Published in Cell Prolif on October 01, 2003
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell (2006) 27.36
Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res (2006) 7.91
Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells. Breast Cancer Res (2004) 5.60
AACR centennial series: the biology of cancer metastasis: historical perspective. Cancer Res (2010) 4.89
Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling. PLoS Biol (2009) 3.67
MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells. PLoS One (2009) 3.66
The properties of high-dimensional data spaces: implications for exploring gene and protein expression data. Nat Rev Cancer (2008) 3.43
Breast cancer: origins and evolution. J Clin Invest (2007) 3.31
Mammary stem cells, self-renewal pathways, and carcinogenesis. Breast Cancer Res (2005) 3.05
Mammosphere culture of metastatic breast cancer cells enriches for tumorigenic breast cancer cells. Breast Cancer Res (2008) 2.96
Epithelial-mesenchymal transition-derived cells exhibit multilineage differentiation potential similar to mesenchymal stem cells. Stem Cells (2010) 2.54
Modeling dynamic reciprocity: engineering three-dimensional culture models of breast architecture, function, and neoplastic transformation. Semin Cancer Biol (2005) 2.53
Pre-EMTing metastasis? Recapitulation of morphogenetic processes in cancer. Clin Exp Metastasis (2007) 2.41
Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres. BMC Cancer (2008) 2.28
Expression of aldehyde dehydrogenase and CD133 defines ovarian cancer stem cells. Int J Cancer (2011) 2.05
Epithelial-mesenchymal transition and cancer stem cells: a dangerously dynamic duo in breast cancer progression. Breast Cancer Res (2011) 1.96
New molecularly targeted therapies for lung cancer. J Clin Invest (2007) 1.86
NOTCH signaling is required for formation and self-renewal of tumor-initiating cells and for repression of secretory cell differentiation in colon cancer. Cancer Res (2010) 1.85
Retracted Marker-independent identification of glioma-initiating cells. Nat Methods (2010) 1.84
A comprehensive panel of three-dimensional models for studies of prostate cancer growth, invasion and drug responses. PLoS One (2010) 1.83
Myeloid-derived suppressor cells enhance stemness of cancer cells by inducing microRNA101 and suppressing the corepressor CtBP2. Immunity (2013) 1.77
Rare steroid receptor-negative basal-like tumorigenic cells in luminal subtype human breast cancer xenografts. Proc Natl Acad Sci U S A (2008) 1.76
MET and MYC cooperate in mammary tumorigenesis. Proc Natl Acad Sci U S A (2005) 1.70
A mammary stem cell population identified and characterized in late embryogenesis reveals similarities to human breast cancer. Cell Stem Cell (2012) 1.65
The molecular pathology of breast cancer progression. J Pathol (2010) 1.65
RARRES3 suppresses breast cancer lung metastasis by regulating adhesion and differentiation. EMBO Mol Med (2014) 1.62
DNA replication licensing and progenitor numbers are increased by progesterone in normal human breast. Endocrinology (2009) 1.55
Suppression of apoptosis inhibitor c-FLIP selectively eliminates breast cancer stem cell activity in response to the anti-cancer agent, TRAIL. Breast Cancer Res (2011) 1.54
Beclin 1 and autophagy are required for the tumorigenicity of breast cancer stem-like/progenitor cells. Oncogene (2012) 1.49
The Role of chemokine receptor CXCR4 in breast cancer metastasis. Am J Cancer Res (2013) 1.44
Metastasis: new perspectives on an old problem. Mol Cancer (2011) 1.42
Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway. Cancer Res (2010) 1.37
MicroRNA regulation of cancer stem cells and therapeutic implications. AAPS J (2009) 1.37
Identification of a stem-like cell population by exposing metastatic breast cancer cell lines to repetitive cycles of hypoxia and reoxygenation. Breast Cancer Res (2010) 1.26
Breast cancer stem cells: implications for therapy of breast cancer. Breast Cancer Res (2008) 1.26
Role of microRNAs in the regulation of breast cancer stem cells. J Mammary Gland Biol Neoplasia (2012) 1.25
Hypoxia regulates CD44 and its variant isoforms through HIF-1α in triple negative breast cancer. PLoS One (2012) 1.25
Pregnancy in the mature adult mouse does not alter the proportion of mammary epithelial stem/progenitor cells. Breast Cancer Res (2009) 1.25
Role of the IL-6-JAK1-STAT3-Oct-4 pathway in the conversion of non-stem cancer cells into cancer stem-like cells. Cell Signal (2013) 1.24
A gene expression profile of stem cell pluripotentiality and differentiation is conserved across diverse solid and hematopoietic cancers. Genome Biol (2012) 1.23
Demystifying basal-like breast carcinomas. J Clin Pathol (2007) 1.22
Notch inhibition as a promising new approach to cancer therapy. Adv Exp Med Biol (2012) 1.20
Hedgehog signalling in breast cancer. Carcinogenesis (2009) 1.18
Epithelial-to-mesenchymal transition (EMT) confers primary resistance to trastuzumab (Herceptin). Cell Cycle (2012) 1.18
Regulated proteolysis of Trop2 drives epithelial hyperplasia and stem cell self-renewal via β-catenin signaling. Genes Dev (2012) 1.17
Therapeutic approaches to modulating Notch signaling: current challenges and future prospects. Semin Cell Dev Biol (2012) 1.17
Disseminated breast cancer cells acquire a highly malignant and aggressive metastatic phenotype during metastatic latency in the bone. PLoS One (2012) 1.15
Selective small molecule Stat3 inhibitor reduces breast cancer tumor-initiating cells and improves recurrence free survival in a human-xenograft model. PLoS One (2012) 1.14
DNA replication licensing and cell cycle kinetics of normal and neoplastic breast. Br J Cancer (2005) 1.12
Tumor-initiating and -propagating cells: cells that we would like to identify and control. Neoplasia (2010) 1.11
Markers of tumor-initiating cells predict chemoresistance in breast cancer. PLoS One (2010) 1.10
Preinvasive breast cancer. Annu Rev Pathol (2010) 1.08
Progestins in hormone replacement therapies reactivate cancer stem cells in women with preexisting breast cancers: a hypothesis. J Clin Endocrinol Metab (2008) 1.07
N-cadherin/FGFR promotes metastasis through epithelial-to-mesenchymal transition and stem/progenitor cell-like properties. Oncogene (2013) 1.07
Expression of aldehyde dehydrogenase 1 as a marker of mammary stem cells in benign and malignant breast lesions of Ghanaian women. Cancer (2012) 1.03
Identification of vitronectin as an extrinsic inducer of cancer stem cell differentiation and tumor formation. Stem Cells (2010) 1.03
PDEF promotes luminal differentiation and acts as a survival factor for ER-positive breast cancer cells. Cancer Cell (2013) 1.01
A differential role for CXCR4 in the regulation of normal versus malignant breast stem cell activity. Oncotarget (2014) 1.00
Notch inhibitors as a new tool in the war on cancer: a pathway to watch. Curr Pharm Biotechnol (2009) 1.00
Adenomyoepithelial tumours and myoepithelial carcinomas of the breast--a spectrum of monophasic and biphasic tumours dominated by immature myoepithelial cells. BMC Cancer (2005) 1.00
Krüppel-like factor 8 promotes tumorigenic mammary stem cell induction by targeting miR-146a. Am J Cancer Res (2013) 0.99
A renal cell carcinoma with components of both chromophobe and papillary carcinoma. Virchows Arch (2006) 0.99
Transdifferentiation-inducing HCCR-1 oncogene. BMC Cell Biol (2010) 0.97
Determining mammosphere-forming potential: application of the limiting dilution analysis. J Mammary Gland Biol Neoplasia (2012) 0.97
EZH2 knockdown suppresses the growth and invasion of human inflammatory breast cancer cells. J Exp Clin Cancer Res (2013) 0.96
Characterization of human breast cancer epithelial cells (HBCEC) derived from long term cultured biopsies. J Exp Clin Cancer Res (2009) 0.96
The haemopoietic stem cell: between apoptosis and self renewal. Yale J Biol Med (2009) 0.96
The RNA-binding protein Musashi-1 regulates proteasome subunit expression in breast cancer- and glioma-initiating cells. Stem Cells (2014) 0.95
Interplay of Stem Cell Characteristics, EMT, and Microtentacles in Circulating Breast Tumor Cells. Cancers (Basel) (2013) 0.94
Clinical relevance of cancer stem cells in bone marrow of early breast cancer patients. Ann Oncol (2013) 0.94
Autophagy Supports Breast Cancer Stem Cell Maintenance by Regulating IL6 Secretion. Mol Cancer Res (2015) 0.93
MicroRNA100 inhibits self-renewal of breast cancer stem-like cells and breast tumor development. Cancer Res (2014) 0.93
Progesterone receptor action: defining a role in breast cancer. Expert Rev Endocrinol Metab (2011) 0.92
Protein kinase C-δ inactivation inhibits the proliferation and survival of cancer stem cells in culture and in vivo. BMC Cancer (2014) 0.91
Expression of EpCAM(MF) and EpCAM(MT) variants in human carcinomas. J Clin Pathol (2014) 0.91
Clinical-pathologic significance of cancer stem cell marker expression in familial breast cancers. Breast Cancer Res Treat (2013) 0.91
Evidence that GTP-binding domain but not catalytic domain of transglutaminase 2 is essential for epithelial-to-mesenchymal transition in mammary epithelial cells. Breast Cancer Res (2012) 0.90
Wound healing and cancer stem cells: inflammation as a driver of treatment resistance in breast cancer. Cancer Growth Metastasis (2015) 0.90
Endothelial cells provide a notch-dependent pro-tumoral niche for enhancing breast cancer survival, stemness and pro-metastatic properties. PLoS One (2014) 0.89
Expression of OCT4A: the first step to the next stage of urothelial bladder cancer progression. Int J Mol Sci (2014) 0.89
Expression and significance of notch signaling pathway in salivary adenoid cystic carcinoma. Ann Diagn Pathol (2013) 0.88
Tumor-initiating cells are enriched in CD44(hi) population in murine salivary gland tumor. PLoS One (2011) 0.87
MicroRNA-34a suppresses the breast cancer stem cell-like characteristics by downregulating Notch1 pathway. Cancer Sci (2015) 0.87
Endothelial derived factors inhibit anoikis of head and neck cancer stem cells. Oral Oncol (2011) 0.87
γ-Secretase inhibitor enhances antitumour effect of radiation in Notch-expressing lung cancer. Br J Cancer (2012) 0.85
Hbo1 is a cyclin E/CDK2 substrate that enriches breast cancer stem-like cells. Cancer Res (2013) 0.85
Putative biomarkers and targets of estrogen receptor negative human breast cancer. Int J Mol Sci (2011) 0.85
Role of the microenvironment in ovarian cancer stem cell maintenance. Biomed Res Int (2012) 0.85
Histone demethylase GASC1--a potential prognostic and predictive marker in invasive breast cancer. BMC Cancer (2012) 0.84
The mammary cellular hierarchy and breast cancer. Cell Mol Life Sci (2014) 0.84
Dormant Wnt-initiated mammary cancer can participate in reconstituting functional mammary glands. Mol Cell Biol (2006) 0.84
Cancer stem cells and side population cells in breast cancer and metastasis. Cancers (Basel) (2011) 0.84
Evolutionary dynamics of BRCA1 alterations in breast tumorigenesis. J Theor Biol (2010) 0.84
Fresh surgical specimens yield breast stem/progenitor cells and reveal their oncogenic abnormalities. Ann Surg Oncol (2011) 0.83
Dietary Sulforaphane in Cancer Chemoprevention: The Role of Epigenetic Regulation and HDAC Inhibition. Antioxid Redox Signal (2014) 0.83
Human lung adenocarcinoma cell cultures derived from malignant pleural effusions as model system to predict patients chemosensitivity. J Transl Med (2016) 0.83
Morphine promotes cancer stem cell properties, contributing to chemoresistance in breast cancer. Oncotarget (2015) 0.83
Stem cells, a two-edged sword: risks and potentials of regenerative medicine. World J Gastroenterol (2008) 0.82
Differentiation of human breast-milk stem cells to neural stem cells and neurons. Neurol Res Int (2014) 0.82
Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A (2003) 59.17
ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell (2007) 22.89
In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev (2003) 20.77
Identification of pancreatic cancer stem cells. Cancer Res (2007) 18.36
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature (2003) 14.35
Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci U S A (2007) 13.58
The prognostic role of a gene signature from tumorigenic breast-cancer cells. N Engl J Med (2007) 13.39
Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature (2003) 11.23
Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature (2009) 10.31
Applying the principles of stem-cell biology to cancer. Nat Rev Cancer (2003) 8.95
CDX2 as a Prognostic Biomarker in Stage II and Stage III Colon Cancer. N Engl J Med (2016) 8.53
Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells. Cell (2009) 8.33
Cancer stem cells: models and concepts. Annu Rev Med (2007) 8.06
Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature. Cancer Res (2009) 7.98
Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res (2006) 7.91
Single-cell dissection of transcriptional heterogeneity in human colon tumors. Nat Biotechnol (2011) 7.84
Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis. Cancer Res (2009) 6.43
The biology of cancer stem cells. Annu Rev Cell Dev Biol (2007) 6.23
Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells. Breast Cancer Res (2004) 5.60
BRCA1 regulates human mammary stem/progenitor cell fate. Proc Natl Acad Sci U S A (2008) 4.79
Self-renewal and solid tumor stem cells. Oncogene (2004) 4.60
Aldehyde dehydrogenase 1-positive cancer stem cells mediate metastasis and poor clinical outcome in inflammatory breast cancer. Clin Cancer Res (2009) 4.47
CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts. J Clin Invest (2010) 4.22
The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proc Natl Acad Sci U S A (2012) 4.20
Colorectal cancer stem cells are enriched in xenogeneic tumors following chemotherapy. PLoS One (2008) 3.97
Bmi1, stem cells, and senescence regulation. J Clin Invest (2004) 3.80
Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling. PLoS Biol (2009) 3.67
Isolation and molecular characterization of cancer stem cells in MMTV-Wnt-1 murine breast tumors. Stem Cells (2007) 3.60
DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency. Cell Stem Cell (2009) 3.48
Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia. Proc Natl Acad Sci U S A (2012) 3.21
Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks. Cancer Res (2011) 3.18
Breast cancer, stem/progenitor cells and the estrogen receptor. Trends Endocrinol Metab (2004) 3.10
Mammary stem cells, self-renewal pathways, and carcinogenesis. Breast Cancer Res (2005) 3.05
Therapeutic implications of cancer stem cells. Curr Opin Genet Dev (2004) 3.04
Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models. Proc Natl Acad Sci U S A (2010) 2.89
Implications of the cancer stem-cell hypothesis for breast cancer prevention and therapy. J Clin Oncol (2008) 2.87
Long-term haematopoietic reconstitution by Trp53-/-p16Ink4a-/-p19Arf-/- multipotent progenitors. Nature (2008) 2.82
Single-marker identification of head and neck squamous cell carcinoma cancer stem cells with aldehyde dehydrogenase. Head Neck (2010) 2.76
Dysregulated gene expression networks in human acute myelogenous leukemia stem cells. Proc Natl Acad Sci U S A (2009) 2.76
Breast cancer stem cells, cytokine networks, and the tumor microenvironment. J Clin Invest (2011) 2.62
Targeting breast cancer stem cells. J Clin Oncol (2010) 2.53
Aldehyde dehydrogenase in combination with CD133 defines angiogenic ovarian cancer stem cells that portend poor patient survival. Cancer Res (2011) 2.50
Activation of an IL6 inflammatory loop mediates trastuzumab resistance in HER2+ breast cancer by expanding the cancer stem cell population. Mol Cell (2012) 2.34
HER2 drives luminal breast cancer stem cells in the absence of HER2 amplification: implications for efficacy of adjuvant trastuzumab. Cancer Res (2013) 2.27
Chromosome 5q deletion and epigenetic suppression of the gene encoding alpha-catenin (CTNNA1) in myeloid cell transformation. Nat Med (2006) 2.23
Recent advances in cancer stem cells. Curr Opin Genet Dev (2008) 2.17
Survival of mammary stem cells in suspension culture: implications for stem cell biology and neoplasia. J Mammary Gland Biol Neoplasia (2005) 2.13
Cancer stem cells and radiotherapy: new insights into tumor radioresistance. J Natl Cancer Inst (2006) 2.10
Cancer stem cells: a step toward the cure. J Clin Oncol (2008) 2.08
Expression of aldehyde dehydrogenase and CD133 defines ovarian cancer stem cells. Int J Cancer (2011) 2.05
Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells. Cancer Res (2009) 2.04
Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells. Clin Cancer Res (2010) 1.96
Stimulation of natural killer cells with a CD137-specific antibody enhances trastuzumab efficacy in xenotransplant models of breast cancer. J Clin Invest (2012) 1.92
Sensitive capture of circulating tumour cells by functionalized graphene oxide nanosheets. Nat Nanotechnol (2013) 1.92
Regulation of cancer stem cells by cytokine networks: attacking cancer's inflammatory roots. Clin Cancer Res (2011) 1.91
Endothelial cell-initiated signaling promotes the survival and self-renewal of cancer stem cells. Cancer Res (2010) 1.88
Cancer stem cells and metastasis: lethal seeds. Clin Cancer Res (2006) 1.84
Circulating tumor cells: not all detected cells are bad and not all bad cells are detected. J Clin Oncol (2011) 1.79
Targeting breast stem cells with the cancer preventive compounds curcumin and piperine. Breast Cancer Res Treat (2009) 1.77
Cancer stem cells in breast: current opinion and future challenges. Pathobiology (2008) 1.77
Selective targeting of cancer stem cells: a new concept in cancer therapeutics. BioDrugs (2007) 1.76
Targeting breast cancer stem cells. Mol Oncol (2010) 1.72
Differential gene expression profiling of adult murine hematopoietic stem cells. Blood (2002) 1.69
Stem cells in mammary development and carcinogenesis: implications for prevention and treatment. Stem Cell Rev (2005) 1.65
HER-2, notch, and breast cancer stem cells: targeting an axis of evil. Clin Cancer Res (2009) 1.59
Bmi-1-green fluorescent protein-knock-in mice reveal the dynamic regulation of bmi-1 expression in normal and leukemic hematopoietic cells. Stem Cells (2007) 1.57
Retinoid signaling regulates breast cancer stem cell differentiation. Cell Cycle (2009) 1.56
Therapeutic implications of the cancer stem cell hypothesis. Semin Radiat Oncol (2009) 1.53
Cancer stem cells and tumor metastasis: first steps into uncharted territory. Cell Stem Cell (2007) 1.48
HER2-associated radioresistance of breast cancer stem cells isolated from HER2-negative breast cancer cells. Clin Cancer Res (2012) 1.47
MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11. Nat Commun (2013) 1.43
Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma. Clin Cancer Res (2013) 1.43
Point: cancer stem cells--the evidence accumulates. Clin Chem (2012) 1.43
Hematopoietic stem cell self-renewal. Curr Opin Genet Dev (2006) 1.42
A genetic determinant that specifically regulates the frequency of hematopoietic stem cells. J Immunol (2002) 1.41
Cancer stem cell vaccination confers significant antitumor immunity. Cancer Res (2012) 1.39
MicroRNA93 regulates proliferation and differentiation of normal and malignant breast stem cells. PLoS Genet (2012) 1.38
An embryonic stem cell-like signature identifies poorly differentiated lung adenocarcinoma but not squamous cell carcinoma. Clin Cancer Res (2009) 1.38
Identification of a cKit(+) colonic crypt base secretory cell that supports Lgr5(+) stem cells in mice. Gastroenterology (2012) 1.32
Role of microRNAs in the regulation of breast cancer stem cells. J Mammary Gland Biol Neoplasia (2012) 1.25
Effects of time since fire on birds: how informative are generalized fire response curves for conservation management? Ecol Appl (2012) 1.22
Preclinical and clinical studies of gamma secretase inhibitors with docetaxel on human breast tumors. Clin Cancer Res (2013) 1.20
Automated microfluidic chromatin immunoprecipitation from 2,000 cells. Lab Chip (2009) 1.17
Ablation of breast cancer stem cells with radiation. Transl Oncol (2011) 1.15
HER2 and breast cancer stem cells: more than meets the eye. Cancer Res (2013) 1.14
Usp16 contributes to somatic stem-cell defects in Down's syndrome. Nature (2013) 1.13
Mammary stem cell number as a determinate of breast cancer risk. Breast Cancer Res (2007) 1.12
Colon cancer stem cells: implications for prevention and therapy. Trends Mol Med (2008) 1.12
Implications of cancer stem cell theory for cancer chemoprevention by natural dietary compounds. J Nutr Biochem (2011) 1.10
MicroRNA-30c targets cytoskeleton genes involved in breast cancer cell invasion. Breast Cancer Res Treat (2012) 1.07
Distinct FAK activities determine progenitor and mammary stem cell characteristics. Cancer Res (2013) 1.04
Cancer stem cells: implications for cancer treatment and prevention. Cancer J (2007) 1.04
Cancer stem cell heterogeneity in hereditary breast cancer. Breast Cancer Res (2008) 1.04
Innate immune response to homologous rotavirus infection in the small intestinal villous epithelium at single-cell resolution. Proc Natl Acad Sci U S A (2012) 0.99