Published in J Mammary Gland Biol Neoplasia on January 01, 2005
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Notch-1 signaling promotes the cyclinD1-dependent generation of mammary tumor-initiating cells that can revert to bi-potential progenitors from which they arise. Oncogene (2012) 0.82
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Side population cells isolated from KATO III human gastric cancer cell line have cancer stem cell-like characteristics. World J Gastroenterol (2012) 0.81
The role of the aryl hydrocarbon receptor in the development of cells with the molecular and functional characteristics of cancer stem-like cells. BMC Biol (2016) 0.80
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Kruppel-like factor 4 signals through microRNA-206 to promote tumor initiation and cell survival. Oncogenesis (2015) 0.79
Effect of glycogen synthase kinase-3 inactivation on mouse mammary gland development and oncogenesis. Oncogene (2014) 0.77
Pro-inflammatory cytokine interleukin-1β promotes the development of intestinal stem cells. Inflamm Res (2012) 0.77
Mammary gland-derived nestin-positive cell populations can be isolated from human male and female donors. Stem Cell Res Ther (2013) 0.76
The Ezh2 polycomb group protein drives an aggressive phenotype in melanoma cancer stem cells and is a target of diet derived sulforaphane. Mol Carcinog (2015) 0.76
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Reduced tumorigenicity and drug resistance through the downregulation of octamer-binding protein 4 and Nanog transcriptional factor expression in human breast stem cells. Mol Med Rep (2014) 0.76
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Senescence-associated IL-6 and IL-8 cytokines induce a self- and cross-reinforced senescence/inflammatory milieu strengthening tumorigenic capabilities in the MCF-7 breast cancer cell line. Cell Commun Signal (2017) 0.75
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ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell (2007) 22.89
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Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature. Cancer Res (2009) 7.98
Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res (2006) 7.91
Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis. Cancer Res (2009) 6.43
Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells. Breast Cancer Res (2004) 5.60
BRCA1 regulates human mammary stem/progenitor cell fate. Proc Natl Acad Sci U S A (2008) 4.79
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Aldehyde dehydrogenase 1-positive cancer stem cells mediate metastasis and poor clinical outcome in inflammatory breast cancer. Clin Cancer Res (2009) 4.47
CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts. J Clin Invest (2010) 4.22
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Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia. Proc Natl Acad Sci U S A (2012) 3.21
Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks. Cancer Res (2011) 3.18
Breast cancer, stem/progenitor cells and the estrogen receptor. Trends Endocrinol Metab (2004) 3.10
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Aldehyde dehydrogenase in combination with CD133 defines angiogenic ovarian cancer stem cells that portend poor patient survival. Cancer Res (2011) 2.50
Activation of an IL6 inflammatory loop mediates trastuzumab resistance in HER2+ breast cancer by expanding the cancer stem cell population. Mol Cell (2012) 2.34
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Expression of aldehyde dehydrogenase and CD133 defines ovarian cancer stem cells. Int J Cancer (2011) 2.05
Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells. Cancer Res (2009) 2.04
Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells. Clin Cancer Res (2010) 1.96
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Targeting breast stem cells with the cancer preventive compounds curcumin and piperine. Breast Cancer Res Treat (2009) 1.77
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HER2-associated radioresistance of breast cancer stem cells isolated from HER2-negative breast cancer cells. Clin Cancer Res (2012) 1.47
Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma. Clin Cancer Res (2013) 1.43
Point: cancer stem cells--the evidence accumulates. Clin Chem (2012) 1.43
Cancer stem cell vaccination confers significant antitumor immunity. Cancer Res (2012) 1.39
MicroRNA93 regulates proliferation and differentiation of normal and malignant breast stem cells. PLoS Genet (2012) 1.38
An embryonic stem cell-like signature identifies poorly differentiated lung adenocarcinoma but not squamous cell carcinoma. Clin Cancer Res (2009) 1.38
Role of microRNAs in the regulation of breast cancer stem cells. J Mammary Gland Biol Neoplasia (2012) 1.25
Preclinical and clinical studies of gamma secretase inhibitors with docetaxel on human breast tumors. Clin Cancer Res (2013) 1.20
Ablation of breast cancer stem cells with radiation. Transl Oncol (2011) 1.15
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Implications of cancer stem cell theory for cancer chemoprevention by natural dietary compounds. J Nutr Biochem (2011) 1.10
Distinct FAK activities determine progenitor and mammary stem cell characteristics. Cancer Res (2013) 1.04
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Stem cells in normal development and cancer. Prog Mol Biol Transl Sci (2010) 0.98
Getting to the root of BRCA1-deficient breast cancer. Cell Stem Cell (2009) 0.95
Cytokine-induced killer (CIK) cells bound with anti-CD3/anti-CD133 bispecific antibodies target CD133(high) cancer stem cells in vitro and in vivo. Clin Immunol (2013) 0.95
Endothelial interleukin-6 defines the tumorigenic potential of primary human cancer stem cells. Stem Cells (2014) 0.93
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New organizational and funds flow models for an academic cancer center. Acad Med (2004) 0.91
Regulatory roles of miRNA in the human neural stem cell transformation to glioma stem cells. J Cell Biochem (2014) 0.91
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Notch reporter activity in breast cancer cell lines identifies a subset of cells with stem cell activity. Mol Cancer Ther (2015) 0.89
Breast cancer stem cells-research opportunities utilizing mathematical modeling. Stem Cell Rev (2007) 0.88
A radial flow microfluidic device for ultra-high-throughput affinity-based isolation of circulating tumor cells. Small (2014) 0.88
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Inflammation and autophagy conspire to promote tumor growth. Cell Cycle (2011) 0.84
CRLX101, an investigational camptothecin-containing nanoparticle-drug conjugate, targets cancer stem cells and impedes resistance to antiangiogenic therapy in mouse models of breast cancer. Breast Cancer Res Treat (2015) 0.84
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Targeting cancer stem cells via dendritic-cell vaccination. Oncoimmunology (2012) 0.82
Identification of single chain antibodies to breast cancer stem cells using phage display. Biotechnol Prog (2009) 0.82
The thyroid cancer PAX8-PPARG fusion protein activates Wnt/TCF-responsive cells that have a transformed phenotype. Endocr Relat Cancer (2013) 0.81
Stemming a tumor with a little miR. Nat Med (2011) 0.81
Migratory gene expression signature predicts poor patient outcome: are cancer stem cells to blame? Breast Cancer Res (2012) 0.78
[Stem cells and epithelial cancers: the example of breast cancer]. Ann Pathol (2008) 0.78
Antiangiogenic agents: fueling cancer's hypoxic roots. Cell Cycle (2012) 0.77
KRAS and cancer stem cells in APC-mutant colorectal cancer. J Natl Cancer Inst (2014) 0.77
Generation of a novel dendritic-cell vaccine using melanoma and squamous cancer stem cells. J Vis Exp (2014) 0.77
Development of 'synthetic lethal' strategies to target BRCA1-deficient breast cancer. Breast Cancer Res (2009) 0.76
Breast tumors: of mice and women. Breast Cancer Res (2010) 0.75
Clinical trial design for testing the stem cell model for the prevention and treatment of cancer. Cancers (Basel) (2011) 0.75
Single cell dual adherent-suspension co-culture micro-environment for studying tumor-stromal interactions with functionally selected cancer stem-like cells. Lab Chip (2016) 0.75
Tumor-initiating cells and treatment resistance: how goes the war? J Mammary Gland Biol Neoplasia (2009) 0.75