout mice. BMC Biol (2007) 1.42
Sleep and wakefulness in Drosophila melanogaster. Ann N Y Acad Sci (2008) 1.39
Changes in brain gene expression after long-term sleep deprivation. J Neurochem (2006) 1.39
Metabolic disruption in Drosophila bang-sensitive seizure mutants. Genetics (2006) 1.38
Repetitive transcranial magnetic stimulation dissociates working memory manipulation from retention functions in the prefrontal, but not posterior parietal, cortex. J Cogn Neurosci (2006) 1.36
Temporal dynamics of cortical sources underlying spontaneous and peripherally evoked slow waves. Prog Brain Res (2011) 1.36
EEG sleep slow-wave activity as a mirror of cortical maturation. Cereb Cortex (2010) 1.35
Temperature-sensitive paralytic mutants are enriched for those causing neurodegeneration in Drosophila. Genetics (2002) 1.34
Closing the (Ran)GAP on segregation distortion in Drosophila. Bioessays (2003) 1.33
Integrated information increases with fitness in the evolution of animats. PLoS Comput Biol (2011) 1.33
Direct evidence for a prefrontal contribution to the control of proactive interference in verbal working memory. Proc Natl Acad Sci U S A (2006) 1.29
Human cortical excitability increases with time awake. Cereb Cortex (2012) 1.25
The Drosophila fragile X mental retardation gene regulates sleep need. J Neurosci (2009) 1.25
Qualia: the geometry of integrated information. PLoS Comput Biol (2009) 1.24
The thalamic reticular nucleus and schizophrenia. Schizophr Bull (2010) 1.23
Effects of skilled training on sleep slow wave activity and cortical gene expression in the rat. Sleep (2009) 1.22
Evaluating frontal and parietal contributions to spatial working memory with repetitive transcranial magnetic stimulation. Brain Res (2008) 1.21
Locus ceruleus control of slow-wave homeostasis. J Neurosci (2005) 1.20
The sleep EEG as a marker of intellectual ability in school age children. Sleep (2011) 1.20
Modeling the effects of transcranial magnetic stimulation on cortical circuits. J Neurophysiol (2005) 1.20
Repetitive Transcranial Magnetic Stimulation Affects behavior by Biasing Endogenous Cortical Oscillations. Front Integr Neurosci (2009) 1.20
Segregation distortion induced by wild-type RanGAP in Drosophila. Proc Natl Acad Sci U S A (2002) 1.18
Effects of sleep and wake on oligodendrocytes and their precursors. J Neurosci (2013) 1.18
Human brain connectivity during single and paired pulse transcranial magnetic stimulation. Neuroimage (2010) 1.16
The serial reaction time task revisited: a study on motor sequence learning with an arm-reaching task. Exp Brain Res (2008) 1.16
Measures of cortical plasticity after transcranial paired associative stimulation predict changes in electroencephalogram slow-wave activity during subsequent sleep. J Neurosci (2008) 1.15
Sleep and synaptic renormalization: a computational study. J Neurophysiol (2010) 1.14