Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity.

PubWeight™: 0.91‹?›

🔗 View Article (PMC 1736055)

Published in J Med Genet on May 01, 2005

Authors

G Andersen1, L Wegner, K Yanagisawa, C S Rose, J Lin, C Glümer, T Drivsholm, K Borch-Johnsen, T Jørgensen, T Hansen, B M Spiegelman, O Pedersen

Author Affiliations

1: Steno Diabetes Center, Niels Steensens Vej 2, NSH2.16, DK-2820 Gentofte, Copenhagen, Denmark. gtta@steno.dk

Associated clinical trials:

Lifestyle Intervention in a General Population for Prevention of Ischaemic Heart Disease | NCT00289237

Articles citing this

Mitochondrial dysfunction in obesity. Curr Opin Endocrinol Diabetes Obes (2010) 1.42

Recent progress in the genetics of common obesity. Br J Clin Pharmacol (2009) 1.40

Redox regulation of mitochondrial biogenesis. Free Radic Biol Med (2012) 1.11

Transcriptional control of mitochondrial biogenesis and its interface with inflammatory processes. Biochim Biophys Acta (2012) 1.10

Genetic regulation of human adipose microRNA expression and its consequences for metabolic traits. Hum Mol Genet (2013) 0.97

Functional crosstalk of PGC-1 coactivators and inflammation in skeletal muscle pathophysiology. Semin Immunopathol (2013) 0.93

Transcriptional co-activator peroxisome proliferator-activated receptor (PPAR)gamma co-activator-1beta is involved in the regulation of glucose-stimulated insulin secretion in INS-1E cells. J Mol Med (Berl) (2008) 0.83

Genetic variation in the peroxisome proliferator-activated receptor (PPAR) and peroxisome proliferator-activated receptor gamma co-activator 1 (PGC1) gene families and type 2 diabetes. Ann Hum Genet (2014) 0.80

PGC-1 coactivators in β-cells regulate lipid metabolism and are essential for insulin secretion coupled to fatty acids. Mol Metab (2015) 0.78

Genetic variants associated with sleep disorders. Sleep Med (2014) 0.78

A common haplotype in the G-protein-coupled receptor gene GPR74 is associated with leanness and increased lipolysis. Am J Hum Genet (2007) 0.78

Diesel exhaust particle-induced airway responses are augmented in obese rats. Int J Toxicol (2014) 0.77

Maternal BMI as a predictor of methylation of obesity-related genes in saliva samples from preschool-age Hispanic children at-risk for obesity. BMC Genomics (2017) 0.75

Articles cited by this

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell (1999) 19.48

Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N Engl J Med (2004) 18.86

A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell (1998) 18.32

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc Natl Acad Sci U S A (2003) 17.10

Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature (2002) 14.37

Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature (2001) 11.72

CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature (2001) 8.44

Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. J Clin Invest (2000) 7.06

The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes. Mol Cell Biol (2000) 6.29

High-throughput development and characterization of a genomewide collection of gene-based single nucleotide polymorphism markers by chip-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Proc Natl Acad Sci U S A (2001) 4.31

A randomized non-pharmacological intervention study for prevention of ischaemic heart disease: baseline results Inter99. Eur J Cardiovasc Prev Rehabil (2003) 4.25

Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor. J Biol Chem (2001) 4.20

Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells. J Biol Chem (2003) 4.12

Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1. Proc Natl Acad Sci U S A (2001) 3.96

Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus. Diabetologia (2001) 3.76

Genomewide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24. Am J Hum Genet (2000) 3.41

A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q. Am J Hum Genet (2001) 3.26

PPARgamma coactivator 1beta/ERR ligand 1 is an ERR protein ligand, whose expression induces a high-energy expenditure and antagonizes obesity. Proc Natl Acad Sci U S A (2003) 2.89

The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha. J Biol Chem (2002) 2.28

PGC-1beta in the regulation of hepatic glucose and energy metabolism. J Biol Chem (2003) 2.20

A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians. Diabetes (2003) 1.92

A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes. Diabetologia (2002) 1.83

Characterization of the human, mouse and rat PGC1 beta (peroxisome-proliferator-activated receptor-gamma co-activator 1 beta) gene in vitro and in vivo. Biochem J (2003) 1.79

Peroxisome proliferator-activated receptor-gamma coactivator-1 gene locus: associations with obesity indices in middle-aged women. Diabetes (2002) 1.54

Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression. Genomics (1999) 1.53

Complex haplotypes of the PGC-1alpha gene are associated with carbohydrate metabolism and type 2 diabetes. Diabetes (2004) 1.52

Cloning and mRNA tissue distribution of human PPARgamma coactivator-1. Int J Obes Relat Metab Disord (1999) 1.28

Increasing prevalence of diabetes mellitus and impaired glucose tolerance among 60-year-old Danes. Diabet Med (2001) 1.18

No association between the G482S polymorphism of the proliferator-activated receptor-gamma coactivator-1 (PGC-1) gene and Type II diabetes in French Caucasians. Diabetologia (2002) 1.04

Identification of a common amino acid polymorphism in the p85alpha regulatory subunit of phosphatidylinositol 3-kinase: effects on glucose disappearance constant, glucose effectiveness, and the insulin sensitivity index. Diabetes (1997) 1.00

Peroxisome proliferator-activated receptor-gamma coactivator-1 gene locus: associations with hypertension in middle-aged men. Hypertension (2003) 1.00

Large-scale studies of the HphI insulin gene variable-number-of-tandem-repeats polymorphism in relation to Type 2 diabetes mellitus and insulin release. Diabetologia (2004) 0.90

The Gly482Ser variant in the peroxisome proliferator-activated receptor gamma coactivator-1 is not associated with diabetes-related traits in non-diabetic German and Dutch populations. Exp Clin Endocrinol Diabetes (2004) 0.87

Articles by these authors

Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science (1993) 25.54

Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care (1997) 23.95

Genome sequence of enterohaemorrhagic Escherichia coli O157:H7. Nature (2001) 23.49

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell (1999) 19.48

A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell (1998) 18.32

Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell (1994) 17.58

Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature (2001) 11.72

15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. Cell (1995) 11.72

Sarcoidosis. N Engl J Med (1997) 11.02

mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer. Genes Dev (1994) 10.44

PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro. Mol Cell (1999) 9.74

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest (1995) 9.59

Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis. Science (2003) 8.79

IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science (1996) 8.57

Transcriptional regulation of adipogenesis. Genes Dev (2000) 8.52

Towards a molecular understanding of adaptive thermogenesis. Nature (2000) 7.04

AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem (1996) 6.93

ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism. Genes Dev (1996) 6.54

Molecular regulation of adipogenesis. Annu Rev Cell Dev Biol (2000) 6.40

PPARgamma : a nuclear regulator of metabolism, differentiation, and cell growth. J Biol Chem (2001) 5.85

Albuminuria reflects widespread vascular damage. The Steno hypothesis. Diabetologia (1989) 5.68

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway. Nature (2000) 5.55

The nucleotide sequence of the cloned rpoD gene for the RNA polymerase sigma subunit from E coli K12. Nucleic Acids Res (1981) 5.52

ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation. Mol Cell Biol (1993) 5.34

Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3) Nature (1996) 5.32

Differentiation and reversal of malignant changes in colon cancer through PPARgamma. Nat Med (1998) 5.16

Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity. Mol Cell (1999) 4.89

Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1. J Clin Invest (1998) 4.85

Crystal structure of TFIID TATA-box binding protein. Nature (1992) 4.85

Intensified multifactorial intervention in patients with type 2 diabetes mellitus and microalbuminuria: the Steno type 2 randomised study. Lancet (1999) 4.81

Tumor necrosis factor alpha: a key component of the obesity-diabetes link. Diabetes (1994) 4.66

Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. Science (1996) 4.61

Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1. Mol Cell (2001) 4.58

Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma. Science (1996) 4.50

Common DNA binding site for Fos protein complexes and transcription factor AP-1. Cell (1988) 4.38

Activation of PPARgamma coactivator-1 through transcription factor docking. Science (1999) 4.33

Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1. Nat Med (2001) 4.19

Molecular cloning of mRNA from 3T3 adipocytes. Regulation of mRNA content for glycerophosphate dehydrogenase and other differentiation-dependent proteins during adipocyte development. J Biol Chem (1983) 4.14

Tumor necrosis factor alpha inhibits signaling from the insulin receptor. Proc Natl Acad Sci U S A (1994) 4.08

Obesity-related glomerulopathy: an emerging epidemic. Kidney Int (2001) 3.98

Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1. Proc Natl Acad Sci U S A (2001) 3.96

Nucleoprotein complexes that regulate gene expression in adipocyte differentiation: direct participation of c-fos. Cell (1987) 3.89

PAX8-PPARgamma1 fusion oncogene in human thyroid carcinoma [corrected]. Science (2000) 3.87

The ADDITION study: proposed trial of the cost-effectiveness of an intensive multifactorial intervention on morbidity and mortality among people with Type 2 diabetes detected by screening. Int J Obes Relat Metab Disord (2000) 3.83

Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus. Diabetologia (2001) 3.76

The effect of proteinuria on relative mortality in type 1 (insulin-dependent) diabetes mellitus. Diabetologia (1985) 3.75

Terminal differentiation of human breast cancer through PPAR gamma. Mol Cell (1998) 3.71

ADD1/SREBP1 activates PPARgamma through the production of endogenous ligand. Proc Natl Acad Sci U S A (1998) 3.61

Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation. Mol Cell Biol (2000) 3.60

The Danish National Diabetes Register: trends in incidence, prevalence and mortality. Diabetologia (2008) 3.59

Cancer incidence in a population-based cohort of patients hospitalized with diabetes mellitus in Denmark. J Natl Cancer Inst (1997) 3.57

Transdifferentiation of myoblasts by the adipogenic transcription factors PPAR gamma and C/EBP alpha. Proc Natl Acad Sci U S A (1995) 3.56

An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways. J Biol Chem (2000) 3.44

Creating a pandemic of prediabetes: the proposed new diagnostic criteria for impaired fasting glycaemia. Diabetologia (2004) 3.26

Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor gamma and the retinoid X receptor. Proc Natl Acad Sci U S A (1997) 3.22

A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture. Genes Dev (1993) 3.21

Fibronectin modulation of cell shape and lipogenic gene expression in 3T3-adipocytes. Cell (1983) 3.19

Organochlorine exposure and risk of breast cancer. Lancet (1998) 3.18

Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha. J Clin Invest (1994) 3.16

Developmental regulation of the enzyme UDP-galactose polysaccharide transferase. Exp Cell Res (1967) 3.14

PPAR gamma 2 regulates adipose expression of the phosphoenolpyruvate carboxykinase gene. Mol Cell Biol (1995) 3.14

Phenotypic diversity and ecosystem functioning in changing environments: a theoretical framework. Proc Natl Acad Sci U S A (2001) 3.13

Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92. Oncogene (2007) 3.11

The stationary-phase sigma factor sigma S (RpoS) is required for a sustained acid tolerance response in virulent Salmonella typhimurium. Mol Microbiol (1995) 3.11

Gliadin-specific, HLA-DQ(alpha 1*0501,beta 1*0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients. J Exp Med (1993) 3.10

Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain. Mol Cell Biol (1995) 3.10

The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes. Diabetologia (2007) 3.07

Apolipoprotein(a) gene accounts for greater than 90% of the variation in plasma lipoprotein(a) concentrations. J Clin Invest (1992) 3.05

Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1. Mol Cell (2000) 3.00

Lysosome biogenesis requires Rab9 function and receptor recycling from endosomes to the trans-Golgi network. J Cell Biol (1994) 2.95

Prediction of risk of liver disease by alcohol intake, sex, and age: a prospective population study. Hepatology (1996) 2.91

Proteinuria: value as predictor of cardiovascular mortality in insulin dependent diabetes mellitus. Br Med J (Clin Res Ed) (1987) 2.88

Signal transduction by the TCR for antigen. Curr Opin Immunol (2000) 2.87

Prevalence of hypertension in type 1 (insulin-dependent) diabetes mellitus. Diabetologia (1990) 2.81

The role of PPAR-gamma in macrophage differentiation and cholesterol uptake. Nat Med (2001) 2.81

mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein. Mol Cell Biol (1996) 2.78

Pleiotropic effects of a null mutation in the c-fos proto-oncogene. Cell (1992) 2.78

Loss-of-function mutations in PPAR gamma associated with human colon cancer. Mol Cell (1999) 2.71

Both lumenal and cytosolic gating of the aqueous ER translocon pore are regulated from inside the ribosome during membrane protein integration. Cell (1997) 2.71

Adipocyte P2 gene: developmental expression and homology of 5'-flanking sequences among fat cell-specific genes. Proc Natl Acad Sci U S A (1986) 2.70

The dynamics of cocirculating influenza strains conferring partial cross-immunity. J Math Biol (1997) 2.69

Targeted expression of a toxin gene to adipose tissue: transgenic mice resistant to obesity. Genes Dev (1993) 2.68

A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP. Science (1995) 2.68

A fat-specific enhancer is the primary determinant of gene expression for adipocyte P2 in vivo. Proc Natl Acad Sci U S A (1990) 2.66

Structural analysis of a set of proteins resulting from a bacterial genomics project. Proteins (2005) 2.59

Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR alpha. Nucleic Acids Res (1994) 2.58

Differential activation of adipogenesis by multiple PPAR isoforms. Genes Dev (1996) 2.58

Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21, WAF1/CIP1, expression in the absence of p53. Oncogene (1994) 2.47

Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma. Proc Natl Acad Sci U S A (1999) 2.45

Regulation of transcription functions of the p53 tumor suppressor by the mdm-2 oncogene. Mol Med (1995) 2.44

Shotgun optical maps of the whole Escherichia coli O157:H7 genome. Genome Res (2001) 2.43

Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study. Diabetologia (2011) 2.43