Published in Nucleic Acids Res on May 13, 2005
Unusual intron conservation near tissue-regulated exons found by splicing microarrays. PLoS Comput Biol (2006) 4.63
The importance of CELF control: molecular and biological roles of the CUG-BP, Elav-like family of RNA-binding proteins. Wiley Interdiscip Rev RNA (2011) 1.54
Identification of MBNL1 and MBNL3 domains required for splicing activation and repression. Nucleic Acids Res (2010) 1.20
Posttranscriptional regulation of gene networks by GU-rich elements and CELF proteins. RNA Biol (2008) 1.18
The disruption of Celf6, a gene identified by translational profiling of serotonergic neurons, results in autism-related behaviors. J Neurosci (2013) 1.05
Regulation of CUG-binding protein 1 (CUGBP1) binding to target transcripts upon T cell activation. J Biol Chem (2011) 1.02
Antagonistic regulation of mRNA expression and splicing by CELF and MBNL proteins. Genome Res (2015) 1.00
Position-dependent and neuron-specific splicing regulation by the CELF family RNA-binding protein UNC-75 in Caenorhabditis elegans. Nucleic Acids Res (2013) 0.99
CUG-BP, Elav-like family (CELF)-mediated alternative splicing regulation in the brain during health and disease. Mol Cell Neurosci (2012) 0.98
CUGBP2 directly interacts with U2 17S snRNP components and promotes U2 snRNA binding to cardiac troponin T pre-mRNA. Nucleic Acids Res (2009) 0.97
Characterization of sequences and mechanisms through which ISE/ISS-3 regulates FGFR2 splicing. Nucleic Acids Res (2006) 0.93
CELF family RNA-binding protein UNC-75 regulates two sets of mutually exclusive exons of the unc-32 gene in neuron-specific manners in Caenorhabditis elegans. PLoS Genet (2013) 0.90
Combinatorial mutagenesis of MBNL1 zinc fingers elucidates distinct classes of regulatory events. Mol Cell Biol (2012) 0.87
Evaluating the effects of CELF1 deficiency in a mouse model of RNA toxicity. Hum Mol Genet (2013) 0.87
CELFish ways to modulate mRNA decay. Biochim Biophys Acta (2013) 0.87
Reduced Expression of RNA Binding Protein CELF2, a Putative Tumor Suppressor Gene in Colon Cancer. Immunogastroenterology (2012) 0.87
Activation and repression functions of an SR splicing regulator depend on exonic versus intronic-binding position. Nucleic Acids Res (2011) 0.86
The C2H2 zinc-finger protein SYD-9 is a putative posttranscriptional regulator for synaptic transmission. Proc Natl Acad Sci U S A (2006) 0.85
Alternative splicing produces structural and functional changes in CUGBP2. BMC Biochem (2012) 0.82
CELF RNA binding proteins promote axon regeneration in C. elegans and mammals through alternative splicing of Syntaxins. Elife (2016) 0.82
All three RNA recognition motifs and the hinge region of HuC play distinct roles in the regulation of alternative splicing. Nucleic Acids Res (2013) 0.81
Position-dependent activity of CELF2 in the regulation of splicing and implications for signal-responsive regulation in T cells. RNA Biol (2016) 0.77
Ancient antagonism between CELF and RBFOX families tunes mRNA splicing outcomes. Genome Res (2017) 0.75
Finishing the euchromatic sequence of the human genome. Nature (2004) 41.40
Mechanisms of alternative pre-messenger RNA splicing. Annu Rev Biochem (2003) 21.11
Alternative pre-mRNA splicing: the logic of combinatorial control. Trends Biochem Sci (2000) 7.54
Alternative splicing of pre-mRNA: developmental consequences and mechanisms of regulation. Annu Rev Genet (1998) 7.15
Disruption of splicing regulated by a CUG-binding protein in myotonic dystrophy. Science (1998) 6.67
Alternative splicing in the human, mouse and rat genomes is associated with an increased frequency of exon creation and/or loss. Nat Genet (2003) 6.09
Aberrant regulation of insulin receptor alternative splicing is associated with insulin resistance in myotonic dystrophy. Nat Genet (2001) 4.48
Autoregulation of polypyrimidine tract binding protein by alternative splicing leading to nonsense-mediated decay. Mol Cell (2004) 4.13
Loss of the muscle-specific chloride channel in type 1 myotonic dystrophy due to misregulated alternative splicing. Mol Cell (2002) 4.05
Muscleblind proteins regulate alternative splicing. EMBO J (2004) 4.01
How prevalent is functional alternative splicing in the human genome? Trends Genet (2004) 3.81
The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing. Mol Cell Biol (2001) 3.68
A vertebrate RNA-binding protein Fox-1 regulates tissue-specific splicing via the pentanucleotide GCAUG. EMBO J (2003) 3.44
Dynamic antagonism between ETR-3 and PTB regulates cell type-specific alternative splicing. Mol Cell (2002) 2.27
Identification of putative new splicing targets for ETR-3 using sequences identified by systematic evolution of ligands by exponential enrichment. Mol Cell Biol (2005) 2.03
A single cardiac troponin T gene generates embryonic and adult isoforms via developmentally regulated alternate splicing. J Biol Chem (1985) 1.99
Muscle-specific splicing enhancers regulate inclusion of the cardiac troponin T alternative exon in embryonic skeletal muscle. Mol Cell Biol (1996) 1.81
Region-specific alternative splicing in the nervous system: implications for regulation by the RNA-binding protein NAPOR. RNA (2002) 1.65
A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator. J Biol Chem (2000) 1.62
Antagonistic regulation of alpha-actinin alternative splicing by CELF proteins and polypyrimidine tract binding protein. RNA (2003) 1.47
CELF6, a member of the CELF family of RNA-binding proteins, regulates muscle-specific splicing enhancer-dependent alternative splicing. J Biol Chem (2004) 1.43
Muscle-specific splicing of a heterologous exon mediated by a single muscle-specific splicing enhancer from the cardiac troponin T gene. Mol Cell Biol (1998) 1.22
ETR-3 and CELF4 protein domains required for RNA binding and splicing activity in vivo. Nucleic Acids Res (2004) 1.16
Multiple domains control the subcellular localization and activity of ETR-3, a regulator of nuclear and cytoplasmic RNA processing events. J Cell Sci (2004) 1.11
The Drosophila Bruno paralogue Bru-3 specifically binds the EDEN translational repression element. Nucleic Acids Res (2004) 1.11
An analysis of the sequence requirements of EDEN-BP for specific RNA binding. Nucleic Acids Res (2002) 1.06
Pre-mRNA splicing and human disease. Genes Dev (2003) 9.13
Splicing in disease: disruption of the splicing code and the decoding machinery. Nat Rev Genet (2007) 7.42
Finding signals that regulate alternative splicing in the post-genomic era. Genome Biol (2002) 4.73
RNA-mediated neuromuscular disorders. Annu Rev Neurosci (2006) 4.24
Loss of the muscle-specific chloride channel in type 1 myotonic dystrophy due to misregulated alternative splicing. Mol Cell (2002) 4.05
Muscleblind proteins regulate alternative splicing. EMBO J (2004) 4.01
Expression of 24,426 human alternative splicing events and predicted cis regulation in 48 tissues and cell lines. Nat Genet (2008) 3.78
The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo. Proc Natl Acad Sci U S A (2011) 3.40
A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart. Proc Natl Acad Sci U S A (2008) 3.33
Functional consequences of developmentally regulated alternative splicing. Nat Rev Genet (2011) 3.27
Increased steady-state levels of CUGBP1 in myotonic dystrophy 1 are due to PKC-mediated hyperphosphorylation. Mol Cell (2007) 3.26
Transgenic mice expressing CUG-BP1 reproduce splicing mis-regulation observed in myotonic dystrophy. Hum Mol Genet (2005) 2.59
The pathobiology of splicing. J Pathol (2010) 2.52
Pathogenic mechanisms of myotonic dystrophy. Biochem Soc Trans (2009) 2.32
Colocalization of muscleblind with RNA foci is separable from mis-regulation of alternative splicing in myotonic dystrophy. J Cell Sci (2005) 2.31
Dynamic antagonism between ETR-3 and PTB regulates cell type-specific alternative splicing. Mol Cell (2002) 2.27
Pre-mRNA splicing in disease and therapeutics. Trends Mol Med (2012) 2.23
Elevation of RNA-binding protein CUGBP1 is an early event in an inducible heart-specific mouse model of myotonic dystrophy. J Clin Invest (2007) 2.14
Identification of putative new splicing targets for ETR-3 using sequences identified by systematic evolution of ligands by exponential enrichment. Mol Cell Biol (2005) 2.03
Dynamic balance between activation and repression regulates pre-mRNA alternative splicing during heart development. Dev Dyn (2005) 1.95
Expanded CTG repeats within the DMPK 3' UTR causes severe skeletal muscle wasting in an inducible mouse model for myotonic dystrophy. Proc Natl Acad Sci U S A (2008) 1.94
MBNL1 and CUGBP1 modify expanded CUG-induced toxicity in a Drosophila model of myotonic dystrophy type 1. Hum Mol Genet (2006) 1.77
Antagonistic regulation of alpha-actinin alternative splicing by CELF proteins and polypyrimidine tract binding protein. RNA (2003) 1.47
CUGBP1 overexpression in mouse skeletal muscle reproduces features of myotonic dystrophy type 1. Hum Mol Genet (2010) 1.44
CELF6, a member of the CELF family of RNA-binding proteins, regulates muscle-specific splicing enhancer-dependent alternative splicing. J Biol Chem (2004) 1.43
RNase H-mediated degradation of toxic RNA in myotonic dystrophy type 1. Proc Natl Acad Sci U S A (2012) 1.40
Global regulation of alternative splicing during myogenic differentiation. Nucleic Acids Res (2010) 1.39
Cardiac tissue-specific repression of CELF activity disrupts alternative splicing and causes cardiomyopathy. Mol Cell Biol (2005) 1.35
Heart-specific overexpression of CUGBP1 reproduces functional and molecular abnormalities of myotonic dystrophy type 1. Hum Mol Genet (2010) 1.35
Minigene reporter for identification and analysis of cis elements and trans factors affecting pre-mRNA splicing. Biotechniques (2006) 1.30
A bichromatic fluorescent reporter for cell-based screens of alternative splicing. Nucleic Acids Res (2006) 1.26
Alternative splicing in disease. Adv Exp Med Biol (2007) 1.22
MicroRNAs coordinate an alternative splicing network during mouse postnatal heart development. Genes Dev (2010) 1.22
Identification of MBNL1 and MBNL3 domains required for splicing activation and repression. Nucleic Acids Res (2010) 1.20
PKC inhibition ameliorates the cardiac phenotype in a mouse model of myotonic dystrophy type 1. J Clin Invest (2009) 1.19
Misregulation of alternative splicing causes pathogenesis in myotonic dystrophy. Prog Mol Subcell Biol (2006) 1.16
ETR-3 and CELF4 protein domains required for RNA binding and splicing activity in vivo. Nucleic Acids Res (2004) 1.16
Multiple domains control the subcellular localization and activity of ETR-3, a regulator of nuclear and cytoplasmic RNA processing events. J Cell Sci (2004) 1.11
RNA-binding proteins in microsatellite expansion disorders: mediators of RNA toxicity. Brain Res (2012) 1.11
Alternative splicing dysregulation secondary to skeletal muscle regeneration. Ann Neurol (2011) 1.09
Myotonic dystrophy mouse models: towards rational therapy development. Trends Mol Med (2011) 1.07
CUGBP2 directly interacts with U2 17S snRNP components and promotes U2 snRNA binding to cardiac troponin T pre-mRNA. Nucleic Acids Res (2009) 0.97
Reexpression of pyruvate kinase M2 in type 1 myofibers correlates with altered glucose metabolism in myotonic dystrophy. Proc Natl Acad Sci U S A (2013) 0.92
Expression, localization and tau exon 10 splicing activity of the brain RNA-binding protein TNRC4. Hum Mol Genet (2007) 0.90
Myotonic dystrophy: discussion of molecular basis. Adv Exp Med Biol (2002) 0.85
Muscleblind-like 1 activates insulin receptor exon 11 inclusion by enhancing U2AF65 binding and splicing of the upstream intron. Nucleic Acids Res (2013) 0.84
Antisense oligonucleotides: rising stars in eliminating RNA toxicity in myotonic dystrophy. Hum Gene Ther (2013) 0.80
Micromanaging alternative splicing during muscle differentiation. Dev Cell (2007) 0.78
RNA-binding proteins in heart development. Adv Exp Med Biol (2014) 0.78
In Brief: (mis)splicing in disease. J Pathol (2014) 0.75
Regulating mRNA complexity in the mammalian brain. Nat Genet (2011) 0.75
Regulation of chloride ion conductance during skeletal muscle development and in disease. Focus on "Chloride channelopathy in myotonic dystrophy resulting from loss of posttranscriptional regulation for CLCN1". Am J Physiol Cell Physiol (2007) 0.75
International Anesthesia Research Society Annual Meeting: then & now. Anesth Analg (2012) 0.75
BNA(NC) gapmers revert splicing and reduce RNA foci with low toxicity in myotonic dystrophy cells. ACS Chem Biol (2017) 0.75