Published in J Cell Sci on May 15, 2005
Phosphoinositides: tiny lipids with giant impact on cell regulation. Physiol Rev (2013) 3.21
Loss of endocytic clathrin-coated pits upon acute depletion of phosphatidylinositol 4,5-bisphosphate. Proc Natl Acad Sci U S A (2007) 2.52
Active Arf6 recruits ARNO/cytohesin GEFs to the PM by binding their PH domains. Mol Biol Cell (2007) 2.15
Exo70 interacts with phospholipids and mediates the targeting of the exocyst to the plasma membrane. EMBO J (2007) 2.03
Phosphatidylinositol 4,5-bisphosphate regulates SNARE-dependent membrane fusion. J Cell Biol (2008) 1.89
Phosphatidylinositol 4,5-bisphosphate mediates the targeting of the exocyst to the plasma membrane for exocytosis in mammalian cells. Mol Biol Cell (2007) 1.77
Coincidence detection in phosphoinositide signaling. Trends Cell Biol (2005) 1.57
Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPases. EMBO J (2006) 1.57
Atg18 regulates organelle morphology and Fab1 kinase activity independent of its membrane recruitment by phosphatidylinositol 3,5-bisphosphate. Mol Biol Cell (2007) 1.52
The Sec14 superfamily and mechanisms for crosstalk between lipid metabolism and lipid signaling. Trends Biochem Sci (2009) 1.46
Molecular Basis for Cooperative Binding of Anionic Phospholipids to the PH Domain of the Arf GAP ASAP1. Structure (2015) 1.45
Phospholipase C-mediated hydrolysis of PIP2 releases ERM proteins from lymphocyte membrane. J Cell Biol (2009) 1.41
Phosphoinositide signaling: new tools and insights. Physiology (Bethesda) (2009) 1.41
Assembly of a Fab1 phosphoinositide kinase signaling complex requires the Fig4 phosphoinositide phosphatase. Mol Biol Cell (2008) 1.40
Coordinated regulation of AP2 uncoating from clathrin-coated vesicles by rab5 and hRME-6. J Cell Biol (2008) 1.31
Krit 1 interactions with microtubules and membranes are regulated by Rap1 and integrin cytoplasmic domain associated protein-1. FEBS J (2007) 1.25
The clathrin adaptor Gga2p is a phosphatidylinositol 4-phosphate effector at the Golgi exit. Mol Biol Cell (2008) 1.17
Two novel phosphatidylinositol-4-phosphate 5-kinase type Igamma splice variants expressed in human cells display distinctive cellular targeting. Biochem J (2009) 1.17
ARL4D recruits cytohesin-2/ARNO to modulate actin remodeling. Mol Biol Cell (2007) 1.16
Phosphoinositides and vesicular membrane traffic. Biochim Biophys Acta (2012) 1.14
Phospholipase D in endocytosis and endosomal recycling pathways. Biochim Biophys Acta (2009) 1.12
Pathogen destruction versus intracellular survival: the role of lipids as phagosomal fate determinants. J Clin Invest (2008) 1.10
Rapid turnover rate of phosphoinositides at the front of migrating MDCK cells. Mol Biol Cell (2008) 1.06
Quantitative analysis of the binding of ezrin to large unilamellar vesicles containing phosphatidylinositol 4,5 bisphosphate. Biophys J (2007) 1.04
Dynamic regulation of mammalian numb by G protein-coupled receptors and protein kinase C activation: Structural determinants of numb association with the cortical membrane. Mol Biol Cell (2006) 1.04
Structural basis of membrane targeting by the Dock180 family of Rho family guanine exchange factors (Rho-GEFs). J Biol Chem (2010) 1.04
Enteropathogenic Escherichia coli subverts phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate upon epithelial cell infection. Mol Biol Cell (2008) 1.03
PTPL1: a large phosphatase with a split personality. Cancer Metastasis Rev (2008) 1.00
The cellular and physiological functions of the Lowe syndrome protein OCRL1. Traffic (2014) 0.99
Quantification of PtdIns(3,4,5)P(3) dynamics in EGF-stimulated carcinoma cells: a comparison of PH-domain-mediated methods with immunological methods. Biochem J (2008) 0.99
Lipid profiling of rat peritoneal surface layers by online normal- and reversed-phase 2D LC QToF-MS. J Lipid Res (2010) 0.96
Acute depletion of plasma membrane phosphatidylinositol 4,5-bisphosphate impairs specific steps in endocytosis of the G-protein-coupled receptor. J Cell Sci (2012) 0.95
Membrane binding and bending in Ebola VP40 assembly and egress. Front Microbiol (2014) 0.95
The PH domain proteins IPIP27A and B link OCRL1 to receptor recycling in the endocytic pathway. Mol Biol Cell (2011) 0.94
Activation of moesin, a protein that links actin cytoskeleton to the plasma membrane, occurs by phosphatidylinositol 4,5-bisphosphate (PIP2) binding sequentially to two sites and releasing an autoinhibitory linker. J Biol Chem (2012) 0.93
Resurrection of a functional phosphatidylinositol transfer protein from a pseudo-Sec14 scaffold by directed evolution. Mol Biol Cell (2011) 0.93
A PH domain in the Arf GTPase-activating protein (GAP) ARAP1 binds phosphatidylinositol 3,4,5-trisphosphate and regulates Arf GAP activity independently of recruitment to the plasma membranes. J Biol Chem (2009) 0.92
Eukaryotic elongation factor 1A2 cooperates with phosphatidylinositol-4 kinase III beta to stimulate production of filopodia through increased phosphatidylinositol-4,5 bisphosphate generation. Mol Cell Biol (2008) 0.91
The homolog of the five SH3-domain protein (HOFI/SH3PXD2B) regulates lamellipodia formation and cell spreading. PLoS One (2011) 0.91
Cellular and molecular interactions of phosphoinositides and peripheral proteins. Chem Phys Lipids (2014) 0.89
The CMT4B disease-causing proteins MTMR2 and MTMR13/SBF2 regulate AKT signalling. J Cell Mol Med (2011) 0.89
Cooperative phosphoinositide and peptide binding by PSD-95/discs large/ZO-1 (PDZ) domain of polychaetoid, Drosophila zonulin. J Biol Chem (2011) 0.87
Phosphoinositides in the mammalian endo-lysosomal network. Subcell Biochem (2012) 0.87
Phosphatidylinositol 4-phosphate 5-kinase α facilitates Toll-like receptor 4-mediated microglial inflammation through regulation of the Toll/interleukin-1 receptor domain-containing adaptor protein (TIRAP) location. J Biol Chem (2013) 0.86
A role for diacylglycerol in annexin A7-mediated fusion of lung lamellar bodies. Biochim Biophys Acta (2007) 0.85
Structural basis for different phosphoinositide specificities of the PX domains of sorting nexins regulating G-protein signaling. J Biol Chem (2014) 0.85
Phosphoinositide binding by the SNX27 FERM domain regulates its localization at the immune synapse of activated T-cells. J Cell Sci (2015) 0.82
Thyroid hormone treatments differentially affect the temperature kinetics properties of FoF1 ATPase and succinate oxidase as well as the lipid/phospholipid profiles of rat kidney mitochondria: a correlative study. J Membr Biol (2007) 0.82
Charcot-Marie-Tooth disease and intracellular traffic. Prog Neurobiol (2012) 0.81
Phosphatidylinositol phosphate kinase PIPKIγ and phosphatase INPP5E coordinate initiation of ciliogenesis. Nat Commun (2016) 0.81
Phosphatidylinositol 4,5-bisphosphate is an HCV NS5A ligand and mediates replication of the viral genome. Gastroenterology (2014) 0.81
Plant actin-binding protein SCAB1 is dimeric actin cross-linker with atypical pleckstrin homology domain. J Biol Chem (2012) 0.81
Neuronal porosome lipidome. J Cell Mol Med (2014) 0.79
Hitchhiking on the heptahelical highway: structure and function of 7TM receptor complexes. Nat Rev Mol Cell Biol (2016) 0.79
Endosomal targeting of the phosphoinositide 3-phosphatase MTMR2 is regulated by an N-terminal phosphorylation site. J Biol Chem (2011) 0.79
Genome-wide association study revealed a promising region and candidate genes for eggshell quality in an F2 resource population. BMC Genomics (2015) 0.79
Profiling lipid-protein interactions using nonquenched fluorescent liposomal nanovesicles and proteome microarrays. Mol Cell Proteomics (2012) 0.79
Schizosaccharomyces pombe Sst4p, a conserved Vps27/Hrs homolog, functions downstream of phosphatidylinositol 3-kinase Pik3p to mediate proper spore formation. Eukaryot Cell (2007) 0.78
Phosphoinositide turnover in Toll-like receptor signaling and trafficking. BMB Rep (2014) 0.78
Insulin/IGF-1 signaling, including class II/III PI3Ks, β-arrestin and SGK-1, is required in C. elegans to maintain pharyngeal muscle performance during starvation. PLoS One (2013) 0.78
Interactions of Pleckstrin Homology Domains with Membranes: Adding Back the Bilayer via High-Throughput Molecular Dynamics. Structure (2016) 0.78
Combined treatment with Myo-inositol and selenium ensures euthyroidism in subclinical hypothyroidism patients with autoimmune thyroiditis. J Thyroid Res (2013) 0.78
Human junctophilin-2 undergoes a structural rearrangement upon binding PtdIns(3,4,5)P3 and the S101R mutation identified in hypertrophic cardiomyopathy obviates this response. Biochem J (2013) 0.78
SLAT promotes TCR-mediated, Rap1-dependent LFA-1 activation and adhesion through interaction of its PH domain with Rap1. J Cell Sci (2015) 0.77
Endocytic pathways and endosomal trafficking: a primer. Wien Med Wochenschr (2016) 0.77
Differential functions of phospholipid binding and palmitoylation of tumour suppressor EWI2/PGRL. Biochem J (2011) 0.77
Phospho-Tyrosine(s) vs. Phosphatidylinositol Binding in Shc Mediated Integrin Signaling. Am J Mol Biol (2015) 0.77
Structural elements that govern Sec14-like PITP sensitivities to potent small molecule inhibitors. J Lipid Res (2016) 0.76
Phosphatidylinositol phosphates directly bind to neurofilament light chain (NF-L) for the regulation of NF-L self assembly. Exp Mol Med (2011) 0.76
The Arabidopsis thaliana immunophilin ROF1 directly interacts with PI(3)P and PI(3,5)P2 and affects germination under osmotic stress. PLoS One (2012) 0.76
Allosteric properties of PH domains in Arf regulatory proteins. Cell Logist (2016) 0.76
Prediction of functional class of proteins and peptides irrespective of sequence homology by support vector machines. Bioinform Biol Insights (2009) 0.76
The C2 domains of granuphilin are high-affinity sensors for plasma membrane lipids. Chem Phys Lipids (2013) 0.76
A role for novel lipid interactions in the dynamic recruitment of SNX27 to the T-cell immune synapse. Bioarchitecture (2015) 0.75
Molecular insights into the binding of phosphoinositides to the TH domain region of TIPE proteins. J Mol Model (2016) 0.75