Published in J Biol Chem on April 29, 2005
In vivo multiphoton microscopy of NADH and FAD redox states, fluorescence lifetimes, and cellular morphology in precancerous epithelia. Proc Natl Acad Sci U S A (2007) 4.53
Fluorescence lifetime measurements and biological imaging. Chem Rev (2010) 3.99
Alternatives to gadolinium-based metal chelates for magnetic resonance imaging. Chem Rev (2010) 2.25
In vivo multiphoton fluorescence lifetime imaging of protein-bound and free nicotinamide adenine dinucleotide in normal and precancerous epithelia. J Biomed Opt (2007) 2.09
Two-photon autofluorescence dynamics imaging reveals sensitivity of intracellular NADH concentration and conformation to cell physiology at the single-cell level. J Photochem Photobiol B (2008) 1.78
Intracellular coenzymes as natural biomarkers for metabolic activities and mitochondrial anomalies. Biomark Med (2010) 1.69
Two-photon NADH imaging exposes boundaries of oxygen diffusion in cortical vascular supply regions. J Cereb Blood Flow Metab (2010) 1.64
Investigating protein-protein interactions in living cells using fluorescence lifetime imaging microscopy. Nat Protoc (2011) 1.47
Genetically encoded fluorescent sensors for intracellular NADH detection. Cell Metab (2011) 1.47
Fluorescence lifetime imaging microscopy for brain tumor image-guided surgery. J Biomed Opt (2010) 1.42
Separating NADH and NADPH fluorescence in live cells and tissues using FLIM. Nat Commun (2014) 1.37
Frontiers in optical imaging of cerebral blood flow and metabolism. J Cereb Blood Flow Metab (2012) 1.36
Regulation of blood flow in activated human brain by cytosolic NADH/NAD+ ratio. Proc Natl Acad Sci U S A (2006) 1.32
Mitochondrial NADH fluorescence is enhanced by complex I binding. Biochemistry (2008) 1.30
Quantitative metabolic imaging using endogenous fluorescence to detect stem cell differentiation. Sci Rep (2013) 1.22
Multimodal magnetic-resonance/optical-imaging contrast agent sensitive to NADH. Angew Chem Int Ed Engl (2009) 1.20
Non-invasive multiphoton imaging of extracellular matrix structures. J Biophotonics (2008) 1.14
Mechanisms of impaired mitochondrial energy metabolism in acute and chronic neurodegenerative disorders. J Neurosci Res (2007) 1.14
Wide-field fluorescence lifetime imaging of cancer. Biomed Opt Express (2010) 1.13
Membrane order and molecular dynamics associated with IgE receptor cross-linking in mast cells. Biophys J (2006) 1.10
Integrated multimodal optical microscopy for structural and functional imaging of engineered and natural skin. J Biophotonics (2012) 1.08
Target-to-background enhancement in multispectral endoscopy with background autofluorescence mitigation for quantitative molecular imaging. J Biomed Opt (2014) 1.07
NAD(+)/NADH and skeletal muscle mitochondrial adaptations to exercise. Am J Physiol Endocrinol Metab (2012) 1.05
Determination of hair cell metabolic state in isolated cochlear preparations by two-photon microscopy. J Biomed Opt (2007) 1.04
Multiphoton microscopy and microspectroscopy for diagnostics of inflammatory and neoplastic lung. J Biomed Opt (2012) 1.03
Spontaneous sharp bending of DNA: role of melting bubbles. Nucleic Acids Res (2006) 1.02
In vivo monitoring of protein-bound and free NADH during ischemia by nonlinear spectral imaging microscopy. Biomed Opt Express (2011) 0.97
Synthesis and characterization of a redox- and light-sensitive MRI contrast agent. Tetrahedron (2009) 0.95
Regulation of poly(ADP-ribose) polymerase-1-dependent gene expression through promoter-directed recruitment of a nuclear NAD+ synthase. J Biol Chem (2012) 0.93
In vivo imaging of cerebral energy metabolism with two-photon fluorescence lifetime microscopy of NADH. Biomed Opt Express (2013) 0.92
Selective detection of NADPH oxidase in polymorphonuclear cells by means of NAD(P)H-based fluorescence lifetime imaging. J Biophys (2008) 0.92
Fluorescence lifetime spectroscopy of tissue autofluorescence in normal and diseased colon measured ex vivo using a fiber-optic probe. Biomed Opt Express (2014) 0.92
Multiphoton microscopy as a diagnostic imaging modality for lung cancer. Proc SPIE Int Soc Opt Eng (2010) 0.91
In vivo tissue-wide synchronization of mitochondrial metabolic oscillations. Cell Rep (2014) 0.90
Optical visualization of Alzheimer's pathology via multiphoton-excited intrinsic fluorescence and second harmonic generation. Opt Express (2009) 0.89
Fluorescence lifetime imaging unravels C. trachomatis metabolism and its crosstalk with the host cell. PLoS Pathog (2011) 0.86
Quantification of cellular autofluorescence of human skin using multiphoton tomography and fluorescence lifetime imaging in two spectral detection channels. Biomed Opt Express (2011) 0.85
Metabolic imaging of the organ of corti--a window on cochlea bioenergetics. Brain Res (2009) 0.85
Two-photon microscopy of cortical NADH fluorescence intensity changes: correcting contamination from the hemodynamic response. J Biomed Opt (2011) 0.83
Anoxia-induced changes in pyridine nucleotide redox state in cortical neurons and astrocytes. Neurochem Res (2006) 0.83
Metabolic imaging using two-photon excited NADH intensity and fluorescence lifetime imaging. Microsc Microanal (2012) 0.82
Mismatch-induced DNA unbending upon duplex opening. Biophys J (2005) 0.81
Multimodal optical imaging system for in vivo investigation of cerebral oxygen delivery and energy metabolism. Biomed Opt Express (2015) 0.81
The role of glucose, serum, and three-dimensional cell culture on the metabolism of bone marrow-derived mesenchymal stem cells. Stem Cells Int (2011) 0.80
Investigating mitochondrial redox state using NADH and NADPH autofluorescence. Free Radic Biol Med (2016) 0.80
Imaging Approaches in Functional Assessment of Implantable Myogenic Biomaterials and Engineered Muscle Tissue. Eur J Transl Myol (2015) 0.80
Probing metabolic states of differentiating stem cells using two-photon FLIM. Sci Rep (2016) 0.79
NADH fluorescence lifetime analysis of the effect of magnesium ions on ALDH2. Chem Biol Interact (2011) 0.79
Application of time-resolved autofluorescence to label-free in vivo optical mapping of changes in tissue matrix and metabolism associated with myocardial infarction and heart failure. Biomed Opt Express (2015) 0.78
Quantification of the Metabolic State in Cell-Model of Parkinson's Disease by Fluorescence Lifetime Imaging Microscopy. Sci Rep (2016) 0.78
Frex and FrexH: Indicators of metabolic states in living cells. Bioeng Bugs (2012) 0.78
Two-photon fluorescence lifetime imaging monitors metabolic changes during wound healing of corneal epithelial cells in vitro. Graefes Arch Clin Exp Ophthalmol (2012) 0.78
High-resolution in vivo optical imaging of stroke injury and repair. Brain Res (2015) 0.78
Label-free imaging of metabolism and oxidative stress in human induced pluripotent stem cell-derived cardiomyocytes. Biomed Opt Express (2016) 0.76
Physiology-based kinetic modeling of neuronal energy metabolism unravels the molecular basis of NAD(P)H fluorescence transients. J Cereb Blood Flow Metab (2015) 0.76
Fluorescence lifetime imaging of alterations to cellular metabolism by domain 2 of the hepatitis C virus core protein. PLoS One (2013) 0.76
Endogenous fluorescence signatures in living pluripotent stem cells change with loss of potency. PLoS One (2012) 0.76
Autofluorescence multiphoton microscopy for visualization of tissue morphology and cellular dynamics in murine and human airways. Lab Invest (2016) 0.75
Evaluation of dual-wavelength excitation autofluorescence imaging of colorectal tumours with a high-sensitivity CMOS imager: a cross-sectional study. BMC Gastroenterol (2015) 0.75
Detection of microregional hypoxia in mouse cerebral cortex by two-photon imaging of endogenous NADH fluorescence. J Vis Exp (2012) 0.75
Multimodal optical coherence tomography and fluorescence lifetime imaging with interleaved excitation sources for simultaneous endogenous and exogenous fluorescence. Biomed Opt Express (2016) 0.75
Multimodal optical analysis discriminates freshly extracted human sample of gliomas, metastases and meningiomas from their appropriate controls. Sci Rep (2017) 0.75
Fluorescence lifetime analysis and effect of magnesium ions on binding of NADH to human aldehyde dehydrogenase 1. Chem Biol Interact (2013) 0.75
Time-resolved fluorescence spectroscopy for clinical diagnosis of actinic cheilitis. Biomed Opt Express (2016) 0.75
Gentamicin differentially alters cellular metabolism of cochlear hair cells as revealed by NAD(P)H fluorescence lifetime imaging. J Biomed Opt (2015) 0.75
From morphology to biochemical state - intravital multiphoton fluorescence lifetime imaging of inflamed human skin. Sci Rep (2016) 0.75
Development of Low-Cost Instrumentation for Single Point Autofluorescence Lifetime Measurements. J Fluoresc (2017) 0.75
Metabolic control by sirtuins and other enzymes that sense NAD(+), NADH, or their ratio. Biochim Biophys Acta (2017) 0.75
Fluorescence lifetime microscopy of NADH distinguishes alterations in cerebral metabolism in vivo. Biomed Opt Express (2017) 0.75
Precise nanometer localization analysis for individual fluorescent probes. Biophys J (2002) 22.24
Nonlinear magic: multiphoton microscopy in the biosciences. Nat Biotechnol (2003) 13.29
Live tissue intrinsic emission microscopy using multiphoton-excited native fluorescence and second harmonic generation. Proc Natl Acad Sci U S A (2003) 8.92
Imaging coexisting fluid domains in biomembrane models coupling curvature and line tension. Nature (2003) 7.90
Water-soluble quantum dots for multiphoton fluorescence imaging in vivo. Science (2003) 6.92
Neural activity triggers neuronal oxidative metabolism followed by astrocytic glycolysis. Science (2004) 5.74
Interpreting second-harmonic generation images of collagen I fibrils. Biophys J (2004) 4.74
Biological and chemical applications of fluorescence correlation spectroscopy: a review. Biochemistry (2002) 4.13
Two-photon fluorescence spectroscopy and microscopy of NAD(P)H and flavoprotein. Biophys J (2002) 4.10
Large-scale fluid/fluid phase separation of proteins and lipids in giant plasma membrane vesicles. Proc Natl Acad Sci U S A (2007) 4.09
In vivo multiphoton microscopy of deep brain tissue. J Neurophysiol (2003) 3.63
Cortical spreading depression causes and coincides with tissue hypoxia. Nat Neurosci (2007) 3.35
Focal volume optics and experimental artifacts in confocal fluorescence correlation spectroscopy. Biophys J (2002) 3.20
Bright and stable core-shell fluorescent silica nanoparticles. Nano Lett (2005) 2.79
Dynamics of heat shock factor association with native gene loci in living cells. Nature (2006) 2.45
Visualization of retrovirus budding with correlated light and electron microscopy. Proc Natl Acad Sci U S A (2005) 2.41
Fluorescence probe partitioning between Lo/Ld phases in lipid membranes. Biochim Biophys Acta (2007) 2.25
Quantification of alpha-synuclein binding to lipid vesicles using fluorescence correlation spectroscopy. Biophys J (2006) 2.05
Optical recording of fast neuronal membrane potential transients in acute mammalian brain slices by second-harmonic generation microscopy. J Neurophysiol (2005) 1.93
Intranuclear distribution and local dynamics of RNA polymerase II during transcription activation. Mol Cell (2007) 1.87
DNA fragment sizing by single molecule detection in submicrometer-sized closed fluidic channels. Anal Chem (2002) 1.84
Uniform polarity microtubule assemblies imaged in native brain tissue by second-harmonic generation microscopy. Proc Natl Acad Sci U S A (2003) 1.81
P-TEFb is critical for the maturation of RNA polymerase II into productive elongation in vivo. Mol Cell Biol (2007) 1.81
Temporally resolved interactions between antigen-stimulated IgE receptors and Lyn kinase on living cells. J Cell Biol (2005) 1.80
Two-photon autofluorescence dynamics imaging reveals sensitivity of intracellular NADH concentration and conformation to cell physiology at the single-cell level. J Photochem Photobiol B (2008) 1.78
Spt6 enhances the elongation rate of RNA polymerase II in vivo. EMBO J (2009) 1.77
Compact and flexible raster scanning multiphoton endoscope capable of imaging unstained tissue. Proc Natl Acad Sci U S A (2011) 1.74
Direct measurement of Gag-Gag interaction during retrovirus assembly with FRET and fluorescence correlation spectroscopy. J Cell Biol (2003) 1.70
Ionic strength-dependent persistence lengths of single-stranded RNA and DNA. Proc Natl Acad Sci U S A (2011) 1.64
Blinking and nonradiant dark fraction of water-soluble quantum dots in aqueous solution. Proc Natl Acad Sci U S A (2005) 1.59
Multiphoton microscopy guides neurotrophin modification with poly(ethylene glycol) to enhance interstitial diffusion. Nat Mater (2004) 1.59
Achieving uniform mixing in a microfluidic device: hydrodynamic focusing prior to mixing. Anal Chem (2006) 1.44
GUV preparation and imaging: minimizing artifacts. Biochim Biophys Acta (2010) 1.39
Identification of a helical intermediate in trifluoroethanol-induced alpha-synuclein aggregation. Proc Natl Acad Sci U S A (2010) 1.37
Mitochondrial superoxide flashes: metabolic biomarkers of skeletal muscle activity and disease. FASEB J (2011) 1.33
Mechanisms of quenching of Alexa fluorophores by natural amino acids. J Am Chem Soc (2010) 1.31
Quantitative analysis of the fluorescence properties of intrinsically fluorescent proteins in living cells. Biophys J (2003) 1.29
Electrophysiological characterization of V2a interneurons and their locomotor-related activity in the neonatal mouse spinal cord. J Neurosci (2010) 1.24
Focal volume confinement by submicrometer-sized fluidic channels. Anal Chem (2004) 1.23
Liver fatty acid-binding protein gene ablation inhibits branched-chain fatty acid metabolism in cultured primary hepatocytes. J Biol Chem (2004) 1.20
Activity of Hb9 interneurons during fictive locomotion in mouse spinal cord. J Neurosci (2009) 1.19
Optical recording of action potentials with second-harmonic generation microscopy. J Neurosci (2004) 1.19
Dynamics of equilibrium structural fluctuations of apomyoglobin measured by fluorescence correlation spectroscopy. Proc Natl Acad Sci U S A (2007) 1.18
Human bladder cancer diagnosis using Multiphoton microscopy. Proc SPIE Int Soc Opt Eng (2009) 1.17
Diffusion of nerve growth factor in rat striatum as determined by multiphoton microscopy. Biophys J (2003) 1.17
Conformational changes of calmodulin upon Ca2+ binding studied with a microfluidic mixer. Proc Natl Acad Sci U S A (2008) 1.13
Membrane order and molecular dynamics associated with IgE receptor cross-linking in mast cells. Biophys J (2006) 1.10
Molecular perspective of antigen-mediated mast cell signaling. J Biol Chem (2007) 1.08
Detection of motional heterogeneities in lipid bilayer membranes by dual probe fluorescence correlation spectroscopy. Biochim Biophys Acta (2005) 1.08
Polarized microtubule arrays in apical dendrites and axons. Proc Natl Acad Sci U S A (2008) 1.07
Multiphoton microscopy of prostate and periprostatic neural tissue: a promising imaging technique for improving nerve-sparing prostatectomy. J Endourol (2009) 1.04
In vivo imaging of unstained tissues using a compact and flexible multiphoton microendoscope. J Biomed Opt (2012) 1.03
Multiphoton microscopy and microspectroscopy for diagnostics of inflammatory and neoplastic lung. J Biomed Opt (2012) 1.03
In vivo imaging of unstained tissues using long gradient index lens multiphoton endoscopic systems. Biomed Opt Express (2012) 1.01
Multiphoton microscopy for structure identification in human prostate and periprostatic tissue: implications in prostate cancer surgery. BJU Int (2011) 1.00
Imaging transcription dynamics at endogenous genes in living Drosophila tissues. Methods (2008) 0.99
Multiphoton microscopy in the evaluation of human bladder biopsies. Arch Pathol Lab Med (2012) 0.98
Multifocal multiphoton endoscope. Opt Lett (2012) 0.96
Dynamics imaging of lipid phases and lipid-marker interactions in model biomembranes. Phys Chem Chem Phys (2006) 0.96
Use of multiphoton imaging for studying cell migration in the mouse. Methods Mol Biol (2005) 0.95
Structural basis of fluorescence fluctuation dynamics of green fluorescent proteins in acidic environments. J Phys Chem B (2006) 0.94
Membrane fluidity and lipid order in ternary giant unilamellar vesicles using a new bodipy-cholesterol derivative. Biophys J (2009) 0.93
Serotonin modulates dendritic calcium influx in commissural interneurons in the mouse spinal locomotor network. J Neurophysiol (2007) 0.93
In vivo imaging of cerebral energy metabolism with two-photon fluorescence lifetime microscopy of NADH. Biomed Opt Express (2013) 0.92
Use of a lensed fiber for a large-field-of-view, high-resolution, fiber-scanning microendoscope. Opt Lett (2012) 0.92
Heterogeneous effects of dopamine on highly localized, voltage-induced Ca2+ accumulation in identified motoneurons. J Neurophysiol (2007) 0.91
Multiphoton microscopy as a diagnostic imaging modality for lung cancer. Proc SPIE Int Soc Opt Eng (2010) 0.91
Miniature varifocal objective lens for endomicroscopy. Opt Lett (2013) 0.91
Precise and millidegree stable temperature control for fluorescence imaging: application to phase transitions in lipid membranes. Rev Sci Instrum (2010) 0.90
Optical visualization of Alzheimer's pathology via multiphoton-excited intrinsic fluorescence and second harmonic generation. Opt Express (2009) 0.89
Spatial profiles of store-dependent calcium release in motoneurones of the nucleus hypoglossus from newborn mouse. J Physiol (2003) 0.89
Spontaneous nucleotide exchange in low molecular weight GTPases by fluorescently labeled gamma-phosphate-linked GTP analogs. Proc Natl Acad Sci U S A (2004) 0.88
Comparison of femtosecond laser and continuous wave UV sources for protein-nucleic acid crosslinking. Photochem Photobiol (2007) 0.87
Multiphoton microscopy: a potential "optical biopsy" tool for real-time evaluation of lung tumors without the need for exogenous contrast agents. Arch Pathol Lab Med (2013) 0.86
Chapter 1: In vivo applications of fluorescence correlation spectroscopy. Methods Cell Biol (2008) 0.86
Spatiotemporal dynamics of rhythmic spinal interneurons measured with two-photon calcium imaging and coherence analysis. J Neurophysiol (2010) 0.83
Two-photon microscopy of cortical NADH fluorescence intensity changes: correcting contamination from the hemodynamic response. J Biomed Opt (2011) 0.83
A desolvation model for trifluoroethanol-induced aggregation of enhanced green fluorescent protein. Biophys J (2012) 0.82
Integrated biophotonics approach for noninvasive and multiscale studies of biomolecular and cellular biophysics. J Biomed Opt (2008) 0.82
Dopamine-induced oscillations of the pyloric pacemaker neuron rely on release of calcium from intracellular stores. J Neurophysiol (2011) 0.81
Multiphoton polarization imaging of steady-state molecular order in ternary lipid vesicles for the purpose of lipid phase assignment. J Phys Chem B (2010) 0.80
Transmission electron microscopy characterization of fluorescently labelled amyloid β 1-40 and α-synuclein aggregates. BMC Biotechnol (2011) 0.80
Dual modality endomicroscope with optical zoom capability. Biomed Opt Express (2013) 0.78
Endoscope lens with dual fields of view and resolutions for multiphoton imaging. Opt Lett (2010) 0.78
Transient hypercapnia reveals an underlying cerebrovascular pathology in a murine model for HIV-1 associated neuroinflammation: role of NO-cGMP signaling and normalization by inhibition of cyclic nucleotide phosphodiesterase-5. J Neuroinflammation (2012) 0.77
Complex molecular dynamics in the spotlight. Nat Biotechnol (2010) 0.75
A single-shot approach for measuring two-photon action cross-section of fluorescent markers. Opt Express (2006) 0.75
Fluorescence Dynamics of a FRET Probe Designed for Crowding Studies. J Phys Chem B (2017) 0.75
Photoinduced charge transfer in short-distance ferrocenylsubphthalocyanine dyads. Inorg Chem (2012) 0.75
DNA-protein cross-linking: model systems for pyrimidine-aromatic amino acid cross-linking. Org Lett (2006) 0.75